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| 1 | Tumor Antigen Specific Activation of Primary Human T-Cells Expressing a Virally Encoded Chimeric T-Cell Receptor Specific for p185HER2显示文摘We have developed and tested chimeric T-cell receptors (TCR) specific for p185HER2. In these experiments, retroviral vectors expressing the N29γ or N29ζ receptors were constructed in pRET6. Amphotropic viral producer cells were established in the GALV-based PG13 packaging cell line. Ficoll purified human peripheral blood lymphocytes (PBL) were virally transduced using an optimized protocol incorporating activation with immobilized anti-CD3/anti-CD28 monoclonal anti- bodies, followed by viral infection in the presence of fibronectin fragment CH296. Transduced cells were co-cultured with human tumor cell lines that overexpress (SK-OV-3) or underexpress (MCF7) p185HER2 to assay for antigen specific im- mune responses. Both CM+ and CD8+ T-cells transduced with the N29γ or N29ζ chTCR demonstrated HER2-specific anti- gen responses, as determined by release of Th1 like cytokines, and cellular cytotoxicity assays. Our results support the fea- sibility of adoptive immunotherapy with genetically modified T-cells expressing a chTCR specific for p185HER2. | 杨建民 Michael S FRIEDMAN Christopher M REYNOLDS Marianne T HUBEN Lee WILKE Jennifer FULLER 李桥 Zelig ESHHAR James J MULE Kevin T MCDONAGH | 2004 | Journal of Microbiology and Immunology2004，2，4： | 5 |
| 2 | 健康领域的文化能力显示文摘1背景
尽管人类对其他社会的兴趣纵贯历史的各个阶段,但是检验不同文化概念对人类健康实践的影响从20世纪才开始,当时是伴随着长期的人类学田野调查产生的,这些田野调查揭露了不同文化之间相关卫生实践的多样性、复杂性和连续性。 | Napier A D Ancarno C Butler B Calabrese j Chater A Chatterjee H Guesnet F Home R Jacyna S Jadhav S Macdonald A Neuendorf U Parkhurst A Reynolds R Scambler G Shamdasani S Smith S Z Stougaard-Nielsen J Thomson L Tyler N Volkmann A M Walker T Watson J Williams AC Willott C Wilson J Woolf K | 2016 | 中国卫生政策研究2016，9，2： | 5 |
| 3 | Risk factors for Barrett’s oesophagus and oesophageal adenocarcinoma:Results from the FINBAR study显示文摘AIM:To investigate risk factors associated with Barrett's oesophagus and oesophageal adenocarcinoma.METHODS:This all-Ireland population-based case-control study recruited 224 Barrett's oesophagus patients,227 oesophageal adenocarcinoma patients and 260 controls.All participants underwent a structured interview with information obtained about potential lifestyle and environmental risk factors.RESULTS:Gastro-oesophageal reflux was associated with Barrett's [OR 12.0(95% CI 7.64-18.7)] and oesophageal adenocarcinoma [OR 3.48(95% CI 2.25-5.41)].Oesophageal adenocarcinoma patients were more likely than controls to be ex-or current smokers [OR 1.72(95% CI 1.06-2.81)and OR 4.84(95% CI 2.72-8.61)respectively] and to have a high body mass index [OR 2.69(95% CI 1.62-4.46)].No significant associations were observed between these risk factors and Barrett's oesophagus.Fruit but not vegetables were negatively associated with oesophageal adenocarcinoma [OR 0.50(95% CI 0.30-0.86)].CONCLUSION:A high body mass index,a diet low in fruit and cigarette smoking may be involved in the progression from Barrett's oesophagus to oesophageal adenocarcinoma. | Lesley A Anderson RG Peter Watson Seamus J Murphy Brian T Johnston Harry Comber Jim Mc Guigan John V Reynolds Liam J Murray | 2007 | World Journal of Gastroenterology2007，13，10： | 5 |
| 4 | 文化、不平等性与卫生服务提供显示文摘1动态不平等性对基层医疗卫生人力的影响
政治、社会、文化、专业群体皆建立在一致且常规的人类行为之上。当遭受巨大变革和内外压力时,这些群体会变得十分脆弱。尤其在动荡时期,这些群体往往更关注社会和文化的差异性,而非二者的一致性。尽管社会中的个体思维和行为会呈现较大的差异,但对健康的感知具有统一性,并在更广范围人群内尤为突出,这主要归因于文化价值观的作用。广义的文化心态会随着时间和地理位置的不同而不同,就像健康的社会决定因素也会因文化类型的不同而产生差异。 | Napier A D Ancarno C Butler B Calabrese J Chater A Chatterjee H Guesnet F Horne R Jacyna S Jadhav S Macdonald A Neuendorf U Parkhurst A Reynolds R Scambler G Shamdasani S Smith S Z Stougaard-Nielsen J Thomson L Tyler N Volkmann A M Walker T Watson J Williams A C Willott C Wilson J Woolf K | 2016 | 中国卫生政策研究2016，9，3： | 2 |
| 5 | Aloe vera leaf gel: a review update 显示文摘 | Reynolds T Dweck A C | 1999 | J Ethnopharm1999，68，： | 2 |
| 6 | Plasma lipid concentrations in hyperlipidemic patients consuming a high-fat diet supplemented with pyruvate for 6 wk显示文摘 | Stanko R T Reynolds H R Lonchar K D | 1992 | Am J Clin Nutr1992，56，5： | 1 |
| 7 | Visualization of the material flow in AA2195 friction-stir welds using a maker insert technology显示文摘 | SEIDEL T U REYNOLDS A P | 2001 | Metall Mater Trans A2001，32，： | 1 |
| 8 | Speaker verification using adapted gaussian mixture models显示文摘 | Reynolds D A Quatieri T F Dunn R B | 2000 | Digital Signal Processing2000，10，1： | 1 |
| 9 | Sexual size dimorphism in shorebirds, gulls, and alcids: the influence of sexual and natural selection 显示文摘 | SZEKELY T REYNOLDS J D FIGUEROLA J | 2000 | Evolution2000，54，： | 1 |
| 10 | A nonparametric procedure for process control based on within-group ranking 显示文摘 | Bakir S T Reynolds M R | 1979 | Technometrics1979，21，17： | 1 |
| 11 | Freezing rate and frozen storage effect on the ultrastructure samples of pork 显示文摘 | NGAPO T M BABARE I H REYNOLDS J | 1999 | Meat Science1999，53，3： | 1 |
| 12 | The effects of rotation on initially anisotropic homogene- ous flows 显示文摘 | Mansour N N Shih T H Reynolds W C | 1991 | Phys Fluids A1991，3，10： | 1 |
| 13 | Titanium e- lastic nails for pediatric femur fractures: a muhicenter study of early results with analysis of complications 显示文摘 | Flynn J M Hresko T Reynolds R A | 2001 | J Pediatr Orthop2001，21，1： | 1 |
| 14 | Two-dimensional friction stir welding process model based on fluid mechanics 显示文摘 | SEIDEL T REYNOLDS A | 2003 | Science and Technology of Welding & Joining2003，8，： | 1 |
| 15 | C -reactive protein as a predictor of outcome after discharge from the intensive care: a prospective observational study 显示文摘 | Al- Subaie N Reynolds T Myers A | 2010 | Br J Anaesth2010，105，3： | 1 |
| 16 | 医疗卫生保健文化的反思及促进健康与文化融合的建议显示文摘1医疗卫生保健文化的反思1.1健康文化与医学知识如果医务人员有充足的时间对患者进行诊断并帮助患者进行社区护理,就可在节省卫生费用的同时改善健康结果。整合型社区护理能缩小不同文化背景和群体健康需求的差异。然而,全球范围内对整合型社区护理的投入较少,原因之一就是20世纪对临床服务的重视弱化了卫生服务提供过程中的同情心理。当然,患者也对医学知识存在显性和隐性的影响(特别是当其因不遵医嘱而受到指责时)。 | Napier A D Ancarno C Butler B Calabrese J Chater A Chatterjee H Guesnet F Horne R Jacyna S Jadhav S Macdonald A Neuendorf U Parkhurst A Reynolds R Scambler G Shamdasani S Smith S Z Stougaard-Nielsen J Thomson L Tyler N Volkmann A M Walker T Watson J Williams A C Willott C Wilson JWoolf K | 2016 | 中国卫生政策研究2016，9，4： | 1 |
| 17 | Doppler flow velocity patterns of the superior vena cava, inferior vena cava, hepatic vein, coronary sinus, and atrial septal defect: a guide for the echocardiographer显示文摘 | Reynolds T Appleton CP | 1991 | J Am Soc Echocardiogr1991，4，5： | 1 |
| 18 | Reconstruction of historical sea surface temperatures using empirical orthogonal functions显示文摘 | Smith T M Reynolds R W Livezey R E | 1996 | J Climate1996，9，6： | 1 |
| 19 | Pyruvate supplementation of a low-cholesterol, low-fat diet:effects on plasma lipid concentrations and body composition in hyperlipidemic patients显示文摘 | Stanko R T Reynolds H R Hoyson R | 1994 | Am J Clin Nutr1994，59，2： | 1 |
| 20 | Shape memory alloy/ glass composite seal for solid oxide electrolyzer and fuel cells显示文摘 | Story C Lu K Reynolds Jr W T | 2008 | International Journal of Hydrogen Energy2008，33，14： | 1 |
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