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| 1 | Urinary nuclear magnetic resonance spectroscopy of a Bangladeshi cohort with hepatitis-B hepatocellular carcinoma: A biomarker corroboration study显示文摘AIM: To establish if a distinct urinary metabolic profile could be identified in Bangladeshi hepatitis-B hepatocellular carcinoma(HCC) patients compared to cirrhosis patients and controls. METHODS: Urine samples from 42 Bangladeshi patients with HCC(39 patients with hepatitis-B HCC), 47 with cirrhosis on a background of hepatitis B, 46 with chronic hepatitis B, and seven ethnically-matched healthy controls were analyzed using nuclear magnetic resonance(NMR) spectroscopy. A full dietary and medication history was recorded for each subject. The urinary NMR data were analyzed using principal component analysis(PCA) and orthogonal partial leastsquared discriminant analysis(OPLS-DA) techniques. Differences in relative signal levels of the most discriminatory metabolites identified by PCA and OPLSDA were compared between subject groups using an independent samples Kruskal-Wallis one-way analysis of variance(ANOVA) test with all pairwise multiple comparisons. Within the patient subgroups, the MannWhitney U test was used to compare metabolite levels depending on hepatitis B e-antigen(HBe Ag) status and treatment with anti-viral therapy. A BenjaminiHochberg adjustment was applied to acquire the level of significance for multiple testing, with a declared level of statistical significance of P < 0.05.RESULTS: There were significant differences in age(P < 0.001), weight(P < 0.001), and body mass index(P < 0.001) across the four clinical subgroups. Serum alanine aminotransferase(ALT) was significantly higher in the HCC group compared to controls(P < 0.001); serum α-fetoprotein was generally markedly elevated in HCC compared to controls; and serum creatinine levels were significantly reduced in the HCC group compared to the cirrhosis group(P = 0.004). A threefactor PCA scores plot showed clustering of the urinary NMR spectra from the four subgroups. Metabolites that contributed to the discrimination between the subgroups included acetate, creatine, creatinine, dimethyamine(DMA), formate, glycine, hippurate, and trimethylamine-N-oxide(TMAO). A comparison of relative metabolite levels confirmed that carnitine was significantly increased in HCC; and creatinine, hippurate, and TMAO were significantly reduced in HCC compared to the other subgroups. HBe Ag negative patients showed a significant increase in creatinine(P = 0.001) compared to HBe Ag positive patients in the chronic hepatitis B subgroup, whilst HBe Ag negative patients showed a significant decrease in DMA(P = 0.004) in the cirrhosis subgroup compared to HBe Ag positive patients. There were no differences in metabolite levels in HCC patients who did or did not receive antiviral treatment. CONCLUSION: Urinary NMR changes in Bangladeshi HCC were identified, corroborating previous findings from Egypt and West Africa. These findings could form the basis for the development of a cost-effective HCC dipstick screening test. | I Jane Cox Abil E Aliev Mary ME Crossey Mahvish Dawood Mamun Al-Mahtab Sheikh M Akbar Salimur Rahman Antonio Riva Roger Williams Simon D Taylor-Robinson | 2016 | World Journal of Gastroenterology2016，22，16： | 4 |
| 2 | Carbon nanotubes for electrochemical biosensing显示文摘 | Rivas G A Rubianes M D Rodriguez M C | 2007 | Talanta2007，74，3： | 1 |
| 3 | 显示文摘 | RUBIANES M D RIVAS G A | 2001 | Anal Chim Acta2001，440，2： | 1 |
| 4 | Animal antimicrobial peptides:an overview显示文摘 | Andreu D Rivas L | 1998 | Biopolymers1998，47，： | 1 |
| 5 | Carbon nanotubes paste electrode 显示文摘 | Rubianes M D Rivas Gustavo A | 2003 | electrochemistry co- mmunications2003，5，： | 1 |
| 6 | Intellectual and language findings and their relationship to EEG characteristics in benign childhood epilepsy with centrotemporal spikes显示文摘 | Riva D Vago C Franceschetti S | 2007 | Epilepsy Behav2007，10，2： | 1 |
| 7 | Treatment of brain arteriovenous malformations by double arterial catheterization with simultaneous injection of Onyx:retrospective series of 17patients显示文摘 | Abud D G Riva R Nakiri G S | 2011 | Am J Neuroradiol2011，32，1： | 1 |
| 8 | A Simple Control Scheme for Hybrid Active Power Filter显示文摘 | Rivas D Moran L Dixon J | 2002 | IEE Proc on Gener Transm and Distrib2002，2002，： | 1 |
| 9 | Plant parasiticnematodes associated with guava plantations in Zulia State,Venezuela显示文摘 | Crozzoli P R Casassa P M Rivas G D | 1991 | Fitopatologia Venezolana1991，4，1： | 1 |
| 10 | Double sleeve uniportal video-assisted thoracoscopic lobectomy for non-small cell lung cancer 显示文摘 | GONZALEZ'-RIVAS D DELGADO M FIEIRA E | 2014 | Ann Car- diothorac Surg2014，3，2： | 1 |
| 11 | Genotoxieity study of water-soluble cationic polymers and their polymer-metal complexes with biocidal activity显示文摘 | Rivas B L Pereira E D Mondaca M A | 2003 | J Appl Polym Sci2003，87，3： | 1 |
| 12 | Animal antimicrobial peptides: an overview显示文摘 | Andreu D Rivas L | 1998 | Biopolymers (Peptide Science)1998，47，6： | 1 |
| 13 | Antitumour activity of the silybin-phosphatidylcholine complex,IdB 1016,against human ovarian cancer显示文摘 | Gallo D Giacomelli S Ferlini C Raspaglio G Apollonio P Prislei S Riva A Morazzoni P Bombardelli E Scambia G | | 0，，： | 1 |
| 14 | Optimization of unpowered descents of commercial aircraft in altitude-dependent wind显示文摘 | Franco A Rivas D Valenzuela A | 2012 | Journal of Aircraft2012，49，5： | 1 |
| 15 | Single-incision laparoscopic cholecystectomy:initial evaluation of a large series of patients显示文摘 | Rivas H Varela E Scott D | 2010 | Surg Endosc2010，24，6： | 1 |
| 16 | Single incision laparoscopic chole- cystectomy : initial evaluation of a large series of patients 显示文摘 | Rivas H Varela E Scott D | 2010 | Surg Endosc2010，24，： | 1 |
| 17 | Condensation in a square minichannel: application of the VOF method 显示文摘 | Bortolin S Da Riva E Del Col D | 2014 | Heat Transfer Engineering2014，35，2： | 1 |
| 18 | An enhanced transient expression system in plants based on suppression of gene silencing by the p19 protein of tomato bushy stunt virus显示文摘 | VOINNET O RIVAS S MESTRE P BAULCOMBE D | 2003 | PZant2003，33，5： | 1 |
| 19 | Single-incision laparoscopic cholecystectomy : initial evaluation of a large series of patients 显示文摘 | Rivas H Varela E Scott D | 2010 | Surg Endosc2010，24，6： | 1 |
| 20 | Clinical outcomes with bioabsorbable polymer-versus durable polymer-based drug-eluting and bare-metal stents:evidence from a comprehensive network meta-analysis显示文摘 | Palmerini T Biondi-Zoccai G Delia Riva D | 2014 | J Am Coll Cardiol2014，63，： | 1 |
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