|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Local immunotherapy with interleuk in-2 delivered from biodegradable p olymer microspheres combined with interstitial chemotherapy:a novel treatme nt for experimental malignant glioma显示文摘OBJECTIVE:Local delivery of carmustine(BCNU)from biodegradable polymers prolon gs survival against experimental brain tumors.Moreover,paracrine administration of inte rleukin-2(IL-2)has been shown to elicit a potent antitumor immune response and to improve survival in animal brain tumor models.We r eport the use of a novel polymeric mic rosphere delivery vehicle to release IL-2.We demonstr ate both in vitro release of cytokine from the microspheres and histological evidence of the inflammatory response elicited by I L-2released from the microspheres i n the rat brain.These microspheres a re used to deliver IL-2,and biodegradable polymer wafers are used to deliver BCNU,directly at the site of an intracranially implanted glioma in the rat.The two agents administered locally show a s ynergistic effect.METHODS:Fischer 344rats challenged intracranially with 9L gliosarcoma received an intracranial implant of either empty microspheres or microspheres containing IL-2(IL-2MS ).Five days later,animals in each group were randomized to receiv e polymer implants loaded with 0,3.8,or 10%BCNU at the tumor site.RESULTS:Animals that received the combination of IL-2MS a nd 3.8%BCNU polymer(median survival,28.5d )or IL-2MS and 10%BCNU polymer(median survival,45.5d )showed significantly improved surv ival compared with animals that rece ived monotherapy with IL-2microsph eres(median survival,24d ),3.8%BCNU polymer(median survival,24d ),or 10%BCNU polymer(median survival,32.5d ).Control animals had a median survival of 18days.The combination of either 3.8or 10%BCNU polymer with IL-2MS resulted in 7and 25%long-term survivors,respectively.CONCLUSION:By showing synergy of IL-2and BCNU in an animal glioma model and using a reproducible synthetic delivery sy stem for each agent (i.e.,one that did not rely on genetic ally engineered cells or viruses),we hope that the combination of local immunotherapy and chemotherapy can take an important step closer to clinical applic ation in patients with malignant brain | Rhines LD DiMeco F Lawson HC Tyler BM Hanes J Olivi A Brem H | 2003 | 癌症2003，22，7： | 2 |
| 2 | Posterior fossa decompression for life-threatening tonsillar herniation in patients with gliomatosis cerebri: report of three cases显示文摘 | Weinberg JS Rhines LD Cohen ZR | 2003 | Neurosurgery2003，52，1： | 2 |
| 3 | O6-benzylguanine potentiates the antitumor effect of locally delivered carmustine against an intracranial rat glioma显示文摘 | Rhines LD Sampath P Dolan ME | 2000 | Cancer Res2000，60，22： | 1 |
| 4 | The role of surgery in the management of metastatic spinal tumors 显示文摘 | Feiz-Erfan I Rhines LD Weinberg JS | 2008 | Semin Oncol2008，35，2： | 1 |
| 5 | Metastatic sacral tumors显示文摘 | Nader R Rhines LD Mendel E | 2004 | Neurosurg Clin N Am2004，15，4： | 1 |
| 6 | The role of surgery inthe management of metastatic spinal tumors显示文摘 | Feiz-Erfan I Rhines LD Weinberg JS | 2008 | Semin Oncol2008，35，2： | 1 |
| 7 | Total en bloc lumbar spondylectomy :case report显示文摘 | Rhines LD weinberg JS | 2001 | J Neurosurg2001，95，2： | 1 |
| 8 | Stereotactic body radiation therapy for management of spinal metastasesin patients without spinal cord compression: a phase 1- 2 trial显示文摘 | Wang XS Rhines LD Shiu AS | 2012 | Lancet Oncol2012，13，4： | 1 |
| 9 | Management of spinal metastases from renal cell carcinoma using stereotactic body radiotherapy显示文摘 | Nguyen QN Shiu AS Rhines LD | 2010 | Int J Radiat Oncol Bi- ol Phys2010，76，4： | 1 |
| 10 | The role of surgery in the management of metastatic spinal tumors显示文摘 | Feiz-Erfan I Rhines LD Weinberg JS | 2008 | Semin Oncol2008，35，2： | 1 |
| 11 | En bloc resection of primary sacral tumors: classification of surgical approaches andoutcome 显示文摘 | Fourney DR Rhines LD Hentschel SJ | 2005 | J Neurosurg Spine2005，3，2： | 1 |
| 12 | En bloc resection of multilevel cervical chordoma with C-2 involvement: case report and description of operative technique 显示文摘 | Rhines LD Fourney DR iadati A | 2005 | J Neurosurg Spine2005，2，2： | 1 |
| 13 | En bloc resection of primary sacral tumors: classification of surgical approaches and outcome 显示文摘 | Fourney DR Rhines LD Hentschel SJ | 2005 | J Neurosurg Spine2005，3，2： | 1 |
| 14 | En bloc resection of primary sacral tumors:classification of surgical approaches and outcome显示文摘 | Fourney DR Rhines LD Hentschel SJ | 2005 | J Nenrosurg Spine2005，3，2： | 1 |
| 15 | Simultaneous anterior-posterior approach to the thoracic and lumbar spine for the radical resection of tumors followed by reconstruction and stabilization显示文摘 | Fourney DR Abisaid D Rhines LD | 2001 | J Neurosurg2001，94，2： | 1 |
| 16 | En bloc resection of primary sacral tumors:classification of surgical approaches and outcome显示文摘 | Fourney DR Rhines LD Hentschel SJ | 2005 | J Neurosurg Spine2005，3，2： | 1 |
| 17 | En bloc resection of primary sacral tumors:classiifcation of surgical approaches and outcome显示文摘 | Fourney DR Rhines LD Hentschel SJ | | 0，，02： | 1 |
| 18 | The role of surgery in the management of metastatic spinal tumors显示文摘 | Feiz-Erfan I Rhines LD Weinberg JS | 2008 | Semin Oncol2008，35，2： | 1 |
| 19 | En bloc resection of primary sacral tumors :classification of surgical approaches and ontcome显示文摘 | Fourney DR Rhines LD Hentschel SJ | 2005 | J Neurosurg Spine2005，3，2： | 1 |
| 20 | En bloc resection of primary sacral tumors: classification of surgical approaches and outcome显示文摘 | Fourney DR Rhines LD Hentschel SJ | 2005 | J Neurosurg Spine2005，3，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员