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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Germanium recovery from gasification fly ash: Evaluation of end-products obtained by precipitation methods 显示文摘 | ARROYO F FONT O FERNANDEZ-PEREIRA C QUEROL X JUAN R RUIZ C COCA P | 2009 | Journal of Hazardous Materials2009，167，123： | 1 |
| 3 | Countercurrent supercritical fluid extraction and fractionation of alcoholic heverages显示文摘 | Senorans F J Ruiz R A Ihanez E | 2001 | J Agric Food Chem2001，49，4： | 1 |
| 4 | Role of follicle-stimulating hormone receptor Ser680Asn polymorphism in the efficacy of follicle-stimulating hormone显示文摘 | de Castro F Ruiz R Montoro L | 2003 | Fertil Steril2003，80，3： | 1 |
| 5 | Spatial pattern analysis of dominant species in the Prepuna: Gaining insight into community dynamics in the semi-arid, subtropical Andes显示文摘 | Lopez R P Alcazar D L Ruiz F Z | 2010 | Journal of Arid Environments2010，74，11： | 1 |
| 6 | The effect of pon- deral index at birth on the relationships between common LEP and LEPR polymorphisms and adiposity in adoles- cents 显示文摘 | Idoia L R Ruiz L A Moreno F B | 2011 | Obesity2011，19，10： | 1 |
| 7 | Discharge of Nutrients from Shrimp Farming to Coastal Waters of the Gulf of California显示文摘 | Paez-osuna F Guerrro S R Ruiz A C | 1999 | Marine Pollution Bulletin1999，38，7： | 1 |
| 8 | calcifying fibrous pseudotumor : clinicopathologic study of 15 cases and analysis of its relationship to inflammatory myofibroblastic tumor 显示文摘 | ALESSANDR A F NASCIMENTO A F RUIZ R | 2002 | Int J Surg Pathol2002，10，3： | 1 |
| 9 | Nutritive value and forage yield of corn hybrids for silage 显示文摘 | Ruiz O Beltran R Salvador F | 2006 | Agricultural Science2006，40，1： | 1 |
| 10 | Analytical speciation as a tool to assess arsenic behaviour in soils polluted by mining显示文摘 | RUIZ C M J LOPEZ S J F RUBIO R | 2007 | Analytical and Bioanalytical Chemistry2007，387，： | 1 |
| 11 | New High performing heuristics for minimizing makespan in permutation flowshops显示文摘 | RAD S F RUIZ R BOROOJERDIAN N | 2009 | Omega-International Journal of Management Science2009，37，2： | 1 |
| 12 | New approaches to the extraction of arsenic species from soils显示文摘 | RUIZ C M J SABE R LOPEZ S J F | 2005 | Microchimica Acta2005，151，： | 1 |
| 13 | Analysis levels within the SINTA defect assessment procedures显示文摘 | Ainsworth R A Gutierrez-Solana F Ruiz Ocejo J | 2000 | Engineering Fracture Mechanics Volume2000，67，6： | 1 |
| 14 | On The Depend- ence of Spray Momentum Flux in Spray Penetration: Momentum Flux Packets Penetration Model显示文摘 | Payri R Ruiz S Salvador F J | 2007 | Jour- nal of Mechanical Science and Technology2007，，21： | 1 |
| 15 | T2 mapping in patellar chondromalacia显示文摘 | Ruiz S F Pozuelo C R Almansa L J | 2014 | EurJRadiol2014，83，6： | 1 |
| 16 | Density multiplication and improved lithography by directedblock copolymer assembly 显示文摘 | RUIZ R KANG H DETCHEVERRY F A | 2008 | Science2008，321，： | 1 |
| 17 | Influence of pH in the elimination of boron by means of reverse osmosis 显示文摘 | PASTOR M R RUIZ A F CHILLON M F | 2001 | Desalination2001，140，： | 1 |
| 18 | Density multiplication and improved lithography by directed block copolymer assembly显示文摘 | Ruiz R Kang H Detcheverry F A Dobisz E Kercher D S Albrecht T R de Pablo J J Nealey P F | | 0，，5891： | 1 |
| 19 | Synthesis of Fe2O3 species embedded in a silica xerogel matrix: a comparative study显示文摘 | Donce-Castaneda S Martinez J R Ruiz F | 2002 | J Sol-Gel Sci Techn2002，25，： | 1 |
| 20 | Regulation by nitricoxide of endotoxin - induced tissue factor and plasminogen activator inhibitor - 1 inendothelial cells显示文摘 | Perez- Ruiz A Montes R Velasco F | 2002 | Thromb Haemost2002，88，2： | 1 |
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