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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Whey and soy protein hydrolysates inhibit lipid oxidation in cooked pork patties 显示文摘 | Pena- Ramos E A Xiong Y L | 2003 | Meat Science2003，64，： | 1 |
| 3 | Whey and soy protein hydrolysates inhibit lipid oxidation in cooked pork pattie 显示文摘 | Pefia- Ramos E A Xiong Y L | 2003 | Meat Science2003，6，3： | 1 |
| 4 | In silico analysis of accurate proteomics, complemented by selective isolation of pep- tides显示文摘 | Y Perez - Riverol A S Nchez Y Ramos | 2011 | Journal of Proteomics2011，74，10： | 1 |
| 5 | AC electrokinetic pumping on symmetric electrode arrays 显示文摘 | YANG H K JIANG H Y RAMOS A | 2009 | Mierofluid Nanofluid2009，7，6： | 1 |
| 6 | Mechanistic studies on Lewis acid catalyzed Biginelli reactions in ionic liquids: Evidence for the reac- tive intermediates and the role of the reagents 显示文摘 | Ramos L M Ponce de Leon Y Tobio A Y dos Santos M R | 2012 | Journal of Organic Chemistry2012，77，10： | 1 |
| 7 | Relationship between occupational stress and burnout among Chinese teachers:a cross-sectional survey in Liaoning,China显示文摘 | Wang Y Ramos A Wu H | 2015 | Int Arch Occup Environ Health2015，88，5： | 1 |
| 8 | Prediction of surgical site infection after colorectal surgery显示文摘 | Pedroso-Fernandez Y Aquirre-Jaime A Ramos MJ | 2016 | Am J Infect Control2016，44，4： | 1 |
| 9 | Whey and soy protein hydrolysates inhibit lipid oxidation in cooked pork patties显示文摘 | Ramos E A Xiong Y L | 2003 | Meat Scince2003，64，3： | 1 |
| 10 | Laparoscopic duodenal-jejunal exclusion in the treatment of type 2 diabetes mellitus in patients with BMI <30 kg/m2显示文摘 | RAMOS A C GALYAO NETO M P de SOUZA Y M | 2009 | Obes Surg2009，19，3： | 1 |
| 11 | Antioxidative activity of whey protein hydrolysates in a liposomal system 显示文摘 | Pena - Ramos E A Xiong Y L | 2001 | Journal ofDairy Science2001，84，： | 1 |
| 12 | Relationship between occupational stress and burnout among Chinese teachers:a cross-sectional survey in Liaoning,China显示文摘 | Wang Y Ramos A Wu H | 2015 | Int Arch Occup Environ Health2015，88，5： | 1 |
| 13 | Meta-analysis on the use of zidovudine and interferon-alfa in adult T-cell leukemia/lymphoma showing improved survival in the leukemic subtypes显示文摘 | Bazarbachi A Plumelle Y Ramos JC | 2010 | J Clin Oncol2010，28，27： | 1 |
| 14 | Fractionation and characterization for antioxidant activity of hydrolyzed whey protein显示文摘 | Pena- Ramos E A Xiong Y L Arteaga G E | 2004 | J Sci Food Agric2004，84，： | 1 |
| 15 | Mechanism of anion retention from EXAFS and density functional calculations:arsenic (V) adsorbed on gibbsite显示文摘 | Ladeira A C Q Ciminelli V S T Duarte H A Alves M C M Ramos A Y | 2001 | Geochemistry at Cosmetic-chemistry Acta2001，65，8： | 1 |
| 16 | Physico-chemical characteristics of goat and sheep milk显示文摘 | PARK Y JU(A)REZ M RAMOS M | | 0，，1： | 1 |
| 17 | Fractionation and characterisation for antioxidant activity of hydrolysed whey protein显示文摘 | Pena- Ramos E A Y L Xiong G E Arteaga | 2004 | Journal of the Science of Food and Agriculture2004，84，： | 1 |
| 18 | SERS-active gold lace nanoshells with built-in hotspots显示文摘 | Ming Y Ramo'n A Hyoung S K | | 0，，10： | 1 |
| 19 | Chitosan scaffolds for osteochondral tissue regeneration 显示文摘 | ABARRATEGI A MORALES Y L RAMOS V | 2010 | Journal of Biomedical Materials Research Part A2010，95，4： | 1 |
| 20 | Taxis response of various denitrifying bacteria to nitrate and nitrite 显示文摘 | Lee D Y Ramos A Macomber L | 2002 | Appl Environ Microbio12002，68，5： | 1 |
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