|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Sulforaphane Protects Astrocytes Against Oxidative Stress and Delayed Death Caused by Oxygen and Glucose Deprivation显示文摘氧化应激是缺血再灌注后星形胶质细胞损伤和死亡的重要分子机制之一,可能成为有效的干预靶点。下述治疗策略可减轻缺血再灌注条件下产生的多种反应性氮氧化合物损伤。这种方法可通过使用化学试剂或适当条件促进转录活化因子NRF2从细胞浆转入细胞核,并与抗氧化基因反应位点结合,来诱导缺血再灌注后损伤细胞的Ⅱ期基因反应。本研究将验证如下假说:NRF2基因表达通路激活剂sulforaphane能对体外无氧无糖环境处理的培养皮质星形胶质细胞起神经保护作用。将皮质星形胶质细胞暴露于无氧无糖环境(OGD)4 h,于干预前48 h或干预后给予5μMsulforaphane(NRF2基因表达通路激活剂)培养48 h,两种培育条件下细胞死亡均明显减少。免疫细胞化学结果表明干预前给予sulforaphane处理,细胞中DNA/RNA氧化标志物8-hydroxy-2-deox-yguanosine的表达在恢复给氧4 h后降低,两种培育条件下胞浆内及胞核内NRF2的免疫反应均增强且NQO1(NRF2转录活化基因产物)的表达和酶活性均增强。本研究提示sulforaphane可通过激活NRF2抗氧化基因表达通路,减少体外缺氧再灌注后星形胶质细胞的死亡。 | CAMELIA A.DANILOV KRISH CHANDRASEKARAN JENNIFER RACZ LUCIAN SOANE CAROL ZIELKE AND GARY FISKUM | 2009 | 神经损伤与功能重建2009，4，2： | 12 |
| 2 | Long-term outcomes of coronary-artery bypass grafting versus stent implantation显示文摘 | Racz MJ Walford G | 2005 | N Engl J Med2005，352，21： | 1 |
| 3 | Laboratory characterization of phosphorus in fresh and oven-dried organic amendments 显示文摘 | Ajiboye B Akinremi O O Racz G J | 2004 | Journal of Environmental Quality2004，33，： | 1 |
| 4 | Autolmmune polyendocrine syndromes and related diseases:pathogenesis and clinical features显示文摘 | Igaz P Racz K Tulassay Z | 2005 | Orv Hetil2005，146，29： | 1 |
| 5 | A modified dialyzer with vitamin E and antioxidant defense parameters显示文摘 | Mydlík M Derzsiova K Racz O | 2001 | Kidney Int Suppl2001，78，： | 1 |
| 6 | A web-based system for design artifact modeling显示文摘 | Simon Szykman Janusz Racz | 2000 | Design Studies2000，21，2： | 1 |
| 7 | A Web-based System for Design Artifact Modeling 显示文摘 | Szykman S Racz J Bochenek C | 2000 | Design Studies2000，，： | 1 |
| 8 | Radiofrequency procedures显示文摘 | Racz GB Ruiz-Lopez R | 2006 | Pain Pract2006，6，1： | 1 |
| 9 | Red cell antioxidant enzymes and prognostic indexes in patients with burns显示文摘 | Frisan E Racz O Chmelarova A | | 0，，03： | 1 |
| 10 | Once daily versus three times daily mesalazine granules in active ulcerative colitis: A doube-blind, double-dummy, randomised, non-inferiority trial 显示文摘 | Kruis W Kiudelis G Racz I | 2009 | Gut2009，58，2： | 1 |
| 11 | Ammonia volatilization from soils fertilized with urea and varying rates of urease inhibitor NBPT显示文摘 | Rawluk C Grant CA Racz GJ | 2001 | Canadian Journal of Soil Science2001，81，2： | 1 |
| 12 | Maintained intraocular pressure reduction with once-a-day application of a new prostaglandin F2α analogue (PhXA41)显示文摘 | RUZSONYI MR NAGY ZT | 1993 | Arch Ophthalmol1993，111，5： | 1 |
| 13 | Ammonia volatilization from soils fertilized with urea and varying rates of urease inhibitor NBPT显示文摘 | RAWLUK C D L GRANT C A RACZ G J | 2001 | Can J Soil Sci2001，81，： | 1 |
| 14 | TIP47protects mitochondrial membrane integrity and inhibits oxidative-stress-induced cell death显示文摘 | Hocsak E Racz B Szabo A | 2010 | FEBS letters2010，584，13： | 1 |
| 15 | Early microstructural and meta- bolic changes following controlled cortical impact injury in rat: a magnetic resonance imaging and spectroscopy study 显示文摘 | Xu S Zhou J Racz J | 2011 | J Neurotrauma2011，28，10： | 1 |
| 16 | Potent CD4 + T cell responses elicited by a bicistronic HIV-1 DNA vaccine expressing gpl20 and GMCSF 显示文摘 | Barouch D H Santra S Racz K T | 2002 | Im- munol2002，168，： | 1 |
| 17 | Dimerization with retinoid X receptors promotes nuclear localization and subnuclear targeting ofvitamin D receptors显示文摘 | Prufer K Racz A Lin GC | 2000 | J Biol Chem2000，275，41： | 1 |
| 18 | ADMA impairs nitricoxide-mediated arteriolar function due to increased super-oxide production by angiotensin II-NADPH oxidase path-way 显示文摘 | Veresh Z Racz A Lotz G | 2008 | Hypertension2008，52，： | 1 |
| 19 | Laboratory characterization of phosphorus in fresh and oven-dried organic amendments显示文摘 | Ajiboye B Akinremi O O Racz G J | 2004 | Journal of Environmental Quality2004，33，： | 1 |
| 20 | Antifoaming action ofpolyoxyethylene-polyoxypropylene-polyoxyethylene-type triblockcopolymers on bas foams 显示文摘 | Nemeth Z Racz G Koczo K | 1997 | Colloid Surface A: PhysicochemEng Asp1997，127，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员