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| 1 | Measurement of body composition as a surrogate evaluation of energy balance in obese patients显示文摘In clinical practice obesity is primarily diagnosed through the body mass index. In order to characterize patients affected by obesity the use of traditional anthropometric measures appears misleading. Beyond the body mass index, there are overwhelming evidences towards the relevance of a more detailed description of the individual phenotype by characterizing the main body componentsas free-fat mass, muscle mass, and fat mass. Among the numerous techniques actually available, bioelectrical impedance analysis seems to be the most suitable in a clinical setting because it is simple, inexpensive, noninvasive, and highly reproducible. To date, there is no consensus concerning the use of one preferred equation for the resting energy expenditure in overweight and/or obese population. Energy restriction alone is an effective strategy to achieve an early and significant weight loss, however it results in a reduction of both fat and lean mass therefore promoting or aggravating an unfavourable body composition(as sarcobesity) in terms of mortality and comorbidities. Therefore the implementation of daily levels of physical activity should be simultaneously promoted. The major role of muscle mass in the energy balance has been recently established by the rising prevalence of the combination of two condition as sarcopenia and obesity. Physical exercise stimulates energy expenditure, thereby directly improving energy balance, and also promotes adaptations such as fiber type, mitochondrial biogenesis, improvement of insulin resistance, and release of myokines, which may influence different tissues, including muscle. | Carlo Maria Rotella Ilaria Dicembrini | 2015 | World Journal of Methodology2015，5，1： | 8 |
| 2 | Bevacizumab in the pre-operative treatment of locally advanced rectal cancer: A systematic review显示文摘Despite advances in the management of patients with locally advanced,non-metastatic rectal adenocarcinoma(LARC),prognosis remains largely unsatisfactory due to a high rate of distant relapse.In fact,currently available neoadjuvant protocols,represented by fluoropyrimidine-based chemo-radiotherapy(CT-RT)or short-course RT,together with improved surgical techniques,have largely reduced the risk of local relapse,with limited impact on distant recurrence.Available results of phaseⅢtrials with additional cytotoxic agents combined with standard CT-RT are disappointing,as no significant reduction in the risk of recurrence has been demonstrated.In order to improve the control of micrometastatic disease,integrating targeted agents into neoadjuvant treatment protocols thus offers a rational approach.In particular,the antiangiogenic agent bevacizumab has demonstrated synergistic activity with both CT and RT in pre-clinical and clinical models,and thusmay represent a suitable companion in the neoadjuvant treatment of LARC.Preliminary results of phase?Ⅰ-Ⅱclinical studies are promising and suggest potential clinical parameters and molecular predictive biomarkers useful for patient selection:treatment personalization is indeed the key in order to maximize the benefit while reducing the risk of more complex neoadjuvant treatment schedules. | Lorenzo Fornaro Chiara Caparello Caterina Vivaldi Virginia Rotella Gianna Musettini Alfredo Falcone Editta Baldini Gianluca Masi | 2014 | World Journal of Gastroenterology2014，20，20： | 5 |
| 3 | Orlistat and sibutramine beyond weight loss显示文摘 | MANNUCCI E DICEMBRINI I ROTELLA F | 2008 | Nutrition Metabolism & Cardiovascular Diseases2008，18，5： | 1 |
| 4 | Incidence andprevalence of idiopathic pulmonary fibrosis: review of the literature显示文摘 | Nalysnyk L Cid-Ruzafa J Rotella P | 2012 | Eur Respir Rev2012，21，126： | 1 |
| 5 | Modeling,analysis, and design of RF LDMOS devices using harmonic- balance device simulation显示文摘 | ROTELLA F M MA G YU Z | 2000 | IEEE Transactions2000，48，6： | 1 |
| 6 | PWM method to eliminate power sources in a nonredundant 27-level inverter for machine drive applications显示文摘 | M Rotella G Penailillo J Pereda J Dixon | | 0，，01： | 1 |
| 7 | The effects of cooling conditions on surface integrity in machining of Ti6A14V alloy 显示文摘 | Rotella G Dillon Jr O W Umbrello D | 2014 | International Journal of Advanced Manufacturing Technology2014，71，1234： | 1 |
| 8 | Biophysical factors, land use, and species viability in and around nature reserves显示文摘 | HANSEN A J ROTELLA J J | 2002 | Conservation Biology2002，16，4： | 1 |
| 9 | Finite element modeling of microstructural changes in dry and cryogenic cutting of Ti6A14V alloy 显示文摘 | Giovanna Rotella Domenico Umbrello | 2014 | CIRP Annals-Manufacturing Technology2014，63，： | 1 |
| 10 | Glucagon-like peptide 1 (GLP-1) and metabolic disease显示文摘 | Rotella CM Pala L Mannucci E | 2005 | J Endocrinol Invest2005，28，8： | 1 |
| 11 | Stereoselective synthesis of erythro alpha- amino epoxides 显示文摘 | ROTELLA D P | 1995 | Tetrahedron Lett1995，36，31： | 1 |
| 12 | Incidence and prevalence of idiopathic pulmonary fibrosis:review of the literature显示文摘 | Nalysnyk L Cid-Ruzafa J Rotella P | 2012 | Eur Respir Rev2012，21，126： | 1 |
| 13 | Modeling,analysis,and design of RF LDMOS devices using harmonic-balance de-vice simulation显示文摘 | ROTELLA F M MA G YU Z | 2000 | Microwave Theory and Techniques IEEE Transactions2000，48，6： | 1 |
| 14 | The effect of cooling conditions on surface integrity in machining of Ti6A14V alloy 显示文摘 | ROTELLA G DILLON O W | 2014 | Int J Adv Manuf Technol2014，71，14： | 1 |
| 15 | Phosphodiesterase 5 inhibitors: current status and potential applications显示文摘 | Rotella DP | 2002 | Nat Rev Drug Discov2002，1，9： | 1 |
| 16 | From Theo- ry to Clinical Practice in the Use of GLP-1 Receptor Agonists and DPP-4 Inhibitors 显示文摘 | Ilaria Dicembrini Laura Pala CarloMaria Rotella | 2011 | Therapy Experimental Diabetes Re- search2011，，： | 1 |
| 17 | Modeling, analysis, and design of RF LDMOS devices using harmonic-bal- ance device simulation 显示文摘 | Rotella F M Ma G Yu Z | 2000 | IEEE Transactions on Mi- crowave Theory and Techniques2000，48，6： | 1 |
| 18 | Simplifled orthodontic toothmovement with dental implants and orthodontic elastics: A clinical report 显示文摘 | Mario Rotella Alessandro Geminiani Carlo Ercoli | 2011 | J Prosthet Dent2011，105，1： | 1 |
| 19 | Inflammatory and neurodegenerative pathways in depression: a new avenue for antidepressant development? 显示文摘 | Catena-Dell'Osso M Bellantuono C Consoli G Baroni S Rotella F Marazziti D | 2011 | Curr Med Chem2011，18，： | 1 |
| 20 | Modeling, Analysis, and Design of RF LDMOS Devices Using Harmonic- Balance Device Simulation 显示文摘 | F M Rotella G Ma Z Yu R W Dutton | 2000 | IEEE Transactions On MTT2000，48，6： | 1 |
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