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| 1 | Therapeutic and prophylactic thalidomide in TNBS-induced colitis: Synergistic effects on TNF-α, IL-12 and VEGF production显示文摘AIM: To evaluated the therapeutic and prophylactic effect of thalidomide on 2, 4, 6-trinitrobenzene sulfonic acid (TNBS)-induced colitis. Thalidomide has been reported to downregulate the expression of tumor necrosis factor a (TNF-α), IL-12, and vascular endothelial growth factor (VEGF), hallmarks of intestinal inflammation in Crohn's disease (CD). METHODS: Male Wistar rats were divided in five groups of ten animals each. Four groups received a rectal infusion of TNBS in ethanol. The first group was sacrificed 7 d after colitis induction. The second and third groups received either thalidomide or placebo by gavage and were sacrificed at 14 d. The fourth group received thalidomide 6 h before TNBS administration, and was sacrificed 7 d after induction. The fifth group acted as the control group and colitis was not induced. Histological inflammatory scores of the colon were performed and lamina propria CD4+ T cells, macrophages, and VEGF+ cells were detected by immunohistochemistry. TNF-a and IL-12 were quantified in the supernatant of organ cultures by ELISA. RESULTS: Significant reduction in the inflammatory score and in the percentage of VEGF+ cells was observed in the group treated with thalidomide compared with animals not treated with thalidomide. Both TNF-αand IL-12 levels were significantly reduced among TNBS induced colitis animals treated with thalidomide compared with animals that did not receive thalidomide. TNF-αlevels were also significantly reduced among the animals receiving thalidomide prophylaxis compared with untreated animals with TNBS-induced colitis. Intestinal levels of TNF-αand IL-12 were significantly correlated with the inflammatory score and the number of VEGF+ cells. CONCLUSION: Thalidomide significantly attenuates TNBS-induced colitis by inhibiting the intestinal production of TNF-α, IL-12, and VEGF. This effect may support the use of thalidomide as an alternate approach in selected patients with CD. | Ana Teresa Carvalho Heitor Souza Antonio Jose Carneiro Morgana Castelo-Branco Kalil Madi Alberto Schanaider Flavia Silva Fernando Antonio Pereira Júnior Márcia G Pereira Cláudio Tortori Ilana Dines Jane Carvalho Eduardo Rocha Celeste Elia | 2007 | World Journal of Gastroenterology2007，13，15： | 6 |
| 2 | The effects of ebsclen on glutamate uptake by synaptic vesicles from rat brain 显示文摘 | PORCIUNCULA L O ROCHA J B GHISLENI G | 2004 | Brain Res2004，1027，12： | 1 |
| 3 | Probiotic potential of Mi-nas fresh cheese prepared with the addition of Lactobacillus paracasei显示文摘 | Buriti F A da Rocha J S Assis E G | | 0，，02： | 1 |
| 4 | Biocompatibilityof anionic collagen matrix as scaffold for bone hea-ling显示文摘 | Rocha LB Goissis G Rossi MA | 2002 | Biomaterials2002，23，2： | 1 |
| 5 | Probiotic potential of Minas fresh cheese prepared with the addition of Lactobacillus paracasei 显示文摘 | BURITI F C A DA ROCHA J S ASSIS E G | 2005 | Lebensmittel-Wissenschaft und Tehonlogie2005，38，2： | 1 |
| 6 | Fluid and electrolyte balance during the first week of life and risk of bronchopulmonary dysplasia in the preterm neonate 显示文摘 | Rocha G Ribeiro O Guimaraes H | 2010 | Clinics (Sao Paulo)2010，65，7： | 1 |
| 7 | Urinary 11-dehydro thromboxane B 2 levels in type 2 diabetic patients before and during aspirin intake显示文摘 | Lillian Harboe Gon?alves Luci Maria Sant'Ana Dusse Ana Paula Fernandes Karina Braga Gomes Mirelle Oliveira Sóter Michelle Teodoro Alves Kathryna Fontana Rodrigues Fernanda Rocha Freitas Flavia Komatsuzaki Marinez Oliveira Sousa Adriana Aparecida Bosco Gér | 2011 | Clinica Chimica Acta2011，，15： | 1 |
| 8 | Detection of rabbit haemorrhagic disease virus (RHDV) in nonspeeificverteb- rate hosts sympatric to the European wild rabbit (Oryctolagus cuniculus)显示文摘 | Merchan T Rocha G Alda F | 2011 | Infect Genet Evol2011，，11： | 1 |
| 9 | Graphene for toughand electroconductive alumina ceramics 显示文摘 | CENTENO A ROCHA V G ALONSO B | 2013 | J Eur Ceram Soc2013，33，32： | 1 |
| 10 | Chloroplast-localized protein kinases:A step forward towards a complete inventory显示文摘 | BAYER R G STAEL S ROCHA A G | 2012 | Journal of Experimental Botany2012，63，4： | 1 |
| 11 | HLA and bronchopul- monary dysplasia susceptibility: a pilot study显示文摘 | Rocha G Proena E Areias A | 2011 | Dis Mark ers2011，31，4： | 1 |
| 12 | Effect of graft source on unrelated donor haemopoietic stem-cell transplantation in adults with acute leukaemia:a retrospective analysis显示文摘 | Eapen M Rocha V Sanz G | 2010 | Lancet Oncol2010，11，7： | 1 |
| 13 | Marine-derived anticancer agents in clinical trials显示文摘 | Schwartsmann G Da Rocha AB Mattei J | 2003 | Expert Opin Investig Drugs2003，12，8： | 1 |
| 14 | Fluid dynamics study of the influence of the position of the feed in fabric filters 显示文摘 | Rocha S M S Vieira L G M Aguiar M L | 2009 | Computer Aided Chemical Engineering2009，27，： | 1 |
| 15 | Hydrothermal origin of soft hematite ore in the Quadrildtero Ferrifero of Minas Gerais,BrazilPetrographic evidence from the Gongo Soco iron ore deposit显示文摘 | Cabral A R Rocha Filho 0 G Jones R D | 2003 | Applied Earth Science: Trans Inst Min Metall B2003，112，： | 1 |
| 16 | Use of rice straw as biosorbent for removal of Cu(Ⅱ),Zn(Ⅱ),Cd(Ⅱ)and Hg(Ⅱ)ion in industrial effluent显示文摘 | ROCHA C G ZZIA D A ALFAYA R V | 2009 | Journal of Hazardous Material2009，166，： | 1 |
| 17 | Total synthesis and evaluation of lamellarin-20-sulfate analogues显示文摘 | Reddy MV Rocha G | 2002 | Bioorg Med Chem2002，10，： | 1 |
| 18 | Protein kinase C-mediated in vitro invasion of human glioma cells through extracellular -signal -regulated kinase and ornithine decarboxylase显示文摘 | Mans DRA Lenz G | 2000 | Pathobiology2000，68，： | 1 |
| 19 | Serum Hsp70 as an ealry perdictor of fatal outcome after severe traumatic brain injury in males显示文摘 | da Rocha A B Zanoni C de Freitas G R | 2005 | J Neuortrauma2005，22，9： | 1 |
| 20 | Lupus nephritis: a retrospective review of 78 cases from a single center显示文摘 | MARTINS L ROCHA G RODRIGUES A | 2002 | Clin Nephrol2002，57，2： | 1 |
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