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		题名	作者	年代	出处	被引量
	1	Hepatocellular carcinoma: Will novel targeted drugs really impact the next future?显示文摘Cancer treatment has been revolutionized by the advent of new molecular targeted and immunotherapeutic agents. Identification of the role of tumor angiogenesis changed the understanding of many tumors. After the unsuccessful results with chemotherapy, sorafenib, by interfering with angiogenic pathways, has become pivotal in the treatment of hepatocellular carcinoma. Sorafenib is the only systemic treatment to show a modest but statistically significant survival benefit. All novel drugs and strategies for treatment of advanced hepatocellular carcinoma must be compared with the results obtained with sorafenib, but no new drug or drug combination has yet achieved better results. In our opinion, the efforts to impact the natural history of the disease will be directed not only to drug development but also to understanding the underlying liver disease(usually hepatitis B virus- or hepatitis C virus-related) and to interrupting the progression of cirrhosis. It will be important to define the role and amount of mutations in the complex pathogenesis of hepatocellular carcinoma and to better integrate locoregional and systemic therapies. It will be important also to optimize the therapeutic strategies with existing chemotherapeutic drugs and new targeted agents.	Liliana Montella Giovannella Palmieri Raffaele Addeo Salvatore Del Prete	2016	World Journal of Gastroenterology2016，22，27：	3
	2	Concomitant treatment of brain metastasis with WholeBrain Radiotherapyand Temozolomideis activeand improves Quality of Life显示文摘	RAFFAELE ADDEO MICHELE CARAGLIA VINCENZO FAIO-LA	2007	BMC Cancer2007，7，：	1

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