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| 1 | Hepatic intra-arterial infusion of yttrium-90 microspheres in the treatment of recurrent hepatocellular carcinoma after liver transplantation: A case report显示文摘Hepatocellular carcinoma (HCC) recurs with a reported frequency of 12%-18% after liver transplantation. Recurrence is associated with a mortality rate exceeding 75%. Approximately one-third of recurrences develop in the transplanted liver and are therefore amenable to local therapy. A variety of treatment modalities have been reported including resection, transarterial chemo- embolization (TACE), radiofrequency ablation (RFA), ethanol ablation, cryoablation, and external beam irradiation. Goals of treatment are tumor control and the minimization of toxic effect to functional parenchyma. Efficacy of treatment is mitigated by the need for ongoing immunosuppression. Yttrium-90 microspheres have been used as a treatment modality both for primary HCC and for pre-transplant management of HCC with promising results. Twenty-two months after liver transplantation for hepatitis C cirrhosis complicated by HCC, a 42-year old man developed recurrence of HCC in his transplant allograft. Treatment of multiple right lobe lesions with anatomic resection and adjuvant chemotherapy was unsuccessful. Multifocal recurrence in the remaining liver allograft was treated with hepatic intra-arterial infusion of yttrium-90 microspheres (SIR-Spheres, Sirtex Medica Inc., Lake Forest, IL, USA). Efficacy was demonstrated by tumor necrosis on imaging and a decrease in alpha-fetoprotein (AFP) level. There were no adverse consequences of initial treatment. | Louis Rivera Huan Giap William Miller Jonathan Fisher Donald J Hillebrand Christopher Marsh Randolph L Schaffer | 2006 | World Journal of Gastroenterology2006，12，35： | 6 |
| 2 | Antimicrobial activity,cytotoxicity,and phytochemical screening of Voacanga globosa(Blanco) Merr.leaf extract(Apocynaceae)显示文摘Objective:To determine the antibacterial,antifungal,antiprotozoal,cytotoxic,and phytochemical properties of ethanol extracts of leaves of Voacanga globosa(Blanco) Merr.(V.globosa). Methods:The extracts were tested against bacteria and fungus through disc diffusion assay; against protozoa through growth curve determination,antiprotozoal and cytotoxicity assays. Results:The extract revealed antibacterial activities,inhibiting the growth of Staphylococcus aureus,Bacillus cereus,Pseudomonas aeruginosa,Micrococcus luteus,and Salmonella typhimurium.Antifungal assay showed that it inhibited Candida albicans.The antiprotozoal assay against Trichomonas vaginalis and Entamoeba histolytica showed that V.globosa can inhibit the parasites,wherein the action can be comparable to metronidazole.With the in situ cell death detection kit.Trichomonas vaginalis and Entamoeba histolytica exposed to V.globosa leaf extract was observed to fluoresce simultaneously in red and yellow signals signifying apoptotic-like changes.Preliminary phytochemical screening revealed the chemical composition of plant extract containing alkaloids,saponins,2-deoxysugars,and hydrolysabie tannins.Conclusions: Thus,thus study provides scientific evidence on the traditional use of V.globosa leaf extract in treating microbial diseases.Further,the leaf extract can possibly be used to produce alternative forms of antimicrobials. | Pierangeli G Vital Windell L Rivera | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，10： | 5 |
| 3 | Fecal immunochemical test accuracy in average-risk colorectal cancer screening显示文摘AIM:To assess the fecal immunochemical test(FIT)accuracy for colorectal cancer(CRC)and advanced neoplasia(AN)detection in CRC screening.METHODS:We performed a multicentric,prospective,double blind study of diagnostic tests on asymptomatic average-risk individuals submitted to screening colonoscopy.Two stool samples were collected and the fecal hemoglobin concentration was determined in the first sample(FIT1)and the highest level of both samples(FITmax)using the OC-sensor.Areas under the curve(AUC)for CRC and AN were calculated.The best FIT1and FITmax cut-off values for CRC were determined.At this threshold,number needed to scope(NNS)to detect a CRC and an AN and the cost per lesion detected were calculated.RESULTS:About 779 individuals were included.An AN was found in 97(12.5%)individuals:a CRC in 5(0.6%)and an advanced adenoma(≥10 mm,villous histology or high grade dysplasia)in 92(11.9%)subjects.For CRC diagnosis,FIT1 AUC was 0.96(95%CI:0.95-0.98)and FITmax AUC was 0.95(95%CI:0.93-0.97).For AN,FIT1 and FITmax AUC were similar(0.72,95%CI:0.66-0.78 vs 0.73,95%CI:0.68-0.79,respectively,P=0.34).Depending on the number of determinations and the positivity threshold cut-off used sensitivity for AN detection ranged between 28%and 42%and specificity between 91%and 97%.At the best cut-off point for CRC detection(115 ng/mL),the NNS to detect a CRC were 10.2 and 15.8;and the cost per CRC was 1814€and 2985€on FIT1 and FITmax strategies respectively.At this threshold the sensitivity,NNS and cost per AN detected were 30%,1.76,and 306€,in FIT1 strategy,and 36%,2.26€and 426€,in FITmax strategy,respectively.CONCLUSION:Performing two tests does not improve diagnostic accuracy,but increases cost and NNS to detect a lesion. | Vicent Hernandez Joaquin Cubiella M Carmen Gonzalez-Mao Felipe Iglesias Concepción Rivera M Begoa Iglesias Lucía Cid Ines Castro Luisa de Castro Pablo Vega Jose Antonio Hermo Ramiro Macenlle Alfonso Martínez-Turnes David Martínez-Ares Pamela Estevez Estela Cid M Carmen Vidal Angeles López-Martínez Elisabeth Hijona Marta Herreros-Villanueva Luis Bujanda Jose Ignacio Rodriguez-Prada the COLONPREV study investigators | 2014 | World Journal of Gastroenterology2014，20，4： | 4 |
| 4 | Comparison of direct fecal smear microscopy,culture,and polymerase chain reaction for the detection of Blastocystis sp.in human stool samples显示文摘Objective:To compare the sensitivity and specificity of direct fecal smear microscopy,culture,and polymerase chain reaction in the detection of Blastocystis sp.in human stool.Methods:Human stool samples were collected from a community in San Isidro,Rodriguez,Rizal,Philippines.These samples were subjected to direct fecal smear microscopy,culture and polymerase chain reaction to detect the presence of Blastocystis sp.Results:Of the 110 stool samples collected,28(25%)were detected positive for the presence of Blastocystis sp.by two or more tests.Culture method detected the highest number of Blastocystis-positive stool samples(n=36),followed by PCR of DNA extracted from culture(n=26),PCR of DNA extracted from stool(n=10),and direct fecal smear(n=9).Compared to culture,the sensitivity of the other detection methods were 66.7%for PCR from culture and 19.4%for both PCR from stool and direct fecal smear.Specificity of the methods was high,with PCR from culture and direct fecal smear having97.3%,while PCR from stool at 95.9%.Conclusions:In this study,in vitro culture is the best method for detecting Blastocystis sp.in human stool samples. | Herbert J Santos Windell L Rivera | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，10： | 3 |
| 5 | Adjuvant radiotherapy for rectal can-cer:Recent results,new questions显示文摘 | Rivera S Villa J Quero L | 2010 | Clin Res Hepatol Gastroenterol2010，23，： | 1 |
| 6 | Quadratic regularization functionals for phase unwrapping显示文摘 | MARROQUIN J L RIVERA M | 1995 | J O S A1995，12，11： | 1 |
| 7 | Immune-mediated mechanisms of parasite tissuesequestration during experimental cerebral malaria显示文摘 | Amante FH Haque A Stanley AC Rivera Fde L Randall LM Wilson YA | 2010 | J Immu-nol2010，185，6： | 1 |
| 8 | Hartmannella vermiformis isolated from the cerebrospinal fluid of a young male patient with meningoencephalitis and bronchopneumonia显示文摘 | Centeno M Rivera F Cerva L | 1996 | Archives of Medical Research1996，27，4： | 1 |
| 9 | Damaging effects of ischemi- a/reperfusion on intestinal muscle 显示文摘 | Pontell L Sharma P Rivera LR | 2011 | Cell Tissue Res2011，343，2： | 1 |
| 10 | Kupffer cell oxidant production in central to the mechanism of peroxisome proliferators显示文摘 | Rose M L Rivera C A Bradford B U | 1999 | Carcinogenesis1999，20，1： | 1 |
| 11 | Out-of-plane Behaviour of Confined Masonry Walls 显示文摘 | Varela - Rivera J L Navarrete-Macias D Fernandez- Baqueiro L E | 2011 | Engineering Structures2011，33，5： | 1 |
| 12 | Quercetin ameliorates metabolic syndrome and improves the inflammatory status in obese Zueker rats显示文摘 | Rivera L Moron R Sanchez M | 2008 | Obesity (Silver Spring)2008，16，9： | 1 |
| 13 | Detection of large-scale variation in the human genome 显示文摘 | Iafrate A J Feuk L Rivera M N | 2004 | Nature Genetics2004，36，9： | 1 |
| 14 | Confined Masonry Walls Subjected to Combined Axial Loads and Out-of-plane Uniform Pressures显示文摘 | Varela - Rivera J Polanco-May M Fernandez-Baqueiro L | 2012 | Canadian Journal of Civil Engineering2012，39，4： | 1 |
| 15 | Shape Optimization for Tool Wear in the Friction-stir Welding of Cast Al359-20%SiCMMC显示文摘 | A R Rivera L E Murr | 2002 | Journal of Materials Science2002，37，10： | 1 |
| 16 | Centric fission,centromcre-telomere fusion and isechromesome formation:a possible origin of a de novo 12p trisomy显示文摘 | Rivera H Gareia-Esquivel L Jimenez-Sainz M | 1987 | Clin Genet1987，31，6： | 1 |
| 17 | Geodynamics of thenorthern Andes:Subductions and intracontinental deformation(Colombia)显示文摘 | Taboada A Rivera L Fuenzalida A | 2000 | Tectonics2000，19，： | 1 |
| 18 | Laparoscopic pancreatoduodenectomy : a review of 285 published cases 显示文摘 | Gumbs AA Rodriguez Rivera AM Milone L | 2011 | Ann Surg Oncol2011，18，5： | 1 |
| 19 | Electrochemical kinetic study about cobalt electrodeposition onto GCE and HOPG substrates from sulfate sodium solutions 显示文摘 | RIOS-REYES C H MENHOZA-HUIZAR L H RIVERA M | 2010 | Journal of Solid State Electrochemistry2010，14，4： | 1 |
| 20 | 显示文摘 | Ren Y Rivera J G He L | 2011 | BMC Biotcchnology2011，11，1： | 1 |
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