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| 1 | Effect of hepatic artery embolization on liver hypertrophy response in a rabbit liver VX2tumor model显示文摘BACKGROUND:Portal vein embolization not only induces hypertrophy of the non-embolized liver,but also enhances tumor growth.The latter could be prevented by embolizing the hepatic arteries supplying the tumor-bearing liver segments.This study aimed to determine the effects of transcatheter arterial embolization(TAE)on tumor volume and liver regeneration in a rabbit VX2 tumor model.METHODS:Twenty-three rabbits underwent subcapsular tumor implantation with a VX2 tumor.Two weeks after implantation,18 rabbits were used for TAE experiments,5were for sham controls.Tumor response and liver regeneration response of the embolized cranial and non-embolized caudal liver lobes were assessed by CT volumetry,liver to body weight index,and the amount of proliferating hepatocytes.RESULTS:All super-selective arterial tumor embolization procedures were performed successfully.Despite embolization,the tumor volume increased after an initial steady state.The tumor volume after embolization was smaller than that of the sham group,but this difference was not significant.Massive necrosis of the tumor,however,was seen after embolization,without damage of the surrounding liver parenchyma.There was a significant atrophy response of the tumor bearing cranial lobe after super-selective arterial embolization of the tumor with a concomitant hypertrophy response of the non-embolized,caudal lobe.This regeneration response was confirmed histologically by a significantly higher number of proliferating hepatocytes on the Ki-67 stained slides.CONCLUSIONS:Super-selective,bland arterial coil embolization causes massive necrosis of the tumor,despite increase of volume on CT scan.Atrophy of the tumor bearing liver lobe is seen after arterial embolization of the tumor with a concomitant hypertrophy response of the non-embolized lobe,despite absence of histological damage of the tumor-surrounding liver parenchyma. | Krijn P van Lienden Lisette T Hoekstra Jessica D van Trigt Joris J Roelofs Otto M van Delden Thomas M van Gulik | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，6： | 2 |
| 2 | Structural organization of the Helieoverpa zea gene encoding the precursor protein for pheromone biosynthesis activating neuropeptide and other neuropeptides 显示文摘 | MA P W K KNIPPLE D C ROELOFS W L | 1994 | Proc Natl Acad Sci USA1994，91，14： | 1 |
| 3 | Enchytraeus crypticus as model species in soil ecotoxicology 显示文摘 | Castro-Ferreira M P Roelofs D van Gestel C A | 2012 | Chemosphere2012，87，11： | 1 |
| 4 | On the structure of activated hydrotalicites as solid base catalysts or liquid-phase aldol condensation 显示文摘 | ROELOFS J C A A LENSVELD D J VAN DILLEN A J | 2001 | Journal of Catalysis2001，203，1： | 1 |
| 5 | Robust low power embedded SRAM:from system considerations to cell design显示文摘 | Toby D Roelof S | 2001 | Journal of Low PowerElectronics2001，6，1： | 1 |
| 6 | 查看详情显示文摘 | J C A A Roelofs D J Lensveld A J van Dillen | | 0，，1： | 1 |
| 7 | Cre recombinase expression can result in phenotypic aberrations in plants 显示文摘 | Coppoolse E R de Vroomen M J Roelofs D | 2003 | Plant Mol Biol2003，51，2： | 1 |
| 8 | Effect of recombinant ADAMTS-13 on micmthrombis and brain injury after experimental subarachnoid hemorrhage显示文摘 | Vergouwen M D Knaup V L Roelofs J J | 2014 | J Thromb Haemost2014，12，6： | 1 |
| 9 | ENA imaging:seeing the invisible显示文摘 | Son Brandt P C Mitchell D G Roelof E C | 2005 | Johns Hopkins APL Technical Digest2005，26，2： | 1 |
| 10 | Cre recombi- nase expression can result in phenotypic aberrations in plants 显示文摘 | Coppoolse ER Vroomen M J Roelofs D | 2003 | Plant Molecular Biology2003，51，： | 1 |
| 11 | Role of inhibition in language switching: Evidence from event-related brain po- tentials in overt picture naming 显示文摘 | Verhoef K Roelofs A Chwilla D J | 2009 | Cognition2009，110，1： | 1 |
| 12 | Structure organization of the Helicoverpa zea gene encoding the precursor protein for pheromone biosynthesis activating neuropeptides 显示文摘 | MAP W KNIPPLE D C ROELOFS W L | 1994 | Proc Natl Acad Sci1994，91，： | 1 |
| 13 | On the structure of activated hydrotalcites as solid base catalysts for liquid-phase aldol condensation显示文摘 | ROELOFS J C A A LENSVELD D J DILLEN A J JONG K P | 2001 | J Catal2001，203，1： | 1 |
| 14 | A proteomics approach to understanding protein ubiquitination显示文摘 | Peng JM Schwartz D Elias JE Thoreen CC Cheng DM Marsischky G Roelofs J Finley D Gygi SP | | 0，，08： | 1 |
| 15 | Nonsteroidal anti-in- flammatory drugs for low back pain: an updated Coehrane review 显示文摘 | ROELOFS P D DEYO R A KOES B W | 2008 | Spine2008，33，16： | 1 |
| 16 | Energetic neutral atoms(E50 keV)from the ring current:IMP 7/8 and ISEE 1 显示文摘 | Roelof E C Mitchell D G Williams D J | 1985 | Journal of Geophysical Research:Space Physics(1978- 2012)1985，90，10： | 1 |
| 17 | First composition measurements of energetic neutral atoms显示文摘 | Lui A T Y Williams D J Roelof E C | 1996 | Geophysical Re- search Letters1996，23，19： | 1 |
| 18 | Field - selected cadmium tolerance in the springtail Orchesella cincta is correlated with increased metallothionein mRNA expression 显示文摘 | Sterenborg I Roelofs D | 2003 | Insect Biochemistry and Molecular Biology2003，33，7： | 1 |
| 19 | Controlling inventoties with stochastic item returns: A basic model 显示文摘 | Moritz F Roelof K Rommert D | 2002 | European Journal of Operational Research2002，138，1： | 1 |
| 20 | On the Structure of Activated Hydrotalcites as Solid Base Catalysts for Liquid-Phase Aldol Condensation显示文摘 | Roelofs J C A A Lensveld D J A J van Dillen | 2001 | Journal of Catalysis2001，203，： | 1 |
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