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| 1 | Calcitriol analog ZK191784 ameliorates acute and chronic dextran sodium sulfate-induced colitis by modulation of intestinal dendritic cell numbers and phenotype显示文摘AIM: To investigate the effects of ZK1916784, a low calcemic analog of calcitriol on intestinal inflammation. METHODS: Acute and chronic colitis was induced by dextran sodium sulfate (DSS) according to standard procedures. Mice were treated intraperitoneally with ZK1916784 or placebo and colonic inflammation was evaluated. Cytokine production by mesenterial lymph node (MLN) cells was measured by ELISA. Immunohistochemistry was performed to detect intestinal dendritic cells (DCs) within the colonic tissue, and the effect of the calcitriol analog on DCs was investigated. RESULTS: Treatment with ZK191784 resulted in significant amelioration of disease with a reduced histological score in acute and chronic intestinal inflammation. In animals with acute DSS colitis, down- regulation of colonic inflammation was associated with a dramatic reduction in the secretion of the proinflammatory cytokine interferon (IFN)-γ and a significant increase in intereleukin (IL)-10 by MLN cells. Similarly, in chronic colitis, IL-10 expression in colonic tissue increased 1.4-fold when mice were treated with ZK191784, whereas expression of the Th1-specific transcription factor T-beta decreased by 81.6%. Lower numbers of infiltrating activated CD11c+ DCs were found in the colon in ZK191784-treated mice with acute DSScolitis, and secretion of proinflammatory cytokines by primary mucosal DCs was inhibited in the presence of the calcitriol analog. CONCLUSION: The calcitriol analog ZK191784 demonstrated significant anti-inflammatory properties in experimental colitis that were at least partially mediated by the immunosuppressive effects of the derivate on mucosal DCs. | Ulrike G Strauch Florian Obermeier Nicole Grunwald Nadja Dunger Heiko C Rath Jürgen Schlmerich A Steinmeyer U Zügel HH Herfarth | 2007 | World Journal of Gastroenterology2007，13，48： | 4 |
| 2 | Loss of CD103^+ intestinal dendritic cells during colonic inflammation显示文摘AIM:To investigate possible differences in dendritic cells(DC)within intestinal tissue of mice before and after induction of colitis. METHODS:Mucosal DC derived from intestinal tissue,as well as from mesenteric lymph nodes and spleen,were analyzed by fluorescence activated cell sorting(FACS) analysis.Supernatants of these cells were analyzed for secretion of different pro-and anti-inflammatory cytokines. Immunohistochemistry and immunofluorescence were performed on cryosections of mucosal tissue derived from animals with colitis as well as from healthy mice. RESULTS:It was shown that DC derived from healthy intestinal lamina propria(LP)represented an immature phenotype as characterized by low-level expression of costimulatory cytokines.In contrast to DC from spleen and mesenteric lymph nodes(MLN)that secreted proinflammatory cytokines,LP-DC produced high levels of the anti-inflammatory cytokine IL-10.After induction of mu-rine colitis in a CD4 + CD62L + transfer model or in chronic Dextran sulfate sodium-colitis,a marked increase of activated CD80 + DC could be observed within the inflamed colonic tissue.Interestingly,in contrast to splenic DC,a significant population of DC within MLN and colonic LP expressed the mucosal integrin CD103 which was lost during colitis. CONCLUSION:The constitutive secretion of antiinflammatory cytokines by immature DC within the intestinal LP might regulate the homeostatic balance between mucosal immunity and tolerance.CD103 + DC could mediate this important function. | Ulrike G Strauch Nicole Grunwald Florian Obermeier Sonja Gürster Heiko C Rath | 2010 | World Journal of Gastroenterology2010，16，1： | 2 |
| 3 | Role of caveolar compartmentation in endothelium-derived hyperpolarizing factor-mediated relaxation:Ca2+ signals and gap junction function are regulated by caveolin in endothelial cells显示文摘 | Saliez J Bouzin C Rath G | | 0，，08： | 1 |
| 4 | Heat of wood pyrolysis显示文摘 | J Rath Wolfinger M G Steiner G | 2003 | Fuel2003，82，1： | 1 |
| 5 | Polarographic determination of nitrate in vegetables显示文摘 | Ximenes M I N Rath S Reyes F G R | 2000 | Talanta2000，51，1： | 1 |
| 6 | The evolutionary history of methicillin - resistant staphylococcus aureus (MRSA)显示文摘 | Enright MC Robinson DA Rathe G | 2002 | Proc Natl Acad Sci USA2002，99，11： | 1 |
| 7 | Insituidentificationofammonia-oxidizing bacteria显示文摘 | Wagner M Rath G Amann R etal | 1995 | SystematicandApplied Microbiology1995，18，2： | 1 |
| 8 | Development and characterization of nanoembedded microparticles forpulmonary delivery of antitubercular drugs against experimental tuberculosis显示文摘 | Goyal AK Garg T Rath G | 2015 | Mol Pharm2015，1201，： | 1 |
| 9 | Effect of intermittent activity on broiler production parameters 显示文摘 | Balog J M G R Bayyari N C Rath | 1997 | Poultry Science1997，76，： | 1 |
| 10 | Insituanalysisofnitrifyingbacteriainsewagetreatmentplants显示文摘 | WagnerM Rath G Koops H P etal | 1996 | WaterScienceand Technology1996，34，12： | 1 |
| 11 | Local warming at injection site helps alleviate pain after rocuronium administration显示文摘 | Mahajan C Rath G P Bithal P K | 2010 | J Anesth2010，24，6： | 1 |
| 12 | In situ analysis of nitrifying bacteria in sewage treatment plants显示文摘 | Wagner M Rath G Koops H P | 1996 | Water Science and Technology1996，34，1： | 1 |
| 13 | Chitinase-3-1ike-1/YKL-40 as marker of circulating tumor cells 显示文摘 | Hamilton G Rath B Burghuber O | 2015 | Transl Lung Cancer Res2015，4，3： | 1 |
| 14 | Dual-energy computed tomography compared with ultrasound in the diagnosis of gout显示文摘 | Gruber M Bodner G Rath E | 2014 | Rheumatology(Oxford)2014，53，： | 1 |
| 15 | Iterative least squares and compression based estimations for a four-parameter linear global motion model and global motion compensation 显示文摘 | Rath G Makur A | 1999 | IEEE Trans Circuit Syst Video Technol1999，9，： | 1 |
| 16 | Generalized B-spline signal processing显示文摘 | R Panda G Rath B N Chatterji | 1996 | Signal Processing1996，55，： | 1 |
| 17 | A Novel Polyurethane Adhesive Based on Hydroxyl-Terminated Polybatadiene显示文摘 | PATRI M RATH S K SURYAVANSI U G | 2006 | Journal of Applied Polymer Science2006，99，： | 1 |
| 18 | 查看详情显示文摘 | K J Günter M Cheneau T Yefsah S P Rath and J Dalibard | | 0，，01： | 1 |
| 19 | Vascular hypoxic preconditioning re- lies on TRPV4-dependent calcium influx and proper intercellular gap junctions communication显示文摘 | Rath G Saliez J Behets G | 2012 | Arterioscler Thromb Vasc Bio12012，32，9： | 1 |
| 20 | Prevention of Escherichia coli respiratory infection in broiler chickens with bacteriophage (SPR02) 显示文摘 | HUFF W E HUFF G R RATH N C | 2002 | Poultry Science2002，81，： | 1 |
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