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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Infectious, atopic and inflammatory diseases, childhood adversities and familial aggregation are independently associated with the risk for mental disorders: Results from a large Swiss epidemiological study显示文摘AIM To examine the associations between mental disorders and infectious, atopic, inflammatory diseases while adjusting for other risk factors.METHODS We used data from PsyC oL aus, a large Swiss Population Cohort Study(n = 3720; age range 35-66). Lifetime diagnoses of mental disorders were grouped into the following categories: Neurodevelopmental, anxiety(early and late onset), mood and substance disorders. They were regressed on infectious, atopic and other inflammatory diseases adjusting for sex, educational level, familial aggregation, childhood adversities and traumatic experiences in childhood. A multivariate logistic regression was applied to each group of disorders. In a complementary analysis interactions with sex were introduced via nested effects. RESULTS Associations with infectious, atopic and other chronic inflammatory diseases were observable together with consistent effects of childhood adversities and familial aggregation, and less consistent effects of trauma in each group of mental disorders. Streptococcal infections were associated with neurodevelopmental disorders(men), and measles/mumps/rubella-infections with early and late anxiety disorders(women). Gastric inflammatory diseases took effect in mood disorders(both sexes) and in early disorders(men). Similarly, irritable bowel syndrome was prominent in a sex-specific way in mood disorders in women, and, moreover, was associated with early and late anxiety disorders. Atopic diseases were associated with late anxiety disorders. Acne(associations with mood disorders in men) and psoriasis(associations with early anxiety disorders in men and mood disorders in women) contributed sex-specific results. Urinary tract infections were associated with mood disorders and, in addition, in a sex-specific way with late anxiety disorders(men), and neurodevelopmental and early anxiety disorders(women).CONCLUSION Infectious, atopic and inflammatory diseases areimportant risk factors for all groups of mental disorders. The sexual dimorphism of the associations is pronounced. | Vladeta Ajdacic-Gross Aleksandra Aleksandrowicz Stephanie Rodgers Margot Mutsch Anja Tesic Mario Müller Wolfram Kawohl Wulf R?ssler Erich Seifritz Enrique Castelao Marie-Pierre F Strippoli Caroline Vandeleur Roland von K?nel Rosa Paolicelli Markus A Landolt Cornelia Witthauer Roselind Lieb Martin Preisig | 2016 | World Journal of Psychiatry2016，6，4： | 2 |
| 3 | Delayed leaf senescence induces extreme drought tolerance in a flowering plant显示文摘 | Rosa M R Mikiko K Amira G | 2007 | Proceedings of the National Academy of Sciences2007，104，19： | 1 |
| 4 | Functional study of the transplanted kidney with power Doppler US and time/intensity curves 显示文摘 | Farina R Pennisi F La Rosa M | 2007 | Radiol Med2007，112，： | 1 |
| 5 | An organic selenium compound attenuates apomorphine-induced stereotypy in mice 显示文摘 | MACHADOA M S ROSA R M DANTAS A S | 2006 | Neurosc Lett2006，410，2： | 1 |
| 6 | Primary Sjogren syndrome in Spain:clinical and immunologic expression in 1010 patients显示文摘 | Ramos-Casals M Solans R Rosas J | 2008 | Medicine2008，87，4： | 1 |
| 7 | Parosteal lipoma of therib: CT findings and pathologic correlation 显示文摘 | Imbriaco M Ignarra R De Rosa N | 2003 | Clin Imaging2003，27，： | 1 |
| 8 | Primary Sjogrenr ssyndrome in Spain: clinical and immunologic expression in 1010patients显示文摘 | Ramos-Casals M Solans R Rosas J | 2008 | Medicine CBaltimore)2008，87，4： | 1 |
| 9 | Vertical root fractures and dentin defects: effects of root canal preparation, filling, and mechanical cycling显示文摘 | SANGOI B M MORAES R D A ROSA R A D | 2012 | J Endod2012，38，8： | 1 |
| 10 | Severe CD4 T cell-mediated immunopathology in murine schistosomiasis is de- pendent on IL-12p40 and correlates with high levels of IL-17 显示文摘 | Rutitzky L I Lopes da Rosa J R Stadecker M J | 2005 | J Immunol2005，175，6： | 1 |
| 11 | Biofilm development and ammonia removal in the nitrification of a saline wastewater显示文摘 | Rosa M F Furtado A A L Albuquerque R T | 1998 | Bioresource Technology1998，65，12： | 1 |
| 12 | Withania somnifera Dunal (Indian ginseng) impairs acquisition and expression of ethanol-elicited conditioned place preference and con- ditioned place aversion 显示文摘 | Spina L Longoni R Rosas M | 2015 | J Psychopharmacol2015，29，11： | 1 |
| 13 | Severe CD4 T Cell- mediated immunopathology in murine schistosomiasis is dependent on IL- 12p40 and correlates with high levels of IL-17 显示文摘 | Rutitzky L I Lopes da Rosa J R Stadecker M J | 2005 | J Immunol2005，175，6： | 1 |
| 14 | Optimization of BFO microwave hydrothermal synthesis:influence of process parameter显示文摘 | C Ponzoni R Rosa M Cannio | 2013 | J Alloys Compd2013，558，： | 1 |
| 15 | Recent finding and new technologies in nephrolithiasisz a review of the recent literature 显示文摘 | ROSA M USAI P MIANO R | 2013 | BMC Urol2013，13，1： | 1 |
| 16 | Micro-wave-assisted extraction of sulfated polysaccharides (fu- coidan) from brown seaweed 显示文摘 | ROSA M R SOLANGE I M LORENZO P | 2011 | Carbohydrate Poly- mers2011，86，3： | 1 |
| 17 | Evaluation of the role of genes encoding for At -pyrroline~5-carboxylate syn- thetase (P5CS) during drought stress in arbuscular mycor- rhizal Glycine max and Lactuca sativa plants 显示文摘 | ROSA P ROSARIO A JUAN M R | 2004 | Physiol Mol Plant P2004，65，4： | 1 |
| 18 | Slow regularization through chaotic oscillation transfer in an unidirectional chain of H-R models显示文摘 | Rosa M La Rabinovich M I Huerta R | 2000 | Phys Lett A2000，266，： | 1 |
| 19 | Is the application of carbendazimharmful to healthy plants?Evidence of weak phytotoxicity in tobacco显示文摘 | Pablo C G Juan M R Rosa M R | 2002 | Journal of Agricultural and Food Chemistry2002，50，： | 1 |
| 20 | Biochemical changes during the reproductive cycle of the deep sea decapod Nephrops norvegicus on the south coast of Portugal显示文摘 | ROSA R NUMES M L | 2002 | Marine Biology2002，141，： | 1 |
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