|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Updates in the pathophysiological mechanisms of Parkinson's disease: Emerging role of bone marrow mesenchymal stem cells显示文摘AIM: To explore the approaches exerted by mesenchymal stem cells(MSCs) to improve Parkinson's disease(PD) pathophysiology.METHODS: MSCs were harvested from bone marrowof femoral bones of male rats, grown and propagated in culture. Twenty four ovariectomized animals were classified into 3 groups: Group(1) was control, Groups(2) and(3) were subcutaneously administered with rotenone for 14 d after one month of ovariectomy for induction of PD. Then, Group(2) was left untreated, while Group(3) was treated with single intravenous dose of bone marrow derived MSCs(BM-MSCs). SRY gene was assessed by PCR in brain tissue of the female rats. Serum transforming growth factor beta-1(TGF-β1), monocyte chemoattractant protein-1(MCP-1) and brain derived neurotrophic factor(BDNF) levels were assayed by ELISA. Brain dopamine DA level was assayed fluorometrically, while brain tyrosine hydroxylase(TH) and nestin gene expression were detected by semi-quantitative real time PCR. Brain survivin expression was determined by immunohistochemical procedure. Histopathological investigation of brain tissues was also done.RESULTS: BM-MSCs were able to home at the injured brains and elicited significant decrease in serum TGF-β1(489.7 ± 13.0 vs 691.2 ± 8.0, P < 0.05) and MCP-1(89.6 ± 2.0 vs 112.1 ± 1.9, P < 0.05) levels associated with significant increase in serum BDNF(3663 ± 17.8 vs 2905 ± 72.9, P < 0.05) and brain DA(874 ± 15.0 vs 599 ± 9.8, P < 0.05) levels as well as brain TH(1.18 ± 0.004 vs 0.54 ± 0.009, P < 0.05) and nestin(1.29 ± 0.005 vs 0.67 ± 0.006, P < 0.05) genes expression levels. In addition to, producing insignificant increase in the number of positive cells for survivin(293.2 ± 15.9 vs 271.5 ± 15.9, P > 0.05) expression. Finally, the brain sections showed intact histological structure of the striatum as a result of treatment with BM-MSCs. CONCLUSION: The current study sheds light on the therapeutic potential of BM-MSCs against PD pathophysiology via multi-mechanistic actions. | Hanaa H Ahmed Ahmed M Salem Hazem M Atta Emad F Eskandar Abdel Razik H Farrag Mohamed A Ghazy Neveen A Salem Hadeer A Aglan | 2016 | World Journal of Stem Cells2016，8，3： | 9 |
| 2 | Detection and diagnosis of faults in induction motor using an improved artificial ant cluste- ring technique显示文摘 | SOUALHI A CLERC G RAZIK H | 2013 | IEEE Transactions on Industrial Electronics2013，60，9： | 1 |
| 3 | On-line efficiency opti- mization of a synchronous reluctance motor 显示文摘 | Lubin T Razik H Rezzoug A | 2007 | Electric Power Systems Research2007，77，56： | 1 |
| 4 | Synthesis of some pyrazolines and pyrimidines derived from polymethoxy chalcones as anticancer and antimicrobial agents显示文摘 | Rostom S A F Badr M H Razik H A | | 0，，： | 1 |
| 5 | Comparison between finite-element analysis and winding function theory for inductances and torque calculation of a synchronous reluctance machine显示文摘 | Lubin T Hamiti T Razik H | 2007 | IEEE Transactions on Magnetics2007，43，8： | 1 |
| 6 | On the modeling and design of dual-stator windings to minimize circulating harmonic currents for VSI fed AC machines 显示文摘 | HADIOUCHE D RAZIK H REZZOUG A | 2004 | IEEE Transactions on IndustrialApplications2004，40，50： | 1 |
| 7 | Analytical approach of the stator current frequency harmonics computation for detection of induction machine rotor faults 显示文摘 | Henao H Razik H Capolino G A | 2005 | IEEE Trans Ind Applicat2005，，41： | 1 |
| 8 | Rotor cage fault detection in induction motor using global modulation index on the instantaneous power spectrum,in Proceedingof Symposum Diagnostics Electric Machines显示文摘 | DIDIER G RAZIK H CASPARY O | 2003 | Power Electronics and Drives(SDEMPED)2003，，： | 1 |
| 9 | Analytical approach of the stator current frequency harmonics computation for detection of induction machine rotor faults 显示文摘 | Henao H Razik H Capolino G A | 2005 | IEEE Transactions on Industry Applications2005，41，3： | 1 |
| 10 | Dielectric properties and AC conduction mechanism for 5, 7-dihydroxy-6-formyl-2-methylbenzo-pyran-4-one bis-schiff base 显示文摘 | Hassib H Abdel Razik A | 2008 | Solid State Communications2008，147，9： | 1 |
| 11 | Dielectric properties and AC conduc tion mechanism for 5, 7-dihydroxy-6-formyl-2-methylbenzo- pyran-4-one his Schiff base显示文摘 | Hassib H Razik A A | 2009 | Solid State Commun2009，9，147： | 1 |
| 12 | An improved model of induction motors for diagnosis purposesslot skewing effect and airgap eccentricity faults显示文摘 | Ghoggal A Zouzou S E Razik H | 2009 | Energy Conversion and Management2009，50，5： | 1 |
| 13 | Fault detection of broken rotor bars in induction motor using a global fault index显示文摘 | DIDIER G TERNISIEN E CASPARY O RAZIK H | 2006 | IEEE Transactions on Industry Applications2006，42，1： | 1 |
| 14 | Detection and Diagnosis of Faults in Induction Motor Using an Improved Artificial Ant Clustering Technique显示文摘 | Soualhi A Clerc G Razik H | 2013 | IEEE Transactions on Industrial Electronies2013，60，9： | 1 |
| 15 | High-temperature oxidation of A1-Mg alloys显示文摘 | Zayan M H Jamjoom O M Razik N A | 1990 | Oxidation of Metals1990，34，3： | 1 |
| 16 | Fault detection and diag-nosis of induction motors based on hidden Markov model显示文摘 | Soualhi A Clerc G Razik H | 2012 | IEEE2012，9，： | 1 |
| 17 | Study and simulation of space vector PWM control of doubl-star induction motors显示文摘 | Hadiouche D Razik H Rezzoug A | 2007 | IEEECI EP Acapulco Mexico2007，10，4： | 1 |
| 18 | An improved model of induction motors for diagnosis purposes-Slot skewing effect and air-gap eccentricity faults 显示文摘 | GI-IOGGAL A ZOUZOU S E RAZIK H | 2009 | Energy Conversion and Management2009，50，5： | 1 |
| 19 | Modelling and analysis of dual-stator induction motors显示文摘 | Razik H Rezzoug A Hadiouche D | 2005 | IEEE Transactions on Industry Applications2005，125，12： | 1 |
| 20 | Involvement of oxygen free radicals in the respiratory uncoupling induced by free calcium and ADP-magnesium in isolated cardiac mitochondria: comparing reoxygenation in cultured cardiomyocytes 显示文摘 | Meynier A Razik H Cordelet C | 2003 | Mol Cell Biochem2003，243，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员