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| 1 | Radiofrequency ablation for treatment of hypersplenism: A feasible therapeutic option显示文摘We present a case of a patient with hypersplenism secondary to portal hypertension due to hepato-splenic schistosomiasis, which was accompanied by severe and refractory thrombocytopenia. We performed spleen ablation and measured the total spleen and ablated volumes with contrast-enhanced computed tomography and volumetry. No major complications occurred, thrombocytopenia was resolved, and platelet levels remained stable, which allowed for early treatment of the patient's underlying disease. Previous work has shown that splenic radiofrequency ablation is an attractive alternative treatment for hypersplenism induced by liver cirrhosis. We aimed to contribute to the currently sparse literature evaluating the role of radiofrequency ablation(RFA) in the management of hypersplenism. We conclude that splenic RFA appears to be a viable and promising option for the treatment of hypersplenism. | Guilherme Lopes P Martins Joao Paulo G Bernardes Marcello S Rovella Raphael G Andrade Publio Cesar C Viana Paulo Herman Giovanni Guido Cerri Marcos Roberto Menezes | 2015 | World Journal of Gastroenterology2015，21，20： | 17 |
| 2 | Does autologous blood transfusion during liver transplantation for hepatocellular carcinoma increase risk of recurrence?显示文摘AIM: To analyze outcomes in patients who underwent liver transplantation(LT) for hepatocellular carcinoma(HCC) and received autologous intraoperative blood salvage(IBS). METHODS: Consecutive HCC patients who underwent LT were studied retrospectively and analyzed according to the use of IBS or not. Demographic and surgical data were collected from a departmental prospective maintained database. Statistical analyses were performed using the Fisher's exact test and the Wilcoxon rank sum test to examine covariate differences between patients who underwent IBS and those who did not. Univariate and multivariate Cox regression models were developed to evaluate recurrence and death,and survival probabilities were estimated using the Kaplan-Meier method and compared by the log-rank test.RESULTS: Between 2002 and 2012,158 consecutive patients who underwent LT in the same medical center and by the same surgical team were identified. Among these patients,122(77.2%) were in the IBS group and 36(22.8%) in the non-IBS group. The overall survival(OS) and recurrence free survival(RFS) at 5 years were 59.7% and 83.3%,respectively. No differences in OS(P=0.51) or RFS(P=0.953) were detected between the IBS and non-IBS groups. On multivariate analysis for OS,degree of tumor differentiation remained as the only independent predictor. Regarding patients who received IBS,no differences were detected in OS or RFS(P=0.055 and P=0.512,respectively) according to the volume infused,even when outcomes at 90 d or longer were analyzed separately(P=0.518 for both outcomes).CONCLUSION: No differences in RFS or OS were detected according to IBS use. Trials addressing this question are justified and should be designed to detect small differences in long-term outcomes. | Raphael LC Araujo Carlos Andrés Pantanali Luciana Haddad Joel Avancini Rocha Filho Luiz Augusto Carneiro D’Albuquerque Wellington Andraus | 2016 | World Journal of Gastrointestinal Surgery2016，8，2： | 14 |
| 3 | Facing the challenge of venous thromboembolism prevention in patients undergoing major abdominal surgical procedures for gastrointestinal cancer显示文摘Venous thromboembolism(VTE)refers to a hypercoa-gulable state that remains an important and preven-table factor in the surgical treatment of malignancies.VTE includes two identical entities with regards to deep vein thrombosis and pulmonary embolism.The incidence of VTE after major abdominal interventions for gastro-intestinal,hepato-biliary and pancreatic neoplastic disor-ders is as high as 25%without prophylaxis.Prophylactic use of classic or low-molecular-weight heparin,anti-Xa factors,antithrombotic stocking,intermittent pneumatic compression devices and early mobilization have been described.Nevertheless,thromboprophylaxis is often dis-continued after discharge,although a serious risk may persist long after the initial triggering event,as the coagu-lation system remains active for at least 14 d post-opera-tively.The aim of this review is to evaluate the results of the current practice of VTE prevention in cancer patients undergoing major abdominal surgical operations,with special attention to adequately elucidated guidelinesand widely accepted protocols.In addition,the recent literature is presented in order to provide an update on the current concepts concerning the surgical manage-ment of the disease. | Aikaterini Mastoraki Sotiria Mastoraki Dimitrios Schizas Raphael Patras Nikolaos Krinos Ioannis S Papanikolaou Andreas Lazaris Theodore Liakakos Nikolaos Arkadopoulos | 2018 | World Journal of Gastrointestinal Oncology2018，10，10： | 7 |
| 4 | Cardiovascular magnetic resonance: Diagnostic utility and specific considerations in the pediatric population显示文摘Cardiovascular magnetic resonance is a non-invasive imaging modality which is emerging as important tool for the investigation and management of pediatric cardiovascular disease. In this review we describe the key technical and practical differences between scanning children and adults, and highlight some important considerations that must be taken into account for this patient population. Using case examples commonly seen in clinical practice, we discuss the important clinical applications of cardiovascular magnetic resonance, and briefly highlight key future developments in this field. | Frances M Mitchell Sanjay K Prasad Gerald F Greil Peter Drivas Vassilios S Vassiliou Claire E Raphael | 2016 | World Journal of Clinical Pediatrics2016，5，1： | 2 |
| 5 | Plasma exchange for Guillain-Bane sysdrome(Cochrane Review)显示文摘 | Chevret S Hughes RA | 2001 | Cochrane Database Syst Rev2001，2，： | 1 |
| 6 | Abnormal nasal glandular secretion in recurrent sinusitis显示文摘 | JENEY E V RAPHAEL G D MEREDITH S D | 1990 | J Allergy Clin Immunol1990，86，： | 1 |
| 7 | Correlation coefficient of the heart rate turbulence slope: an independent risk stralifier in post-infarction patients 显示文摘 | Petra B Raphael S Axel B | 2001 | Circulation2001，104，17： | 1 |
| 8 | Plasma exchange for Guillain-Barre syndrome(Cochrane Review)显示文摘 | Chevret S Hughes RA Annane D | 2001 | Cochrane Database Syst Rev2001，2，00： | 1 |
| 9 | Development of a zebrafish 4-day embryo-larval bioassay to assess toxicity of chemicals显示文摘 | BENOIT F RAPHAEL M S JEANNE G | 2006 | Ecotoxicology and Environmental Safety2006，63，2： | 1 |
| 10 | Homeless in America, homeless in California 显示文摘 | Quigley J M Raphael S Smolensky E | 2001 | The Review of Economics and Sta tistics2001，83，1： | 1 |
| 11 | Genetic linkage of familial granulomatous inflammatory arthritis, skin rash, and uveitis to chromosome 16显示文摘 | Tromp G Kuivaniemi H Raphael S | 1996 | Am J Hum Genet1996，59，： | 1 |
| 12 | Cancer pain: part 2: physical, interventional and complimentary therapies; management in the community; acute, treatment-related and complex cancer pain: a perspective from the British Pain Society endorsed by the UK Association of Palliative Medicine and the Royal College of General Practitioners显示文摘 | Raphael J Hester J Ahmedzai S | 2010 | Pain Med2010，11，6： | 1 |
| 13 | Volatile anesthetic pre-conditioning attenuates myocardial apoptosis in rabbits after regional ischemia and reperfusion via Akt signaling and modulation of Bcl-2 family proteins显示文摘 | Raphael J Abedat S Rivo J | 2006 | J Pharmacol Exp Ther2006，318，1： | 1 |
| 14 | An automated salt-tracing gauge for flow-velocity measurement 显示文摘 | Olivier P Norbert S Raphael G | 2005 | Earth Surf Process Landforms2005，30，： | 1 |
| 15 | Plasma exchange for Guil- lain-Barr6 syndrome 显示文摘 | Raphael JC Cfievret S Hughes RA | 2012 | Coehrane Database of Systematic Reviews2012，7，00： | 1 |
| 16 | In vitro eva luation of the antibacterial activity of extracts from 34 species of North American lichens 显示文摘 | SHRESTHA G RAPHAEL J LEAVITT S D | 2014 | Pharm Biol2014，52，10： | 1 |
| 17 | Data mining techniques for improving the reliability of system identification 显示文摘 | SAiTTA S RAPHAEL B SMITH F C | 2005 | Advanced Engineering Informatics2005，19，4： | 1 |
| 18 | T cell subsets and their signature eytokines in autoimmune and inflammatory diseases显示文摘 | Raphael I Nalawade S Eagar TN | 2015 | Cytokine2015，74，1： | 1 |
| 19 | Combination of ring-opening polymerization and 'click chemistry': Toward functionalization and grafting of poly( e-caprolactone)显示文摘 | Raphael Riva S S Christine Jerome Robert Jerome | 2007 | Macromolecules2007，40，4： | 1 |
| 20 | Cancer pain: part 1: Patho- physiology; oncological, pharmacological, and psychological treat- ments: a perspective from the British Pain Society endorsed by the UK Association of Palliative Medicine and the Royal College of General Practitioners显示文摘 | Raphael J Ahmedzai S HesterJ | 2010 | Pain Med2010，11，5： | 1 |
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