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| 1 | Emerging role of caldesmon in cancer:A potential biomarker for colorectal cancer and other cancers显示文摘Colorectal cancer(CRC) is a devastating disease, mainly because of metastasis. As a result, there is a need to better understand the molecular basis of invasion and metastasis and to identify new biomarkers and therapeutic targets to aid in managing these tumors. The actin cytoskeleton and actin-binding proteins are known to play an important role in the process of cancer metastasis because they control and execute essential steps in cell motility and contractility as well as cell division. Caldesmon(CaD) is an actin-binding protein encoded by the CALD1 gene as multiple transcripts that mainly encode two protein isoforms: High-molecular-weight CaD, expressed in smooth muscle, and low-molecular weight CaD(l-CaD), expressed in nonsmooth muscle cells. According to our comprehensive review of the literature, CaD, particularly l-CaD, plays a key role in the development, metastasis, and resistance to chemoradiotherapy in colorectal, breast, and urinary bladder cancers and gliomas, among other malignancies. CaD is involved in many aspects of the carcinogenic hallmarks, including epithelial mesenchymal transition via transforming growth factor-beta signaling, angiogenesis, resistance to hormonal therapy, and immune evasion. Recent data show that CaD is expressed in tumor cells as well as in stromal cells, such as cancerassociated fibroblasts, where it modulates the tumor microenvironment to favor the tumor. Interestingly, CaD undergoes selective tumor-specific splicing, and the resulting isoforms are generally not expressed in normal tissues, making these transcripts ideal targets for drug design. In this review, we will analyze these features of CaD with a focus on CRC and show how the currently available data qualify CaD as a potential candidate for targeted therapy in addition to its role in the diagnosis and prognosis of cancer. | Alya R Alnuaimi Vidhya A Nair Lara J Bou Malhab Eman Abu-Gharbieh Anu Vinod Ranade Gianfranco Pintus Mohamad Hamad Hauke Busch Jutta Kirfel Rifat Hamoudi Wael M Abdel-Rahman | 2022 | World Journal of Gastrointestinal Oncology2022，14，9： | 2 |
| 2 | Molecular analyses of methanogen diversity associated with cattle dung 显示文摘 | RASTOGI G RANADE D R YEOLE T Y | 2008 | World Journal of Microbiology and Biotechnology2008，24，12： | 1 |
| 3 | Hydrodynamics of trickle bed reactors:experiments and CFD modeling显示文摘 | Gunjal P R Kashid M N Ranade V V Chaudhuri R V | | 0，，16： | 1 |
| 4 | Reversal of phototaxis in the larvae of Polydora pulchra Carazzi (Polychaeta,Spionidae)显示文摘 | RANADE M R | 1957 | Nature1957，179，： | 1 |
| 5 | Dynamics of drop impact on solid surface:experiments and VOF simulations显示文摘 | GUNJAL P R RANADE V V CHAUDHARI R V | 2005 | AIChE J2005，51，1： | 1 |
| 6 | Pressure drop across vortex diodes: experiments and design guidelines 显示文摘 | Kulkami A A Ranade V V Rajeev R Koganti S B | 2009 | Chemical Engineering Science2009，64，： | 1 |
| 7 | Evaluating EMMS model for simulating high solid flux risers显示文摘 | Naren P R Lali A M Ranade V V | | 0，，8： | 1 |
| 8 | Development of green engineered cementitious composites using iron ore tailings as aggregates 显示文摘 | Huang X Y Ranade R Li V C | 2013 | Construction and Building Materials2013，44，： | 1 |
| 9 | Effect of various polymers concentrations on physicochemical properties of floating microspheres显示文摘 | Y Jagtap R Bhujbal A Ranade N Ranpise | 2012 | Indian Journal of Pharmaceutical Sciences2012，，6： | 1 |
| 10 | Instrumentation system for thermal analysis of electro-explosive devices显示文摘 | Kankane D K Ranade S N Sohoni R B Deshpande G S | 1999 | Defence Science Journal1999，49，1： | 1 |
| 11 | Gas-liquid flow in stirred reactors:trailing vortices and gas accumulation behind impeller blades显示文摘 | Ranade V V Deshpande V R | 1999 | Chem Eng Sci1999，54，13： | 1 |
| 12 | Anatomical variations of the thyroid gland: passible surgical implications显示文摘 | Ranade AV Rai R Pai MM | 2008 | Singapore Med J2008，49，10： | 1 |
| 13 | Anaerobic degradation of adsorbable organic halides(AOX)from pulp and paper industry wastewater显示文摘 | Savant D V Abdul-Rahman R Ranade D R | 2006 | Bioresource Technology2006，97，9： | 1 |
| 14 | Release of oral submucous fibrosis and reconstruction using superficial temporal fascia flap and split skin graft--a new technique显示文摘 | RAJE R S RANADE S V | 2005 | Br J Plast Surg2005，58，8： | 1 |
| 15 | Anae- robic degradation of adsorbable organic halides (AOX) from pulp and paper industry wastewater显示文摘 | SAVANT D V ABDUL RAHMAN R RANADE D R | 2006 | Bioresource Technolo- gy2006，97，9： | 1 |
| 16 | Gas-liquid flow generated by a Rushton turbine in stirred vessel: CARPT/CT measurements and CFD simulations 显示文摘 | KHOPKAR A R RAMMOHAN A R RANADE V V | 2005 | Chemical Engineering Science2005，60，89： | 1 |
| 17 | Pressure Drop Across Vortex Diodes: Experiments and Design Guide Lines 显示文摘 | Kulkarni A A Ranade V V Rajeev R | 2009 | Chemical Engineering Science2009，64，： | 1 |
| 18 | Biological treatment of a pharmaceutical waste显示文摘 | Yeole T Y Gadre V Ranade D R | 1996 | Indian J Environ Health1996，38，： | 1 |
| 19 | Clinicopathological evalua- tion of 100 cases of mucinous carcinoma of breast with emphasis on axillary staging and special reference to a micropapillary pattern 显示文摘 | Ranade A Batra R Sandhu G | | J Clin Pathol0，63，12： | 1 |
| 20 | Hy- drodynamics of bubble column reactors at high gas velocity: experiments and computational fluid dynamics (CFD) sim- ulations 显示文摘 | RAMPURE M R KULKARNI A A RANADE V V | 2007 | Industrial & Engineering Chemistry Research2007，46，25： | 1 |
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