|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | High-intensity focused ultrasound ablation:An effective bridging therapy for hepatocellular carcinoma patients显示文摘AIM:To analyze whether high-intensity focused ultrasound(HIFU) ablation is an effective bridging therapy for patients with hepatocellular carcinoma(HCC).METHODS:From January 2007 to December 2010,49 consecutive HCC patients were listed for liver transplantation(UCSF criteria).The median waiting time for transplantation was 9.5 mo.Twenty-nine patients received transarterial chemoembolization(TACE) as a bringing therapy and 16 patients received no treatment before transplantation.Five patients received HIFU ablation as a bridging therapy.Another five patients with the same tumor staging(within the UCSF criteria) who received HIFU ablation but not on the transplant list were included for comparison.Patients were comparable in terms of Child-Pugh and model for end-stage liver disease scores,tumor size and number,and cause of cirrhosis.RESULTS:The HIFU group and TACE group showed no difference in terms of tumor size and tumor number.One patient in the HIFU group and no patient in the TACE group had gross ascites.The median hospital stay was 1 d(range,1-21 d) in the TACE group and two days(range,1-9 d) in the HIFU group(P < 0.000).No HIFU-related complication occurred.In the HIFU group,nine patients(90%) had complete response and one patient(10%) had partial response to the treatment.In the TACE group,only one patient(3%) had response to the treatment while 14 patients(48%) had stable disease and 14 patients(48%) had progressive disease(P = 0.00).Seven patients in the TACE group and no patient in the HIFU group dropped out from the transplant waiting list(P = 0.559).CONCLUSION:HIFU ablation is safe and effective in the treatment of HCC for patients with advanced cirrhosis.It may reduce the drop-out rate of liver transplant candidate. | Tan To Cheung Sheung Tat Fan See Ching Chan Kenneth SH Chok Ferdinand SK Chu Caroline R Jenkins Regina CL Lo James YY Fung Albert CY Chan William W Sharr Simon HY Tsang Wing Chiu Dai Ronnie TP Poon Chung Mau Lo | 2013 | World Journal of Gastroenterology2013，19，20： | 23 |
| 2 | TRAIL-induced apoptosis of hepatocellular carcinoma cells is augmented by targeted therapies显示文摘AIM:To analyze the effect of chemotherapeutic drugs and specific kinase inhibitors,in combination with the death receptor ligand tumor necrosis factor-related apoptosis inducing ligand(TRAIL),on overcoming TRAIL resistance in hepatocellular carcinoma(HCC)and to study the efficacy of agonistic TRAIL antibodies,as well as the commitment of antiapoptotic BCL-2 proteins, in TRAIL-induced apoptosis. METHODS:Surface expression of TRAIL receptors (TRAIL-R1-4)and expression levels of the antiapoptotic BCL-2 proteins MCL-1 and BCL-xL were analyzed by flow cytometry and Western blotting,respectively. Knock-down of MCL-1 and BCL-xL was performed by transfecting specific small interfering RNAs.HCC cellswere treated with kinase inhibitors and chemotherapeutic drugs.Apoptosis induction and cell viability were analyzed via flow cytometry and 3-(4,5-Dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. RESULTS:TRAIL-R1 and-R2 were profoundly expressed on the HCC cell lines Huh7 and Hep-G2. However,treatment of Huh7 and Hep-G2 with TRAIL and agonistic antibodies only induced minor apoptosis rates.Apoptosis resistance towards TRAIL could be considerably reduced by adding the chemotherapeutic drugs 5-fluorouracil and doxorubicin as well as the kinase inhibitors LY294002[inhibition of phosphoinositol- 3-kinase(PI3K)],AG1478(epidermal growth factor receptor kinase),PD98059(MEK1),rapamycin(mam- malian target of rapamycin)and the multi-kinase inhibitor Sorafenib.Furthermore,the antiapoptotic BCL-2 proteins MCL-1 and BCL-xL play a major role in TRAIL resistance:knock-down by RNA interference increased TRAIL-induced apoptosis of HCC cells.Additionally, knock-down of MCL-1 and BCL-xL led to a significant sensitization of HCC cells towards inhibition of both c-Jun N-terminal kinase and PI3K.CONCLUSION:Our data identify the blockage of survival kinases,combination with chemotherapeutic drugs and targeting of antiapoptotic BCL-2 proteins as promising ways to overcome TRAIL resistance in HCC. | Bruno Christian Koehler Toni Urbanik Binje Vick Regina Johanna Boger Steffen Heeger Peter R Galle Marcus Schuchmann Henning Schulze-Bergkamen | 2009 | World Journal of Gastroenterology2009，15，47： | 9 |
| 3 | Auricular Acupuncture with Laser 显示文摘 | Regina R Gerhard L Frank B | 2013 | Evid Based Complement Ahernat Med2013，2013，98： | 1 |
| 4 | Lymphangiogenesis concurrent with haemangiogenesis in the human cornea显示文摘 | Regina M Zimmerman R Malik G | | 0，，6： | 1 |
| 5 | IRAP and REMAP: two new retrotransposon based DNA fingerprinting techniques显示文摘 | Kalendar R Grob T Regina M T | 1999 | Theoretical and Applied Genetics1999，98，： | 1 |
| 6 | Synthetic strategies of nonpeptidic β-secretase(BACE1)inhibitors显示文摘 | Regina GL Piscitelli F Silvestri R | 2009 | J Heterocyclic Chem2009，40，29： | 1 |
| 7 | Pharmacodyn amic profile of prostacyclin 显示文摘 | John R Vane D Regina M | 1995 | Am JCardiol1995，75，3： | 1 |
| 8 | Naphthenic Acids, Total Acid Number and Sulfur Content Profile Cha- racterization in Isthmus and Maya Crude Oils显示文摘 | GEORGINA C L CARLA R L REGINA E A | 2004 | Fuel2004，83，： | 1 |
| 9 | Fungi from geothermal soils in Yellowstone National Park显示文摘 | Regina S R Anastassial L Kathy BS | 1999 | Applied Environment Microbiology1999，65，12： | 1 |
| 10 | IRAP and REMAP ? Two new retrotransposon based DNA fingerprinting techniques 显示文摘 | Kalendar R Grob T Regina M | 1999 | Theor ApplGenet1999，98，5： | 1 |
| 11 | Altitude influence on the quality of 'Chardonnay' and 'Pinot Noir' grapes in the state of Minas Gerais显示文摘 | de Albuquerque Regina M do Carmo E L Fonseca A R | 2010 | Revista Brasileira de Fruticultura2010，32，1： | 1 |
| 12 | Redox-Based Resistive Switching Memories-Nanoionic Mechanisms,Prospects,and Challenges显示文摘 | Waser R Regina D Georgi S | 2009 | Advanced Materials2009，21，2526： | 1 |
| 13 | Surveillance of nosocomial infections in a neurology intensive care unit显示文摘 | Markus Dettenkofer Winfried Ebner Thomas Els Regina Babikir Carl Lücking Klaus Pelz Henning Rüden Franz Daschner | 2001 | Journal of Neurology2001，，11： | 1 |
| 14 | FLT3 internal tandem duplication during myelodysplastic syndrome follow-up: a marker of transformation to acute myeloid leukemia显示文摘 | Ronald Feitosa Pinheiro Eloisa de Sá Moreira Maria Regina Régis Silva Fernando Lopes Alberto Maria de Lourdes L.F. Chauffaille | 2008 | Cancer Genetics and Cytogenetics2008，，2： | 1 |
| 15 | 显示文摘 | REGINA M M G ELISABETH W JAMILE R R | 2007 | Bioresource Technology2007，99，： | 1 |
| 16 | Anti-HIV-1 activity of pyrr- yl aryl sulfone (PAS) derivatives : synthesis and SAR studies of novel esters and amides at the position 2 of the pyrrole nucleus 显示文摘 | Silvestri R Artico M Regina G | 2004 | Farmaco2004，59，3： | 1 |
| 17 | Apolipoprotein E polymorphism influences orthotopic liver transplantation outcomes in patients with hepatitis C virus-induced liver cirrhosis显示文摘BACKGROUND Hepatitis C virus(HCV)infection is responsible for a chronic liver inflammation,which may cause end-stage liver disease and hepatocellular carcinoma.Apolipoprotein E(protein:ApoE,gene:APOE),a key player in cholesterol metabolism,is mainly synthesized in the liver and APOE polymorphisms may influence HCV-induced liver damage.AIM To determine whether APOE alleles affect outcomes in HCV-infected patients with liver cirrhosis following orthotopic liver transplantation(OLT).METHODS This was a cohort study in which 179 patients,both genders and aged 34-70 years,were included before or after(up to 10 years follow-up)OLT.Liver injury severity was assessed using different criteria,including METAVIR and models for endstage liver disease.APOE polymorphisms were analyzed by quantitative real-time polymerase chain reaction.RESULTS The APOE3 allele was the most common(67.3%).In inflammation severity of biopsies from 89 OLT explants and 2 patients in pre-transplant,the degree of severe inflammation(A3F4,0.0%)was significantly less frequent than in patients with minimal and moderate degree of inflammation(≤A2F4,16.2%)P=0.048,in patients carrying the APOE4 allele when compared to non-APOE4.In addition,a significant difference was also found(≤A2F4,64.4%vs A3F4,0.0%;P=0.043)and(A1F4,57.4%vs A3F4,0.0%;P=0.024)in APOE4 patients when compared to APOE3 carriers.The fibrosis degree of the liver graft in 8 of 91 patients and the lack of the E4 allele was associated with more moderate fibrosis(F2)(P=0.006).CONCLUSION Our results suggest that the E4 allele protects against progression of liver fibrosis and degree of inflammation in HCV-infected patients. | José Carlos Rodrigues Nascimento Lianna C Pereira Juliana Magalhães C Rêgo Ronaldo P Dias Paulo Goberlânio B Silva Silvio Alencar C Sobrinho Gustavo R Coelho Ivelise Regina C Brasil Edmilson F Oliveira-Filho James S Owen Pierluigi Toniutto Reinaldo B Oriá | 2021 | World Journal of Gastroenterology2021，27，11： | 1 |
| 18 | Familial isolated growth hormone deficiency is associated with increased systolic blood pressure 显示文摘 | Augusto J Regina M Salvatoti R | 2002 | J Clin Endocrinol Metab2002，87，5： | 1 |
| 19 | Prevalence of infectious hypodermal and hematopoietic necrosis virus(IHHNV)in Penaeus vannamei cultured in northeastern Brazil显示文摘 | REGINA LGIAG R MAURCIO | 2009 | Aquaculture2009，288，2： | 1 |
| 20 | Aging effect on the refleetivity measurements of polyc hloroprene matrices containing carbon black and carbonyl-iron powder显示文摘 | Magali S P Maria L G Regina C R N | 2001 | Poly- mer Degradation and Stability2001，73，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员