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| 1 | 塔里木西南缘(齐姆根弧)前陆构造及形成机理显示文摘在对齐姆根弧形构造地表地质构造和深部地球物理资料综合分析的基础上 ,阐述了齐姆根弧形构造的几何学、运动学和分段性 ,提出了齐姆根弧形构造由依格孜牙薄皮推覆构造段、齐姆根主弧形三角带构造段和叶尔羌—棋盘对冲构造段组成 ,各弧形构造段之间以横向走滑—斜冲断层为界 ;发现了齐姆根弧形构造中规模巨大的塔里木西南盆地白垩系—新生界沉积盖层向西昆仑—帕米尔被动反 (逆 )冲逆掩构造系统 ,阐述了齐姆根主弧形构造段由铁克里克主动逆冲推覆系统、塔里木西南盆地被动反冲逆掩系统和深部双重构造组成。齐姆根弧形构造的隆升时期为喜马拉雅运动 ,新生代 。 | 曲国胜 李亦纲 张宁 李岩峰 陈杰 陈新安 尹军平 张兴林 Joseph CANEROT Joachin DERAMOND Jacques REY | 2004 | 地质论评2004，50，6： | 21 |
| 2 | H pylori and host interactions that influence pathogenesis显示文摘H pylori is probably the most prevalent human patho- gen worldwide. Since it was initially suggested in 1983 by Marshall and Warren to be implicated in gastritis and peptic ulcer disease, H pylori has also been implicated in gastric carcinoma and was classified as a class I car- cinogen. In the last two decades, a noteworthy body of research has revealed the multiple processes that this gram negative bacterium activates to cause gastroduo- denal disease in humans. Most infections are acquired early in life and may persist for the life of the individual. While infected individuals mount an inflammatory re- sponse that becomes chronic, along with a detectable adaptive immune response, these responses are ineffec- tive in clearing the infection. H pylori has unique features that allow it to reside within the harsh conditions of the gastric environment, and also to evade the host immune response. In this review, we discuss the various virulence factors expressed by this bacterium and how they inter- act with the host epithelium to influence pathogenesis. | Ellen J Beswick Giovanni Suarez Victor E Reyes | 2006 | World Journal of Gastroenterology2006，12，35： | 20 |
| 3 | The Beauty of Being a Variant: H2A.Z and the SWR1 Complex in Plants显示文摘众多的研究证明了 nucleosome 是强烈影响基因表示的动态结构。精力使不同 nucleosomal 特征担心,包括位置, posttranslational 修正,和 histone 作文。在 nucleosome 以内,因此,正规 histones 能被 histone 变体蛋白质交换,特定的 functionsa 过程作为 histone 代替知道。histone 变体 H2A.Z 在抄写有一个重要函数并且在最后几年期间,它在植物开发和有免疫力的反应的角色变得明显。从几个实验室编基因、生物化学的研究表明了植物包含 multiprotein 建筑群,类似于从酵母和动物的 SWR1/SRCAP 建筑群,在 H2A.Z 包含了免职。尽管有在不同有机体的强烈研究, H2A.Z 由影响抄写的机制仍然是未知的。然而,从 Arabidopsis 的最近的结果显示出在 H2A.Z 和 DNA methylation 之间的强壮的反的关联,建议 H2A.Z 可能保护基因免受 silencing 的伤害。 | Rosana March-Diaz Jose C. Reyes | 2009 | Molecular Plant2009，2，4： | 15 |
| 4 | Effect of Helicobacter pylori on gastric epithelial cells显示文摘The gastrointestinal epithelium has cells with features that make them a powerful line of defense in innate mucosal immunity. Features that allow gastrointestinal epithelial cells to contribute in innate defense include cell barrier integrity, cell turnover, autophagy, and innate immune responses. Helicobacter pylori(H. pylori) is a spiral shape gram negative bacterium that selectively colonizes the gastric epithelium of more than half of the world's population. The infection invariably becomes persistent due to highly specialized mechanisms that facilitate H. pylori 's avoidance of this initial line of host defense as well as adaptive immune mechanisms. The host response is thus unsuccessful in clearing the infection and as a result becomes established as a persistent infection promoting chronic inflammation. In some individuals the associated inflammation contributes to ulcerogenesis or neoplasia. H. pylori has an array of different strategies to interact intimately with epithelial cells and manipulate their cellular processes and functions. Among the multiple aspects that H. pylori affects in gastric epithelial cells are their distribution of epithelial junctions, DNA damage, apoptosis, proliferation, stimulation of cytokine production, and cell transformation. Some of these processes are initiated as a result of the activation of signaling mechanisms activated on binding of H. pylori to cell surface receptors or via soluble virulence factors that gain access to the epithelium. The multiple responses by the epithelium to the infection contribute to pathogenesis associated with H. pylori. | Shatha Alzahrani Taslima T Lina Jazmin Gonzalez Irina V Pinchuk Ellen J Beswick Victor E Reyes | 2014 | World Journal of Gastroenterology2014，20，36： | 15 |
| 5 | Epstein-Barr virus-associated gastric carcinoma: Evidence of age-dependence among a Mexican population显示文摘AIM: To investigate features of Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVaGC) among a Mexican population.METHODS: Cases of primary gastric adenocarcinoma were retrieved from the files of the Departments of anatomic site of the gastric neoplasia was identified, and carcinomas were histologically classified as intestinal and diffuse types and subclassified as proposed by the Japanese Research Society for Gastric Cancer. EBV-encoded small non-polyadenylated RNA-1 (EBER-1)in situ hybridization was conducted to determine the presence of EBV in neoplastic cells.RESULTS: We studied 330 consecutive, non-selected,primary gastric carcinomas. Among these, there were173 male and 157 female patients (male/female ratio1.1/1). EBER-1 was detected in 24 (7.3%) cases (male/female ratio: 1.2/1). The mean age for the entire group was 58.1 years (range: 20-88 years), whereas the mean age for patients harboring EBER-1-positive gastric carcinomas was 65.3 years (range: 50-84 years). Age and histological type showed statistically significant differences, when EBER-1-positive and -negative gastric carcinomas were compared. EBER-1 was detected in hyperplastic- and dysplastic-gastric mucosa surrounding two EBER-1-negative carcinomas, respectively.CONCLUSION: Among Latin-American countries, Mexico has the lowest frequency of EBVaGC. Indeed, the Mexican population >50 years of age was selectively affected. Ethnic variations are responsible for the epidemiologic behavior of EBVaGC among the worldwide population. | Roberto Herrera-Goepfert Suminori Akiba Chihaya Koriyama Shan Ding Edgardo Reyes Tetsuhiko Itoh Yoshie Minakami Yoshito Eizuru | 2005 | World Journal of Gastroenterology2005，11，39： | 14 |
| 6 | 两个地面运动分量作用下建筑物的三维振型静力弹塑性分析及其对高层建筑的评估显示文摘目前局限于一个水平地面运动分量的振型静力弹塑性分析(MPA)程序,扩展到了建筑物在同时受两个水平地面运动分量作用下平面内对称或非对称结构的三维分析程序。也给出了该方法的变异形式,称为实用振型静力弹塑性分析(PMPA)程序,这种分析方法直接从地震响应(或设计)谱中估算地震需求。对它计算超高层建筑的地震需求的准确度进行了评估,说明该程序对非线性系统的分析和线性系统的响应谱分析几乎一样准确。因此,对于实际应用而言,实用振型静力弹塑性分析程序提供了一个诱人的可替代方法,使得地震需求可以直接从(弹性)设计响应谱估算出,从而避免了非线性响应谱时程分析中选择和标定地面运动的复杂性。 | J. C. Reyes A. K. Chopra 梁铁锚(译) 崔秋文(校) | 2011 | 世界地震译丛2011，42，4： | 11 |
| 7 | Pro12Ala polymorphism of the peroxisome proliferator-activated receptor γ2 in patients with fatty liver diseases显示文摘AIM:To test the occurrence of the Pro12Ala mutation of the peroxisome proliferator-activated receptor-γ (PPARγ)2-gene in patients with non-alcoholic fatty liver disease (NAFLD) or alcoholic fatty liver disease (AFLD).METHODS:DNA from a total of 622 specimens including 259 blood samples of healthy blood donors and 363 histologically categorized liver biopsies of patients with NAFLD (n=263) and AFLD (n=100) were analyzed by Real-time polymerase chain reaction using allele-specific probes.RESULTS:In the NAFLD and the AFLD collective,3% of the patients showed homozygous occurrence of the Ala12 PPARγ2-allele,differing from only 1.5% cases in the healthy population.In NAFLD patients,a high incidence of the Ala12 mutant was not associated with the progression of fatty liver disease.However,we observed a significantly higher risk (odds ratio=2.50,CI:1.05-5.90,P=0.028) in AFLD patients carrying the mutated Ala12 allele to develop inflammatory alterations.The linkage of the malfunctioning Ala12-positive PPARγ2 isoform to an increased risk in patients with AFLD to develop severe steatohepatitis and fibrosis indicates a more prominent anti-inflammatory impact of PPARγ2 in progression of AFLD than of NAFLD.CONCLUSION:In AFLD patients,the Pro12Ala single nuclear polymorphism should be studied more extensively in order to serve as a novel candidate in biomarker screening for improved prognosis. | Johannes W Rey Andrea Noetel Aline Hardt Ali Canbay Hakan Alakus Axel zur Hausen Hans Peter Dienes Uta Drebber Margarete Odenthal | 2010 | World Journal of Gastroenterology2010，16，46： | 11 |
| 8 | Watch and wait approach in rectal cancer:Current controversies and future directions显示文摘According to the main international clinical guidelines,the recommended treatment for locally-advanced rectal cancer is neoadjuvant chemoradiotherapy followed by surgery.However,doubts have been raised about the appropriate definition of clinical complete response(cCR)after neoadjuvant therapy and the role of surgery in patients who achieve a cCR.Surgical resection is associated with significant morbidity and decreased quality of life(QoL),which is especially relevant given the favourable prognosis in this patient subset. Accordingly, therehas been a growing interest in alternative approaches with less morbidity,including the organ-preserving watch and wait strategy, in which surgery isomitted in patients who have achieved a cCR. These patients are managed with aspecific follow-up protocol to ensure adequate cancer control, including the earlyidentification of recurrent disease. However, there are several open questionsabout this strategy, including patient selection, the clinical and radiologicalcriteria to accurately determine cCR, the duration of neoadjuvant treatment, therole of dose intensification (chemotherapy and/or radiotherapy), optimal followupprotocols, and the future perspectives of this approach. In the present review,we summarize the available evidence on the watch and wait strategy in thisclinical scenario, including ongoing clinical trials, QoL in these patients, and thecontroversies surrounding this treatment approach. | Fernando López-Campos Margarita Martín-Martín Roberto Fornell-Pérez Juan Carlos García-Pérez Javier Die-Trill Raquel Fuentes-Mateos Sergio López-Durán JoséDomínguez-Rullán Reyes Ferreiro AlejandroRiquelme-Oliveira Asunción Hervás-Morón Felipe Couñago | 2020 | World Journal of Gastroenterology2020，26，29： | 10 |
| 9 | Comparison of clinical outcomes between femtosecond laser-assisted versus conventional phacoemulsification显示文摘Background:To compare femtosecond laser-assisted versus conventional phacoemulsification in terms of visual and refractive outcomes,cumulative dissipated energy,anterior chamber inflammation and endothelial cell loss.Methods:In this retrospective cohort study,records of eyes that underwent femtosecond laser-assisted cataract surgery(FLACS)or conventional phacoemulsification(CP)were reviewed.The Victus femtosecond laser(Bausch and Lomb,Germany)was used to carry out corneal incisions,anterior capsulotomy,and lens fragmentation in FLACS procedures.Manifest refraction spherical equivalence(MRSE),uncorrected distance visual acuity(UDVA),corrected distance visual acuity(CDVA),cumulative dissipated energy(CDE),postoperative cells and flare and endothelial cell count data were collected.Subgroup analysis of the visual acuity tests was performed based on the type of intraocular lens implanted(monofocal,monofocal toric,multifocal,multifocal toric,accommodating).Results:A total of 735 eyes were included in the study(296 eyes for the FLACS group and 439 eyes for the CP group).At one year follow-up,120 eyes comprised the FLACS group and 265 eyes for the CP group.MRSE in the FLACS group was−0.16±0.58 D and−0.20±0.52 D in the CP group(P=0.50).UDVA in the FLACS group was 20/25(mean logMAR 0.12±0.13)and 20/25(mean logMAR 0.11±0.13)in the CP group(P=0.48).CDVA was 20/20(mean logMAR 0.03±0.07)in the FLACS group and 20/20(mean logMAR 0.02±0.06)in the CP group(P=0.15).No statistically significant trend was seen for FLACS versus CP by intraocular type for visual acuity.CDE for the different cataract grades ranged from 6.97±5.74 to 29.02±16.07 in the FLACS group and 7.59±6.42 to 35.69±18.30 in the CP group.The FLACS group was significantly lower for post-operative central corneal edema(P=0.05),cells and flare(P=0.01),and endothelial cell loss(P=0.04).Conclusions:Femtosecond laser-assisted cataract surgery and conventional phacoemulsification had similar refractive and visual outcomes.Phacoemulsification energy,anterior chamber inflammation and corneal endothelial cell loss were less in the femtosecond laser group. | Robert Edward Ty Ang Michelle Marie Salcedo Quinto Emerson Marquez Cruz Mark Christian Reyes Rivera Gladness Henna Austria Martinez | 2018 | Eye and Vision2018，5，1： | 10 |
| 10 | CD74 in antigen presentation,inflammation,and cancers of the gastrointestinal tract显示文摘CD74 is a protein whose initial role in antigen presentation was recognized two decades ago. Recent studies have revealed that it has additional functions as a receptor for macrophage migration inhibitory factor and as a receptor for an important human pathogen, Helicobacter pylori (H pylori). The role of CD74 as a receptor is important because after binding of migration inhibitory factor or H pylori, NF-κB and Erk1/2 activation occurs, along with the induction of proinflammatory cytokine secretion. This review provides an up-to-date account of the functions of CD74 and how it might be involved in inflammation and cancer within the gastrointestinal tract. | Ellen J Beswick Victor E Reyes | 2009 | World Journal of Gastroenterology2009，15，23： | 10 |
| 11 | 多道听觉脑干植入的临床应用显示文摘目的 探讨多道听觉脑干植入的手术方法及其对恢复双侧听神经瘤所致全聋患者听力的效果。方法 7例双侧听神经瘤患者 ,在肿瘤摘除后将 2 1道听觉脑干植入 (auditorybrainstemimplant,ABI)电极植入于第四脑室外侧隐窝内 ,直接刺激脑干耳蜗核 ,术中以面神经电图、舌咽神经肌电图及电诱发听觉脑干反应 (electricallyevokedauditorybrainstemresponses,EABR)确定电极的正确位置。术后 6周开通装置并调试 ,定期行言语识别能力测试。结果 6例患者术中均能准确定位外侧隐窝 ,并能记录到典型的EABR ;术后均能获得不同程度的言语识别能力 ,其中 2例获得开放句识别能力。另 1例患者术中解剖定位困难 ,术中未能记录到EABR。术后电极刺激 1例无非听觉反应、5例部分电极产生非听觉反应、1例全部电极均产生非听觉反应 ,有非听觉反应的相应电极被关闭。结论 多道听觉脑干植入能使因双侧听神经瘤而全聋的患者产生有意义的听觉 ,术中正确定位脑干耳蜗核为手术成功的关键。 | 吴皓 Olivier Sterkers Alain Rey Didier | 2000 | 中华耳鼻咽喉科杂志2000，35，2： | 9 |
| 12 | Immune evasion strategies used by Helicobacter pylori显示文摘Helicobacter pylori(H. pylori) is perhaps the most ubiquitous and successful human pathogen, since it colonizes the stomach of more than half of humankind. Infection with this bacterium is commonly acquired during childhood. Once infected, people carry the bacteria for decades or even for life, if not treated. Persistent infection with this pathogen causes gastritis, peptic ulcer disease and is also strongly associated with the development of gastric cancer. Despite induction of innate and adaptive immune responses in the infected individual, the host is unable to clear the bacteria. One widely accepted hallmark of H. pylori is that it successfully and stealthily evades host defense mechanisms. Though the gastric mucosa is well protected against infection, H. pylori is able to reside under the mucus, attach to gastric epithelial cells and cause persistent infection by evading immune responses mediated by host. In this review, we discuss how H. pylori avoids innate and acquired immune response elements, uses gastric epithelial cells as mediators to manipulate host T cell responses and uses virulence factors to avoid adaptive immune responses by T cells to establish a persistent infection. We also discuss in this review how the genetic diversity of this pathogen helps for its survival. | Taslima T Lina Shatha Alzahrani Jazmin Gonzalez Irina V Pinchuk Ellen J Beswick Victor E Reyes | 2014 | World Journal of Gastroenterology2014，20，36： | 7 |
| 13 | 三维锥体束CT评价Hyrax扩弓器治疗上颌第二前磨牙区的变化显示文摘目的:本研究旨在利用CBCT技术比较Hyrax扩弓矫治器治疗前后上颌第二前磨牙(P2)区颌-复合体宽度及牙齿、牙槽嵴倾斜度的变化。方法:23例,(女17例,男6例;平均年龄(12.70±1.89)岁上颌牙弓狭窄、后牙反的患者。所有患者经Hyrax扩弓治疗,治疗前后采用CBCT技术采集并重建双侧P2区的三维结构,测量牙齿、牙槽嵴和颌骨不同平面的宽度以及牙齿、牙槽嵴与腭骨的相关角度,然后进行配对样本t检验。结果:RPE治疗后P2区颌骨宽度变化无统计学意义;P2及其牙槽嵴宽度显著增加(p<0.001);牙齿和牙槽嵴倾斜度变化也有统计学意义(p<0.05)。结论:Hyrax扩弓器对生长发育期患者P2区颌-复合体的作用主要表现为牙齿颊倾和牙槽嵴改建,颌骨宽度变化较小。 | 赵颖 Armine Kartalian Elizabeth Gohl Reyes Enciso | 2009 | 口腔医学研究2009，25，4： | 7 |
| 14 | Hearing and Cochlear structures in a Swine Model显示文摘Objective To study the audition and inner ear structure in a normal swine model.Methods Auditory brainstem responses(ABRs) were determined in swine at 1 day and 1 month after birth.The form of the cochlea and hair cells were examined under a scanning electron microscope and on cochlear slices.Results ABR thresholds at 1 day and 1 month post-birth were between 40 and 50 dB SPL.The latencies of waves I,III and V in 1 day old swine were 1.97 ± 0.13,3.01± 0.16 and 4.26±0.20 ms,respectively.At 1 month,the lantancies of waves I,III and V were 2.01 ± 0.05,3.11±0.08 and 4.65 ± 0.14 ms,respectively,slightly longer than those at 1 day,although not statistically significant(p>0.05).The swine cochlea was constituted of 3 and a half turns and the cochlear hair cells lined up in four rows.Hair cell cilia in the apical turn were longer than those in other turns.Conclusions The swine cochlea is mature at the time of birth.Swine ABR thresholds are slightly higher than humans and rats.Swine appears to be a precocial animal species. | GUO Wei-wei1,Cheng Lei2,Liu Hui-zhan1,Sun Jian-he1,YANG Shi-ming1,1 Department of Otolaryngology,Head & Neck Surgery,Institute of Otolaryngology,Chinese PLA General Hospital,Beijing 100853,China 2 State Rey laboratory for Agrobio technology China Agrical universiy Beijing 100193,PR,China | 2010 | Journal of Otology2010，5，2： | 7 |
| 15 | Hypothalamic-pituitary-adrenal axis function during perinatal depression显示文摘Abnormal function of the hypothalamic–pituitary–adrenal(HPA) axis is an important pathological finding in pregnant women exhibiting major depressive disorder. They show high levels of cortisol proinflammatory cytokines, hypothalamic-pituitary peptide hormones and catecholamines, along with low dehydroepiandrosterone levels in plasma. During pregnancy, the TH2 balance together with the immune system and placental factors play crucial roles in the development of the fetal allograft to full term. These factors, when altered, may generate a persistent dysfunction of the HPA axis that may lead to an overt transfer of cortisol and toxicity to the fetus at the expense of reduced activity of placental 11β-hydroxysteroid dehydrogenase type 2. Epigenetic modifications also may contribute to the dysregulation of the HPA axis. Affective disorders in pregnant women should be taken seriously, and therapies focused on preventing the deleterious effects of stressors should be implemented to promote the welfare of both mother and baby. | Phillipe Leff Gelman Mónica Flores-Ramos Margarita López-Martínez Carlos Cruz Fuentes Juan Pablo Reyes Grajeda | 2015 | Neuroscience Bulletin2015，31，3： | 6 |
| 16 | 抗苗勒管激素作为卵巢颗粒细胞瘤肿瘤标记物的实验研究显示文摘目的 研究抗苗勒管激素 (anti mullerianhormone ,AMH)在诊断卵巢颗粒细胞瘤(granulosacelltumor,GCT)中作为特异性肿瘤标记物的实验依据。方法 采用免疫组织化学、原位杂交、Northern杂交法研究转基因小鼠早、晚期卵巢GCT中AMH及其受体mRNA的表达 ,并用放射性碘( 12 5I)标记法、Northern杂交法研究经培养的卵巢GCT细胞中AMH及其受体mRNA的表达。结果 转基因小鼠早期卵巢GCT中 ,AMH的免疫组织化学检测和AMH受体mRNA的原位杂交检测结果显示 ,两者的阳性表达率均为 10 0 % ;而晚期卵巢GCT中 ,两者的阳性表达均为 8例中 2例 ,分别比较 ,差异均有极显著性 (P <0 .0 1)。Northern杂交研究同样显示 ,早期卵巢GCT和卵巢GCT细胞AMH受体mRNA的阳性表达率均为 10 0 %。放射性自显影的研究显示 ,在卵巢GCT细胞膜处有放射性亮点 ,12 5I标记的AMH与卵巢GCT细胞结合率达 10 0 %。结论 AMH可作为一种特异性的肿瘤标记物 ;可用于卵巢疑难肿瘤的鉴别诊断以及早期卵巢GCT的诊断 ; | 龙雯晴 王伟民 Rodolfo REY 喇端端 季晓琼 | 2000 | 中华妇产科杂志2000，35，6： | 6 |
| 17 | The Many Faces of Plant SWI/SNF Complex显示文摘 | Jose C. Reyes | 2014 | Molecular Plant2014，7，3： | 6 |
| 18 | First step in pre-miRNAs processing by human Dicer显示文摘 | Carlos Fabian FLORES-JASSO Catalinal. ARENAS-HUERTERO Jose Luis REYES Cecilia CONTRERAS-CUBAS Alejandra COVARRUBIAS Luis VACA | 2009 | Acta Pharmacologica Sinica2009，30，8： | 5 |
| 19 | 法国烟雾血管病临床实践指南显示文摘1序言
1.1制定机构
本指南在法国卫生部的组织下由法国脑部和眼部罕见血管疾病中心(reference center for rare vascular diseases of the brain and eye,CERVCO)与法国儿童卒中中心联合起草。 | D. Herve(著) M. Kossorotoff(著) D. Bresson(著) T. Blauwblomme(著) M. Carneiro(著) E. Touze(著) F. Proust(著) I. Desguerre(著) S. Alamowitch(著) J.-P. Bleton(著) A. Borsali(著) E. Brissaud F.Brunelle(著) L. Calviere(著) M. Chevignard(著) G. Geffroy-Greco(著) S. Faesch(著) M.-O. Habert(著) H.De Larocque(著) P. Meyer(著) S. Reyes L. Thines(著) E. Tournier-Lasserve(著) H.Chabriat 郝方斌(译) 张勇(译) 韩聪(译) 段炼(译) | 2018 | 国际脑血管病杂志2018，26，5： | 5 |
| 20 | Validation of a new scoring system: Rapid assessment faecal incontinence score显示文摘AIM: To implement a quick and simple test- rapid assessment faecal incontinence score(RAFIS) and show its reliability and validity.METHODS: From March 2008 through March 2010, we evaluated a total of 261 consecutive patients, including 53 patients with faecal incontinence. Demographic and comorbidity information was collected. In a single visit, patients were administered the RAFIS. The results obtained with the new score were compared with those of both Wexner score and faecal incontinence quality of life scale(FIQL) questionnaire. The patient withoutinfluence of the surgeon completed the test. The role of surgeon was explaining the meaning of each section and how he had to fill. Reliability of the RAFIS score was measured using intra-observer agreement and Cronbach's alpha(internal consistency) coefficient. Multivariate analysis of the main components within the different scores was performed in order to determine whether all the scores measured the same factor and to conclude whether the information could be encompassed in a single factor. A sample size of 50 patients with faecal incontinence was estimated to be enough to detect a correlation of 0.55 or better at 5% level of significance with 80% power.RESULTS: We analysed the results obtained by 53 consecutive patients with faecal incontinence(median age 61.55 ± 12.49 years) in the three scoring systems. A total of 208 healthy volunteers(median age 58.41 ± 18.41 years) without faecal incontinence were included in the study as negative controls. Pearson's correlation coefficient between 'state' and 'leaks' was excellent(r = 0.92, P < 0.005). Internal consistency in the comparison of 'state' and 'leaks' yielded also excellent correlation(Cronbach's α = 0.93). Results in each score were compared using regression analysis and a correlation value of r = 0.98 was obtained with Wexner score. As regards FIQL questionnaire, the values of 'r ' for the different subscales of the questionnaire were: 'lifestyle' r =-0.87, 'coping/behaviour' r =-0.91, 'depression' r =-0.36 and 'embarrassment' r =-0.90,(P < 0.01). A multivariate analysis showed that all the scoring systems measured the same factor. A single factor may explain 80.84% of the variability of FI, so all the scoring systems measure the same factor. Patient's continence improves when RAFIS and Jorge-Wexner scores show low values and when the values obtained in the FIQL questionnaire are high.CONCLUSION: RAFIS is a valid and reliable tool to assess Faecal Incontinence. | Fernando de la Portilla Arantxa Calero-Lillo Rosa M Jiménez-Rodríguez Maria L Reyes Manuela Segovia-González María Victoria Maestre Ana M García-Cabrera | 2015 | World Journal of Gastrointestinal Surgery2015，7，9： | 5 |
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