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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Pleiotropic effects of lactate dehydrogenase inactivationin Lactobacillus casei显示文摘 | María J José L G Vicente M Gaspar P | 2005 | Research in Microbiology2005，156，： | 1 |
| 3 | Historical CO2 emission and concentrations due to land use change of croplands and pastures by country显示文摘 | Campos C P D Muylaert M S Rosa L P | 2005 | Science of the Total Environment2005，346，： | 1 |
| 4 | Nm23/nucleoside diphosphate kinase:toward a structural and biochemical understanding of its bio logical functions显示文摘 | de la Rosa A Williams R L Steeg P S | 1995 | Bioessays1995，17，1： | 1 |
| 5 | Enhanced Cooperative Absorption and Upconversion in Yb^3+ Doped YAG Nanophosphors显示文摘 | Diaz-Torres L A Rosa E D Salas P | 2005 | Optical Matersials2005，27，： | 1 |
| 6 | Static and Dynamic Behavior of a Rigid Rotor on Journal Bearings显示文摘 | Della P L De Rosa E | 1991 | Meccanica1991，26，4： | 1 |
| 7 | Role of nitric oxide in the functional response to ischemia reperfusion of heart mitochondria from hyperthyroid rats显示文摘 | Venditti P De Rosa R Cigliano L | 2004 | Cell Mol Life Sci2004，61，17： | 1 |
| 8 | The Brazilian Energy Crisis and a Study to Support Building Efficiency Legislation 显示文摘 | Rosa L P Lomardo L L B | 2004 | Energy and Buildings2004，36，2： | 1 |
| 9 | 查看详情显示文摘 | Skrobot F C Rosa L V M arques P A | | 0，，： | 1 |
| 10 | Phytoplankton biomass is mainly controlled by hydrology and phosphorus concentrations in tropical hydroelectric reservoirs 显示文摘 | Rangel L M Silva L H S Rosa P | 2012 | Hydrobiologia2012，693，1： | 1 |
| 11 | IgG fe receptors provide an alternative infection route for murine gamma-herpesvirus-68显示文摘 | Rosa G T Gillet L Smith C M de Lima B D Stevenson P G | 2007 | PLoS ONE2007，2，： | 1 |
| 12 | Expansion and reduction of thin-walled tubes using a die : Experimental and theoretical investigation 显示文摘 | Almeida B P P Alves M L Rosa P A R | 2006 | International Journal of Machine Tools and Manufacture2006，46，1213： | 1 |
| 13 | Greenhouse gas emissions from hydroelectric reserw~irs 显示文摘 | ROSA L P SCHAEFFER R | 1994 | Ambio1994，23，： | 1 |
| 14 | Gross greenhouse gas fluxes from hydro-power reservoir compared to thermo-power plants显示文摘 | Dos Santos M A Rosa L P Sikar B | 2006 | Energy Policy2006，34，4： | 1 |
| 15 | Gas release from a reservoir in the filling stage显示文摘 | MATVIENKO B E SIKAR E ROSA L P | 2000 | Verh Int Vcrein l imnol2000，27，： | 1 |
| 16 | Primary cardiac tumour: early and late results of surgical treatment in 91 patients显示文摘 | Gentofanti P Di Rosa E Deorsola L | 1999 | Ann Thorac Surg1999，68，： | 1 |
| 17 | Gross greenhouse gas fluxes from hydro-power reservoir compared to thermo-power plants显示文摘 | Santos M A Rosa L P Matvienko B | 2005 | Energy Policy2005，34，1： | 1 |
| 18 | Statistical evaluation of E1S and ENM data collected for monitoring corrosion barrier prop- erties of organic coatings on AI - 2024 - T3 显示文摘 | De Rosa R L Earl D A Bierwagen G P | 2002 | Corrosion Sci- ence2002，44，： | 1 |
| 19 | A competitive mean-squared error approach to beamforming 显示文摘 | Eldar Y C Nehorai A Rosa L P S | 2007 | Signal Processing IEEE Transactions2007，55，11： | 1 |
| 20 | Compression bead- ing and nosing of thin-walled tubes using a die : Experimental and theoretical investigation 显示文摘 | Gouveia B P P Alves M L Rosa P A R | 2006 | International Journal of Mechanics & Materials in Design2006，3，1： | 1 |
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