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| 1 | Role of tissue microenvironment resident adipocytes in colon cancer显示文摘Colorectal cancer(CRC) is a multifactorial disease characterized by several genetic and epigenetic alterations occurring in epithelial cells. It is increasingly recognized that tumour progression is also regulated by tumour microenvironment(TME). The bidirectional cross-talk between tumour resident adipocytes and cancer cells within TME has been proposed as active contributor to carcinogenesis. Tumour resident adipocytes exhibit an activated phenotype characterized by increased secretion of pro-tumorigenic factors(angiogenic/inflammatory/immune) which contribute to cancer cell proliferation, invasion, neoangiogenesis, evasion of immune surveillance and therapy resistance. Furthermore, adipocytes represent a fuel rich source for increasing energy demand of rapidly proliferating tumour cells. Interestingly, a relationship between obesity and molecular variants in CRC has recently been identified. Whether adipose tissue promotes cancer progression in subsets of molecular phenotypes or whether local tissue adipocytes are involved in inactivation of tumour suppressor genes and/or activation of oncogenes still needs to be explored. This editorial highlights the major findings related to crosstalk between adipocytes and colon cancer cells and how local paracrine interactions may promote cancer progression. Furthermore, we provide future strategies in studying colonic TME which could provide insights in bidirectional cross-talk mechanisms between adipocytes and colonic epithelial cells. This could enable to decipher critical signalling pathways of both early colonic carcinogenesis and cancer progression. | Maria Tabuso Shervanthi Homer-Vanniasinkam Raghu Adya Ramesh P Arasaradnam | 2017 | World Journal of Gastroenterology2017，23，32： | 6 |
| 2 | Neutrophil to lymphocyte ratio and albumin bilirubin grade in hepatocellular carcinoma: A systematic review显示文摘BACKGROUND Hepatocellular carcinoma(HCC)is a frequent cause of cancer related death globally.Neutrophil to lymphocyte ratio(NLR)and albumin bilirubin(ALBI)grade are emerging prognostic indicators in HCC.AIM To study published literature of NLR and ALBI over the last five years,and to validate NLR and ALBI locally in our centre as indicators of HCC survival.METHODS A systematic review of the published literature on PubMed of NLR and ALBI in HCC over the last five years.The search followed the guidelines of the preferred reporting items for systematic reviews and meta-analyses.Additionally,we also investigated HCC cases between December 2013 and December 2018 in our centre.RESULTS There were 54 studies describing the relation between HCC and NLR and 95 studies describing the relation between HCC and ALBI grade over the last five years.Our local cohort of patients showed NLR to have a significant negative relationship to survival(P=0.011).There was also significant inverse relationship between the size of the largest HCC nodule and survival(P=0.009).Median survival with alpha fetoprotein(AFP)<10 KU/L was 20 mo and with AFP>10 KU/L was 5 mo.We found that AFP was inversely related to survival,this relationship was not statically significant(P=0.132).Mean survival for ALBI grade 1 was 37.7 mo,ALBI grade 2 was 13.4 months and ALBI grade 3 was 4.5mo.ALBI grades performed better than Child Turcotte Pugh score in detecting death from HCC.CONCLUSION NLR and ALBI grade in HCC predict survival better than the conventional alpha fetoprotein.ALBI grade performs better than Child Turcotte Pugh score.These markers are done as part of routine clinical care and in cases of normal alpha fetoprotein,these markers could give a better understanding of the patient disease progression.NLR and ALBI grade could have a role in modified easier to learn staging and prognostic systems for HCC. | Ayman Bannaga Ramesh P Arasaradnam | 2020 | World Journal of Gastroenterology2020，26，33： | 2 |
| 3 | Kernel-based object tracking显示文摘 | Ramesh V Meer P | 2003 | IEEE Transactions on Pattern Analysis and Machine Intelligence2003，25，5： | 1 |
| 4 | Kernal-based objec tracking显示文摘 | COMANICIU D RAMESH V MEER P | 2003 | IEEE Trans on Pattern Analysis and Machine Inteligence2003，25，： | 1 |
| 5 | The combination of clofarabine and cytarabine in pediatric relapsed acute lymphoblastic leukemia: a case report 显示文摘 | Gidwani P Ramesh KH Liu Y | 2008 | Chemotherapy2008，54，2： | 1 |
| 6 | Can patient with dementia be assessed at a distance? The use of Telehealth and Standardized assessments 显示文摘 | Loh P K Ramesh P Marher S | 2004 | Intern Med J2004，34，5： | 1 |
| 7 | Molecular markers and their applications in wheat breeding显示文摘 | P K Gupta R K Varshney P C Sharma B Ramesh | 1999 | Plant Breeding1999，118，： | 1 |
| 8 | Simulation methods for micro electro mechanical Structures(MEMS) with application to a microtweezer显示文摘 | SHI F RAMESH P MUKHERJEE S | 1995 | Computer & structures1995，56，5： | 1 |
| 9 | Magnetite induces oxi-dative stress and apoptosis in lung epithelial cells 显示文摘 | Ramesh V Ravichandran P Copeland CL | 2012 | Mol Cell Bio-c1iem2012，363，12： | 1 |
| 10 | Kernel-ba-sed object tracking显示文摘 | Comaniciu D Ramesh V P Meer | 2003 | IEEE Trans on Pattern Analysis and Machine Intelligent2003，25，5： | 1 |
| 11 | Recent trends in the microbial production, analysis and application of fructooligosaccharides显示文摘 | SANGEETHA P T RAMESH M N PRAPULLA S G | 2005 | Trends in Food Science and Technology2005，16，： | 1 |
| 12 | The association of serum os- teocalcin with the bone mineral density in post menopausal women显示文摘 | Vs 1( K P Ramesh M | 2013 | J Clin Diagn Res2013，7，5： | 1 |
| 13 | Randomized clinical study to compare the accuracy of navigated and nonnavigated thoracic pedicle screws in deformity correction surgeries显示文摘 | Rajasekaran S Vidyadhara S Ramesh P | 2007 | Spine2007，32，2： | 1 |
| 14 | Kernel-based object tracking显示文摘 | Comaniciu D Ramesh V Meer P | 2003 | IEEE Transactions on Pattern Analysis and Machine Intelligence2003，25，5： | 1 |
| 15 | Kernel-based Object Tracking显示文摘 | COMANICIU D RAMESH V MEER P | 2003 | IEEE Transactions on Pattern Analysis Machine Intelligence2003，25，5： | 1 |
| 16 | Recovery of large prean- tral follicles from buffalo ovary:effect of season and corpus luteum显示文摘 | Gupta P S Ramesh H S Nandi S | 2007 | Anita Reprod Sci2007，101，12： | 1 |
| 17 | Carbothermal reduction and nitridation reaction of SiOx and preoxidized SiOx:formation of α-Si3N4 fibers显示文摘 | RAMESH P D RAO K J | 1994 | J Mater Res1994，9，9： | 1 |
| 18 | Preparation and physicochemical and electrochemical characterization of exfoliated graphite oxide 显示文摘 | Ramesh P Bhagyalakshmi S Sampath S | 2004 | Journal of Colloid and Interface Science2004，274，1： | 1 |
| 19 | Application of a convenient DNA extraction method and multiplex PCR for the direct detection of Staphylococcus aureus and Yersinia enterocolitica in milk samples显示文摘 | Ramesh A Padmapriya B P Chrashekar A | 2002 | Mol Cell Probes2002，16，4： | 1 |
| 20 | Polarization switching in epitaxial BiFeO3 films显示文摘 | Zavaliche F Shafer P Ramesh R | 2005 | Applied Physics Letters2005，87，25： | 1 |
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