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| 1 | Colometer:A real-time quality feedback system for screening colonoscopy显示文摘AIM:To investigate the performance of a new software-based colonoscopy quality assessment system.METHODS:The software-based system employs a novel image processing algorithm which detects the levels of image clarity,withdrawal velocity,and level of the bowel preparation in a real-time fashion from live video signal.Threshold levels of image blurriness and the withdrawal velocity below which the visualization could be considered adequate have initially been determined arbitrarily by review of sample colonoscopy videos by two experienced endoscopists.Subsequently,an overall colonoscopy quality rating was computed based on the percentage of the withdrawal time with adequate visualization(scored 1-5;1,when the percentage was 1%-20%;2,when the percentage was 21%-40%,etc.).In order to test the proposed velocity and blurriness thresholds,screening colonoscopy withdrawal videos from a specialized ambulatory colon cancer screening center were collected,automatically processed and rated.Quality ratings on the withdrawal were compared to the insertion in the same patients.Then,3 experienced endoscopists reviewed the collected videos in a blinded fashion and rated the overall quality of each withdrawal(scored 1-5;1,poor;3,average;5,excellent) based on 3 major aspects:image quality,colon preparation,and withdrawal velocity.The automated quality ratings were compared to the averaged endoscopist quality ratings using Spearman correlation coefficient.RESULTS:Fourteen screening colonoscopies were assessed.Adenomatous polyps were detected in 4/14(29%) of the collected colonoscopy video samples.As a proof of concept,the Colometer software rated colonoscope withdrawal as having better visualization than the insertion in the 10 videos which did not have any polyps(average percent time with adequate visualization:79% ± 5% for withdrawal and 50% ± 14% for insertion,P < 0.01).Withdrawal times during which no polyps were removed ranged from 4-12 min.The median quality rating from the automated system and the reviewers was 3.45 [interquartile range(IQR),3.1-3.68] and 3.00(IQR,2.33-3.67) respectively for all colonoscopy video samples.The automated rating revealed a strong correlation with the reviewer's rating(ρ coefficient= 0.65,P = 0.01).There was good correlation of the automated overall quality rating and the mean endoscopist withdrawal speed rating(Spearman r coefficient= 0.59,P = 0.03).There was no correlation of automated overall quality rating with mean endoscopists image quality rating(Spearman r coefficient= 0.41,P = 0.15).CONCLUSION:The results from a novel automated real-time colonoscopy quality feedback system strongly agreed with the endoscopists' quality assessments.Further study is required to validate this approach. | Dobromir Filip Xuexin Gao Leticia Angulo-Rodriguez Martin P Mintchev Shane M Devlin Alaa Rostom Wayne Rosen Christopher N Andrews | 2012 | World Journal of Gastroenterology2012，18，32： | 2 |
| 2 | BRCA mutated pancreatic cancer:A change is coming显示文摘Pancreatic cancer remains a leading cause of cancer-related death with few available therapies for advanced disease.Recently,patients with germline BRCA mutations have received increased attention due to advances in the management of BRCA mutated ovarian and breast tumors.Germline BRCA mutations significantly increase risk of developing pancreatic cancer and can be found in up to 8%of patients with sporadic pancreatic cancer.In patients with germline BRCA mutations,platinum-based chemotherapies and poly(ADP-ribose)polymerase inhibitors are effective treatment options which may offer survival benefits.This review will focus on the molecular biology,epidemiology,and management of BRCA-mutated pancreatic cancer.Further-more,we will discuss future directions for this area of research and promising active areas of research. | Michael N Rosen Rachel A Goodwin Michael M Vickers | 2021 | World Journal of Gastroenterology2021，27，17： | 2 |
| 3 | Can quantum-mechanical description of physical reality be considered complete? 显示文摘 | EINSTEIN A PODOLSKY B ROSEN N | 1935 | Phys Rev1935，47，： | 2 |
| 4 | Reactive oxygen species have a causal role in multiple forms of insulin resistance显示文摘 | Houstis N Rosen ED Lander ES | 2006 | Nature2006，440，7086： | 1 |
| 5 | Characterization of flavonoids in cranberry (Vaccinium macrocarpon) powder显示文摘 | VVEDENSKAYA I O ROSEN R T GUIDO J E RUSSELL D J MILLS K A VORSA N | 2004 | Journal of Agricultural and Food Chemistry2004，52，： | 1 |
| 6 | The International Index of Erectile Function (IIEF) : a state-of-the science review 显示文摘 | Rosen RC Cappelleri JC Gendrano N | 2002 | Int J Impot Res2002，14，： | 1 |
| 7 | MRI imaging for the preoperative planning of sphincter-saving surgery for tumors of the lower third of the rectum:use of intravenous and endorectal contrast materials显示文摘 | Urban M Rosen HR Holbling N | 2000 | Radiology2000，214，2： | 1 |
| 8 | Reactive oxygen species have a causal role in multiple forms of insulin resistance 显示文摘 | Houstis N Rosen ED Lander ES | 2006 | Nature2006，440，7086： | 1 |
| 9 | CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphoeyte egress from lymphoid organs显示文摘 | Shiow LR Rosen DB Brdickova N | 2006 | Nature2006，440，7083： | 1 |
| 10 | The treatment of pulmonary metastasis in osteogenic sarcoma 显示文摘 | Marcove RC Martini N Rosen G | 1975 | Clin Orthop Relat Res1975，9，111： | 1 |
| 11 | Can Quantum-Me-chanical Description of Physical Reality be Considered Complete?显示文摘 | Podolsky B Rosen N | 1935 | Phys Rev1935，47，10： | 1 |
| 12 | Reactive oxygen species have a causal role in multiple forms of insulin resistance显示文摘 | Houstis N Rosen ED Lander ES | 2006 | Nature2006，440，： | 1 |
| 13 | Induced corneal astigmatism by palpebral spring for the treatment of lagophthalmos 显示文摘 | Avni-Zauberman N Rosen N Ben Simon GJ | 2008 | Comea2008，27，7： | 1 |
| 14 | Reactive oxygen species have a causal role in muhiple forms of insulin resistance 显示文摘 | Houstis N Rosen E D Lander E S | 2006 | Nature2006，440，7086： | 1 |
| 15 | The role of existential meaning as a buffer against stress显示文摘 | Mascaro N Rosen DH | 2006 | J Human Psychol2006，46，2： | 1 |
| 16 | HsP90:a novel target for cancer therapy显示文摘 | Solit DB Rosen N | 2006 | Curr Top Med Chem2006，6，11： | 1 |
| 17 | Important qualities in physi- atrists :perceptions of rehabilitation team members and patients 显示文摘 | Moroz A Prufer N Rosen Z Eisenberg C | 2000 | Arch Phys Med Rehabil2000，81，6： | 1 |
| 18 | On gravitational waves显示文摘 | Einstein A Rosen N | 1937 | Journal of The Franklin Institute1937，223，： | 1 |
| 19 | Labour Markets in Professional Sports显示文摘 | Rosen S Sanderson n | 2001 | The Economic Journal2001，3，： | 1 |
| 20 | Immunosuppressive treatment ofaplastic ane- mia with antithymocyte globulin and cyclosporine显示文摘 | Frickhofen N Rosen SJ | 2001 | Semin Hematol2001，37，1： | 1 |
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