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| 1 | 卵巢子宫内膜样癌的分子学异质性:对166例采用子宫内膜癌的分子分类分析显示文摘在临床和生物学上,卵巢子宫内膜样癌(EOC)是不同于其他组织学类型的卵巢癌,但在形态学和分子生物学特征上与子宫内膜样癌有相似之处。根据新的子宫内膜癌分子分类分析EOC的分子学异质性,并评价该分子分类的预后意义。作者对166例早期EOC行免疫组化分析错配修复蛋白和p53的表达,并用Sanger测序法检测聚合酶epsilon的核酸外切酶结构域(POLL EDM)。另外,通过二代测序分析POLE EDM的突变,以确认超突变情况。8例肿瘤示POLE EDM突变,属超突变(5%);29例肿瘤示错配修复缺陷,属高突变(18%);16例肿瘤示p53表达突变,属p53异常(11%);114个肿瘤无上述改变,属非特异类型(66%)。5例肿瘤示>1个分类标准。 | Leskela S Romero I Rosa-Rosa J M 赵芳(译) 魏建国(审校) | 2021 | 临床与实验病理学杂志2021，37，4： | 3 |
| 2 | Natural products:Perspectives in the pharmacological treatment of gastrointestinal anisakiasis显示文摘Objective: To evaluate the activity of different natural products against L3 larvae of Anisakis type I. Methods: Information on investigations into the activity of natural products against the L3 larvae of Anisakis simplex was collected from scientific journals, books, theses and reports via a library and electronic search(using Pubmed, Scopus, Medline, Web of Science and Science Direct). The search terms included: natural products, medicinal plants, essential oils, terpenic derivatives, Anisakis, antinematodal activity. Results: In the literature reviewed numerous papers were found concerning the in vitro and in vivo activity against Anisakis type I of various natural products(plant extracts, essential oils and their major components). Analysis of the results showed that in vitro tests the Melaleuca alternifolia essential oil and the ar-turmerone isolated from Curcuma longa displayed the greatest activity. In vivo, the most active compound was perillaldehyde, the main component of Perilla frutescens essential oil. Conclusions: This study shows that some natural products exhibited promising antianisakis properties. | Valero A Romero MC Gómez-Mateos M Hierro I Navarro MC | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，8： | 2 |
| 3 | 益生菌抑制自发性高血压大鼠的菌群失调和血压升高:短链脂肪酸的作用显示文摘该研究旨在评估益生菌短双歧杆菌CECT7263(BFM)及发酵乳酸杆菌CECT5716(LC40)、短链脂肪酸丁酸盐及醋酸盐对自发性高血压大鼠(spontaneously hypertensive rat,SHR)心血管的作用。方法和结果:5周龄的Wistar Kyoto大鼠(WKY)10只和周龄匹配的SHR 50只随机分为6组:对照WKY、对照SHR、BFM干预的SHR、LC40干预的SHR、丁酸盐干预的SHR和醋酸盐干预的SHR。 | 袁源(译) 练桂丽(审校) Robles-Vera I Toral M de la Visitación N Sánchez M Gómez-Guzmán M Romero M Yang T Izquierdo-Garcia JL Jiménez R Ruiz-Cabello J Guerra-Hernández E Raizada MK Pérez-Vizcaíno F Duarte J | 2020 | 中华高血压杂志2020，28，9： | 2 |
| 4 | Getting the interactions right: Will higher O3 levels interfere with induced defenses to aphid feeding? 显示文摘 | Menendez A I Romero A M Folcia A M | 2008 | Basic and Applied Ecology2008，10，3： | 1 |
| 5 | Interception of the electron transport chain in bacteria with hydrophilic redox mediators显示文摘 | Lithgow A M Romero L Sanchez I C | 1986 | J Chem Res Synop1986，，5： | 1 |
| 6 | Temperature conversion (mesophilic to thermophilic) of municipal sludge digestion 显示文摘 | De la Rubia M A Romero L I Sales D | 2005 | Aiche Journal2005，51，9： | 1 |
| 7 | Transmission network expansion planning considering uncertainty in demand显示文摘 | Silva I J Rider M J Romero R | 2006 | IEEE Transactions on Power Systems2006，21，4： | 1 |
| 8 | The tumour suppressor Fhit positively regulates MHC class I expression on cancer cells显示文摘 | Romero I Martinez M Garrido C | 2012 | J Pathol2012，227，3： | 1 |
| 9 | A short mutational hot spot in the first intron of BCL-6 is associated with increased BCL-6 expression and with longer overall survival in large B-Cell lymphoma显示文摘 | Artiga M J Sáez A I Romero C | 2002 | American Journal of Pathology2002，160，7： | 1 |
| 10 | Effect of high CO2 pretreatment on quality, fungal decay and molecular regulation of stilbene phytoalexin biosynthesis in stored table grapes显示文摘 | SANCHEZ-BALLESTA M T JIMINEZ J B ROMERO I | 2006 | Postharvest Biology and Technology2006，42，3： | 1 |
| 11 | Effect of substrate concentration on dry mesophilic anaerobic digestion of organic fraction of municipal solid waste (OFMSW) 显示文摘 | Ferna'ndez J Pe'rez M Romero L I | 2008 | Bioresource Technology2008，99，14： | 1 |
| 12 | Transitive approximation to pairwise comparison matri- ces by using interval goal programming 显示文摘 | Gonzdlez-Pach6n J Rodrguez-Galiano M I Romero C | 2003 | Journal of Operational Research Society2003，54，5： | 1 |
| 13 | Kinetics of mesophilic anaerobic digestion of the organic fraction of municipal solid waste: Influence of initial total solid concentration显示文摘 | Fern6ndez J Perez M Romero L I | 2010 | Bioresource Technology2010，101，16： | 1 |
| 14 | Effect of substrate concentr-ation on dry mesophilic anaerobic digestion of fraction of municipal solid waste显示文摘 | FERN(A)NDEZ J P(E)REZ M ROMERO L I | 2008 | Bioresour Technol2008，99，14： | 1 |
| 15 | Influence of total solid and inoculum contents on performance of anaerobic reactors treating food waste 显示文摘 | Forster-Carneiro T Perez M Romero L I | 2008 | Bioresource Technology2008，99，15： | 1 |
| 16 | Effect of substrateconcentration on dry mesophilic anaerobic digestion of or-ganic fraction of municipal solid waste ( OFMSW) 显示文摘 | Femdndez J P6rez M Romero L I | 2008 | Bioresource Technology2008，99，14： | 1 |
| 17 | Quantitative Assessment of As- sisted Problem--based Learning in a Pharmaceuties Course显示文摘 | Romero R M Eriksen S P Haworth I S | 2010 | American Jour- nal of Pharmaceutical Education2010，74，4： | 1 |
| 18 | Interception of electron-transport chain in bacteria with hydrophilic redox mediators显示文摘 | LITHGOW A M ROMERO L SANCHEZ I C | 1986 | Chemical Research1986，5，3： | 1 |
| 19 | Transitive approximation to pairwise comparison matrices by using interval goal programming显示文摘 | Gonza1ez-Pachan J Rodrlguez-Galiano M I Romero C | 2003 | Journal of Operational Research Society2003，54，5： | 1 |
| 20 | Influence of total solid and inoculum contents on performance of anaerobic reactors treating food waste显示文摘 | Forster-Carneiro T Perez M Romero L I | 2008 | Bioresonrce Technology2008，99，15： | 1 |
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