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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Current role of palliative interventions in advanced pancreatic cancer显示文摘Pancreatic adenocarcinoma is the third leading cause of cancer death in the United States. Unfortunately, at diagnosis, most patients are not candidates for curative resection. Surgical palliation, a procedure performed with the intention of relieving symptoms or improving quality of life, comes to the forefront of management. This article reviews the palliative management of unresectable pancreatic cancer, including obstructive jaundice, duodenal obstruction and pain control with celiac plexus block. Although surgical bypasses for both biliary and duodenal obstructions usually achieve good technical success, they result in considerable perioperative morbidity and mortality, even when performed laparoscopically. The effectiveness of selfexpanding metal stents for biliary drainage is excellent with low morbidity. Surgical gastrojejunostomy for duodenal obstruction appears to be best for patients with a life expectancy of greater than 2 mo while endoscopic stenting has been shown to be feasible with good symptom relief in those with a shorter life expectancy. Regardless of the palliative procedure performed, all physicians involved must be adequately trained in end of life management to ensure the best possible care for patients. | Chelsey C Ciambella Rachel E Beard Thomas J Miner | 2018 | World Journal of Gastrointestinal Surgery2018，10，7： | 4 |
| 3 | Para-aortic lymph node involvement should not be a contraindication to resection of pancreatic ductal adenocarcinoma显示文摘BACKGROUND Para-aortic lymph nodes(PALN)are found in the aortocaval groove and they are staged as metastatic disease if involved by pancreatic ductal adenocarcinoma(PDAC).The data in the literature is conflicting with some studies having associated PALN involvement with poor prognosis,while others not sharing the same results.PALN resection is not included in the standard lymphadenectomy during pancreatic resections as per the International Study Group for Pancreatic Surgery and there is no consensus on the management of these cases.AIM To investigate the prognostic significance of PALN metastases on the oncological outcomes after resection for PDAC.METHODS This is a retrospective cohort study of data retrieved from a prospectively maintained database on consecutive patients undergoing pancreatectomies for PDAC where PALN was sampled between 2011 and 2020.Statistical comparison of the data between PALN+and PALN-subgroups,survival analysis with the Kaplan-Meier method and risk analysis with univariable and multivariable time to event Cox regression analysis were performed,specifically assessing oncological outcomes such as median overall survival(OS)and disease-free survival(DFS).RESULTS 81 cases had PALN sampling and 17(21%)were positive.Pathological N stage was significantly different between PALN+and PALN-patients(P=0.005),while no difference was observed in any of the other characteristics.Preoperative imaging diagnosed PALN positivity in one case.OS and DFS were comparable between PALN+and PALN-patients with lymph node positive disease(OS:13.2 mo vs 18.8 mo,P=0.161;DFS:13 mo vs 16.4 mo,P=0.179).No difference in OS or DFS was identified between PALN positive and negative patients when they received chemotherapy either in the neoadjuvant or in the adjuvant setting(OS:23.4 mo vs 20.6 mo,P=0.192;DFS:23.9 mo vs 20.5 mo,P=0.718).On the contrary,when patients did not receive chemotherapy,PALN disease had substantially shorter OS(5.5 mo vs 14.2 mo;P=0.015)and DFS(4.4 mo vs 9.8 mo;P<0.001).PALN involvement was not identified as an independent predictor for OS after multivariable analysis,while it was for DFS doubling the risk of recurrence.CONCLUSION PALN involvement does not affect OS when patients complete the indicated treatment pathway for PDAC,surgery and chemotherapy,and should not be considered as a contraindication to resection. | Rupaly Pande Shafiq Chughtai Manish Ahuja Rachel Brown David C Bartlett Bobby V Dasari Ravi Marudanayagam Darius Mirza Keith Roberts John Isaac Robert P Sutcliffe Nikolaos A Chatzizacharias | 2022 | World Journal of Gastrointestinal Surgery2022，14，5： | 2 |
| 4 | Angiotensin Ⅱ and the fibroproliferative response to acute lung injury显示文摘 | Richard P M Peter G Rachel C | 2004 | Am J Physiol Lung Cell Mol Physiol2004，286，： | 2 |
| 5 | School-based intervention for adolescents with social anxiety disorder:Result of a controlled study显示文摘 | Carrie Masia-Warner Rachel G Klein Heather C Dent | 2005 | Journal of Abnormal Child Psychology2005，33，6： | 1 |
| 6 | Custom- made, root-analogue direct laser metal forming im- plant: a case report 显示文摘 | Francesco M Bruno C Rachel S | 2012 | Lasers in medical science2012，27，6： | 1 |
| 7 | Using riskranking of metals to identify which poses the greatest threat to freshwater organisms in the UK显示文摘 | Rachel L R Andrew C J Claudia M | 2014 | Environmental Pollution2014，194，： | 1 |
| 8 | Gender differences in preferences显示文摘 | Rachel C Gneezy U | | 0，，02： | 1 |
| 9 | Mycoplasma pneumoniae infection increases airway collagen deposition in a murine model of allergic airway inammotion显示文摘 | Hong-Wei C John GR Rachel BW | 2005 | Am J Physiol Lung Cell Mol Physiol2005，289，： | 1 |
| 10 | Changes in the intra- metropolitan loca- tion of producer services in the France (1978--1997) : Do informa- tion technologies promote a more dispersed spatial pattern? 显示文摘 | ORAIN C B RACHEl G | 2004 | Ur- ban Geography2004，25，6： | 1 |
| 11 | Organizational Choice in R&D Alliances:Knowledge-Ba sed and Transaction Cost Perspectives显示文摘 | Sampson Rachelle C | 2004 | Managerial & Decision Economics2004，，67： | 1 |
| 12 | Hypoxia/aglycemia altersexpression of occludin and actin in brain endothelial cells 显示文摘 | Rachel C Brown P Thomas P | 2005 | Biochem and Biophy Res2005，327，4： | 1 |
| 13 | Activated carbon liron oxide magnetic composites for the adsorption of contaminants in water 显示文摘 | Oliveira Luiz C A Rios Rachel V R A Jos D | 2002 | Carbon2002，40，： | 1 |
| 14 | Hormone therapy and Alzheimer disease dementia:new findings from the Cache County Study显示文摘 | Shao Hui-bo John C Breitner Rachel A Whitmer | 2012 | Neurology2012，79，18： | 1 |
| 15 | In vitro reactivity to implant metals demonstrates a person-dependent association with both T-Cell and B-Cell activation 显示文摘 | Nadim JH Marco C Rachel E | 2009 | Journal of Biomedical Materials Research2009，，： | 1 |
| 16 | Disease-associated mutations in conserved residues of ALK-1 kinase domain显示文摘 | SALMA AA URSZULA C RACHEL M J | 2003 | Euro J Hum Genet2003，11，： | 1 |
| 17 | Evaluation the reinforcing effects of choice in comparison to reinforcement rate 显示文摘 | Rachel H T Wayne W F Stephanie A C | 1998 | Research in Developmental Disabilities1998，19，2： | 1 |
| 18 | Evaluation the reinforcing effects of choice in comparison to reinforcement rate显示文摘 | Rachel H T Wayne W F Stephanie A C | 1998 | Research in Developmental Disabilities1998，19，2： | 1 |
| 19 | A novel cell culture model for studying differentiation and apoptosis in the mouse mammary gland显示文摘 | Katrina E G Bert B Rachel S C | 2000 | Breast Cancer Res2000，2，3： | 1 |
| 20 | Africa's emerging AIDS -orphans crisis显示文摘 | Rachel C Baggaley MB Dale Needham | 1997 | Canadian Medical Association Journal1997，156，6： | 1 |
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