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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Historical CO2 emission and concentrations due to land use change of croplands and pastures by country显示文摘 | Campos C P D Muylaert M S Rosa L P | 2005 | Science of the Total Environment2005，346，： | 1 |
| 3 | 查看详情显示文摘 | Skrobot F C Rosa L V M arques P A | | 0，，： | 1 |
| 4 | Glutathione deficiency is associated with impaired survival in HIV disease 显示文摘 | HERZENBERG L A DE ROSA S C DUBS J G | 1997 | Proc Nat Acad Sci1997，94，5： | 1 |
| 5 | 查看详情显示文摘 | De Rosa C Auriemma F De Lucia G Resconi L | | 0，，： | 1 |
| 6 | Moguisteine: a novel peripheral nonnarcotie antitussive drug显示文摘 | Gallieo L Borghi A Dalla Rosa C | 1994 | Br J Pharm1994，112，： | 1 |
| 7 | IL- 10 and TNF- ? Polymorphisms and Recovery from HCV Infection显示文摘 | Domenico L Calogero C Rosa DS | 2003 | Human Immunology2003，64，7： | 1 |
| 8 | IgG fe receptors provide an alternative infection route for murine gamma-herpesvirus-68显示文摘 | Rosa G T Gillet L Smith C M de Lima B D Stevenson P G | 2007 | PLoS ONE2007，2，： | 1 |
| 9 | A first linkage map of olive( O-lea europaea L )cultivars using RAPD,AFLP,RFLP and SSR markers显示文摘 | Rosa R L Angiolillo A Guerrero C | | 0，，07： | 1 |
| 10 | An energetic and conceptual model of the physiological role of dietary carbohydrates and salinity on Litopenaeus vannamei juveniles显示文摘 | Rosas C Cuzon G Gaxiola l | 2002 | Aquaculture2002，268，： | 1 |
| 11 | Mycobiota And Mycotoxins In Malted Barley And Brewer's Spent Grain From Argentinean Breweries 显示文摘 | Gonzalez Pereyra M L Rosa C A Dalcero A M | 2011 | Letters In Applied Microbiology2011，55，6： | 1 |
| 12 | Microtubule cytoskeleton perturbation induced by taxol and colchicine affects chaperonin containing TCP-1 (CCT) subunit gene expression in Tetrahymena cells 显示文摘 | Casalou C Cyme L Rosa MR | 2001 | Biochim Biophys Acta2001，1522，1： | 1 |
| 13 | Diffusion-weigh- ted imaging findings in Perthes disease with dynamic gadolini- um-enhanced subtracted (DGS) MR correlation: a preliminary study 显示文摘 | Merlini L Combescure C De Rosa V | 2010 | Pediatr Radiol2010，40，3： | 1 |
| 14 | Preparation and characterization of new room temperature ionic liquids 显示文摘 | Braneo L C Rosa J N Moura Ramos J J | 2002 | Chem Eur J2002，，： | 1 |
| 15 | Preparation and characterization of new room temperature ionic liquids显示文摘 | Branco L C Rosa J N Moura Ramos J J et a1 | 2002 | Chem Eur J2002，8，16： | 1 |
| 16 | Weight gain management in patients with schizophrenia during treatment with olanzapine in association with nizatidine显示文摘 | Assuncao SS Ruschel SI Rosa L C | 2006 | Rev Bras Psiquiatr2006，28，4： | 1 |
| 17 | A competitive mean-squared error approach to beamforming 显示文摘 | Eldar Y C Nehorai A Rosa L P S | 2007 | Signal Processing IEEE Transactions2007，55，11： | 1 |
| 18 | 显示文摘 | Branco L C Rosa J N Moura Ramos J J | 2002 | Chem Eur J2002，8，： | 1 |
| 19 | Neridronate improves bone mineral density and reduces back pain in β-thalassaemia patients with osteoporosis:results from a phase 2,randomized,parallel-arm,open-label study显示文摘 | Forni GL Perrotta S Giusti A Quarta G Pitrolo L Cappellini MD D'Ascola DG Borgna Pignatti C Rigano P Filosa A Iolascon G Nobili B Baldini M Rosa A Pinto V Palummeri E | | 0，，： | 1 |
| 20 | Family Psycho-educational Interventions for Schizophrenia in Routine Setting:Impact of Patients' Clinical Status and Social Functioning and on relatives' Burden and Resources显示文摘 | Magliano L Fiorillo A Magliano C De Rosa C Favata G Sasso A Prezioso M | | 0，，03： | 1 |
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