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| 1 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 2 | Phase II trial (BREAK-2) of the BRAF Inhibitor Dabrafenib (GSK2118436)in patients with metastatic melanoma 显示文摘 | Ascierto PA Minor D Ribas A | 2013 | J Clin Oncol2013，31，26： | 1 |
| 3 | VEGFR1 positive haematopoietic bone marrow progenitors initiate the pre meta static niche显示文摘 | Kaplan R N Riba R D Zaeharoulis S | 2005 | Nature2005，438，7069： | 1 |
| 4 | VEGFR1-positive haematopoietic bone marrrow progenitors initiate the pre-metastatic niche显示文摘 | KAPLAN R N RIBA R D ZACHAROULIS S | 2005 | Nature2005，438，7069： | 1 |
| 5 | BREAK-2:a Phase IIA trial of the selective BRAF kinase inhibitor GSK2118436 in patients with BRAF mutation-positive (V600E/K) metastatic melanoma显示文摘 | TREFZER U MINOR D RIBAS A | | 0，，： | 1 |
| 6 | Combining cancer immunotherapy and targeted therapy 显示文摘 | Ribas A Wolchok J D | 2013 | Current opinion in immunology2013，25，2： | 1 |
| 7 | Teicoplanin population pharmacokinetic analysis in hospitalized patients显示文摘 | Soy D Lopez E Ribas J | 2006 | Ther Drug Monit2006，28，6： | 1 |
| 8 | VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche显示文摘 | KAPLAN R N RIBA R D ZACHAROULIS S | 2005 | Nature2005，438，7069： | 1 |
| 9 | The evolution of checkpoint blockade as a cancer therapy: what's here, what's next? 显示文摘 | Shin D S Ribas A | 2015 | Curr Opin hnmunol2015，33，： | 1 |
| 10 | Single-nueleotide polymorphism detection by denaturing high-performance liquid chromatography and direct sequencing in genes in the MHC class Ⅲ region encoding novel cell surface molecules显示文摘 | Ribas G Neville M J Campbell R D | 2001 | Immunogenetics2001，53，5： | 1 |
| 11 | VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche显示文摘 | Kaplan R N Riba R D Zacharoulis S | 2005 | Nature2005，438，7069： | 1 |
| 12 | Clinical profile of systemic inflammatory response after pediatric cardiac surgery with cardiopulmonary bypass显示文摘 | Soares LC Ribas D Spring R | 2010 | Arquivos Brasileiros de Cardidogia2010，94，1： | 1 |
| 13 | Anti-programmed-death- receptor-Ⅰ treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomized dosecomparison cohort of a phase 1 trial 显示文摘 | Robert C Ribas A Wolchok J D | 2014 | Lancet2014，384，： | 1 |
| 14 | Comparison of a homemade cocoa shell activated carbon with commercial acti vated carbon for the removal of reactive violet 5 dye from aqueous solutions显示文摘 | RIBAS M C ADEBAYO M A PROLA L D T | 2014 | Chemical Engineering Journal2014，248，： | 1 |
| 15 | Comparison of a home- made cocoa shell activated carbon with commercial aetivated carbon for the removal of reactive violet 5 dye from aqueous solutions显示文摘 | Ribas M C Adebayo M A Prola L D | 2014 | Chemical Engineering Journal2014，248，： | 1 |
| 16 | Role of lipoprotein-associatedphospholipase A2 activity for the prediction of silent brain infarcts inwomen显示文摘 | Riba LI Penalba A Pelegrf D | 2014 | Atherosclerosis2014，237，2： | 1 |
| 17 | Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma显示文摘 | Ribas A Pavlov D Marshall M A | 2013 | Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology2013，31，5： | 1 |
| 18 | Final efficacy results of a367 1009 , a phase 3 study of tremelimumab vs chemotherapy (dacarbazine or temozolomide) in rst line patients with unresectable melanoma显示文摘 | RIBAS A PAVLOV D MARSHALL MA | | J Immunother0，34，2： | 1 |
| 19 | VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche显示文摘 | KAPLAN R N RIBA R D ZACHAROULIS S | 2005 | Nature2005，438，7069： | 1 |
| 20 | Single-nucleotide polymorphism detection by denaturing high-performance liquid chromatography and direct sequencing in genes in the MHC class Ⅲ region encoding novel cell surface molecules 显示文摘 | Ribas G Neville M J Campbell R D | 2001 | Immunogenetics2001，53，5： | 1 |
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