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| 1 | A randomized open-label trial of on-demand rabeprazole vs ranitidine for patients with non-erosive reflux disease显示文摘AIM:To compare the efficacy of the proton-pump inhibitor,rabeprazole,with that of the H 2-receptor antagonist,ranitidine,as on-demand therapy for relieving symptoms associated with non-erosive reflux disease(NERD).METHODS:This is a single center,prospective,randomized,open-label trial of on-demand therapy with rabeprazole(group A) vs ranitidine(group B) for 4 wk.Eighty-three patients who presented to the American University of Beirut Medical Center with persistent gastroesophageal reflux disease(GERD) symptoms and a normal upper gastrointestinal endoscopy were eligible for the study.Patients in group A(n = 44) were allowed a maximum rabeprazole dose of 20 mg twice daily,while those in group B(n = 39) were allowed a maximum ranitidine dose of 300 mg twice daily.Efficacy was assessed by patient evaluation of global symptom relief,scores of the SF-36 quality of life(QoL) questionnaires,total number of pills used,and number of medication-free days.RESULTS:Among the 83 patients who were enrolled in the study,76 patients(40 in the rabeprazole group and 36 in the ranitidine group) completed the 4-wk trial.Baseline characteristics were comparable between both groups.After 4 wk,there was no significant difference in the subjective global symptom relief between the rabeprazole and the ranitidine groups(71.4% vs 65.4%,respectively;P = 0.9).There were no statistically significant differences between mean cumulative scores of the SF-36 QoL questionnaire for the two study groups(rabeprazole 22.40 ± 27.53 vs ranitidine 17.28 ± 37.06;P = 0.582).There was no significant difference in the mean number of pills used(rabeprazole 35.70 ± 29.75 vs ranitidine 32.86 ± 26.98;P = 0.66).There was also no statistically significant difference in the mean number of medication-free days between both groups.CONCLUSION:Rabeprazole has a comparable efficacy compared to ranitidine when given on-demand for the treatment of NERD.Both medications were associated with improved quality of life. | Abdallah A Kobeissy Jana G Hashash Faek R Jamali Assaad M Skoury Reham Haddad Sarah El-Samad Rami Ladki Rola Aswad Assaad M Soweid | 2012 | World Journal of Gastroenterology2012，18，19： | 4 |
| 2 | Assessment of lnc RNA GAS5, lnc RNA HEIH, lnc RNA BISPR and its m RNA BST2 as serum innovative non-invasive biomarkers: Recent insights into Egyptian patients with hepatitis C virus type 4显示文摘BACKGROUND Hepatitis C virus(HCV)infection and its consequent complications are undeniably a public health burden worldwide,particularly in Egypt.Emerging evidence suggests that many lncRNAs have relevant roles in viral infections and antiviral responses.AIM To investigate the expression profiles of circulating lncRNAGAS5,lncRNAHEIH,lncRNABISPR and mRNABST2 in naïve,treated and relapsed HCV Egyptian patients,to elucidate relation to HCV infection and their efficacy as innovative biomarkers for the diagnosis and prognosis of HCV GT4.METHODS One hundred and thirty HCV-infected Egyptian patients and 20 healthy controls were included in this study.Serum lncRNAs and mRNABST2 were measured using quantitative real-time polymerase chain reaction(qRT-PCR).RESULTS Our results indicated that serum lncRNAGAS5 and LncRNABISPR were upregulated,whereas mRNA BST2 and LncRNA HEIH were downregulated in naïve patients.In contrast,HCV patients treated with sofosbuvir and simeprevir;with sofosbuvir and daclatasvir;or with sofosbuvir,daclatasvir and ribavirin exhibited lower levels of lncRNAGAS5 and lncRNABISPR with higher mRNABST2 compared to naïve patients.Notably,patients relapsed from sofosbuvir and simeprevir showed higher levels of these lncRNAs with lower mRNABST2 compared to treated patients.LncRNAGAS5 and lncRNABISPR were positively correlated with viral load and ALT at P<0.001,whereas mRNABST2 was negatively correlated with viral load at P<0.001 and ALT at P<0.05.Interestingly,a significant positive correlation between lncRNA HEIH and AFP was observed at P<0.001.CONCLUSION Differential expression of these RNAs suggests their involvement in HCV pathogenesis or antiviral response and highlights their promising roles in diagnosis and prognosis of HCV. | Nourhan M El Samaloty Marwa I Shabayek Ramy S Ghait Shohda A El-Maraghy Sherine M Rizk Maha M El-Sawalhi | 2020 | World Journal of Gastroenterology2020，26，2： | 2 |
| 3 | Potential role of killer immunoglobulin receptor genes among individuals vaccinated against hepatitis B virus in Lebanon显示文摘AIM To explore the role of killer immunoglobulin receptor(KIR) genes in responsiveness or non-responsiveness to vaccination against hepatitis B virus.METHODS We recruited 101 voluntary participants between March 2010 and December 2011. Sera samples from vaccinated and non-vaccinated participants were tested for the presence of anti-HBs antibodies as a measure of protection against hepatitis B, hepatitis B surface antigen and hepatitis B core antibody as indicators ofinfection by enzyme-linked immunosorbent assay. KIR gene frequencies were determined by polymerase chain reaction.RESULTS Sera samples from 99 participants were tested for the levels of anti-HBs as an indicator of protection(≥ 10 mI U/ml) following vaccination as defined by the World Health Organization international reference standard. Among the vaccinated participants, 47%(35/74) had anti-HBs titers above 100 mI U/ml, 22%(16/74) had antiHBs ranging between 10-100 mI U/ml, and 20%(15/74) had values of less than 10 mI U/ml. We report the lack of significant association between the number of vaccine dosages and the titer of antibodies among our vaccinated participants. The inhibitory KIR2Dl1, KIR2Dl4, KIR3Dl1, KIR3Dl2, and KIR3 Dl were detected in more than 95%, whereas KIR2Dl2, KIR2Dl3, KIR2Dl5(KR2Dl5A and KIR2Dl5B) were expressed in 56%, 84% and 42%(25% and 29%) of participants, respectively. The observed frequency of the activating KIR genes ranged between 35% and 55% except for KIR2DS4, detected in 95% of the study participants(40.6% 2DS4*001/002; 82.2% 2DS4*003/007). KIR2DP1 pseudogene was detected in 99% of our participants, whereas KIR3DP*001/02/04 and KIR3DP1*003 had frequencies of 17% and 100%, respectively. No association between the frequency of KIR genes and anti-HBs antibodies was detected. When we compared the frequency of KIR genes between vaccinated individuals with protective antibodies titers and those who lost their protective antibody levels, we did not detect a significant difference. KIR2Dl5 B was significantly different among different groups of vaccinated participants(group Ⅰ > 100 mI U/ml, group Ⅱ 10-100 mI U/ml, group Ⅲ < 10 mI U/ml and group Ⅳ with undetectable levels of protective antibodies). CONCLUSION To our knowledge, this is the first study screening for the possible role of KIR genes among individuals vaccinated against hepatitis B virus(HBV). Our results can be used to design larger studies to better understand the role of KIR genes in protection against or susceptibility to HBV post vaccination. | Nada M Melhem Rami A Mahfouz Khalil Kreidieh Rabab Abdul-Khalik Rolla El-Khatib Reem Talhouk Umayya Musharrafieh Ghassan Hamadeh | 2016 | World Journal of Hepatology2016，8，29： | 2 |
| 4 | LMI optimization for nonstandard riccati equations arising in stochastic control显示文摘 | RAMI M A GHAOUI L E | 1996 | IEEE Transactions on Automatic Control1996，41，11： | 1 |
| 5 | Catalytic abatement of NQx: Chemical and mechanistic aspects 显示文摘 | BUSCA G LARRUBIA M A ARRIGHI L RAMIS G | 1993 | Catalysis Toda-1993，16，： | 1 |
| 6 | An FT-IR study of the adsorption and oxidation of N-containing compounds over Fe 2 O 3 -TiO 2 SCR catalysts显示文摘 | Larrubia M A Ramis G Busca G | 2001 | Applied Catalysis B:Environmental2001，30，12： | 1 |
| 7 | Type of renal calcu- li: variation with age and sex显示文摘 | Costa-Bauza A Ramis M Montesinos V | 2007 | World J Urol2007，25，4： | 1 |
| 8 | Polyurethane-unsaturated polyester interpenetrating polymer networks: thermal and dynamic mechanical thermal behaviour 显示文摘 | RAMIS A CADENATO J M MORANCHO J M | 2001 | Polymer2001，42，： | 1 |
| 9 | Type of renal cal- culi: variation with age and sex显示文摘 | Costa-Bauza A Ramis M Montesinos V | 2007 | World J Urol2007，25，4： | 1 |
| 10 | Caloric restriction,resveratrol and melatonin:role of SIRT1 and implications for aging and related-diseases显示文摘 | Ramis M R Esteban S Miralles A | 2015 | Mech Ageing Dev2015，146，： | 1 |
| 11 | Robust exact pole placement via an LMI based algorithm 显示文摘 | Ait Rami M E1 Faiz S Benzaouia A | 2009 | IEEE Transactions on Automatic Control2009，54，2： | 1 |
| 12 | Rice root genetic architecture: meta analysis from a drought QTL database显示文摘 | Courtois B Ahmadi N Khowaja F Price A H Rami J F Frouin J Hamelin C Ruiz M | 2009 | Rice2009，，2： | 1 |
| 13 | Curing of a thermosetting powder coating by ~s of DMTA,TMA and DSC显示文摘 | Ramis X Cadenato A Morancho J M | 2003 | Polymer2003，44，07： | 1 |
| 14 | Solvability of Static Output-feedback Stabilization for LIM Positive systems显示文摘 | RAMI M A | 2011 | Systems and Control2011，60，1： | 1 |
| 15 | Solvability of static output-feedback stabilization for LIM positive systems 显示文摘 | Rami M A | 2011 | Systems and Control2011，，60： | 1 |
| 16 | Type of renal nalculi: variation with age and sex显示文摘 | COSTA-BAUZ A RAMIS M MONTESINOS V | 2007 | World Journal of Urology2007，25，4： | 1 |
| 17 | On the chemistry of ammonia over oxide catalysts:Fourier transform infrared study of ammonia,hydrazine and hydroxylamine adsorption over iron-titania catalyst显示文摘 | Ramis G Larrubia M A Busca G | 2000 | Topics in Catalysis2000，1112，1： | 1 |
| 18 | An FT-IR study of the adsorption of urea and ammonia over V2O5-MoO3-TiO2 SCR catalysts显示文摘 | Larrubia M A Ramis G Busca G | 2000 | Applied Catalysis B: Environment2000，27，3： | 1 |
| 19 | Positive observation problem for time-delays linear positive system显示文摘 | RAMI M A HELMKE U TADEO F | 2007 | Mediterranean Conf Control and Automation2007，51，5： | 1 |
| 20 | An FT-IR study of the adsorption of urea and ammonia over V2O5-MoO3-TiO2 SCR catalysts显示文摘 | Larrubia M A Ramis G Busca G | 2000 | Applied Catalysis B: Environmental2000，27，3： | 1 |
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