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| 1 | Transplantation of engineered exosomes derived from bone marrow mesenchymal stromal cells ameliorate diabetic peripheral neuropathy under electrical stimulation显示文摘Diabetic peripheral neuropathy(DPN)is a long-term complication associated with nerve dysfunction and uncontrolled hyperglycemia.In spite of new drug discoveries,development of effective therapy is much needed to cure DPN.Here,we have developed a combinatorial approach to provide biochemical and electrical cues,considered to be important for nerve regeneration.Exosomes derived from bone marrow mesenchymal stromal cells(BMSCs)were fused with polypyrrole nanoparticles(PpyNps)containing liposomes to deliver both the cues in a single delivery vehicle.We developed DPN rat model and injected intramuscularly the fused exosomal system to understand its long-term therapeutic effect.We found that the fused system along with electrical stimulation normalized the nerve conduction velocity(57.60±0.45 m/s)and compound muscle action potential(16.96±0.73 mV)similar to healthy control(58.53±1.10 m/s;18.19±1.45 mV).Gastrocnemius muscle morphology,muscle mass,and integrity were recovered after treatment.Interestingly,we also observed paracrine effect of delivered exosomes in controlling hyperglycemia and loss in body weight and also showed attenuation of damage to the tissues such as the pancreas,kidney,and liver.This work provides a promising effective treatment and also contribute cutting edge therapeutic approach for the treatment of DPN. | Anamika Singh Alok Raghav Parvaiz Ahmad Shiekh Ashok Kumar | 2021 | Bioactive Materials2021，6，8： | 4 |
| 2 | Tunable photonic crystals based on ferroelectric and ferromagnetic materials by focused ion beam显示文摘By making photonic crystals in ferroelectric and ferromagnetic materials,field-provoked tunability of photonic crystals is broadening the interest in new applications of on-chip photonic devices.We report a nano-precise fabrication of various designs of photonic crystals in these non-conventional materials using the focused ion beam milling technique.Standard methods are developed and parameters for different materials are calibrated.Optical responses such as bandgaps and polarization status changing from planar film waveguide system with these patterns have been examined on ferromagnetic materials. | Ziyou Zhou Xiaoyue Huang Raghav Vanga Rong Li | 2007 | Chinese Optics Letters2007，5，12： | 3 |
| 3 | Recent advances in production,purification and applications of phycobiliproteins显示文摘An obligatory sunlight requirement for photosynthesis has exposed cyanobacteria to different quantity and quality of light. Cyanobacteria can exhibit efficient photosynthesis over broad region(450 to 650 nm) of solar spectrum with the help of brilliantly coloured pigment proteins called phycobiliproteins(PBPs). Besides light-harvesting, PBPs are found to involve in several life sustaining phenomena including photoprotection in cyanobacteria. The unique spectral features(like strong absorbance and fluorescence), proteineous nature and, some imperative properties like hepato-protective, antioxidants, anti-inflammatory and anti-aging activity of PBPs enable their use in food, cosmetics, pharmaceutical and biomedical industries. PBPs have been also noted to show beneficial effect in therapeutics of some disease like Alzheimer and cancer. Such large range of applications increases the demand of PBPs in commodity market. Therefore, the large-scale and coast effective production of PBPs is the real need of time. To fulfil this need, many researchers have been working to find the potential producer of PBPs for the production and purification of PBPs. Results of these efforts have caused the inventions of some novel techniques like mixotrophic and heterotrophic strategies for production and aqueous two phase separation for purification purpose. Overall, the present review summarises the recent findings and identifies gaps in the field of production, purification and applications of this biological and economically important proteins. | Ravi Raghav Sonani Rajesh Prasad Rastogi Rutvij Patel Datta Madamwar | 2016 | World Journal of Biological Chemistry2016，7，1： | 2 |
| 4 | Imaging Electronic Structure of Carbon Nanotubes by Voltage-Contrast Scanning Electron Microscopy显示文摘We introduce voltage-contrast scanning electron microscopy(VC-SEM)for visual characterization of the electronic properties of single-walled carbon nanotubes.VC-SEM involves tuning the electronic band structure and imaging the potential profi le along the length of the nanotube.The resultant secondary electron contrast allows to distinguish between metallic and semiconducting carbon nanotubes and to follow the switching of semiconducting nanotube devices,as confi rmed by in situ electrical transport measurements.We demonstrate that high-density arrays of individual nanotube devices can be rapidly and simultaneously characterized.A leakage current model in combination with fi nite element simulations of the device electrostatics is presented in order to explain the observed contrast evolution of the nanotube and surface electrodes.This work serves to fi ll a void in electronic characterization of molecular device architectures. | Aravind Vijayaraghavan Sabine Blatt Christoph Marquardt Simone Dehm Raghav Wahi Frank Hennrich Ralph Krupke | 2008 | Nano Research2008，1，4： | 2 |
| 5 | A trust-based consumer decision-making model in electronic commerce: The role of trust, perceived risk, and their antecedents显示文摘 | Dan J. Kim Donald L. Ferrin H. Raghav Rao | 2007 | Decision Support Systems2007，，2： | 2 |
| 6 | Management and outcomes of hetero- taxy syndrome associated with pulmonary atresia or pulmonary stenosis 显示文摘 | Vinod AS Javier B Raghav M | 2014 | AnnThnracSurg2014，98，6： | 1 |
| 7 | Inflammatory- linear verrueous epi- dermal nevus syndrome with its polymorphie presentation - A rare case report显示文摘 | Kumar CA Yeluri G Raghav N | 2012 | Contemp Clin Dent2012，3，1： | 1 |
| 8 | An insight into molecular mechanisms of human T helper cell differentiation显示文摘 | Rautajoki KJ Kylaniemi MK Raghav SK | 2008 | Ann Med2008，40，5： | 1 |
| 9 | Fatigue behavior of internally ring-stiffened welded steel tubular steel tubular joints 显示文摘 | GANDHI P RAGHAVE G RAMACHANDRA M D S | 2000 | Journal of Structural Engineering ASCE2000，126，7： | 1 |
| 10 | Purification and characterization of Enterobacter sakazakii enterotoxin 显示文摘 | Raghav M Aggarwal PK | 2007 | Can Microbiol2007，53，6： | 1 |
| 11 | The Effect of Pre-and Post-service Performance on Consumer Evaluation of Online Retailers显示文摘 | Park Insu Cho Jeewon Rao H Raghav | 2012 | Decision Support Systems2012，52，2： | 1 |
| 12 | Reversible antifertility effect of aqueous rhizome extract of Curcuma longa L. in male laboratory mice显示文摘 | Raghav Kumar Mishra Shio Kumar Singh | 2009 | Contraception2009，，6： | 1 |
| 13 | Enhanced heterodim- erization of Bax by Bcl-2 mutants improves irradiated cell sur- vival显示文摘 | VERMA YK RAGHAV PK RAJ HG | 2013 | Apoptosis2013，18，2： | 1 |
| 14 | Purification and characterization of En- terobacter sakazakii enterotoxin 显示文摘 | Raghav M Aggarwal PK | 2007 | Can J Microbiol2007，53，6： | 1 |
| 15 | An adaptive fuzzy thresholding algorithm for exon prediction显示文摘 | Ankit Agrawal Ankush Mittal Rahul Jain Raghav Takkar | 2008 | IEEE ICCCET2008，，： | 1 |
| 16 | Approach towards zero discharge tanning:Exploration of NaOH based opening up method显示文摘 | Thanikaivelan P Raghav Rao J Nair B U | 2001 | JALCA2001，96，6： | 1 |
| 17 | Enhanced heterodimerizationof Bax by Bcl-2 mutants improves irradiated cell survival 显示文摘 | Verma YK Raghav PK Raj HG | 2013 | Apop-tosis2013，18，2： | 1 |
| 18 | An insight into mo- lecular mechanisms of human T helper cell differentiation显示文摘 | Rautajoki KJ Kylaniemi MK Raghav SK | 2008 | Ann Med2008，40，5： | 1 |
| 19 | Neurological sequelae of intrauterine warfarin exposure显示文摘 | Raghav S Reutens D | 2007 | Journal of Clinical Neuroscience2007，14，2： | 1 |
| 20 | TNF-A-based ac- centuation in cryoinjury-dose, delivery, and response显示文摘 | Raghav Goel David Swanlund James Coad | 2007 | Molecular Cancer Therapeutics2007，6，7： | 1 |
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