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| 1 | Visceral hypersensitivity and electromechanical dysfunction as therapeutic targets in pediatric functional dyspepsia显示文摘Functional gastrointestinal disorders(FGID) are common clinical syndromes diagnosed in the absence of biochemical,structural,or metabolic abnormalities. They account for significant morbidity and health care expenditures and are identifiable across variable age,geography,and culture. Etiology of abdominal pain associated FGIDs,including functional dyspepsia(FD),remains incompletely understood,but growing evidence implicates the importance of visceral hypersensitivity and electromechanical dysfunction. This manuscript explores data supporting the role of visceral hypersensitivity and electromechanical dysfunction in FD,with focus on pediatric data when available,and provides a summary of potential therapeutic targets. | John M Rosen Jose T Cocjin Jennifer V Schurman Jennifer M Colombo Craig A Friesen | 2014 | World Journal of Gastrointestinal Pharmacology and Therapeutics2014，5，3： | 16 |
| 2 | The European registry of quality outcomes for cataract and refractive surgery(EUREQUO):a database study of trends in volumes,surgical techniques and outcomes of refractive surgery显示文摘Background:A European web-based registry for refractive surgery was established in 2008;The European Registry of Quality Outcomes for Cataract and Refractive Surgery(EUREQUO).The aim of the registry was to improve treatment and standards of care for refractive surgery.Further aims were to offer a tool for benchmarking by establishing a reference database and for surgeons to enter and analyze their own outcomes.The purpose of this study was to characterize the registry and analyze the data collected during its first decade.Methods:The characteristics of the web-based registry are described.Data collected from February 4^(th) 2004 until June 30th 2014 are included in the analysis.The database is analyzed in terms of surgical technique,indications for surgery,complications,and refractive and visual outcomes.Results:Data have been reported from 47 centers in 14 countries until mid-2014.About 4,000 procedures were reported annually.The most frequent procedure was laser-assisted in-situ keratomileusis(LASIK)with 11697 reported surgeries.Over time in the database,LASIK declined(p<0.001)while photorefractive keratectomy(PRK)and refractive lens exchange(RLE)increased(p<0.001 for both procedures).The indications for surgery,in terms of preoperative refraction and age,were stable over time,for all types of procedures.Surgical complications were reported infrequently and with a well-known relationship to the type of surgical procedure.The reported refractive outcomes were good.The visual outcomes indicate a significant increase of visual acuity after high myopia treatment by phakic intraocular lens in the anterior(phakic IOL AC)and the posterior(phakic IOL PC)chamber and a poorer visual outcome,after both myopia and hyperopia treatment,by epithelial LASIK(Epi-LASIK).Conclusions:We describe the establishment of a European registry for refractive surgery.The database increases at a rate of approximately 4000 refractive procedures per year.The most frequent procedure is LASIK,but both PRK and RLE are an increasing part of the reported procedures.The indications for surgery have been stable over time.Surgical complications and visual outcome vary,depending on the type of surgery. | Mats Lundström Sonia Manning Peter Barry Ulf Stenevi Ype Henry Paul Rosen | 2015 | Eye and Vision2015，2，1： | 3 |
| 3 | 吲哚-3-甲醇对肺癌细胞放射敏感性的EGFR依赖性调节显示文摘背景与目的吲哚-3-甲醇(indole-3-carbinol,I3C)是十字花科蔬菜中一种主要的有效植物化学物质,且具有防癌和抗癌作用。本研究旨在观察I3C是否影响表皮生长因子受体(epidermal growth factor receptor,EGFR)表达水平不同的肺癌细胞放射敏感性。方法采用MTT和克隆形成实验方法分别检测肺癌细胞的生长和存活率;siRNA转染方法降低细胞中EGFR蛋白表达水平;Western blot和RT-PCR法分别测定EGFR蛋白和mRNA的表达。结果采用无明显毒副作用的5mol/L剂量的I3C预处理明显降低了EGFR表达阳性的人肺腺癌H1975和人肺鳞癌H226细胞对γ-射线照射的放射敏感性,而I3C对EGFR表达阴性的人肺鳞癌NIH-H520细胞的放射敏感性则影响非常小。Western blot结果显示I3C可以增加H1975和H226细胞中EGFR蛋白的表达水平和Y845位点磷酸化水平。EGFR siRNA降低了NIH-H1975细胞中EGFR蛋白的表达,增加了细胞的放射敏感性,并有效地降低和抑制了I3C导致的细胞耐辐射效应。结论我们的研究结果首次证实I3C可以通过调节EGFR表达和磷酸化水平从而影响肺癌细胞的放射治疗敏感性,提示EGFR可能是I3C影响肺癌放射治疗敏感性的重要靶蛋白. | 肖骁 孟庆慧 徐加英 焦旸 Eliot M Rosen 樊赛军 | 2012 | 中国肺癌杂志2012，15，7： | 2 |
| 4 | Minimally invasive surgery显示文摘 | ROSEN M PONSKY J | 2001 | Endoscopy2001，33，： | 2 |
| 5 | Colometer:A real-time quality feedback system for screening colonoscopy显示文摘AIM:To investigate the performance of a new software-based colonoscopy quality assessment system.METHODS:The software-based system employs a novel image processing algorithm which detects the levels of image clarity,withdrawal velocity,and level of the bowel preparation in a real-time fashion from live video signal.Threshold levels of image blurriness and the withdrawal velocity below which the visualization could be considered adequate have initially been determined arbitrarily by review of sample colonoscopy videos by two experienced endoscopists.Subsequently,an overall colonoscopy quality rating was computed based on the percentage of the withdrawal time with adequate visualization(scored 1-5;1,when the percentage was 1%-20%;2,when the percentage was 21%-40%,etc.).In order to test the proposed velocity and blurriness thresholds,screening colonoscopy withdrawal videos from a specialized ambulatory colon cancer screening center were collected,automatically processed and rated.Quality ratings on the withdrawal were compared to the insertion in the same patients.Then,3 experienced endoscopists reviewed the collected videos in a blinded fashion and rated the overall quality of each withdrawal(scored 1-5;1,poor;3,average;5,excellent) based on 3 major aspects:image quality,colon preparation,and withdrawal velocity.The automated quality ratings were compared to the averaged endoscopist quality ratings using Spearman correlation coefficient.RESULTS:Fourteen screening colonoscopies were assessed.Adenomatous polyps were detected in 4/14(29%) of the collected colonoscopy video samples.As a proof of concept,the Colometer software rated colonoscope withdrawal as having better visualization than the insertion in the 10 videos which did not have any polyps(average percent time with adequate visualization:79% ± 5% for withdrawal and 50% ± 14% for insertion,P < 0.01).Withdrawal times during which no polyps were removed ranged from 4-12 min.The median quality rating from the automated system and the reviewers was 3.45 [interquartile range(IQR),3.1-3.68] and 3.00(IQR,2.33-3.67) respectively for all colonoscopy video samples.The automated rating revealed a strong correlation with the reviewer's rating(ρ coefficient= 0.65,P = 0.01).There was good correlation of the automated overall quality rating and the mean endoscopist withdrawal speed rating(Spearman r coefficient= 0.59,P = 0.03).There was no correlation of automated overall quality rating with mean endoscopists image quality rating(Spearman r coefficient= 0.41,P = 0.15).CONCLUSION:The results from a novel automated real-time colonoscopy quality feedback system strongly agreed with the endoscopists' quality assessments.Further study is required to validate this approach. | Dobromir Filip Xuexin Gao Leticia Angulo-Rodriguez Martin P Mintchev Shane M Devlin Alaa Rostom Wayne Rosen Christopher N Andrews | 2012 | World Journal of Gastroenterology2012，18，32： | 2 |
| 6 | BRCA mutated pancreatic cancer:A change is coming显示文摘Pancreatic cancer remains a leading cause of cancer-related death with few available therapies for advanced disease.Recently,patients with germline BRCA mutations have received increased attention due to advances in the management of BRCA mutated ovarian and breast tumors.Germline BRCA mutations significantly increase risk of developing pancreatic cancer and can be found in up to 8%of patients with sporadic pancreatic cancer.In patients with germline BRCA mutations,platinum-based chemotherapies and poly(ADP-ribose)polymerase inhibitors are effective treatment options which may offer survival benefits.This review will focus on the molecular biology,epidemiology,and management of BRCA-mutated pancreatic cancer.Further-more,we will discuss future directions for this area of research and promising active areas of research. | Michael N Rosen Rachel A Goodwin Michael M Vickers | 2021 | World Journal of Gastroenterology2021，27，17： | 2 |
| 7 | Sintering,microstructure,and properties of sub-micrometer cemented carbides 显示文摘 | Leiderman M Botstein O Rosen A | 1997 | Powder Metallurgy1997，40，13： | 1 |
| 8 | Circulating IGF-1 : New perspectives for a new century显示文摘 | Rosen CJ Pollak M | 1999 | Trends Endocrinol Metab1999，10，4： | 1 |
| 9 | Gemini surfactants 显示文摘 | Rosen M J TracyD J | 1998 | J SurfDetergents1998，，4： | 1 |
| 10 | Adsorption of gemini and conventional cationic Surfactants onto montmorillonite and the removal of some pollutants by the clay显示文摘 | Li F Rosen M J | 2000 | Journal of Colloid and Interface Science2000，234，2： | 1 |
| 11 | Safety,pharmacokinetics,and efficacy of AMG 706,an oral multikinase inhibitor,in patients with advanced solid tumors显示文摘 | ROSEN LS KURZROCK R MULAY M | 2007 | J Clin Oncol2007，25，： | 1 |
| 12 | Superspreading of trisiloxane surfactant mixtures on hydrophobic surfaces:Interaction and spreading of aqueous trisiloxane surfactant-N-alkyl-pyrrolidinone mixtures in contact with polyethylene显示文摘 | Wu Y Rosen M J | 2002 | Langmuir2002，18，： | 1 |
| 13 | Geminis:A new generation of surfactants显示文摘 | Rosen M J | 1993 | Chem Tech1993，，： | 1 |
| 14 | Phase Ⅱ trial of ZD1839 in recurrent or metastatic squamous cell carcinoma of the head and neck显示文摘 | Cohen E E Rosen F Stadler W M | 2003 | J Clin Oncol2003，21，10： | 1 |
| 15 | Effect of Added Asparagine and Glycine on Acrylamide Content in Yeast-Leavened bread显示文摘 | Fink M Andersson R Rosen J | 2006 | Cereal Chemistry2006，83，2： | 1 |
| 16 | A double - blind, controllecl trial in primarycare patients with generalized anxiety: a comparison between buspirone and oxazeparm显示文摘 | Strand M Hetta J Rosen A | 1990 | J Clin Psychiatry1990，51，9： | 1 |
| 17 | Electrophysiology and pharmacyology of cardic arrhythmias (IX): Cardiac electrophysiologic effects of betaadrenergic receptor stimulation and blockade Parta A显示文摘 | Wit A L Hoffman B F Rosen M R | 1975 | Am Heart J1975，90，4： | 1 |
| 18 | Synergism in binary mixtures of surfactants(Ⅳ):Effectiveness of surface tension reduction显示文摘 | BU Yao-zhu ROSEN M J | 1984 | J Colloid Interface Sci1984，99，2： | 1 |
| 19 | Behavioral features in semantic dementia vs other forms of progressive aphasias显示文摘 | Rosen H J Allison S C Ogar J M | 2006 | Neurology2006，67，： | 1 |
| 20 | MRI imaging for the preoperative planning of sphincter-saving surgery for tumors of the lower third of the rectum:use of intravenous and endorectal contrast materials显示文摘 | Urban M Rosen HR Holbling N | 2000 | Radiology2000，214，2： | 1 |
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