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| 1 | Rapid improvement of grain weight via highly efficient CRISPR/Cas9-mediated multiplex genome editing in rice显示文摘Most of the important agronomic traits in crop plants,such as yield,quality and stress response,are quantitative and jointly controlled by many genomic loci or major genes.Improving these complex traits depends on the combination of beneficial alleles at the quantitative trait loci(QTLs).However,the conventional cross breeding method is extremely time-consuming and laborious for pyramiding multiple QTLs.In certain cases,this approach | Rongfang Xu Yachun Yang Ruiying Qin Hao Li Chunhong Qiu Li Li Pengcheng Wei Jianbo Yang | 2016 | Journal of Genetics and Genomics2016，43，8： | 47 |
| 2 | Biosorption mechanisms involved in immobilization of soil Pb by Bacillus subtilis DBM in a multi-metal-contaminated soil显示文摘Mechanisms of soil Pb immobilization by Bacillus subtilis DBM, a bacterial strain isolated from a heavy-metal-contaminated soil, were investigated. Adsorption and desorption experiments with living bacterial cells as well as dead cells revealed that both extracellular adsorption and intracellular accumulation were involved in the Pb2+removal from the liquid phase. Of the sequestered Pb(II), 8.5% was held by physical entrapment within the cell wall, 43.3% was held by ion-exchange, 9.7% was complexed with cell surface functional groups or precipitated on the cell surface, and 38.5% was intracellularly accumulated.Complexation of Pb2+with carboxyl, hydroxyl, carbonyl, amido, and phosphate groups was demonstrated by Fourier transform infrared spectroscopic analysis. Precipitates of Pb5(PO4)3OH, Pb5(PO4)3Cl and Pb10(PO4)6(OH)2that formed on the cell surface during the biosorption process were identified by X-ray diffraction analysis. Transmission electron microscopy–energy dispersive spectroscopic analysis confirmed the presence of the Pb(II)precipitates and that Pb(II) could be sequestered both extracellularly and intracellularly.Incubation with B. subtilis DBM significantly decreased the amount of the weak-acid-soluble Pb fraction in a heavy-metal-contaminated soil, resulting in a reduction in Pb bioavailability, but increased the amount of its organic-matter-bound fraction by 71%. The ability of B.subtilis DBM to reduce the bioavailability of soil Pb makes it potentially useful for bacteria-assisted phytostabilization of multi-heavy-metal-contaminated soil. | Jun Bai Xiuhong Yang Ruiying Du Yanmei Chen Shizhong Wang Rongliang Qiu | 2014 | Journal of Environmental Sciences2014，26，10： | 22 |
| 3 | Hierarchical graphene foam-based phase change materials with enhanced thermal conductivity and shape stability for efficient solar-to-thermal energy conversion and storage显示文摘最近, graphene 泡沫(GF ) 与一三维(3D ) 互连指导模板的化学蒸汽免职(CVD ) 生产的网络被用来与提高的热电导率准备合成阶段变化材料(脉冲编码调制) 。然而, GF 的毛孔尺寸象几百测微计一样大,导致为从在到 GF 神气墙的大毛孔内的 PCM 的热转移的一个显著热电阻。在这研究,新奇 3D 层次 GF (HGF ) 被用空 graphene 网络填满 GF 的毛孔获得。HGF 然后被用来准备基于的石蜡蜡(PW ) 合成脉冲编码调制。PW/HGF 合成脉冲编码调制的热传导性分别地比 PW/GF 合成脉冲编码调制和纯 PW 的高是 87% 和 744% 。PW/HGF 合成脉冲编码调制也与在 100 次骑车比 PW/GF 合成脉冲编码调制,在阶段变化温度的可以忽略的变化,是 95% 纯 PW 的高热的精力存储密度,好热可靠性,和化学稳定性展出更好的形状稳定性。更重要地, PW/HGF 合成脉冲编码调制与高 light-to-thermal 精力变换和存储效率允许光驱动的热精力存储,显示它为在太阳能的利用和存储的应用的大潜力。 | Guoqiang Qi Jie Yang Ruiying Bao Dongyun Xia Min Cao Wei Yang Mingbo Yang Dacheng Wei | 2017 | Nano Research2017，10，3： | 18 |
| 4 | Development of Plant Prime-Editing Systems for Precise Genome Editing显示文摘Prime-editing systems have the capability to perform efficient and precise genome editing in human cells.In this study,we first developed a plant prime editor 2(pPE2)system and test its activity by generating a targeted mutation on an HPT^(-ATG) reporter in rice.Our results showed that the pPE2 system could induce programmable editing at different genome sites.In transgenic T0 plants,pPE2-generated mutants occurred with 0%–31.3%frequency,suggesting that the efficiency of pPE2 varied greatly at different genomic sites and with prime-editing guide RNAs of diverse structures.To optimize editing efficiency,guide RNAs were introduced into the pPE2 system following the PE3 and PE3b strategy in human cells.However,at the genomic sites tested in this study,pPE3 systems generated only comparable or even lower editing frequencies.Furthemore,we developed a surrogate pPE2 system by incorporating the HPT^(-ATG) reporter to enrich the prime-edited cells.The nucleotide editing was easily detected in the resistant calli transformed with the surrogate pPE2 system,presumably due to the enhanced screening efficiency of edited cells.Taken together,our results indicate that plant prime-editing systems we developed could provide versatile and flexible editing in rice genome. | Rongfang Xu Juan Li Xiaoshuang Liu Tiaofeng Shan Ruiying Qin Pengcheng Wei | 2020 | Plant Communications2020，1，3： | 10 |
| 5 | 卒中和口咽吞咽困难显示文摘 正常口咽吞咽过程通常包括四个阶段:(1)口准备阶段,食物通过咀嚼形成食团为吞咽做准备;(2)口阶段,舌通过顺序地向上向后的推挤动作将食物从口腔前部送至后部;(3)咽阶段,该阶段由脑干诱发,表现为软腭上提防止食物进入鼻腔,食管上括约肌打开使食物进入食管,喉和舌骨上抬并向前运动以保证气道关闭以及食管上括约肌的打开[1];(4)食管阶段,食物通过食管进入胃内.…… | Jeri A.Logemann Ruiying Ding | 2007 | 中国卒中杂志2007，2，3： | 8 |
| 6 | CRISPR/Cas9-Mediated Adenine Base Editing in Rice Genome显示文摘Precise base editing is highly desired in plant functional genomic research and crop molecular breeding. In this study, we constructed a rice-codon optimized adenine base editor(ABE)-nC as9 tool that induced targeted A·T to G·C point mutation of a key single nucleotide polymorphism site in an important agricultural gene. Combined with the modified single-guide RNA variant, our plant ABE tool can efficiently achieve adenine base editing in the rice genome. | LI Hao QIN Ruiying LIU Xiaoshuang LIAO Shengxiang XU Rongfang YANG Jianbo WEI Pengcheng | 2019 | Rice science2019，26，2： | 7 |
| 7 | Genome editing mediated by SpCas9 variants with broad non-canonical PAM compatibility in plants显示文摘Streptococcus pyogenes Cas9(SpCas9)is the most widely used genome editing tool in plants.The editing induced by SpCas9 strictly requires a canonical NGG protospacer-adjacent motif(PAM),significantly limiting its scope of application.Recently,five SpCas9 variants,SpCas9-NRRH,SpCas9-NRCH,SpCas9-NRTH,SpG,and SPRY,were developed to recognize non-canonical PAMs in human cells.In this study,these variants were engineered for plant genome editing,and their targeted mutagenesis capabilities were comprehensively examined at various canonical and non-canonical PAM sites in rice(Oryza sativa)by stable transformation.Moreover,both cytosine base editors using a rat APOBEC1 or a human APO-BEC3a and adenine base editors using a directly evolved highly compatible TadA*-8e deaminase were developed from these SpCas9 variants.Our results demonstrated that the developed SpCas9 variantsbased base editors readily generated conversions between C.G and T.A in the target sites with noncanonical PAMs in transgenic rice lines.Collectively,the toolbox developed in this study substantially expands the scope of SpCas9-mediated genome editing and will greatly facilitate gene disruption and precise editing in plants. | Juan Li Rongfang Xu Ruiying Qin Xiaoshuang Liu Fanna Kong Pengcheng Wei | 2021 | Molecular Plant2021，14，2： | 6 |
| 8 | Dual-lens beam compression for optical coupling in superconducting nanowire single-photon detectors显示文摘The optical coupling of superconducting nanowire single-photon detectors(SNSPDs) has always been restricted to a single-mode fiber for a limited detection area. In this study, for enhancing photon coupling, a dual-lens system operating at 2.2 K was used to compress the beam size on the basis of the Gaussian beam theory and geometric approximation. A magnification of approximately 0.3 was obtained, and a focused spot with diameter of approximately 10 lm was measured from a multimode fiber. Assisted with the compressed beam, a system efficiency of 55 %(1550 nm) was achieved for a SNSPD with a detection area of 10 lm 9 10 lm and 62.5 lm multimode fiber coupling. At the same time, a high speed of106 MHz was measured with the proposed system. The realization of a highly compressed optical beam reduced the optical coupling requirement and helped maintain a high speed for the SNSPD. | Labao Zhang Chao Wan Min Gu Ruiying Xu Sen Zhang Lin Kang Jian Chen Peiheng Wu | 2015 | Science Bulletin2015，60，16： | 6 |
| 9 | Zircon U-Pb Age and Geochemistry of the Ore-hosting Ultramafic Complex of Zhou'an PGE-Cu-Ni Deposit,Henan Province,Central China显示文摘The Zhou'an PGE-Cu-Ni deposit was recently discovered in the Qinling orogenic belt bound by the Yangtze and the North China Cratons. It is a blind deposit thoroughly covered by the Cenozoic alluvial sediments in the Nanyang Basin. As the first large PGE-Cu-Ni deposit discovered in the Qinling-Dabie-Sulu orogenic belt, its geological and geochemical characteristic, isotope age, genesis and tectonic setting are of wide concern in both scientific studies and ore exploration. In this contribution, we report the results obtained from a pioneering study. The Zhou'an ultramafic complex is ferruginous, with m/f=4.79-5.08, and shows the nature of tholeiite series. It is rich in light rare earth elements, Rb, Th, U, La, Sm, Zr and Hf, and poor in heavy rare earth elements, Nd and Ta, suggesting an intraplate setting. It has high 87Sr/86Sr and low 143Nd/144Nd ratios. The ratios of Zr/Nb, La/Nb, Ba/Nb, Rb/Nb, Th/Nb, Th/La and Ba/La, suggest the magma originated from lithosphere mantle. The Fo values of olivine and Pd/Ir-Ni/Cu diagram suggest primary magma was High Mg basalt. The laser ablation inductively coupled plasma atomic emission spectroscopy zircon U-Pb age is 641.5±3.7 Ma. | YAN Haiqing DING Ruiying TANG Zhongli WANG Yalei LIU Shuang MA Jiahong HU Yanqiang CHEN Kena | 2012 | Acta Geologica Sinica(English Edition)2012，86，6： | 6 |
| 10 | 电视透视下吞咽能力检查在口咽期吞咽障碍中的应用显示文摘目的分析吞咽障碍患者电视透视下吞咽能力检查(VFSS)结果。方法 16例知情同意吞咽障碍患者接受VFSS检查。分别采用稀钡餐(50%w/v)、稠钡餐(270%w/v)、饼干沾稠钡餐进行咀嚼测试。一口量为10 ml。采用正位、侧位动态造影测试,依次观察双侧梨状窝对称情况、口期时长、咽期起始时间、咽期时长、滞留、误吸及其时间、剂量等。结果 5例为口期吞咽障碍;3例为咽期吞咽障碍,显示存在咽期起始迟缓,并且有1例表现为吞咽后误吸;8例为口咽期吞咽障碍,其中5例不伴误吸,3例伴有误吸,其中2例为安静误吸,1例表现为吞咽前误吸,1例表现为吞咽后误吸(梨状窝滞留引起),1例无法判断误吸时间。4例误吸患者中,3例存在钡剂25%以上的重度误吸,1例存在5%的轻度误吸,同时配合吞咽康复治疗。结论 VFSS检测可为制订吞咽障碍的康复方案提供参考。 | 万萍 Ding Ruiying 祝乐群 黄立 张宏 黄昭鸣 | 2011 | 中国康复理论与实践2011，17，12： | 5 |
| 11 | Green hydrogen:A promising way to the carbon-free society显示文摘With increasing importance attached by the international community to global climate change and the pressing energy revolution,hydrogen energy,as a clean,efficient energy carrier,can serve as an important support for the establishment of a sustainable society.The United States and countries in Europe have already formulated relevant policies and plans for the use and development of hydrogen energy.While in China,aided by the“30·60”goal,the development of the hydrogen energy,production,transmission,and storage industries is steadily advancing.This article comprehensively considers the new energy revolution and the relevant plans of various countries,focuses on the principles,development status and research hot spots,and summarizes the different green hydrogen production technologies and paths.In addition,based on its assessment of current difficulties and bottlenecks in the production of green hydrogen and the overall global hydrogen energy development status,this article discusses the development of green hydrogen technologies. | Ying Zhou Ruiying Li Zexuan Lv Jian Liu Hongjun Zhou Chunming Xu | 2022 | Chinese Journal of Chemical Engineering2022，35，3： | 5 |
| 12 | Ethylene and salicylic acid synergistically accelerate leaf senescence in Arabidopsis显示文摘The phytohormones ethylene and salicylic acid(SA) have long been known to promote senescence, but their interplay during this process remains elusive. Here we report the synergistic effects of ethylene and SA on promoting leaf senescence in Arabidopsis. EIN3, a key transcription factor of ethylene signaling, physically interacted with the core SA signaling regulator NPR1 in senescing leaves. EIN3 and NPR1 synergistically promoted the expression of the senescence-associated genes ORE1 and SAG29.The senescence phenotype was more delayed for the ein3 eil1 npr1 triple mutant than ein3 eil1 or npr1 with ethylene or/and SA treatment. NPR1-promoted leaf senescence may depend on functional EIN3/EIL1. | Chaoqi Wang Shouyi Dai Zhong‐Lin Zhang Wenqing Lao Ruiying Wang Xianqing Meng Xin Zhou | 2021 | Journal of Integrative Plant Biology2021，63，5： | 4 |
| 13 | Microstructure and mechanical properties at elevated temperature of Mg-Al-Ni alloys prepared through powder metallurgy显示文摘Mg-Al-Ni alloys were prepared by powder metallurgy, and their microstructure and elevated temperature mechanical properties were investigated. Results indicate that, in addition to α-Mg matrix, both coarse Al_3Ni_2 particles and fine Al Ni nano-particles exist in the Mg-Al-Ni alloys. The strength at 150?C is improved with the increase in Ni content. Mg-18.3Al-8Ni alloy possesses a compressive strength of234.7 MPa and a yield strength of 146.5 MPa. Plasticity is also improved with a low concentration of Ni. Mg-11.3Al-2Ni alloy possesses a compression ratio of 17.3%. The phases of Al_3Ni_2 and Al Ni in the alloys block the movements of grain boundaries and dislocations during the deformation at elevated temperature. The existence of Al Ni phase provides a non-basal slip system, leading to the improvement in plasticity. Finally, the formation mechanism of Al-Ni phases in the process is discussed with thermodynamics and kinetics. | Legan Hou Bingcheng Li Ruizhi Wu Lin Cui Peng Ji Ruiying Long Jinghua Zhang Xinlin Li Anping Dong Baode Sun | 2017 | Journal of Materials Science & Technology2017，33，9： | 4 |
| 14 | Development of an efficient plant dual cytosine and adenine editor显示文摘An enhanced CDA-like(eCDAL)was established from Japanese lamprey CDA1-like 4 to achieve a high editing frequency in a broad region as a C-terminal cytosine base editors(CT-CBE).Then,a novel plant dual-base editor version1(pDuBE1)was developed by integrating TadA-8e into eCDAL.The editing efficiency of pDuBE1 could reach to 87.6%,with frequencies of concurrent A-to-G and C-to-T conversions as high as 49.7%in stably transformed plant cells.Our results showed that pDuBE1 could mediate robust dual editing in plant genome,providing a powerful manipulation tool for precise crop breeding and screening platforms for in planta direct evolution. | Rongfang Xu Fanna Kong Ruiying Qin Juan Li Xiaoshuang Liu Pengcheng Wei | 2021 | Journal of Integrative Plant Biology2021，63，9： | 4 |
| 15 | Impact of diabetes on promoting the growth of breast cancer显示文摘Background:Type Ⅱ diabetes mellitus(DM2)is a significant risk factor for cancers,including breast cancer.However,a proper diabetic breast cancer mouse model is notwell-established for treatment strategy design.Additionally,the precise diabetic signaling pathways that regulate cancer growth remain unresolved.In the present study,we established a suitable mouse model and demonstrated the pathogenic role of diabetes on breast cancer progression.Methods:We successfully generated a transgenic mouse model of human epidermal growth factor receptor 2 positive(Her2^(+) or ERBB2)breast cancer with DM2 by crossing leptin receptor mutant(Lepr^(db/+))mice with (MMTV-ErbB2/neu)mice.Themousemodelswere administrated with antidiabetic drugs to assess the impacts of controlling DM2 in affecting tumor growth.Magnetic resonance spectroscopic imaging was employed to analyze the tumor metabolism.Results:Treatment with metformin/rosiglitazone in MMTV-ErbB2/Lepr^(db/db) mousemodel reduced serum insulin levels,prolonged overall survival,decreased cumulative tumor incidence,and inhibited tumor progression.Anti-insulin resistance medications also inhibited glycolytic metabolism in tumors in vivo as indicated by the reduced metabolic flux of hyperpolarized ^(13)C pyruvate-to-lactate reaction.The tumor cells from MMTV-ErbB2/Lepr^(db/db) transgenic mice treated with metformin had reprogrammed metabolism by reducing levels of both oxygen consumption and lactate production.Metformin decreased the expression of Myc and pyruvate kinase isozyme 2(PKM2),leading to metabolism reprogramming.Moreover,metformin attenuated the mTOR/AKT signaling pathway and altered adipokine profiles.Conclusions:MMTV-ErbB2/Lepr^(db/db) mouse model was able to recapitulate diabetic HER2^(+) human breast cancer.Additionally,our results defined the signaling pathways deregulated in HER2^(+) breast cancer under diabetic condition,which can be intervened by anti-insulin resistance therapy. | Ping-Chieh Chou Hyun Ho Choi Yizhi Huang Enrique Fuentes-Mattei Guermarie Velazquez-Torres Fanmao Zhang Liem Phan Jaehyuk Lee Yanxia Shi James A.Bankson Yun Wu Huamin Wang Ruiying Zhao Sai-Ching Jim Yeung Mong-Hong Lee | 2021 | Cancer Communications2021，41，5： | 4 |
| 16 | Nanostructured Anode Materials for Non-aqueous Lithium Ion Hybrid Capacitors显示文摘The rapid advancement in electronic devices,electric vehicles,and grid storage stations have lead to a high demand for energy storage devices with enhanced power and energy densities as well as extended lifespans.Lithium ion hybrid capacitors are constructed with battery-type anodes and capacitor-type cathodes,which enables the direct integration of the high energy from lithium ion batteries and high power and long lifetime from supercapacitors,making lithium ion hybrid capacitor one of the most promising energy storage devices.In the past two decades,tremendous efforts have been put into the search for suitable battery-type anode materials with improved Faradaic reaction kinetics so that it can match with the fast non-Faradaic charging rate of the capacitive cathodes.This review aims to provide an up-to-date and comprehensive summary of the battery-type anode materials for high-performance lithium ion hybrid capacitors.To date,a large variety of battery-type anode materials have been explored with smart material design strategies,such as carbonaceous materials,metal oxides,alloys,sulfides,nitirdes,and Mxenes,etc.,which will be discussed in detail.A perspective to the challenges and future developing trends of lithium ion hybrid capacitors is proposed to close. | Cuiping Han Hongfei Li Ruiying Shi Lei Xu Junqin Li Feiyu Kang Baohua Li | 2018 | Energy & Environmental Materials2018，1，2： | 3 |
| 17 | On-treatment serum HBsAg level is predictive of sustained off-treatment virologic response to telbivudine in HBeAg-positive chronic hepatitis B patients显示文摘 | Wei Cai Qing Xie Baoyan An Hui Wang Xiaqiu Zhou Guomin Zhao Qing Guo Ruiying Gu Shisan Bao | 2010 | Journal of Clinical Virology2010，，1： | 3 |
| 18 | Sentiment Analysis of Code-Mixed Bambara-French Social Media Text Using Deep Learning Techniques显示文摘 | Arouna KONATE DU Ruiying | 2018 | Wuhan University Journal of Natural Sciences2018，23，3： | 3 |
| 19 | Two outward potassium current types are expressed during the neural differentiation of neural stem cells显示文摘The electrophysiological properties of potassium ion channels are regarded as a basic index for determining the functional differentiation of neural stem cells.In this study,neural stem cells from the hippocampus of newborn rats were induced to differentiate with neurotrophic growth factor,and the electrophysiological properties of the voltage-gated potassium ion channels were observed.Immunofluorescence staining showed that the rapidly proliferating neural stem cells formed spheres in vitro that expressed high levels of nestin.The differentiated neurons were shown to express neuron-specific enolase.Flow cytometric analysis revealed that the neural stem cells were actively dividing and the percentage of cells in the S+G2/M phase was high.However,the ratio of cells in the S+G2/M phase decreased obviously as differentiation proceeded.Whole-cell patch-clamp recordings revealed apparent changes in potassium ion currents as the neurons differentiated.The potassium ion currents consisted of one transient outward potassium ion current and one delayed rectifier potassium ion current,which were blocked by 4-aminopyridine and tetraethylammonium,respectively.The experimental findings indicate that neural stem cells from newborn rat hippocampus could be cultured and induced to differentiate into functional neurons under defined conditions in vitro.The differentiated neurons expressed two types of outward potassium ion currents similar to those of mature neurons in vivo. | Ruiying Bai Guowei Gao Ying Xing Hong Xue | 2013 | Neural Regeneration Research2013，8，28： | 3 |
| 20 | Recent advances in developing small-molecule inhibitors against SARS-CoV-2显示文摘The COVID-19 pandemic caused by the novel SARS-CoV-2 virus has caused havoc across the entire world.Even though several COVID-19 vaccines are currently in distribution worldwide,with others in the pipeline,treatment modalities lag behind.Accordingly,researchers have been working hard to understand the nature of the virus,its mutant strains,and the pathogenesis of the disease in order to uncover possible drug targets and effective therapeutic agents.As the research continues,we now know the genome structure,epidemiological and clinical features,and pathogenic mechanism of SARS-CoV-2.Here,we summarized the potential therapeutic targets involved in the life cycle of the virus.On the basis of these targets,small-molecule prophylactic and therapeutic agents have been or are being developed for prevention and treatment of SARS-CoV-2 infection. | Rong Xiang Zhengsen Yu Yang Wang Lili Wang Shanshan Huo Yanbai Li Ruiying Liang Qinghong Hao Tianlei Ying Yaning Gao Fei Yu Shibo Jiang | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 3 |
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