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| 1 | Collagen/hyaluronan based hydrogels releasing sulfated hyaluronan improve dermal wound healing in diabetic mice via reducing inflammatory macrophage activity显示文摘Sustained inflammation associated with dysregulated macrophage activation prevents tissue formation and healing of chronic wounds.Control of inflammation and immune cell functions thus represents a promising approach in the development of advanced therapeutic strategies.Here we describe immunomodulatory hyaluronan/collagen(HA-AC/coll)-based hydrogels containing high-sulfated hyaluronan(sHA)as immunoregulatory component for the modulation of inflammatory macrophage activities in disturbed wound healing.Solute sHA downregulates inflammatory activities of bone marrow-derived and tissue-resident macrophages in vitro.This further affects macrophage-mediated pro-inflammatory activation of skin cells as shown in skin ex-vivo cultures.In a mouse model of acute skin inflammation,intradermal injection of sHA downregulates the inflammatory processes in the skin.This is associated with the promotion of an anti-inflammatory gene signature in skin macrophages indicating a shift of their activation profile.For in vivo translation,we designed HA-AC/coll hydrogels allowing delivery of sHA into wounds over a period of at least one week.Their immunoregulatory capacity was analyzed in a translational experimental approach in skin wounds of diabetic db/db mice,an established model for disturbed wound healing.The sHA-releasing hydrogels improved defective tissue repair with reduced inflammation,augmented pro-regenerative macrophage activation,increased vascularization,and accelerated new tissue formation and wound closure. | Sophia Hauck Paula Zager Norbert Halfter Elke Wandel Marta Torregrossa Ainur Kakpenova Sandra Rother Michelle Ordieres Susann Räthel Albrecht Berg Stephanie Möller Matthias Schnabelrauch Jan C.Simon Vera Hintze Sandra Franz | 2021 | Bioactive Materials2021，6，12： | 7 |
| 2 | Blockade of intravascular hemolysis in PNH with the Terminal Complement Inhibitor Eculizumab Unmasks Low-level hemolysis potentially occurring through C3 opsonization显示文摘 | Hill A P Rother R M Risitano A | 2006 | Blood2006，，108： | 1 |
| 3 | The Effect of Slight Deformation on Droplet Coalescence in Linear Flows显示文摘 | Rother M Davis R | 2001 | Physics of Fluids2001，13，5： | 1 |
| 4 | Preclinical characterisation of NSAIDs in ultradeformable carriers or conventional topical gels 显示文摘 | CEVC G MAZGAREANU S ROTHER M | 2008 | Int J Pharm2008，360，12： | 1 |
| 5 | Buoyancy driven Coalescence of Slightly Deformable Drops 显示文摘 | Rother M Zinchenko A Davis R | 1997 | Journal of Fluid Mechanics1997，346，： | 1 |
| 6 | A multiple-dose, open-label, safety, compliance, and usage evaluation study of epicutaneously applied Diractin (ketoprofen in Transfersome) in joint/musculoskeletal pain or soft tissue inflammation 显示文摘 | KNEER W ROTHER I ROTHER M | 2009 | Curr Drug Saf2009，4，1： | 1 |
| 7 | Acute stroke evaluated by time to peak mapping during initial and early follow upper fusion CT studies显示文摘 | Reichenbach JR Rother J Jonetz M | 1999 | AJNR1999，20，： | 1 |
| 8 | Ubiquitin-proteasome pathway as a new target for the prevention of restenosis显示文摘 | Meiners S Laule M Rother W Guenther C Prauka 1 Muschick P | 2002 | Circulation2002，105，4： | 1 |
| 9 | Efficacy of epicutaneous Diractin (ketoprofen in Transfersome gel) for the treatment of pain related to eccentric muscle contractions 显示文摘 | ROTHER M SEIDEL E J CLARKSON P M | 2009 | Drug Des Devel Ther2009，，3： | 1 |
| 10 | Systemic risk score evaluation in isehemic stroke patients ( SCALA ): a prospective cross sectional study in 85 German stroke units显示文摘 | eimar C Goertler M Rother J | 2007 | J Neurol2007，254，11： | 1 |
| 11 | Ubiquit-in-proteasome pathway as a new target for the prevention of restenosis显示文摘 | Meiners S Laule M Rother W | 2002 | Circulation2002，105，4： | 1 |
| 12 | Selenoprotein synthesis in archaea显示文摘 | Rother M Rescha Wilting R | 2001 | Biofactors2001，14，： | 1 |
| 13 | Effects of bamboo stands on seed rain and seed limitation in a rainforest 显示文摘 | Rother D C Rodrigues R R Pizo M A | 2009 | Forest Ecology and Management2009，257，3： | 1 |
| 14 | Predictive value of the essen stroke risk score and ankle braehial index in acute isehaemic stroke patients from 85 German stroke units显示文摘 | Weimar C Goertler M Rother J | 2008 | J Neurol Neurosurg Psychi atry2008，79，12： | 1 |
| 15 | PDK1 defi- ciency in POMC-expressing cells reveals FOXOl-dependent and - independent pathways in control of energy homeostasis and stress response显示文摘 | BELGARDT B F H A ROTHER E ERNST M 13 | 2008 | Cell Metab2008，，7： | 1 |
| 16 | Systemic Risk Score Evaluation in Ischemic Stroke Patients (SCALA): a prospective cross sectional study in 85 German stroke units显示文摘 | Weimar C Goertler M Rother J | 2007 | J Neurol2007，254，4： | 1 |
| 17 | First scalar magnetic anomaly map from CHAMP satellite data indicates weak lithospheric field 显示文摘 | Maus S Rother M R Holme H | 2002 | Geophys Res Lett2002，29，14： | 1 |
| 18 | Effects of exenatide alone and in combination with daclizumab on beta-cell function in long- standing type 1 diabetes显示文摘 | Rother K I Spain L M Wesley R A | 2009 | Diabetes Care2009，32，12： | 1 |
| 19 | Predictive value of the Essen Stroke Risk Score and Ankle Brachial Index in acute ischaemic stroke patients from 85 German stroke units 显示文摘 | Weimar C Goertler M Rother J | 2008 | J Neurol Neurosurg Psychiatry2008，79，12： | 1 |
| 20 | , EartWs lithospheric magnetic field determined to spherical harmonic degree 90 from CHAMP satellite measurements 显示文摘 | Maus S Rother M Hemant K | 2006 | Geophys J Int2006，164，319： | 1 |
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