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| 1 | Decreased expression of Klotho in cardiac atria biopsy samples from patients at higher risk of atherosclerotic cardiovascular disease显示文摘BackgroundKlotho 蛋白质(α - 并且 β) 是基于膜的传播调整细胞新陈代谢的蛋白质,以及成纤维细胞生长因素(FGF ) 的 lifespan modulating 活动。最近的数据证明了更高的血浆传播 Klotho 层次减少心血管的风险,建议 Klotho 有在心血管的疾病的一个保护的角色。然而,尽管到目前为止它在各种各样的机关被识别了,它是未知的是否,并且高心血管的风险是否能影响 Klotho 的心脏的表示 cardiomyocytes 快车 Klotho 和 FGF , FGF 和另外的 molecules.MethodsWe 与心血管的疾病和 10 匹配年龄的控制使遭到,估计的10年的低风险经历的一名估计的10年的高动脉粥样硬化患者选择了 20 个病人为除冠的动脉以外的原因的心脏的外科绕过。在心肌的活体检视,我们由免疫组织化学评估了 Klotho 和 FGF 是否在 cardiomyocytes 被表示,并且更高心血管的风险是否影响涉及 endoplasmic 蜂窝胃应力的另外的分子的表示,氧化应力,发炎并且 fibrosis.ResultsOnly ,有更高心血管的风险的病人的 cardiomyocytes 显示出 Klotho 的更低的表示,但是 FGF 的更高的表情。而且,更高心血管的风险与增加的表示被联系氧化并且网状的应力,发炎和 fibrosis.ConclusionsThis 学习的 endoplasmic 第一次证明 Klotho 蛋白质在人的 cardiomyocytes 被表示, Klotho 的那心脏的表情在更高心血管的风险病人是下面调整的,当压力相关的分子的表示显著地被增加时。 | Giovanni Corsetti Evasio Pasini Tiziano M Scarabelli Claudia Romano Pratik R Agrawal Carol Chen-Scarabelli Richard Knight Louis Saravolatz Jagat Narula Mario Ferrari-Vivaldi Vincenzo Flati Deodato Assanelli Francesco S Dioguardi | 2016 | Journal of Geriatric Cardiology2016，13，8： | 7 |
| 2 | Ondansetron inhibits the analgesic effects of tramadol: a possible 5-HT(3) spinal receptor involvement in acute pain in humans 显示文摘 | ARCIONI R DELLA ROCCA M ROMANO S | 2002 | Anesth Analg2002，94，6： | 1 |
| 3 | Biweekly administration of gemcitabine and vinorelbine as first line therapy in elderly advanced breast cancer 显示文摘 | Dinota A Bilancia D Romano R | 2005 | Breast Cancer Res Treat2005，89，1： | 1 |
| 4 | Gastro-duodenal perforations: conventional plain film, US and CT findings in 166 consecutive patients 显示文摘 | Grassi R Romano S Pinto A | 2004 | Ear J Radiol2004，50，1： | 1 |
| 5 | Effects of Er:YAG laser and ultrasonic treatment on fibroblast attachment to root surfaces: an in vitro study显示文摘 | Crespi R Romanos GE Cassinelli C | 2006 | J Periodontol2006，77，7： | 1 |
| 6 | Monitoring activities from multiple video streams: Establishing a common coordinate frame显示文摘 | ROMANO R LEE L STEIN G | 2000 | IEEE Transactions on Pattern Analysis and Machine Intelligence( PAMI)2000，22，8： | 1 |
| 7 | Rapamycin stimulates apop- tosis of childhood acute lymphoblastic leukemia cells显示文摘 | AveUino R Romano S Parasole R | 2005 | Blood2005，106，： | 1 |
| 8 | Endothelin B receptor antagonists attenuate subarachnoid hemorrhage-induced cerebral vasospasm 显示文摘 | Zuccarello M Boccaletti R Romano A | 1998 | Stroke1998，29，9： | 1 |
| 9 | Thyroid cancer in pregnancy显示文摘 | Yasmeen S Cress R Romano PS | 2005 | Int J Gynaecol Obstet2005，91，1： | 1 |
| 10 | The Promise and Peril of Cor- porate Governance Indices显示文摘 | Bhagat S Bohon B J Romano R | 2008 | Columbia Law Review2008，108，8： | 1 |
| 11 | Synthesis of dimethyl carbonate from methanol, carbon monoxide, and oxygen catalyzed by copper compounds 显示文摘 | Romano U Tesel R Mauri M M Rebora P | 1980 | Industrial & Engineering Chemistry Product Research and Development1980，19，3： | 1 |
| 12 | Double Moral Hazard and Resale Price Maintenance显示文摘 | Romano R | 1994 | RAND Journal of Economics1994，，： | 1 |
| 13 | Aspects of R&D subsidization显示文摘 | Romano R E | 1989 | Quar- terly Journal of Economics1989，104，4： | 1 |
| 14 | Space weather- ing of silicates simulated by nanosecond pulse UV excimer laser 显示文摘 | Brunetto R Romano F Blanco A | 2006 | Icarus2006，180，2： | 1 |
| 15 | Naturally occurring antisperm antibodies in men: Interference with fertility and implications for treatment 显示文摘 | Francavilla F Romano R Santucci R | 1999 | Frontiers in Bioscience1999，4，1： | 1 |
| 16 | Vertical forces in labial and lingual orthodontics applied on maxillary incisors-a theoretical approach 显示文摘 | Geron S Romano R | 2004 | Angle Orthodontist2004，74，2： | 1 |
| 17 | Immuno modulatory effects of Laetobaeillus plantarum on hu- man colon cancer cells 显示文摘 | Paolillo R Romano C C Sorrentino S | 2009 | Int Immunopharmaeol2009，9，11： | 1 |
| 18 | Alkylphenol ethoxylates in the environment显示文摘 | Naylor C G Mieure J P Adams W J Weeks J A Castaldl F J Ogle L D Romano R R | 1992 | American Oil Chemists Society1992，69，： | 1 |
| 19 | Treatment of aqueous effluents of the leather industry by membrane processes显示文摘 | A Cassano R Molinari M Romano E Drioli | 2001 | Journal of Membrane Science2001，，1： | 1 |
| 20 | GP73, a resi- dent Golgi glycoprotein, is a novel serum marker for hepatocel-lular carcinoma 显示文摘 | Marrero J A Romano P R Nikolaeva O | 2005 | J Hepatol2005，43，6： | 1 |
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