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| 1 | FSH dosage effect on conventional sperm parameters:a meta-analysis of randomized controlled studies显示文摘Follicle-stimulating hormone(FSH)represents a therapeutic option in normogonadotropic patients with idiopathic oligozoospermia.The aim of this review was to evaluate the possible dose-and drug-dependent efficacy of FSH treatment on conventional sperm parameters.We performed a comprehensive systematic review via a meta-analysis of all available randomized controlled trials,in which FSH administration was compared with placebo or no treatment when administered to normogonadotropic patients with idiopathic oligozoospermia.Of the 971 articles that were retrieved,5 were fin ally included,in eluding a total of 372 patie nts and 294 controls.Overall,FSH treatment was effective in ameliorating the sperm concentration,total count,progressive motility,but not normal forms.On the basis of the weekly dosage,the studies were classified into those using low(175-262.5 IU per week),intermediate(350-525 IU per week),and high(700-1050 IU per week)doses.At low doses,FSH improved only sperm motility.At intermediate doses,FSH ameliorated sperm concentration and morphology.Total sperm count and progressive motility showed a trend toward the increase.At high doses,FSH increased sperm concentration,total sperm count,and progressive motility.Sperm morphology showed a trend toward the increase.Finally,both highly purified FSH(hpFSH)and recombinant human FSH(rhFSH)improved sperm concentration,total sperm count,progressive motility,but not morphology.No different efficacy was observed between these two preparations.This meta-analysis provides evidence in favor of high FSH doses.The FSH efficacy was not related to the preparation type(recombinant vs highly purified).Further studies are needed to evaluate the effectiveness of Iong-standing treatment regimes. | Rossella Cannarella Sandro La Vignera Rosita A Condorelli Laura M Mongioi Aldo E Calogero | 2020 | Asian Journal of Andrology2020，22，3： | 2 |
| 2 | Next-generation sequencing:toward an increase in the diagnostic yield in patients with apparently idiopathic spermatogenic failure显示文摘A large proportion of patients with idiopathic spermatogenic failure(SPGF;oligozoospermia or nonobstructive azoospermia[NOA])do not receive a diagnosis despite an extensive diagnostic workup.Recent evidence has shown that the etiology remains undefined in up to 75%of these patients.A number of genes involved in germ-cell proliferation,spermatocyte meiotic divisions,and spermatid development have been called into play in the pathogenesis of idiopathic oligozoospermia or NOA.However,this evidence mainly comes from case reports.Therefore,this study was undertaken to identify the molecular causes of SPGF.To accomplish this,15 genes(USP9Y,NR5A1,KLHL10,ZMYND15,PLK4,TEX15,TEX11,MEIOB,SOHLH1,HSF2,SYCP3,TAF4B,NANOS1,SYCE1,and RHOXF2)involved in idiopathic SPGF were simultaneously analyzed in a cohort of 25 patients with idiopathic oligozoospermia or NOA,accurately selected after a thorough diagnostic workup.After next-generation sequencing(NGS)analysis,we identified the presence of rare variants in the NR5A1 and TEX11 genes with a pathogenic role in 3/25(12.0%)patients.Seventeen other different variants were identified,and among them,13 have never been reported before.Eleven out of 17 variants were likely pathogenic and deserve functional or segregation studies.The genes most frequently mutated were MEIOB,followed by USP9Y,KLHL10,NR5A1,and SOHLH1.No alterations were found in the SYCP3,TAF4B,NANOS1,SYCE1,or RH0XF2 genes.In conclusion,NGS technology,by screening a specific custom-made panel of genes,could help increase the diagnostic rate in patients with idiopathic oligozoospermia or NOA. | Rossella Cannarella Rosita A Condorelli Stefano Paolacci Federica Barbagallo Giulia Guerri Matteo Bertelli Sandro La Vignera Aldo E Calogero | 2021 | Asian Journal of Andrology2021，23，1： | 2 |
| 3 | Endocrine aspects of women's sexual function显示文摘 | Margaret E Rossella E Nancy A etal | 2010 | Sex Med2010，7，1： | 1 |
| 4 | Cabozantinib in progressive medullary thyroid cancer显示文摘 | Rossella E Martin JS Stefan PM | 2013 | J Clin Oncol2013，31，29： | 1 |
| 5 | Women's voices in the menopause: results from an international survey on vaginal atrophy显示文摘 | ROSSELLA E MATI'A K K | 2010 | Maturitas2010，67，3： | 1 |
| 6 | Consumer acceptability of vegetable soups 显示文摘 | Monaco DI Rossella Cavella S Torrieri E | 2007 | Journal of Sensory Studies2007，22，1： | 1 |
| 7 | HMGB1 interacts differentially with members of the Rel family of transcription factors显示文摘 | Alessandra Agresti Rossella Lupo Marco E Bianchi Susanne Müller | 2003 | Biochemical and Biophysical Research Communications2003，，： | 1 |
| 8 | Cabozantinib in progressive medullary thyroid cancer 显示文摘 | Rossella E Schlumberger M J Mtiller S P | 2013 | J Clin Oncol Official J Am Society Clin Oncol2013，31，29： | 1 |
| 9 | Women's voices in the menopause:Results from an international survey on vaginal atrophy显示文摘 | Rossella E Matta KK | 2010 | Maturitas2010，67，3： | 1 |
| 10 | Development and validation of a gas chromatography/mass spectrometry method for the assessment of genomic DNA methylation显示文摘 | ROSSELLA F POLLEDRI E BOLLATI V | 2009 | Rapid Commun Mass Spectrom2009，23，17： | 1 |
| 11 | Cabozantinib in progressive medullary thy- roid cancer显示文摘 | ROSSELLA E SCHLUMBERGER M J MLLER S P | 2013 | J Clin Oncol2013，31，： | 1 |
| 12 | Lycopene inhibits NF-KB-Mediated IL-8 expression and changes redox and PPARe signalling in cigarette smoke-stimulated maemphages 显示文摘 | Rossella E Mareo R Assunta C | 2011 | PLos One2011，6，5： | 1 |
| 13 | Nanoemulsions : A new vehicle for chemical additive delivery 显示文摘 | Lucilla Del Gaudio Eni E Rossella P | 2007 | SPE 1060162007，，： | 1 |
| 14 | SOX13 gene downregulation in peripheral blood mononuclear cells of patients with Klinefelter syndrome显示文摘Klinefelter syndrome(KS)is the most common sex chromosome disorder in men.It is characterized by germ cell loss and other variable clinical features,including autoimmunity.The sex-determining region of Y(SRY)-box 13(Sox13)gene is expressed in mouse spermatogonia.In addition,it has been identified as islet cell autoantigen 12(ICA12),which is involved in the pathogenesis of autoimmune diseases,including type 1 diabetes mellitus(DM)and primary biliary cirrhosis.SOX13 expression has never been investigated in patients with KS.In this age-matched,case-control study performed on ten patients with KS and ten controls,we found that SOX13 is significantly downregulated in peripheral blood mononuclear cells of patients with KS compared to controls.This finding might be consistent with the germ cell loss typical of patients with KS.However,the role of SOX13 in the pathogenesis of germ cell loss and humoral autoimmunity in patients with KS deserves to be further explored. | Rossella Cannarella Michele Salemi Rosita A Condorelli Laura Cimino Giorgio Giurato Giovanna Marchese Angela Cordella Corrado Romano Sandro La Vignera Aldo E Calogero | 2021 | Asian Journal of Andrology2021，23，2： | 0 |
| 15 | Anejaculation in a patient with Charcot-Marie-Tooth显示文摘 | Rossella Cannarella Giovanni Burgio Sandro La Vignera Enzo S Vicari Aldo E Calogero | 2018 | Asian Journal of Andrology2018，20，5： | 0 |
| 16 | Testosterone replacement therapy and vascular thromboembolic events: a systematic review and meta-analysis显示文摘To evaluate the relationship between testosterone replacement therapy(TRT)and arterial and/or venous thrombosis in patients with pre-treatment total testosterone(TT)<12 nmol I-1,we performed a meta-analysis following the Population Intervention Comparison Outcome model.Population:men with TT<12 nmol 1-1 or clear mention of hypogonadism in the inclusion criteria of patients;intervention:TRT;comparison:placebo or no therapy;outcomes:arterial thrombotic events(stroke,myocardial infarction[MI],upper limbs,and lower limbs),VTE(deep vein thrombosis[DVT],portal vein thrombosis,splenic thrombosis,and pulmonary embolism),and mortality.A total of 2423 abstracts were assessed for eligibility.Twenty-four studies,including 14 randomized controlled trials(RCTs),were finally included,with a total of 4027 and 310288 hypotestosteronemic male patients,from RCTs and from observational studies,respectively.Based on RCT-derived data,TRT did not influence the risk of arterial thrombosis(odds ratio[OR]=1.27,95%confidence interval[CI]:0.47-3.43,P=0.64),stroke(OR=1.34,95%CI:0.09-18.97,P=0.83),MI(OR=0.51,95%CI:0.11-2.31,P=0.39),VTE(OR=1.42,95%CI:0.22-9.03,P=0.71),pulmonary embolism(OR=1.38,95%CI:0.27-7.04,P=0.70),and mortality(OR=0.70,95%CI:0.20-2.38,P=0.56).Meanwhile,when only observational studies are considered,a significant reduction in the risk of developing arterial thrombotic events,Ml,venous thromboembolism,and mortality was observed.The risk for DVT remains uncertain,due to the paucity of RCT-based data.TRT in men with TT<12 nmol I^(-1) is safe from the risk of adverse cardiovascular events.Further studies specifically assessing the risk of DVT in men on TRT are needed. | Rossella Cannarella Carmelo Gusmano Claudia Leanza Vincenzo Garofalo Andrea Crafa Federica Barbagallo Rosita A Condorelli Sandro La Vignera Aldo E Calogero | 2024 | Asian Journal of Andrology2024，26，2： | 0 |
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