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| 1 | Diffusion-weighted magnetic resonance imaging and micro-RNA in the diagnosis of hepatic fibrosis in chronic hepatitis C virus显示文摘BACKGROUND Diffusion-weighted magnetic resonance imaging has shown promise in the detection and quantification of hepatic fibrosis. In addition, the liver has numerous endogenous micro-RNAs(miRs) that play important roles in the regulation of biological processes such as cell proliferation and hepatic fibrosis.AIM To assess diffusion-weighted magnetic resonance imaging and miRs in diagnosing and staging hepatic fibrosis in patients with chronic hepatitis C.METHODS This prospective study included 208 patients and 82 age-and sex-matched controls who underwent diffusion-weighted magnetic resonance imaging of the abdomen, miR profiling, and liver biopsy. Pathological scoring was classified according to the METAVIR scoring system. The apparent diffusion coefficient (ADC) and miR were calculated and correlated with pathological scoring.RESULTS The ADC value decreased significantly with the progression of fibrosis, from controls(F0) to patients with early fibrosis(F1 and F2) to those with late fibrosis(F3 and F4)(median 1.92, 1.53, and 1.25 × 10^(-3) mm^2/s, respectively)(P = 0.001).The cut-off ADC value used to differentiate patients from controls was 1.83 × 10^(-3) mm^2/s with an area under the curve(AUC) of 0.992. Combining ADC and miR-200 b revealed the highest AUC(0.995) for differentiating patients from controls with an accuracy of 96.9%. The cut-off ADC used to differentiate early fibrosis from late fibrosis was 1.54 × 10^(-3) mm^2/s with an AUC of 0.866. The combination of ADC and miR-200 b revealed the best AUC(0.925) for differentiating early fibrosis from late fibrosis with an accuracy of 80.2%. The ADC correlated with miR-200 b(r =-0.61, P = 0.001), miR-21(r =-0.62, P = 0.001), and miR-29(r = 0.52,P = 0.001).CONCLUSION Combining ADC and miRs offers an alternative surrogate non-invasive diagnostic tool for diagnosing and staging hepatic fibrosis in patients with chronic hepatitis C. | Tarek Besheer Hatem Elalfy Mohamed Abd El-Maksoud Ahmed Abd El-Razek Saher Taman Khaled Zalata Wagdy Elkashef Hossam Zaghloul Heba Elshahawy Doaa Raafat Wafaa Elemshaty Eman Elsayed Abdel-Hady El-Gilany Mahmoud El-Bendary | 2019 | World Journal of Gastroenterology2019，25，11： | 9 |
| 2 | Microsatellite-Aided Screening for Fertility Restoration Genes (Rf) Facilitates Hybrid Improvement显示文摘DNA markers enabled to determine the chromosomal locations of the two Rf genes(Rf3 and Rf4) in the wild-abortive cytoplasmic male sterility(WA-CMS) system. Four simple sequence repeats(SSRs) RM171, RM258, RM315 and RM443 were used to detect the allelic status with respect to the fertility restoration genes(Rf3 and Rf4) in 300 rice cultivars or breeding lines. The results revealed that out of 300 lines, 90 lines screened had Rf3, 65 lines had Rf4, and 45 lines had Rf3 and Rf4 alleles. Furthermore, 45 lines selected using SSR markers were mated with a CMS line(IR58025A) to analyze their restoring ability. Offspring of all the test lines except HHZ8-SAL9DT1-Y1, HHZ5-SAL9-Y3-1 and IDSA77 exhibited higher pollen and spikelet fertility(> 80%), thus confirming they bear the Rf alleles. The hybrid offspring of ARH12-6-1-1-B-3-1, IR32307-10-3-2-1 and Sahel 329 had the highest pollen fertility(97.39%, 98.30% and 97.10%, respectively) and spikelet fertility(95.10%, 97.07% and 96.10%, respectively). | Raafat El-Namaky Saber Sedeek Yonnelle Dea Moukoumbi Rodomiro Ortiz Baboucarr Manneh | 2016 | Rice science2016，23，3： | 2 |
| 3 | Survey of literature on continuously deteriorating inventory models 显示文摘 | Raafat F | 1991 | Journal of the Operational Research Society1991，42，： | 1 |
| 4 | Some experiments on oil whirl and oil whip显示文摘 | EI-Shafei A Tawfick S H Raafat M S | | 0，，01： | 1 |
| 5 | An inventory model for deteriorating item显示文摘 | Raafat F Wolfe P M Eldin H K | 1991 | Computers and Industrial Engineering1991，20，1： | 1 |
| 6 | Relevance of serology for Mycoplasma pneumoniae diagnosis compared with PCR and culture in acute exacerbation of bronchial asthma显示文摘 | El SZ Raafat D EI MA | 2009 | Am J Clin Pathol2009，131，1： | 1 |
| 7 | Mechanistic action of mesenchymal stem cell injection in the treatment of chemically induced ovarian failure in rabbits显示文摘 | Abd-Allah SH Shalaby SM Pasha HF El-Shal AS Raafat N Shabrawy SM | 2013 | Cytotherapy2013，15，1： | 1 |
| 8 | The United Kingdom Children's Cancer Study Group's second germ cell tumor study: carboplatin, etoposide, and bleomycin are effective treatment for children with malignant extracranial germ cell tumors, with acceptable toxicity 显示文摘 | Mann J R Raafat F Robinson K | 2000 | J Clin Oncol2000，18，22： | 1 |
| 9 | Survey of literature on continuously deteriorating inventory model显示文摘 | | 1991 | Journal of the Operational Research Society1991，42，： | 1 |
| 10 | Survey of literature on continuously deteriorating inventory models显示文摘 | RAAFAT F | 1991 | Journal of Operational Research Society1991，42，1： | 1 |
| 11 | Malignant hepatic tumours in children:incidence,clinical features and aetiology显示文摘 | Mann JR Kasthuri N Raafat F | 1990 | Paediatr Perinat Epidemiol1990，4，3： | 1 |
| 12 | Survey of literature on continuously deteriorating inventorymodels显示文摘 | Raafat F | 1991 | Journal of the operational research society1991，42，： | 1 |
| 13 | Chitosan and its antimicrobial potential-acritical literature survey 显示文摘 | Raafat Dina Sahl | 2009 | Microbial Biotechnology2009，2，2： | 1 |
| 14 | Survey of literature on continuously deteriorating inventory models 显示文摘 | Raafat F | 1991 | The Journal of the Operational Research1991，42，1： | 1 |
| 15 | Using a Novel Fiber Cement System to Control Lost Circulation显示文摘 | El-Hassan Raafat Abbas Haitham Jarouj | | SPE/IADC853240，，： | 1 |
| 16 | Innovative system for prestressing fiber-reinforced polymer sheets显示文摘 | Raafat EI-Hacha R Gordon Wight and Mark F Green | 2003 | ACI Structural Journal2003，100，3： | 1 |
| 17 | Sustained release dosage forms dissolution behavior prediction: A study of matrix tablets using NIR spectroscopy显示文摘 | Simin Hassannejad Tabasi Vikas Moolchandani Raafat Fahmy | 2009 | International Journal of Pharmaceutics2009，382，12： | 1 |
| 18 | Herding in humans显示文摘 | Raafat R M Chater N Frith C | | 0，，10： | 1 |
| 19 | Viability of the ' Technology Acceptance Model' in Multimedia Learning Environments : A Comparative Study 显示文摘 | Raafat G Nebebe F Tan W W | 2007 | Interdisciplinary Journal of Knowledge and Learning Objects2007，3，： | 1 |
| 20 | Fingerprint image po-stprocessing:A combined statistical and structural approach显示文摘 | | 1991 | Pattern Recognition1991，24，10： | 1 |
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