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| 1 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 2 | Dynamic expression of the Slit-Robo GTPase activating protein genes during development of the murine nervous system 显示文摘 | Bacon C Endris V Rappold G | 2009 | J Comp Neurel2009，513，2： | 1 |
| 3 | Implant Breakage of the Proximal Femoral Nail (PFN):Reasons and Case Reports显示文摘 | Rappold G Hertz H Spitaler R | 2001 | Eur J Trauma2001，27，6： | 1 |
| 4 | Deletions of the homeobox gene SHOX (short stature homeobox) are an important cause of growth failure in children with short stature 显示文摘 | Rappold G Fukami M Niesler B | 2002 | J Clin Endocrinol Metab2002，87，： | 1 |
| 5 | Genotypes and phe- notypes in children with short stature: clinieal indicators of SHOX haploinsuffieiency 显示文摘 | Rappold G Blum WF Shavfikova EP | 2007 | Med Genet2007，44，5： | 1 |
| 6 | Growth hormone and gonadotropin - releasing hormone analog therapy in haploin- sufficiency of SHOX显示文摘 | Ogata T Onigata K Hotsubo T Matsuo N Rappold G | 2001 | Endocr J2001，48，： | 1 |
| 7 | 5-HT(3)receptors:role in diseaseand target of drugs显示文摘 | Walstab J Rappold G Niesler B | 2010 | Pharmacol Ther2010，128，1： | 1 |
| 8 | Plating of fresh claviclefrac-tures:results of 122 operations显示文摘 | Rappold G Fischer W | 1992 | Injury1992，23，2： | 1 |
| 9 | Plating of fresh calvicular fractures: Results of 122 operations 显示文摘 | Poigenfurst J Rappold G Fischer W | 1992 | Injury1992，23，2： | 1 |
| 10 | Dynamic expression of the Slit-Robo GTPase activating protein genes during development of the murine nervous system显示文摘 | Bacon C Endris V Rappold G | 2009 | J Comp Neurol2009，513，2： | 1 |
| 11 | Imp lant breakage of the proximalfemo ral nail (PFN) 显示文摘 | Rappold G Hertz H Sp italar R | 2001 | Eur J Trauma2001，27，： | 1 |
| 12 | Plating of fresh clavicular fractures:results of 122 operations显示文摘 | Poigenfu rst J Rappold G Fischer W | 1992 | Injury1992，23，4： | 1 |
| 13 | High-pressure injection injuries of the hand, pathogen- esis, problems and therapy 显示文摘 | Rappold G Rosenmayr E | 2001 | Handchir Mikrochir Plast chir2001，33，5： | 1 |
| 14 | Genotypes and phenotypes in children with short stature : clinical indicators of SHOX haploinsufficiency显示文摘 | Rappold G Blum W F Shavrikova E P | 2007 | J Med Genet2007，44，5： | 1 |
| 15 | Genotypes and phenotypes in children with short stature: clinical indicators of SHOX haploinsufficiency显示文摘 | Rappold G Blum WF Shavrikova EP | 2007 | J Med Genet2007，44，5： | 1 |
| 16 | Plating of fresh clavicular fracturest results of 122 operations显示文摘 | Poigenfurst J Rappold G Fischer W | 1992 | Injury1992，23，： | 1 |
| 17 | SHOX at a glance: from gene to protein 显示文摘 | Marchini A Rappold G Schneider K U | 2007 | Arch Physiol Biochem2007，113，3： | 1 |
| 18 | Plating of fresh clavicular fractures : results of 122 operations显示文摘 | Poigenfurst J Rappold G Fischer W | 1992 | Injury1992，23，4： | 1 |
| 19 | Plating of fresh clavicular fractures:results of 122 operations显示文摘 | Poigenfiurst J Rappold G Fischer W | 1992 | Injury1992，23，： | 1 |
| 20 | Deletions of the homeobox gene SHOX (short stature homeobox ) are an important cause of growth failure in children with short stature 显示文摘 | Rappold G Fukami M Niesler B | 2002 | J Clin Endocrinol Metab2002，873，： | 1 |
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