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| 1 | Treatment of chronic viral hepatitis with nitazoxanide and second generation thiazolides显示文摘Nitazoxanide,the first thiazolide,was originally developed for the treatment of Cryptosporidium parvum.More recently,antiviral activity of nitazoxanide against hepatitis B virus(HBV)and hepatitis C virus was recognized in in vitro systems.These basic studies led to phaseⅡclinical trials that demonstrated the safety and efficacy of nitazoxanide in combination with peginterferon,with or without ribavirin,in the treatment of chronic hepatitis C genotype 4.The sustained virologic response rate was 79%and 80%in two studies,which was higher than the response rate of 50%with the standard of care with peginterferon plus ribavirin.In very preliminary studies of patients with chronic hepatitis B,nitazoxanide suppressed serum HBV DNA and led to loss of hepatitis B e antigen in the majority of patients and hepatitis B surface antigen in approximately a quarter of patients.Randomized controlled studies of naive and nonresponder patients with chronic hepatitis C genotype 1 are underway,new second generation and controlled release thiazolides are being developed,and future studies of patients with chronic hepatitis B are planned. | Emmet B Keeffe Jean-Franois Rossignol | 2009 | World Journal of Gastroenterology2009，15，15： | 5 |
| 2 | 射血分数保留的心力衰竭患者服用螺内酯治疗难治性高血压的效果显示文摘最近的研究表明,醛固酮受体拮抗剂螺内酯应作为治疗难治性高血压(resistant hypertension,RHTN)优选的第四线抗高血压药物。目前螺内酯是否能改善射血分数保留的心力衰竭(heart failure with preserved ejection fraction,HFpEF)和RHTN患者的血压控制情况尚不清楚。 | Rossignol P Claggett BL Liu J Vardeny O Pitt B Zannad F Solomon S 陈云(编译) 叶鹏(审校) | 2019 | 中华高血压杂志2019，0，3： | 5 |
| 3 | 端粒缩短,而不是端粒消耗率,与颈动脉粥样硬化相关显示文摘端粒是真核生物细胞线性染色体末端一段特殊的DNA蛋白质复合物,有两个主要功能:(1)防止染色体末端识别为有害的DNA双链断裂;(2)通过募集端粒酶(一种合成新的端粒DNA重复序列的逆转录酶)来确保完整的DNA复制。端粒缩短参与了机体的衰老。端粒的过度损耗导致血管内皮细胞、内皮祖细胞以及平滑肌细胞衰老和功能障碍, | Toupance S Labat C Temmar M Rossignol P Kimura M Aviv A Benetos A 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，7： | 4 |
| 4 | Galectin-3 Mediates Aldosterone-Induced Vascular Fibrosis显示文摘 | Laurent Calvier Maria Miana Pascal Reboul Victoria Cachofeiro Ernesto Martinez-Martinez Rudolf A. de Boer Fran?oise Poirier Patrick Lacolley Faiez Zannad Patrick Rossignol Natalia López-Andrés | 2013 | Arteriosclerosis, Thrombosis, and Vascular Biology2013，，1： | 2 |
| 5 | The ULT1 and ULT2 trxG Genes Play Overlapping Roles in Arabidopsis Development and Gene Regulation显示文摘基因表示的 epigenetic 规定为在特定的发展阶段保证定义染色体抄写程序的合适的推广和稳定性是批评的。稳定的基因表达式状态的细胞的存储器被 Polycomb 的反对活动在动物和植物开发期间调停组(PcG ) 因素和 trithorax 组(trxG ) 因素。尽管有他们的重要性,然而,一些仅仅 trxG 因素在植物被描绘了,他们在调整植物开发的角色糟糕被定义。在这个工作,我们报导密切相关的 Arabidopsis trxG 基因 ULTRAPETALA1 (ULT1 ) 和 ULT2 在调整射击和花的干细胞累积有重叠功能,与起一个主要作用的 ULT1 但是也做次要的贡献的 ULT2。二基因也在建立雌蕊的 apicalbasal 极性轴举办一项新奇、冗余的活动,显示他们在区分纸巾工作。象 ULT1 蛋白质一样, ULT2 蛋白质有双原子、细胞质的本地化,并且二蛋白质身体上在 planta 联系。最后,我们证明 ULT1 和 ULT2 有很类似的 overexpression 显型并且调整重要进展目标基因的一个普通集合,包括花的疯盒子的基因和一级 KNOX 基因。我们的结果表明改变的那染色质由 ULT1 和 ULT2 蛋白质调停了是必要的控制分裂组织和繁殖机关的发展。他们也建议植物 trxG 蛋白质象他们的动物对应物一样,可以在多蛋白质建筑群工作到起来调整关键阶段特定、织物特定的发展规章的基因的表达式。 | Mona M. Monfared | 2013 | Molecular Plant2013，6，5： | 2 |
| 6 | Overexpression and purification of the hepatitis B e antigen precursor显示文摘 | Laine S Salhi S Rossignol J M | 2002 | Journal of Virological Methods2002，103，： | 1 |
| 7 | E5531,A synthetic non-toxin lipid A derivate blicks the immunbiological activities of liopolysaccharide显示文摘 | Bristol J R Rossignol D P | 1999 | Br J Pharmacol1999，127，4： | 1 |
| 8 | Production of exocellular pigment by the marine diatom Haslea ostrearia Simonsen in a photobioreactor equipped with immersed ultrafiltration membranes 显示文摘 | ROSSIGNOL N JAOUEN P ROBERT J M | 2000 | Bioresource Technology2000，73，2： | 1 |
| 9 | Influence of blood sam- pling procedure on plasma concentrations of matrix metalloproteinas- es and their tissue inhibitors显示文摘 | Rossignol P Cambillau M Bissery A | 2007 | Chn Exp Pharmacol Physio12007，35，4： | 1 |
| 10 | Mineralocorticoid receptor antagonists for heart failure with reduced ejection fraction:integrating evidence into clinical practice显示文摘 | Zannad F Gattis Stough W Rossignol P | 2012 | Eur Heart J2012，33，22： | 1 |
| 11 | Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH 显示文摘 | Rossignol M Kolb-Cheynel I Egly JM | 1997 | EMBO J1997，16，7： | 1 |
| 12 | Ontogeny of the neutral amino acid transporter SNAT 1 in the developing rat 显示文摘 | Weiss MD Donnelly WH Rossignol C | 2005 | J Mol Histol2005，36，4： | 1 |
| 13 | Acoustic waves generated by a laser line pulse in a transversely isotropic cylinder 显示文摘 | PAN Y ROSSIGNOL C AUDOIN B | 2003 | Ap- plied Physics Letters2003，82，24： | 1 |
| 14 | Transplantation ofmultipo- tent astrocytic stem cells into a rat model of neonatal hypoxic-ischemic encephalopathy 显示文摘 | Zheng T Rossignol C Leibovici A | 2006 | Brain Res2006，1112，： | 1 |
| 15 | Renal effects of low-dose dopamine in patients with sepsis syndrome or septic shock treated with catecholamines显示文摘 | Lherm T Troche G Rossignol M | 1996 | Intensive Care Med1996，22，3： | 1 |
| 16 | TLR4 antagonists for endotoxemia and beyond显示文摘 | Rossignol DP Lynn M | 2005 | Curt Opin Investig Drugs2005，6，5： | 1 |
| 17 | Ultrastructure of the mitochondrion and its bearing on function and bioenergetics 显示文摘 | Benard Giovanni Rossignol Rodrigue | 2008 | Antioxid Redox Signal2008，10，8： | 1 |
| 18 | Vascular structure and function iscorrelated to cognitive performance and whitematter hyperintensities in older hypertensivepatients with subjective memory complaints显示文摘 | KearneySchwartz A Rossignol P BracardS | | Stroke0，40，4： | 1 |
| 19 | A role for cardiotrophin-1 in myocardial remodeling induced by aldosterone显示文摘 | L(O)PEZ ANDR(E)S N MARTIN FERNANDEZ B ROSSIGNOL P el al | | 0，，06： | 1 |
| 20 | Association of galectin-3 and fibrosis markers with long-temm cardiovascular outcomes in patients with heart failure,left ventricular dysfunction,and dyssynchrony:insights from the CARE-HF (Cardiac Resynchronization in Heart Failure) trial显示文摘 | Lopez-Andrès N Rossignol P Iraqi W | | 0，，01： | 1 |
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