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| 1 | New trends in molecular and cellular biomarker discovery for colorectal cancer显示文摘Colorectal cancer(CRC) is the third leading cause of cancer death worldwide, which is consequence of multistep tumorigenesis of several genetic and epigenetic events. Since CRC is mostly asymptomatic until it progresses to advanced stages, the early detection using effective screening approaches, selection of appropriate therapeutic strategies and efficient follow-up programs are essential to reduce CRC mortalities. Biomarker discovery for CRC based on the personalized genotype and clinical information could facilitate the classification of patients with certain types and stages of cancer to tailor preventive and therapeutic approaches. These cancer-related biomarkers should be highly sensitive and specific in a wide range of specimen(s)(including tumor tissues, patients' fluids or stool). Reliable biomarkers which enable the early detection of CRC, can improve early diagnosis, prognosis, treatment response prediction, and recurrence risk. Advances in our understanding of the natural history of CRC have led to the development of different CRC associated molecular and cellular biomarkers. This review highlights the new trends and approaches in CRC biomarker discovery, which could be potentially used for early diagnosis, development of new therapeutic approaches and follow-up of patients. | Parisa Aghagolzadeh Ramin Radpour | 2016 | World Journal of Gastroenterology2016，22，25： | 5 |
| 2 | Single-cell analysis of tumors:Creating new value for molecular biomarker discovery of cancer stem cells and tumor-infiltrating immune cells显示文摘Biomarker-driven individualized treatment in oncology has made tremendous progress through technological developments, new therapeutic modalities and a deeper understanding of the molecular biology for tumors, cancer stem cells and tumor-infiltrating immune cells. Recent technical developments have led to the establishment of a variety of cancer-related diagnostic, prognostic and predictive biomarkers. In this regard, different modern OMICs approaches were assessed in order to categorize and classify prognostically different forms of neoplasia. Despite those technical advancements, the extent of molecular heterogeneity at the individual cell level in human tumors remains largely uncharacterized. Each tumor consists of a mixture of heterogeneous cell types. Therefore, it is important to quantify the dynamic cellular variations in order to predict clinical parameters, such as a response to treatment and or potential for disease recurrence. Recently, single-cell based methods have been developed to characterize the heterogeneity in seemingly homogenous cancer cell populations prior to and during treatment. In this review, we highlight the recent advances for single-cell analysis and discuss the challenges and prospects for molecular characterization of cancer cells, cancer stem cells and tumor-infiltrating immune cells. | Ramin Radpour Farzad Forouharkhou | 2018 | World Journal of Stem Cells2018，10，11： | 3 |
| 3 | Molecular modulation of autophagy: New venture to target resistant cancer stem cells显示文摘Autophagy is a highly regulated catabolic process in which superfluous,damaged organelles and other cytoplasmic constituents are delivered to the lysosome for clearance and the generation of macromolecule substrates during basal or stressed conditions.Autophagy is a bimodal process with a context dependent role in the initiation and the development of cancers.For instance,autophagy provides an adaptive response to cancer stem cells to survive metabolic stresses,by influencing disease propagation via modulation of essential signaling pathways or by promoting resistance to chemotherapeutics.Autophagy has been implicated in a cross talk with apoptosis.Understanding the complex interactions provides an opportunity to improve cancer therapy and the clinical outcome for the cancer patients.In this review,we provide a comprehensive view on the current knowledge on autophagy and its role in cancer cells with a particular focus on cancer stem cell homeostasis. | Harpreet K Mandhair Miroslav Arambasic Urban Novak Ramin Radpour | 2020 | World Journal of Stem Cells2020，12，5： | 2 |
| 4 | Tracing and targeting cancer stem cells:New venture for personalized molecular cancer therapy显示文摘Tumors consist of a mixture of heterogeneous cell types. Cancer stem cells(CSCs) are a minor sub-population within the bulk cancer fraction which has been foundto reconstitute and propagate the disease and to be frequently resistant to chemotherapy, irradiation, cytotoxic drugs and probably also against immune attack. CSCs are considered as the seeds of tumor recurrence, driving force of tumorigenesis and metastases. This underlines the urgent need for innovative methods to identify and target CSCs. However, the role and existence of CSCs in therapy resistance and cancer recurrence remains a topic of intense debate. The underlying biological properties of the tumor stem cells are extremely dependent on numerous signals, and the targeted inhibition of these stem cell signaling pathways is one of the promising approaches of the new antitumor therapy approaches. This perspective review article summarizes the novel methods of tracing CSCs and discusses the hallmarks of CSC identification influenced by the microenvironment or by having imperfect detection markers. In addition, explains the known molecular mechanisms of therapy resistance in CSCs as reliable and clinically predictive markers that could enable the use of new targeted antitumor therapy in the sense of personalized medicine. | Ramin Radpour | 2017 | World Journal of Stem Cells2017，9，10： | 2 |
| 5 | Two novel missense andone novel nonsense CFTR mutations in Iranian males with congenitalbilateral absence of the vas deferens显示文摘 | Radpour R Gourabi H Gilani M A | 2006 | Mol Hum Reprod2006，12，11： | 1 |
| 6 | Hypermethylation of tumor suppressor genes involved in critical regulatory pathways for develo- ping a blood-based test in breast cancer 显示文摘 | Radpour R Barekati Z Kohler C | 2011 | PLoS One2011，，： | 1 |
| 7 | Epigenetic regulation of autophagy: A key modification in cancer cells and cancer stem cells显示文摘Aberrant epigenetic alterations play a decisive role in cancer initiation and propagation via the regulation of key tumor suppressor genes and oncogenes or by modulation of essential signaling pathways.Autophagy is a highly regulated mechanism required for the recycling and degradation of surplus and damaged cytoplasmic constituents in a lysosome dependent manner.In cancer,autophagy has a divergent role.For instance,autophagy elicits tumor promoting functions by facilitating metabolic adaption and plasticity in cancer stem cells(CSCs)and cancer cells.Moreover,autophagy exerts pro-survival mechanisms to these cancerous cells by influencing survival,dormancy,immunosurveillance,invasion,metastasis,and resistance to anti-cancer therapies.In addition,recent studies have demonstrated that various tumor suppressor genes and oncogenes involved in autophagy,are tightly regulated via different epigenetic modifications,such as DNA methylation,histone modifications and non-coding RNAs.The impact of epigenetic regulation of autophagy in cancer cells and CSCs is not wellunderstood.Therefore,uncovering the complex mechanism of epigenetic regulation of autophagy provides an opportunity to improve and discover novel cancer therapeutics.Subsequently,this would aid in improving clinical outcome for cancer patients.In this review,we provide a comprehensive overview of the existing knowledge available on epigenetic regulation of autophagy and its importance in the maintenance and homeostasis of CSCs and cancer cells. | Harpreet K Mandhair Urban Novak Ramin Radpour | 2021 | World Journal of Stem Cells2021，13，6： | 1 |
| 8 | Methylation signature of lymphnode metastases in breast cancer patients 显示文摘 | Barekati Z Radpour R Lu Q | 2012 | BMC Cancer2012，12，1： | 1 |
| 9 | Hypermethylation of tumor suppressor genes involved in critical regulatory pathways for developing a blood-based test in breast cancer显示文摘 | Radpour R Barekati Z Kohler C | 2011 | PLoS One2011，6，16： | 1 |
| 10 | Hypermethylation of tmnor suppressor genes involved in critical regulatory pathways for developing a blood-based test in breast cancer 显示文摘 | Radpour R Barekati Z Kohler C | 2011 | PLoS One2011，6，16： | 1 |
| 11 | Association between MTH-FR polymorphism(C677T)with nor familial colorectal cancer显示文摘 | Haghighim M Radpour R Mahmoud IT | 2009 | Oncol Res2009，18，23： | 1 |
| 12 | Cell-free DNA in the cir- culation as a potential cancer biomarker 显示文摘 | Kohler C Barekati Z Radpour R | 2011 | Anticancer Res2011，31，8： | 1 |
| 13 | Hypermethylation of tumor suppressor genes involved in critical regulatory pathways for developing a blood-based test in breast cancer显示文摘 | Radpour R Barekati Z Kohler C | 2011 | PLo S One2011，6，16： | 1 |
| 14 | MALDI - TOFmass array analysis of RASSF1A and SERPINB5 methylationpatterns in human placenta and plasma显示文摘 | Bellido ML Radpour R Lapaire 0 | 2010 | Biol Reprod2010，82，4： | 1 |
| 15 | Consecutive cervical pregnancies 显示文摘 | RADPOUR C J KEENAN J A | 2004 | Fertil Steril2004，81，1： | 1 |
| 16 | Consecutive cervical pregnancies显示文摘 | Radpour CJ Keenan JA | 2004 | Fertil Steril2004，81，1： | 1 |
| 17 | Association between MTHFR polymorphism (C677T) with nonfamilial colorectal cancer显示文摘 | Haghighi MM Radpour R Mahmoudi T | 2009 | Oncol Res2009，18，23： | 1 |
| 18 | Consecutive cervical pregnancies 显示文摘 | Radpour C J Keenan J A | 2004 | Fertil Steril2004，81，1： | 1 |
| 19 | MALDI-TOF mass array analysis of RASSF1A and SERPINB5 methylation patterns in human placenta and plasma显示文摘 | Bellido ML Radpour R Lapaire O | 2010 | Biol Reprod2010，82，4： | 1 |
| 20 | Kind analysis for MATLAB显示文摘 | Jesse Doherty Laurie Hendren Soroush Radpour | 2011 | ACM SIGPLAN Notices2011，，10： | 1 |
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