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| 1 | pRB expression in esophageal mucosa of individuals at high risk for squamous cell carcinoma of the esophagus显示文摘AIM: To investigate the pRb expression in a large group of patients with history of chronic exposure to the main risk factors for development of squamous cell carcinoma of the esophagus. METHODS: One hundred and seventy asymptomatic individuals at high risk for esophageal squamous cell carcinoma (consumption of more than 80 g of ethanol and 10 cigarettes/d for at least 10 years) underwent upper gastrointestinal endoscopy with biopsies of the esophageal mucosa. As a control group, specimens of esophageal mucosa obtained from 20 healthy subjects were also studied. Immunohistochemical assessment of the tissues was performed using a monoclonal antibody anti-pRB protein. RESULTS: Absence of the pRB staining, indicating loss of RB function, was observed in 33 (19.4%) of the individuals at risk for esophageal cancer, but in none of the healthy controls (P < 0.02). Loss of pRb expression increased in a stepwise fashion according to the severity of the histological findings (P < 0.005): normal mucosa (11/97 or 11.3%), chronic esophagitis (17/60 or 28.3%), low-grade dysplasia (3/10 or 30%), high-grade dysplasia 1/2 or 50%) and squamous cell carcinoma (1/1 or 100%). CONCLUSION: Our findings suggest that abnormal expression of the pRB protein may be implicated in the process of esophageal carcinogenesis. Additional studies are warranted to define the role of the pRBprotein as a biomarker for development of esophageal squamous cell carcinoma in individuals at high risk for this malignancy. | Simone S Contu Paulo C Contu Daniel C Damin Renato B Fagundes Fabiano Bevilacqua Aline S Rosa Joo C Prolla Luis F Moreira | 2007 | World Journal of Gastroenterology2007，13，11： | 5 |
| 2 | Increased serum glial cell line-derived neurotrophic factor immunocontent during manic and depressive episodes in individuals with bipolar disorder显示文摘 | ROSA A R FREY B N ANDREAZZA A C | 2006 | Neurosci Lett2006，407，： | 1 |
| 3 | IgG fe receptors provide an alternative infection route for murine gamma-herpesvirus-68显示文摘 | Rosa G T Gillet L Smith C M de Lima B D Stevenson P G | 2007 | PLoS ONE2007，2，： | 1 |
| 4 | Effects of low UV-B doses on the accumulation of UV-B absorbing compounds and total phenolics and carbohydrate metabolism in the peel of harvest lemons显示文摘 | Interdonato R Rosa M Nieva C B | 2011 | Environmental and Experimental Botany2011，，70： | 1 |
| 5 | A validated solid - liquid extraction method for the HPLC determination of polyphenols in apple tissues Comparison with pressurised liquid extraction显示文摘 | ROSA M ALEJANDRO B EDURNE C LUIS A BLANCA G FRANCISCA V | 2005 | Talanta2005，，65： | 1 |
| 6 | The influence of spec- tral power distribution on contrast sensitivity 显示文摘 | Arranz I Matesanz B M Rosa C | 2012 | Lighting Research and Technology2012，44，3： | 1 |
| 7 | Porosity-cement ratio controlling strength of artificially cemented clays显示文摘 | CONSOLI N C ROSA A D CORTE M B | 2011 | Materials in Civil Engineering2011，23，8： | 1 |
| 8 | Activation of 5-hydroxytryptamine 1 B/1 D/1F receptors as a mechanism of action of antimigraine drugs 显示文摘 | RAMIREZ ROSAS M B LABRUIJERE S VILLALON C M | 2013 | Expert Opin Pharmacother2013，14，12： | 1 |
| 9 | Effect of salinity and inorganic nitrogen concentrations on nitrification and denitrification rates in intertidal sediments and rocky biofilms of the Douro River estuary, Portugal 显示文摘 | Magalhaes C M Samantha B J Rosa M M | 2005 | Water Res2005，39，5： | 1 |
| 10 | Neridronate improves bone mineral density and reduces back pain in β-thalassaemia patients with osteoporosis:results from a phase 2,randomized,parallel-arm,open-label study显示文摘 | Forni GL Perrotta S Giusti A Quarta G Pitrolo L Cappellini MD D'Ascola DG Borgna Pignatti C Rigano P Filosa A Iolascon G Nobili B Baldini M Rosa A Pinto V Palummeri E | | 0，，： | 1 |
| 11 | Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD1839(Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor显示文摘 | Fortunato C Rosa C Roberto B Vincenzo D Grazia P Sabino De Placido | 2000 | Clin Cancer Res2000，6，： | 1 |
| 12 | Effects of low UV-B doses on the accumulation of UV-B absorbing compounds and total phe- nolics and carbohydrate metabolism in the peel of harvest lemons 显示文摘 | Interdonato R Rosa M Nieva C B | 2011 | Environmental and Experimental Botany2011，70，： | 1 |
| 13 | Differentially ex- pressed genes in eutopic and ectopic endometrium of women with endometriosis显示文摘 | Meola J Rosa e Silva J C Dentillo D B | 2010 | Fertil Steril2010，93，6： | 1 |
| 14 | Synthesis and characterization of molecularly imprinted silica mediated by Al for solid phase extraction of quercetin in Ginkgo biloba L显示文摘 | Braga L R Rosa A A Dias A C B | 2014 | Analytical Methods2014，6，12： | 1 |
| 15 | Unusual molecular forms of hCG in gestational trophoblastic neoplasia显示文摘 | Rosa C Wehmann S Birken S and Nisula B | 1984 | Annales Endocrinol (Paris)1984，45，： | 1 |
| 16 | Maedi-visna virus infection of ovine mammary epithelial cells显示文摘 | Rosa B Eva M Librado C | 2006 | Veterinary Research2006，37，： | 1 |
| 17 | Bootstrap study of ge-nome -enabled prediction reliabilities using haplotype blocks acrossNordic Red cattle breeds显示文摘 | CUYABANO B C SU G ROSA G J | 2015 | J Dairy Sci2015，98，： | 1 |
| 18 | Influence of the Anesthetic Technique on the Hemodynamic Changes in Renal Transplantation显示文摘 | Eunice Sizue H Maria Fernanda B Rosa Ines C | 2009 | A Retrospective Study Rev Bras Anesthesiology2009，59，2： | 1 |
| 19 | C - reactive protein in acute myocardial infarction association with heart failure 显示文摘 | Ginseppe B Rocco C Rosa P | 2003 | Am Heart J2003，145，4： | 1 |
| 20 | Variation within 3 ' UTRs of base excision repair genes and response to terapy in clorectalccer patients: A potential modulation of microRNAs binding 显示文摘 | Pardini B Rosa F Barone E Di Gaetano C Slyskova J Novotny J | 2013 | Clin Cancer Res2013，19，21： | 1 |
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