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| 1 | Growth of Large-Area Single- and Bi-Layer Graphene by Controlled Carbon Precipitation on Polycrystalline Ni Surfaces显示文摘We report graphene films composed mostly of one or two layers of graphene grown by controlled carbon precipitation on the surface of polycrystalline Ni thin films during atmospheric chemical vapor deposition(CVD).Controlling both the methane concentration during CVD and the substrate cooling rate during graphene growth can signifi cantly improve the thickness uniformity.As a result,one-or two-layer graphene regions occupy up to 87%of the fi lm area.Single layer coverage accounts for 5%11%of the overall fi lm.These regions expand across multiple grain boundaries of the underlying polycrystalline Ni fi lm.The number density of sites with multilayer graphene/graphite(>2 layers)is reduced as the cooling rate decreases.These fi lms can also be transferred to other substrates and their sizes are only limited by the sizes of the Ni fi lm and the CVD chamber.Here,we demonstrate the formation of fi lms as large as 1 in^(2).These fi ndings represent an important step towards the fabrication of large-scale high-quality graphene samples. | Alfonso Reina Stefan Thiele Xiaoting Jia Sreekar Bhaviripudi Mildred S.Dresselhaus Juergen A.Schaefer Jing Kong | 2009 | Nano Research2009，2，6： | 21 |
| 2 | Nonalcoholic fatty liver disease and hepatic cirrhosis: comparison with viral hepatitis-associated steatosis显示文摘Nonalcoholic fatty liver disease(NAFLD) including nonalcoholic steatohepatitis(NASH) is globally increasing and has become a world-wide health problem. Chronic infection with hepatitis B virus or hepatitis C virus(HCV) is associated with hepatic steatosis. Viral hepatitis-associated hepatic steatosis is often caused by metabolic syndrome including obesity,type 2 diabetes mellitus and/or dyslipidemia. It has been reported that HCV genotype 3 exerts direct metabolic effects that lead to hepatic steatosis. In this review,the differences between NAFLD/NASH and viral hepatitis-associated steatosis are discussed. | Yuki Haga Tatsuo Kanda Reina Sasaki Masato Nakamura Shingo Nakamoto Osamu Yokosuka | 2015 | World Journal of Gastroenterology2015，21，46： | 20 |
| 3 | Safety trial of high-intensity focused ultrasound therapy for pancreatic cancer显示文摘AIM:To evaluate the safety and clinical application of high-intensity focused ultrasound(HIFU)therapy for unresectable pancreatic cancer(PC).METHODS:Thirty PC patients(16 cases in stage III and 14 cases in stage IV)with visualized pancreatic tumors were admitted for HIFU therapy as an optional local therapy in addition to systemic chemotherapy or chemoradiotherapy.Informed consent was obtained.This study began at the end of 2008 and was approved by the ethics committee of our hospital[Institutional Review Board(IRB):890].The HIFU device used was the FEP-BY02(Yuande Bio-Medical Engineering,Beijing,China).RESULTS:The mean tumor size after HIFU therapy changed to 30.9±1.7 mm from 31.7±1.7 mm at pre-therapy.There were no significant changes in tumor size,mean number of treatment sessions(2.7±0.1 mm),or mean total treatment time(2.4±0.1 h).The rate of symptom relief effect was 66.7%.The effectiveness of primary lesion treatment was as follows:complete response,0;partial response,4;stable disease,22;progressive disease,4.Treatment after HIFU therapy included 2 operations,24 chemotherapy treatments,and 4 best supportive care treatments.Adverse events occurred in 10%of cases,namely pseudocyst formation in 2 cases and mild pancreatitis development in 1.However,no severe adverse events occurred in this study.CONCLUSION:We suggest that HIFU therapy is safe and has the potential to be a new method of combination therapy for PC. | Atsushi Sofuni Fuminori Moriyasu Takatomo Sano Fumihide Itokawa Takayoshi Tsuchiya Toshio Kurihara Kentaro Ishii Syujiro Tsuji Nobuhito Ikeuchi Reina Tanaka Junko Umeda Ryosuke Tonozuka Mitsuyoshi Honjo Shuntaro Mukai Mitsuru Fujita Takao Itoi | 2014 | World Journal of Gastroenterology2014，20，28： | 12 |
| 4 | Current status of preoperative drainage for distal biliary obstruction显示文摘Preoperative biliary drainage(PBD) was developed to improve obstructive jaundice, which affects a number of organs and physiological mechanisms in patients waiting for surgery. However, its role in patients who will undergo pancreaticoduodenectomy for biliary obstruction remains controversial. This article aims to review the current status of the use of preoperative drainage for distal biliary obstruction. Relevant articles published from 1980 to 2015 were identified by searching MEDLINE and Pub Med using the keywords 'PBD', 'pancreaticoduodenectomy', and 'obstructive jaundice'. Additional papers were identified by a manual search of the references from key articles. Current studies have demonstrated that PBD should not be routinely performed because of the postoperative complications. PBD should only be considered in carefully selected patients, particularly in cases where surgery had to be delayed. PBD may be needed in patients with severe jaundice, concomitant cholangitis, or severe malnutrition. The optimal method of biliary drainage has yet to be confirmed. PBD should be performed by endoscopic routes rather than by percutaneous routes to avoid metastatic tumor seeding. Endoscopic stenting or nasobiliary drainage can be selected. Although more expensive, the use of metallic stents remains a viable option to achieve effective drainage without cholangitis and reintervention. | Harutoshi Sugiyama Toshio Tsuyuguchi Yuji Sakai Rintaro Mikata Shin Yasui Yuto Watanabe Dai Sakamoto Masato Nakamura Reina Sasaki Jun-ichi Senoo Yuko Kusakabe Masahiro Hayashi Osamu Yokosuka | 2015 | World Journal of Hepatology2015，7，18： | 11 |
| 5 | Outer membrane VDAC1 controls permeability transition of the inner mitochondrial membrane in cellulo during stress-induced apoptosis显示文摘电压依赖者阴离子隧道(VDAC ) 1 是 mitochondrial 的主要隧道外部膜(妈妈) 和它被建议了是渗透转变毛孔(PTP ) 的部分, mitochondrial 渗透转变(MPT ) 的一个通常认为的 multiprotein 建筑群候选人代理人。在单个实时房间水平工作,我们发现 VDAC1 的 overexpression 在 mitochondrial 触发 MPT 内部膜(MIM ) 。相反地,在 MPT 的抑制的 silencing VDAC1 表示结果由导致亚硒酸盐的氧化应力引起了。这 MOM-MIM 串音被 Cyclosporin A 和 mitochondrial Cyclophilin D,然而并非由 Bcl-2 和 Bcl-XL 调制, PTP 的陈述语气操作。VDAC1 依赖的 MPT 雇佣包含反应的氧种类和 p38-MAPK 的一个积极反馈环,并且在第二包括 Bax 激活,细胞色素 c 版本和 caspase 触发正规 apoptotic 回答 3 激活。我们的数据因此支持在 MOM 包含 VDAC1 的 PTP 建筑群的一个模型,并且显示 VDAC1 依赖的 MPT 是在氧化导致压力的 apoptosis 起一个原因的作用的在上游的机制。 | Flora Tomasello Angela Messina Lydia Lartigue Laura Schembri Chantal Medina Simona Reina Didier Thoraval Marc Crouzet Frangois Ichas Vito De Pinto Francesca De Giorgi | 2009 | Cell Research2009，19，12： | 6 |
| 6 | Prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis by pancreatic duct stenting using a loop-tipped guidewire显示文摘AIM: To examine whether it is possible to prevent the occurrence of post-endoscopic retrograde cholangiopancreatography(ERCP) pancreatitis in patients experiencing difficulties with selective biliary duct cannulation by pancreatic duct stenting using a looptipped guidewire.METHODS: Procedure success rate, frequency of unintended insertion of the guidewire into side branches of the pancreatic duct, and incidence of procedural accidents were examined using a loop-tipped guidewire(Group A, 20 patients), and a conventional straighttype guidewire(Group B, 20 patients).RESULTS: The success rate of the procedure was 100% in both groups. Unintended insertion of the guidewire into a side branch of the pancreatic duct occurred 0.056 ± 0.23(0-1) times in Group A and 2.3 ±1.84(0-5) times in Group B; thus, unintended insertion of the guidewire into a side branch of the pancreatic duct was seen significantly less frequently in Group A. There were no procedural accidents in Group A, whereas pancreatitis occurred in one Group B patient; however, the difference between the two groups was not statistically significant. The serum amylase level after ERCP was 257.15 ± 136.4(88-628) IU/L in Group A, and 552.05 ± 534.57(101-2389) IU/L in Group B, showing a significantly lower value in Group A. Hyperamylasemia was found in two patients(10%) in Group A, and nine(45%) in Group B, showing a significantly lower value in Group A.CONCLUSION: The results suggest that in patients who experience difficulties with biliary cannulation, the use of a loop-tipped guidewire for pancreatic duct stenting may assist with the prevention of post-ERCP pancreatitis, and thereby to a reduction of the risk of post-ERCP pancreatitis or hyperamylasemia. | Yuji Sakai Toshio Tsuyuguchi Harutoshi Sugiyama Masahiro Hayashi Jun-ichi Senoo Reina Sasaki Yuko Kusakabe Masato Nakamura Shin Yasui Rintaro Mikata Masaru Miyazaki Osamu Yokosuka | 2016 | World Journal of Clinical Cases2016，4，8： | 5 |
| 7 | Pathogenesis and risk factors for gastric cancer after Helicobacter pylori eradication显示文摘Helicobacter pylori(H.pylori) infection was thought to be the main cause of gastric cancer,and its eradication showed improvement in gastric inflammation and dec-reased the risk of gastric cancer.Recently,a number of studies reported the occurrence of gastric cancer after successful eradication.Patients infected with H.pylori,even after eradication,have a higher risk for the occurrence of gastric cancer when compared with uninfected patients.Metachronous gastric cancer occurs frequently following the endoscopic removal of early gastric cancer.These data indicate that metachronous cancer leads to the occurrence of gastric cancer even after successful eradication of H.pylori.The pathogenesis of this metachronous cancer remains unclear.Further research is needed to identify biomarkers to predict the development of metachronous gastric cancer and methods for gastric cancer screening.In this article,we review the role of the H.pylori in carcinogenesis and the histological and endoscopic characteristics and risk factors for metachronous gastric cancer after eradication.Additionally,we discuss recent risk predictions and possible approaches for reducing the risk of metachro-nous gastric cancer after eradication. | Reina Ohba Katsunori Iijima | 2016 | World Journal of Gastrointestinal Oncology2016，8，9： | 5 |
| 8 | Sofosbuvir treatment and hepatitis C virus infection显示文摘Hepatitis C virus(HCV) infection is a serious problem worldwide.The use of interferon-based therapy has made HCV eradication challenging.The recent appearance of direct-acting antiviral agents(DAAs) has changed HCV therapy.Combining the use of DAAs with peginterferon and ribavirin has improved treatment efficacy.Furthermore,the combination of different orally administered DAAs has enabled interferon-free therapy with much higher efficacy and safety.In particular,sofosbuvir,a nucleotide-based NS5 B inhibitor,prevents HCV RNA synthesis by acting as a 'chain terminator'.Treatment with sofosbuvir has attained an extremely high rate of sustained virologic response.The current review summarizes the efficacy and safety of sofosbuvir therapy. | Masato Nakamura Tatsuo Kanda Yuki Haga Reina Sasaki Shuang Wu Shingo Nakamoto Shin Yasui Makoto Arai Fumio Imazeki Osamu Yokosuka | 2016 | World Journal of Hepatology2016，8，3： | 4 |
| 9 | Endoscopic papillary large balloon dilation for bile duct stones in elderly patients显示文摘AIM: To investigate whether endoscopic papillary large balloon dilation(EPLBD) can be safety and effectively performed in patients aged ≥ 80 years. METHODS: Lithotomy by EPLBD was conducted in 106 patients with bile duct stones ≥ 13 mm in size or with three or more bile duct stones ≥ 10 mm. The patients were divided into group A(< 80 years) and group B(≥ 80 years). Procedure success rate, number of endoscopic retrograde cholangiopancreatographies(ERCP), and incidence of complications were examined in both groups.RESULTS: Group B tended to include significantly more patients with peripapillary diverticulum, hypertension, hyperlipemia, cerebrovascular disease/dementia, respiratory disease/cardiac disease, and patients administered an anticoagulant or antiplatelet agent(P < 0.05). The success rate of the initial lithotomy was 88.7(94/106)%. The final lithotomy rate was 100(106/106)%. Complications due to treatment procedure occurred in 4.72(5/106)% of the patients. There was no significant difference in procedure success rate, number of ERCP, or incidence of complications between group A and group B.CONCLUSION: EPLBD can be safely performed in elderly patients, the same as in younger patients. | Yuji Sakai Toshio Tsuyuguchi Harutoshi Sugiyama Reina Sasaki Dai Sakamoto Masato Nakamura Yuuto Watanabe Takao Nishikawa Shin Yasui Rintaro Mikata Osamu Yokosuka | 2015 | World Journal of Clinical Cases2015，3，4： | 4 |
| 10 | Innovative Metallized Formulations for Solid Rocket Propulsion显示文摘Several metallized solid rocket propellants,AP/Metal/HTPB in the ratio 68/18/14,were experimentally analyzed at the Space Propulsion Laboratory of Politecnico di Milano.Effects of the metals(micrometric and nanometric Al,B,Mg,and a variety of dual metals) on the performance of the propellant were studied and contrasted to a conventional micrometric aluminum(30 μm average grain size) taken as reference.It is shown that the propellant microstructure plays a fundamental role in controlling the critical aggregation/agglomeration phenomena occurring below and near the burning surface.Two specific effects of microstructure in terms of steady burning rate and average agglomerate size are illustrated. | Luigi T DeLUCA Luciano GALFETTI Filippo MAGGI Giovanni COLOMBO Alice REINA Stefano DOSSI Daniele CONSONNI Melissa BRAMBILLA | 2012 | 含能材料2012，20，4： | 3 |
| 11 | Fracture-dislocations of the femoral head显示文摘 | P. Chiron V. Lafontan N. Reina | 2012 | Orthopaedics & Traumatology: Surgery & Research2012，，： | 2 |
| 12 | Endoscopic management of unresectable malignant gastroduodenal obstruction with a nitinol uncovered metal stent: a prospective Japanese multicenter study显示文摘AIM: To determine the safety and efficacy of endoscopic duodenal stent placement in patients with malignant gastric outlet obstruction.METHODS: This prospective, observational, multicenter study included 39 consecutive patients with malignant gastric outlet obstruction. All patients underwent endoscopic placement of a nitinol, uncovered, selfexpandable metal stent. The primary outcome was clinical success at 2 wk after stent placement that was defined as improvement in the Gastric Outlet Obstruction Scoring System score relative to the baseline.RESULTS: Technical success was achieved in all duodenal stent procedures. Procedure-related complications occurred in 4 patients(10.3%) in the form of mild pneumonitis. No other morbidities or mortalitieswere observed. The clinical success rate was 92.3%. The mean survival period after stent placement was 103 d. The mean period of stent patency was 149 d and the patency remained acceptable for the survival period. Stent dysfunction occurred in 3 patients(7.7%) on account of tumor growth.CONCLUSION: Endoscopic management using duodenal stents for patients with incurable malignant gastric outlet obstruction is safe and improved patients' quality of life. | Reina Sasaki Yuji Sakai Toshio Tsuyuguchi Takao Nishikawa Tatsuya Fujimoto Shigeru Mikami Harutoshi Sugiyama Osamu Yokosuka | 2016 | World Journal of Gastroenterology2016，22，14： | 2 |
| 13 | Engineering heterogenous catalysts for chemical CO_(2) utilization:Lessons from thermal catalysis and advantages of yolk@shell structured nanoreactors显示文摘The development of catalytic materials for the recycling CO_(2) through a myriad of available processes is an attractive field,especially given the current climate change.While there is increasing publication in this field,the reported catalysts rarely deviate from the traditionally supported metal nanoparticle morphology,with the most simplistic method of enhancement being the addition of more metals to an already complex composition.Encapsulated catalysts,especially yolk@shell catalysts with hollow voids,offer answers to the most prominent issues faced by this field,coking and sintering,and further potential for more advanced phenomena,for example,the confinement effect,to promote selectivity or offer greater protection against coking and sintering.This work serves to demonstrate the current position of catalyst development in the fields of thermal CO_(2) reforming and hydrogenation,summarizing the most recent work available and most common metals used for these reactions,and how yolk@shell catalysts can offer superior performance and survivability in thermal CO_(2) reforming and hydrogenation to the more traditional structure.Furthermore,this work will briefly demonstrate the bespoke nature and highly variable yolk@shell structure.Moreover,this review aims to illuminate the spatial confinement effect and how it enhances yolk@shell structured nanoreactors is presented. | Cameron Alexander Hurd Price Tomas Ramirez Reina Jian Liu | 2021 | Journal of Energy Chemistry2021，30，6： | 2 |
| 14 | Engineering morphologies of yttrium oxide supported nickel catalysts for hydrogen production显示文摘The catalytic performance is highly related to the catalyst structure.Herein,a series of Ni nanoparticles supported on Y_(2)O_(3) with different morphologies were successfully synthesized via hydrothermal process screening different pH environments.These Ni/Y_(2)O_(3)catalysts were applied to efficiently produce CO_(x)-free H2through ammonia decomposition.We identify a significant impact of Y_(2)O_(3)supports on nickel nanoclusters sizes and dispersion.The experimental results show that Ni/Y11 catalyst achieves 100% ammonia decomposition conversion under a gas hour space velocity(GHSV) of 12,000 ml·h^(-1)·gcat^(-1) and temperature of 650℃.Such a high level of activity over Ni/Y11 catalyst was attributed to a large specific surface area,appropriate alkalinity,and small Ni nanoparticles diameter with high dispersion. | Rong-Bin Zhang Zi-Ao Tu Shuai Meng Gang Feng Zhang-Hui Lu Ying-Zhi Yu Tomas Ramirez Reina Fei-Yang Hu Xiao-Han Chen Run-Ping Ye | 2023 | Rare Metals2023，42，1： | 2 |
| 15 | Histopathological changes in sheep experimentally infected with Babesia ovis 显示文摘 | Habela M A Reina D Navarrete I | 1991 | Veterinary Parasitology1991，38，1： | 2 |
| 16 | Hepatitis C virus-associated hepatocellular carcinoma after sustained virologic response显示文摘The introduction of a direct-acting antiviral(DAA) for patients with hepatitis C virus(HCV) infection, could lead to higher sustained virologic response(SVR)rates with fewer adverse events, and it could shorten the treatment duration relative to the interferon era. Although most recent clinical studies have demonstrated that the occurrence rates of hepatocellular carcinoma(HCC) are decreased by SVR with both interferon-based and interferon-free-regimens, there are several reports about the unexpected observation of high rates of early tumor occurrence and recurrence in patients with HCV-related HCC undergoing interferon-free therapy despite SVR. Several mechanisms of HCC occurrence and rapid immunological changes, including cytokines and chemokines during and after DAA treatment, have also been reported. We focused on the possibilities that HCC occurs or recurs during and after DAA treatment, based on the reported clinical and basic studies. Further studies and observations will be needed to determine the short-term and long-term effects on hepatocarcinogenesis caused by the eradication of HCV with DAAs. New serum biomarkers and a follow-up system for HCV-patients with SVR should be established. | Reina Sasaki Tatsuo Kanda Naoya Kato Osamu Yokosuka Mitsuhiko Moriyama | 2018 | World Journal of Hepatology2018，10，12： | 2 |
| 17 | Geometrical approach for the study of Gf prime J band in the Raman spectrum of monolayer graphene,bilayer graphene,and bulk graphite显示文摘 | Cangado L G Reina A Kong J | 2008 | Physical Review B2008，77，24： | 1 |
| 18 | Kinetic study of the pyrolysis of waste wood 显示文摘 | Reina J Velo E Puigjaner L | 1998 | Industrial and Engineering Chemistry Research1998，37，11： | 1 |
| 19 | Mentalhealth, depression, and anxiety in patients on maintaindialysis显示文摘 | Feroze U Martin D Reina - Patton A | 2010 | IranJ Kidney Dis2010，4，3： | 1 |
| 20 | Erythropoietin protects the in vitro blood brain barrier against VEGF-induced permeability显示文摘 | Martínez-Estrada O M Rodríguez-Millán E González-De Vicente E Reina M Vilaró S Fabre M | 2003 | Eur J Neurosci2003，18，： | 1 |
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