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| 1 | In vivo radiometric analysis of glucose uptake and distribution in mouse bone显示文摘Bone formation and remodeling occurs throughout life and requires the sustained activity of osteoblasts and osteoclasts,particularly during periods of rapid bone growth.Despite increasing evidence linking bone cell activity to global energy homeostasis,little is known about the relative energy requirements or substrate utilization of bone cells.In these studies,we measured the uptake and distribution of glucose in the skeleton in vivo using positron-emitting^(18)F-fluorodeoxyglucose([^(18)F]-FDG) and non-invasive,high-resolution positron emission tomography/computed tomography(PET/CT) imaging and ex vivo autoradiography.Assessment of [^(18)F]-FDG uptake demonstrated that relative to other tissues bone accumulated a significant fraction of the total dose of the glucose analog.Skeletal accumulation was greatest in young mice undergoing the rapid bone formation that characterizes early development.PET/CT imaging revealed that [^(18)F]-FDG uptake was greatest in the epiphyseal and metaphyseal regions of long bones,which accords with the increased osteoblast numbers and activity at this skeletal site.Insulin administration significantly increased skeletal accumulation of [^(18)F]-FDG,while uptake was reduced in mice lacking the insulin receptor specifically in osteoblasts or fed a high-fat diet.Our results indicated that the skeleton is a site of significant glucose uptake and that its consumption by bone cells is subject to regulation by insulin and disturbances in whole-body metabolism. | Meredith L Zoch Diane S Abou Thomas L Clemens Daniel LJ Thorek Ryan C Riddle | 2016 | Bone Research2016，4，1： | 9 |
| 2 | A Study of electrocardiographic patterns in a population of commercial broiler chickens 显示文摘 | Olkowski A A Classen H L Riddle C | 1997 | Veterinary Research Communications1997，21，： | 2 |
| 3 | Hypoxia-inducible factor-1a restricts the anabolic actions of parathyroid hormone显示文摘The hypoxia inducible factors(Hifs) are evolutionarily conserved transcriptional factors that control homeostatic responses to low oxygen. In developing bone, Hif-1 generated signals induce angiogenesis necessary for osteoblast specification, but in mature bone, loss of Hif-1 in osteoblasts resulted in a more rapid accumulation of bone. These findings suggested that Hif-1 exerts distinct developmental functions and acts as a negative regulator of bone formation. To investigate the function of Hif-1a in osteoanabolic signaling, we assessed the effect of Hif-1a loss-of-function on bone formation in response to intermittent parathyroid hormone(PTH). Mice lacking Hif-1a in osteoblasts and osteocytes form more bone in response to PTH, likely through a larger increase in osteoblast activity and increased sensitivity to the hormone. Consistent with this effect, exposure of primary mouse osteoblasts to PTH resulted in the rapid induction of Hif-1a protein levels via a post-transcriptional mechanism. The enhanced anabolic response appears to result from the removal of Hif-1a-mediated suppression of b-catenin transcriptional activity. Together, these data indicate that Hif-1a functions in the mature skeleton to restrict osteoanabolic signaling. The availability of pharmacological agents that reduce Hif-1a function suggests the value in further exploration of this pathway to optimize the therapeutic benefits of PTH. | Julie L Frey David P Stonko Marie-Claude Faugere Ryan C Riddle | 2014 | Bone Research2014，2，1： | 2 |
| 4 | Separation of sulfonate and carboxylate mixtures by ion-exchange high performance liquid chromatography显示文摘 | LAWLEY C W RIDDLE R M | 1984 | J Of Chromatography1984，30，2： | 1 |
| 5 | The treat-to-target trial: randomized addition of glargine or human NPH insulin to oral therapy of type 2 diabetic patients显示文摘 | Riddle M C Rosenstock J Gerich J | 2003 | Diabetes Care2003，26，2： | 1 |
| 6 | Long-term in vivo gene expression via delivery of PEI-DNA condensates from porous polymer scaffolds 显示文摘 | HUANG Y C RIDDLE K RICE K G | 2005 | Hum Gene Ther2005，16，5： | 1 |
| 7 | Structural basis for the specificity of ubiquitin C-terminal hydrolases 显示文摘 | JOHNSTON S C RIDDLE S M COHEN R E | 2000 | EMBO J2000，18，14： | 1 |
| 8 | Insulin re-ceptor signaling in osteoblasts regulates postnatal bone acquisition and body composition显示文摘 | FULZELE K RIDDLE R C DIGIROLAMO D | | 0，，02： | 1 |
| 9 | Effects of age and insulin-like growth factor-1 on neuron and synapse numbers in area CA3 of hippocampus显示文摘 | Poe BH Linville C Riddle DR | 2001 | Neuroscience2001，107，2： | 1 |
| 10 | Glycemia treatment strategies in the action to control cardiovascular risk in diabetes (ACCORD) trial 显示文摘 | Gerstein H C Riddle M C Kendall D M | 2007 | Am J Cardiol2007，99，12： | 1 |
| 11 | Effects of exenatide (exendin-4) on glyeemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea 显示文摘 | KENDALL D M RIDDLE M C ROSENSTOCK J | 2005 | Diabetes Care2005，28，5： | 1 |
| 12 | Combining systemic retinoids with biologic agents for moderate to severe psoriasis显示文摘 | SMITH EC RIDDLE C MENTER MA | 2008 | IntJDermatol2008，47，5： | 1 |
| 13 | The treat-to-target trial:randomized addition of glargine or human NPH insulin to oral theraoy of type 2 diabetic patients显示文摘 | Riddle M C Rosenstock J Gerich J | 2003 | Diabetes Care2003，26，11： | 1 |
| 14 | Role of hypoxia-inducible factor-lalpha in angiogenic-osteogenic coupling 显示文摘 | RIDDLE R C KHATRI R SCHIPANI E | 2009 | J Mol Med (Bed)2009，87，6： | 1 |
| 15 | Glyce-mia treatment strategies in the Action to Control Cardio-vascular Risk in Diabetes(ACCORD)trial 显示文摘 | Gerstein H C Riddle M C Kendall D M | 2007 | Am JCardiol2007，99，12： | 1 |
| 16 | Central axons preparing to myelinate are highly sensitivity to ischemic injury显示文摘 | Alix J J Zammit C Riddle A | 2012 | Ann Neurol2012，72，6： | 1 |
| 17 | In search of the molecular basis of heterosis显示文摘 | BIRCHLER J A AUGER D L RIDDLE N C | | 0，，： | 1 |
| 18 | Effects of exanatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with mefform in and a sulfonylurea显示文摘 | Kendall D M Riddle M C Rosenstock J | 2005 | Diabetes Care2005，28，5： | 1 |
| 19 | MAP kinase and calcium signaling mediate fluid flow-induced human mesenchymal stem cell proliferation 显示文摘 | RIDDLE R C TAYLOR A F GENETOS D C | 2006 | Am J Physiol Cell Physiol2006，290，3： | 1 |
| 20 | Successful treatment with injected hyaluronic acid in a patient with lip asymmetry after surgical correction of cleft lip显示文摘 | SCHWE1GER E S RIDDLE C C TONKOVI-CAPIN V | 2008 | Dermatol Surg2008，34，5： | 1 |
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