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| 1 | National trends in resection of the distal pancreas显示文摘AIM:To investigate national trends in distal pancreatectomy(DP) through query of three national patient care databases.METHODS:From the Nationwide Inpatient Sample(NIS,2003-2009),the National Surgical Quality Improvement Project(NSQIP,2005-2010),and the Surveillance Epidemiology and End Results(SEER,2003-2009) databases using appropriate diagnostic and procedural codes we identified all patients with a diagnosis of a benign or malignant lesion of the body and/or tail of the pancreas that had undergone a partial or distal pancreatectomy.Utilization of laparoscopy was defined in NIS by the International Classification of Diseases,Ninth Revision correspondent procedure code;and in NSQIP by the exploratory laparoscopy or unlisted procedure current procedural terminology codes.In SEER,patients were identified by the International Classification of Diseases for Oncology,Third Edition diagnosis codes and the SEER Program Code Manual,third edition procedure codes.We analyzed the databases with respect to trends of inpatient outcome metrics,oncologic outcomes,and hospital volumes in patients with lesions of the neck and body of the pancreas that underwent operative resection.RESULTS:NIS,NSQIP and SEER identified 4242,2681 and 11 082 DP resections,respectively.Overall,laparoscopy was utilized in 15%(NIS) and 27%(NSQIP).No significant increase was seen over the course of the study.Resection was performed for malignancy in 59%(NIS) and 66%(NSQIP).Neither patient Body mass index nor comorbidities were associated with operative approach(P = 0.95 and P = 0.96,respectively).Mortality(3% vs 2%,P = 0.05) and reoperation(4% vs 4%,P = 1.0) was not different between laparoscopy and open groups.Overall complications(10% vs 15%,P < 0.001),hospital costs [44 741 dollars,interquartile range(IQR) 28 347-74 114 dollars vs 49 792 dollars,IQR 13 299-73 463,P = 0.02] and hospital length of stay(7 d,IQR 4-11 d vs 7 d,IQR 6-10,P < 0.001) were less when laparoscopy was utilized.One and two year survival after resection for malignancy were unchanged over the course of the study(ductal adenocarinoma 1-year 63.6% and 2-year 35.1%,P = 0.53;intraductal papillary mucinous neoplasm and nueroendocrine 1-year 90% and 2-year 84%,P = 0.25).The majority of resections were performed in teaching hospitals(77% NIS and 85% NSQIP),but minimally invasive surgery(MIS) was not more likely to be used in teaching hospitals(15% vs 14%,P = 0.26).Hospitals in the top decile for volume were more likely to be teaching hospitals than lower volume deciles(88% vs 43%,P < 0.001),but were no more likely to utilize MIS at resection.Complication rate in teaching and the top decile hospitals was not significantly decreased when compared to non-teaching(15% vs 14%,P = 0.72) and lower volume hospitals(14% vs 15%,P = 0.99).No difference was seen in the median number of lymph nodes and lymph node ratio in N1 disease when compared by year(P = 0.17 and P = 0.96,respectively).CONCLUSION:There appears to be an overall underutilization of laparoscopy for DP.Centralization does not appear to be occurring.Survival and lymph node harvest have not changed. | Armando Rosales-Velderrain Steven P Bowers Ross F Goldberg Tatyan M Clarke Mauricia A Buchanan John A Stauffer Horacio J Asbun | 2012 | World Journal of Gastroenterology2012，18，32： | 8 |
| 2 | Platelet-rich plasma increases transforming growth factor-beta1 expression at graft-host interface following autologous osteochondral transplantation in a rabbit model显示文摘AIM: To explore the effect of platelet-rich plasma on protein expression patterns of transforming growth factor-beta1(TGF-β1) in cartilage following autologous osteochondral transplantation(AOT) in a rabbit knee cartilage defect model.METHODS: Twelve New Zealand white rabbits received bilateral AOT. In each rabbit, one knee was randomized to receive an autologous platelet rich plasma(PRP) injection and the contralateral knee received saline injection. Rabbits were euthanized at 3, 6 and 12 wk post-operatively. Articular cartilage sections were stained with TGF-β1 antibody. Histological regions of interest(ROI)(left, right and center of the autologous grafts interfaces) were evaluated using Meta Morph. Percentage of chondrocytes positive for TGF-β1 was then assessed.RESULTS: Percentage of chondrocytes positive for TGF-β1 was higher in PRP treated knees for selected ROIs(left; P = 0.03, center; P = 0.05) compared to control and was also higher in the PRP group at each post-operative time point(P = 6.6 × 10^(-4), 3.1 × 10^(-4) and 7.3 × 10^(-3) for 3, 6 and 12 wk, respectively). TGF-β1 expression was higher in chondrocytes of PRP-treated knees(36% ± 29% vs 15% ± 18%)(P = 1.8 × 10^(-6)) overall for each post-operative time point and ROI. CONCLUSION: Articular cartilage of rabbits treated with AOT and PRP exhibit increased TGF-β1 expression compared to those treated with AOT and saline. Our findings suggest that adjunctive PRP may increase TGF-β1 expression, which may play a role in the chondrogenic effect of PRP in vivo. | Lorraine A Boakye Keir A Ross John M Pinski Niall A Smyth Amgad M Haleem Charles P Hannon Lisa A Fortier John G Kennedy | 2015 | World Journal of Orthopedics2015，6，11： | 7 |
| 3 | Relationship between depression and diabetes in pregnancy: A systematic review显示文摘AIM To systematically review the literature on women with both diabetes in pregnancy(DIP) and depression during or after pregnancy. METHODS In this systematic literature review, PubM ed/MEDLINE and EMBASE were searched(13 November 2015) using terms for diabetes(type 1, type 2, or gestational), depression, and pregnancy(no language or date restrictions). Publications that reported on women who had both DIP(any type) and depression or depressive symptoms before, during, or within one year after pregnancy were considered for inclusion. All study types were eligible for inclusion; conference abstracts, narrative reviews, nonclinical letters, editorials, and commentaries were excluded, unless they provided treatment guidance.RESULTS Of 1189 articles identified, 48 articles describing women with both DIP and depression were included(sample sizes 36 to > 32 million). Overall study quality was poor; most studies were observational, and only 12 studies(mostly retrospective database studies) required clinical depression diagnosis. The prevalence of concurrent DIP(any type) and depression in general populations of pregnant women ranged from 0% to 1.6%(median 0.61%; 12 studies). The prevalence of depression among women with gestational diabetes ranged from 4.1% to 80%(median 14.7%; 16 studies). Many studies examined whether DIP was a risk factor for depression or depression was a risk factor for DIP. However, there was no clear consensus for either relationship. Importantly, we found limited guidance on the management of women with both DIP and depression. CONCLUSION Given the increasing prevalence of diabetes and depression, high-quality research and specific guidance for management of pregnant women with both conditions are warranted. | Glynis P Ross Henrik Falhammar Roger Chen Helen Barraclough Ole Kleivenes Ian Gallen | 2016 | World Journal of Diabetes2016，7，19： | 3 |
| 4 | The prospects for ultrashort pulse duration and ultrahigh intensity using optical parameter chirped pulse amplifiers 显示文摘 | Ross I N Matousek P | 1997 | Optics Communications1997，144，： | 2 |
| 5 | Increasing starter cell lysis in Cheddar cheese using a bacteriocin- producing adjunct显示文摘 | MORGAN S ROSS R P HILL C | 1997 | J Dairy Sci1997，80，： | 2 |
| 6 | Toxicity of pesticides to aquatic microorganisms: a review显示文摘 | Delorenzo M E Scott G I Ross P E | 2001 | Environ Toxicol Chem2001，20，1： | 2 |
| 7 | Influence of Endogone mycorrhiza on Phytophthora rot of soybean显示文摘 | Ross J P | 1972 | Phytopathology1972，62，： | 2 |
| 8 | Diabetic nephropathy:worldwide epidemic and effects of curtent treatment on natural history显示文摘 | Rossing P | 2006 | Curr Diab Rep2006，6，6： | 1 |
| 9 | A review and update of animal toxicoses associated with fumonisin contaminated feeds and production of fumonisins by Fusarium isolates显示文摘 | ROSS P F RICE L G OSWEILER G D | 1992 | Mycopthol1992，117，： | 1 |
| 10 | Preservation and fermentation: Past, present and future显示文摘 | ROSS R P MORGAN S HILL C | 2002 | International Journal of Food Microbiology2002，79，12： | 1 |
| 11 | Assessment ofpostoperative pain management:patient satisfaction and perceivedhelpfulness显示文摘 | JAMISON R N ROSS M J HOOPMAN P | 1997 | Clin J Pain1997，13，3： | 1 |
| 12 | Kinetics of oxygen reduction on Pt(hkl) electrode:Implication for the crystallite size effect with supported Pt dectrocatalysts显示文摘 | Markovic N Gasteiger H Ross P N | 1997 | J Electrochem Soc1997，144，5： | 1 |
| 13 | Information Hiding-A Survey显示文摘 | Fabien A P Petitcolas Ross J Anderson Markus G Kuhn | 1999 | Prpceedings of the IEEE1999，87，7： | 1 |
| 14 | Formic acid oxidation on pure and Bi-modified Pt( 111): temper-ature effects 显示文摘 | Schmidt T J Behm R J Grgur B N Markovic N M Ross P N | 2000 | Langmuir2000，16，21： | 1 |
| 15 | Rapid identifieation of bacteria by direct matrix-assisted laser desorption/ionization mass spectrometric analysis of whole cells 显示文摘 | KRISHNAMURTHY T ROSS P L | 1996 | Rapid Commun Mass Spectrom1996，10，： | 1 |
| 16 | Degenerative diskdisease:assessment of changes in vertebral body marrow with MRimaging显示文摘 | Modic M T Steinberg P M Ross J S | | 0，，1： | 1 |
| 17 | The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme显示文摘 | Krishnamurthy P Ross DD Nakanishi T | | 0，，23： | 1 |
| 18 | Cellulose biosynthesis and function in bacteria显示文摘 | Ross P Mayer R Benziman M | 1991 | Microbiological Reviews1991，55，1： | 1 |
| 19 | Escherichia coli heat-labile enterotoxin promotes protective Thl7 responses against infection by driving innate IL-1 and IL-23 production显示文摘 | Brereton C F Sutton C E Ross P J | 2011 | J Immunol2011，186，10： | 1 |
| 20 | Generalizing from the Use of Earlier Examples in Problem Solving显示文摘 | Ross B H Kennedy P T | 1990 | Journal of Experimental Psychology:Learning Memory and Cognition1990，16，1： | 1 |
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