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| 1 | D-二聚体预测稳定型冠状动脉性心脏病患者的长期病因特异性死亡率、心血管事件和癌症显示文摘交联纤维蛋白的降解产物D-二聚体是高凝状态和血栓形成事件的标志。D-二聚体水平中度升高与血管疾病患者静脉和动脉事件的风险相关。在缺血性疾病长期普伐他汀干预(long-term intervention with pravastatin in ischemic disease,LIPID)试验中,研究者在存在其他危险因素的背景下,评估了D-二聚体水平在预测长期血管转归、病因特异性死亡率和新发癌症中的作用。 | 刘青 叶鹏 Simes J Robledo KP White HD Espinoza D Stewart RA Sullivan DR Zeller T Hague W Nestel PJ Glasziou PP Keech AC Elliott J Blankenberg S Tonkin AM LIPID study investigators | 2018 | 中华高血压杂志2018，26，3： | 6 |
| 2 | CYP24A1 inhibition facilitates the anti-tumor effect of vitamin D3 on colorectal cancer cells显示文摘AIM:The effects of vitamin D3 have been investigated on various tumors, including colorectal cancer (CRC). 25-hydroxyvitamin-D3-24-hydroxylase (CYP24A1), the enzyme that inactivates the active vitamin D3 metabolite 1,25-dihydroxyvitamin D3 (1,25-D3), is considered to be the main enzyme determining the biological halflife of 1,25-D3. During colorectal carcinogenesis, the expression and concentration of CYP24A1 increases significantly, suggesting that this phenomenon could be responsible for the proposed efficacy of 1,25-D3 in the treatment of CRC. The aim of this study was to investigate the anti-tumor effects of vitamin D3 on the human CRC cell line Caco-2 after inhibition of the cytochrome P450 component of CYP24A1 activity. METHODS:We examined the expression of CYP24A1 mRNA and the effects of 1,25-D3 on the cell line Caco-2 after inhibition of CYP24A1. Cell viability and proliferation were determined by means of sulforhodamine-B staining and bromodeoxyuridine incorporation, respectively, while cytotoxicity was estimated via the lactate dehydrogenase content of the cell culture supernatant. CYP24A1 expression was measured by realtime reverse transcription polymerase chain reaction. A number of tetralone compounds were synthesized to investigate their CP24A1 inhibitory activity. RESULTS:In response to 1,25-D3, CYP24A1 mRNA expression was enhanced significantly, in a time- and dose-dependent manner. Caco-2 cell viability and proliferation were not influenced by the administration of 1,25-D3 alone, but were markedly reduced by coadministration of 1,25-D3 and KD-35, a CYP24A1-inhibiting tetralone. Our data suggest that the mechanism of action of co-administered KD-35 and 1,25-D3 does not involve a direct cytotoxic effect, but rather the inhibition of cell proliferation. CONCLUSION:These findings demonstrate that the selective inhibition of CYP24A1 by compounds such as KD-35 may be a new approach for enhancement of the anti-tumor effect of 1,25-D3 on CRC. | János P Kósa Péter Horváth János Wlfling Dóra Kovács Bernadett Balla Péter Mátyus Evelin Horváth Gábor Speer István Takács Zsolt Nagy Henrik Horváth Péter Lakatos | 2013 | World Journal of Gastroenterology2013，19，17： | 5 |
| 3 | 系统性药物治疗儿童银屑病的安全性显示文摘银屑病是一种常见的慢性炎症性皮肤病。成年人的发病率为2%~3%,其中大约有三分之一的患者在18岁之前发病。在儿童期,该病的发病率呈线性增长。从1970年至2000年,儿童银屑病的发病率增加了一倍多。尽管对许多轻度银屑病患儿而言,局部治疗已足够,但对更多可能影响生活质量的重度或顽固性的银屑病患儿,则往往需要系统性治疗。 | bronckers imgj seyger mmb west dp lara-corrales i tollefson m tom wl hogeling m belazarian l zachariae c mahé e siegfried e philipp s szalai z vleugels ra holland k murphy r baselga e cordoro k lambert j alexopoulos a mrowietz u kievit w paller as 邓婕(编译) 张锡宝(审校) 无 | 2017 | 皮肤性病诊疗学杂志2017，24，5： | 3 |
| 4 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 5 | Apoptosis in developing anthers and the role of ABA in this process during androgenesis in Hordeum vulgate L显示文摘 | WANG M HOEKSTRA S VAN BERGEN S LAMERS GEM OPPEDIJK B J VAN DER HEUDEN M W DE PRIESTER W SCHILPEROORT RA 1 | 1999 | Plant Mol Biol1999，39，： | 1 |
| 6 | Expression of the vascularpermeability factor/vascular endothelial factor gene in central nervoussystem neoplasms显示文摘 | Berionan RA Merrill M Reinhold W | 1993 | J Clin Invest1993，91，： | 1 |
| 7 | How to write a systematic review显示文摘 | Wright RW Brand RA Dunn W | 2007 | Clin Orthop Relat Res2007，455，2： | 1 |
| 8 | Effects of severe hypertension on endothelial and platelet microparticles显示文摘 | Preston RA Jy W Jimenez JJ | 2003 | Hypertension2003，41，2： | 1 |
| 9 | Effect of angiogenesis in- hibition by Id loss and the contribution of bone-marrow-derived en- dothelial cells in spontaneous murine tumors 显示文摘 | Ruzinova MB Schoer RA Gerald W | 2003 | Cancer Cell2003，4，4： | 1 |
| 10 | Efficacy and safety of d, 1-sotalol in patients with ventricular tachycardia and in survivors of cardiac arrest显示文摘 | Haverkamp W Martines RA Hief C et ai | 1997 | J Am Coll Cardiol1997，30，： | 1 |
| 11 | Detection of extra thoracic metastases by positron emission tomography in lung cancer显示文摘 | Weder W Schmid RA Bruchhaus H | 1998 | Ann Thorac Surg1998，66，3： | 1 |
| 12 | ' Perfect' markers for the Rht-B1b and Rht-D1b dwarfing genes in wheat 显示文摘 | Ellis MH Spielmeyer W Gale KR Rebetzke GJ & Richards RA | 2002 | Theoretical and Applied Genetics2002，105，： | 1 |
| 13 | Profile chan-ges associated with maxillary incisor retraction in the postad-olescent orthodontic patient显示文摘 | Kokodynski RA Marshall SD Ayer W | 1997 | Int J Adult Orthodon Or-thognath Surg1997，12，2： | 1 |
| 14 | Insights from a cardiac re- synchronization optimization clinic as part of a heart failure disease management program 显示文摘 | Mullens W Grimm RA Verga T | 2009 | J Am Coil Cardiol2009，53，9： | 1 |
| 15 | Systematic and integrative a- nalysis of large gene lists using DAVID bioinformatics resources显示文摘 | Huang da W Sherman BT Lempicki RA | 2009 | Nat Protoc2009，4，1： | 1 |
| 16 | Transient focal cerebral isch- emia induces long-term cognitive function deficit in an experi- mental ischemic stroke model 显示文摘 | Li W Huang R Shetty RA | 2013 | Neurobiol Dis2013，59，： | 1 |
| 17 | Pulmouary man ifestatious of systimic lupus erythematosus 显示文摘 | Murin S W iedemann HP Matthay RA | 1998 | Clin Chest Med1998，19，64： | 1 |
| 18 | Effects of severe hypertension on endothelial and platelet microparticles显示文摘 | Jy W Jimenez JJ | 2003 | Hypertension2003，41，： | 1 |
| 19 | Safety and efficacy of darbepo- etin alpha in previously untreated extensive-stage smallceu lung cancer treated with platinum plus etoposide 显示文摘 | Pirker R Ramlau RA Schuette W | 2008 | J Clin 0ncol2008，36，14： | 1 |
| 20 | Revision surgery following operations for lumbar stenosis显示文摘 | Deyo RA Martin BI Kreuter W | 2011 | ] Bone Joint Surg Am2011，93，21： | 1 |
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