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| 1 | Early-onset colorectal cancer:A separate subset of colorectal cancer显示文摘Colorectal cancer(CRC)has a great impact on the world population.With increasing frequency,CRC is described according to the presenting phenotype,based on its molecular characteristics.Classification of CRC tumors according to their genetic and/or epigenetic alterations is not only important for establishing the molecular bases of the disease,but also for predicting patient outcomes and developing more individualized treatments.Early-onset CRC is a heterogeneous disease,with a strong familial component,although the disease is sporadic in an important proportion of cases.Different molecular alterations appear to contribute to the apparent heterogeneity of the early-onset population and subgroups can be distinguished with distinct histopathologic and familial characteristics.Moreover,compared with late-onset CRC,there are characteristicsthat suggest that early-onset CRC may have a different molecular basis.The purpose of this review was to analyze the current state of knowledge about earlyonset CRC with respect to clinicopathologic,familial and molecular features.Together,these features make it increasingly clear that this subset of CRC may be a separate disease,although it has much in common with late-onset CRC. | Irene Osorio Silla Daniel Rueda Yolanda Rodríguez Juan Luis García Felipe de la Cruz Vigo José Perea | 2014 | World Journal of Gastroenterology2014，20，46： | 4 |
| 2 | Laser in situkeratomileusis for mixed and simple myopic astigma- tism withthe Nidek EC-5000 laser 显示文摘 | RUEDA L PINEDA-FERNANDEZ A HUANG D NUR J | 2002 | J Refract Surg2002，18，3： | 1 |
| 3 | Thermo -mechanical prop- erties of candelilla wax and dotriacontane organogels in saf- flower oil 显示文摘 | MORALES - RUEDA J A DIBILDOX - ALVARADO E CHAR- ALONSO M A | 2009 | Eur J Lipid Sci Tech2009，111，2： | 1 |
| 4 | Endometrial cancer in women 40 years old or younger显示文摘 | Duska LR Garrett A Rueda BR | 2001 | Gynecol Oncol2001，83，2： | 1 |
| 5 | A Prussian blue-based flow-through renewable surface opt sensor for analysis of ascorbic acid显示文摘 | RUEDAS RAMA M J RUIZ MEDINA A MOLINA DIAZ A | 2004 | Microchemical Journal2004，78，： | 1 |
| 6 | endometrial cancer in women of 40 years old or yanger显示文摘 | Dusk a LR Garrett A Rueda BR | 2001 | GynecolOncol2001，83，2： | 1 |
| 7 | Struc- ture and cytotoxicity of new polyhydroxylated sterols from the Caribbean gorgonian Plexaurella grisea 显示文摘 | Ana Rueda Eva Zuh'a Mara J Orteg'a | 2001 | Steroids2001，66，： | 1 |
| 8 | R-CHOP-14 in patients with diffuse large B-cell lymphoma younger than 70 years: a multicentre, prospective study显示文摘 | Rueda A Sabin P Rifa J | 2008 | Hematol Oncol2008，26，1： | 1 |
| 9 | Association between functional haplotypes of vascular endothelial growth factor and renal complications in Henoch-Schonlein purpura 显示文摘 | Rueda B Perez A C Lopez L S | 2006 | Journal of Rheumatology2006，33，1： | 1 |
| 10 | Interactive effects of attributional styles for positive and negative events on psychological distress显示文摘 | Sanjuan P Pérez A Rueda B Ruiz(A) | | 0，，： | 1 |
| 11 | Optimality Crieria in Mathimatical Programming Involving Genelized Invexity显示文摘 | RUEDA N G HANSON M A | 1998 | J Math Anal Appl1998，130，3： | 1 |
| 12 | Relativistic Thomas Fermi treatment of compressed atoms and com- pressed nuclear matter cores of stellar dimensions显示文摘 | Rotondo M Rueda J A Ruffini R | 2011 | Phys Rev C2011，83，04： | 1 |
| 13 | The association be- tween pneumococcal pneumonia and cardiac events 显示文摘 | Musher D M Rueda A M Kaka A S | 2007 | Clin Inefet Dis2007，45，： | 1 |
| 14 | Synthesis and microstructure - mechanical property relationships of segmented polyurethanes based on a PCL - PTHF - PCL block copolymer as soft segment 显示文摘 | RUEDA - LARRAZ L D'ARLAS B F TERCJAK A | 2009 | European Polymer Journal2009，45，7： | 1 |
| 15 | Novelsuppressive function of transitional2B cells in experimental arthritis显示文摘 | Evans JG Chavez Rueda KA Eddaoudi A | 2007 | J Immunol2007，178，12： | 1 |
| 16 | Water content estimation in vegetation with MODIS reflectance data and model inversion methods显示文摘 | ZARCO-TEJADA P J RUEDA C A USTIN S L | 2003 | Remote Sensing of Environment2003，85，1： | 1 |
| 17 | Thermal and textural properties of organogels developed by candelilla wax in safflower oil 显示文摘 | TORO-VAZQUEZ J F MORALES -RUEDA J A DIBILDOX - ALYARADO E | 2007 | J Am Oil Chem Soe2007，84，11： | 1 |
| 18 | Endometrial can- cer in women of 40 years old or younger 显示文摘 | Duska LR Carrett A Rueda BR | 2001 | Gynecol On- col2001，83，20： | 1 |
| 19 | In terleukin-18 promoter polymorphisms are not relevant in rheumatoid arthritis显示文摘 | Rueda B Gonzalez-Gay M A Mataran L | 2005 | TissueAntigens2005，65，6： | 1 |
| 20 | Optimality criteria in mathematical programming involving generalized invexity显示文摘 | Rueda N G Hanson M A | 1998 | J Math Anal Appl1998，130，： | 1 |
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