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| 1 | Genetically modified mouse models for the study of nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD) is associated with obesity,insulin resistance,and type 2 diabetes.NAFLD represents a large spectrum of diseases ranging from(1) fatty liver(hepatic steatosis);(2) steatosis with inflammation and necrosis;to(3) cirrhosis.The animal models to study NAFLD/nonalcoholic steatohepatitis(NASH) are extremely useful,as there are still many events to be elucidated in the pathology of NASH.The study of the established animal models has provided many clues in the pathogenesis of steatosis and steatohepatitis,but these remain incompletely understood.The different mouse models can be classified in two large groups.The first one includes genetically modified(transgenic or knockout) mice that spontaneously develop liver disease,and the second one includes mice that acquire the disease after dietary or pharmacological manipulation.Although the molecular mechanism leading to the development of hepatic steatosis in the pathogenesis of NAFLD is complex,genetically modified animal models may be a key for the treatment of NAFLD.Ideal animal models for NASH should closely resemble the pathological characteristics observed in humans.To date,no single animal model has encompassed the full spectrum of human disease progression,but they can imitate particular characteristics of human disease.Therefore,it is important that the researchers choose the appropriate animal model.This review discusses various genetically modified animal models developed and used in research on NAFLD. | Perumal Nagarajan M Jerald Mahesh Kuma Ramasamy Venkatesan Subeer S Majundar Ramesh C Juyal M Jerald Mahesh Kuma | 2012 | World Journal of Gastroenterology2012，18，11： | 7 |
| 2 | Microsurgical epididymal sperm aspiration: indications, techniques and outcomes显示文摘Microsurgical epididymal 精子渴望(方山) 从被选择并且取样了使用一台操作显微镜提供的高力量的光放大的 epididymis 的最佳的区域指包含精子的液体的检索。检索精子随后被使用让 intracytoplasmic 精子注射(ICSI ) 导致授精和怀孕。方山被是为在有给它复杂并发症的优秀精子,优秀报导授精和怀孕率,和低风险的高收益的妨碍的精子缺乏的人的精子检索的标准答案技术的许多专家考虑。然而,方山必须在一个操作房间里被执行,要求 microsurgical 技巧并且为用 ICSI 的复制仅仅是有用的。此处我们在场为方山,过程的技术表演和被报导了的结果的候选人病人的评估的概述。 | Aaron M Bernie Ranjith Ramasamy Doron S Stember Peter J Stahl | 2013 | Asian Journal of Andrology2013，15，1： | 4 |
| 3 | Mesenchymal Stem Cells Inhibit Dendritic Cell Differentiation and Function by Preventing Entry Into the Cell Cycle显示文摘 | Rajesh Ramasamy Henrietta Fazekasova Eric W.-F. Lam Inês Soeiro Giovanna Lombardi Francesco Dazzi | 2007 | Transplantation2007，，1： | 2 |
| 4 | Aldose reductase inhibition protects diabetic and nondiabetic rat hearts from ischemic injury显示文摘 | Ramasamy R Oates P J Schaefer S | 1997 | Diabetes1997，46，2： | 1 |
| 5 | Fourier Transform Raman Approach to Structural Correlation in Hemoglobin Derivatives 显示文摘 | VENKATESH B RAMASAMY S MYLRAJAN M | 1999 | Spectrochimica Acta Part A: Molecular Spectroscopy1999，55，： | 1 |
| 6 | A prospective and nationwide study investigating endophthalmitls following pars plana vitrectomy:incidence and risk factors 显示文摘 | Park JC Ramasamy B Shaw S | 2014 | Br J Ophthalmol2014，98，： | 1 |
| 7 | Growth and characterization of antimony doped tin oxide thin films显示文摘 | Shanthi S Subramanian C Ramasamy P | 1999 | Journal of Crystal Growth1999，197，4： | 1 |
| 8 | Low frequency and low intensity pulsed electromagnetic field exerts its antiinflammatory effect through restoration of plasma membrane calcium ATPase activity 显示文摘 | Ramasamy Selvam Kalaivani Ganesan Narayana Raju K V S | 2007 | Life Sciences2007，80，26： | 1 |
| 9 | Expression of markers for both neuronal and glial cells in human amniotic epithelial cells显示文摘 | Ramasamy T Masashi M | 1996 | Neurosci Lett1996，209，1： | 1 |
| 10 | Growth of unidirectional potassium dihydrogen orthophosphate single crystal by SR method and its characterization 显示文摘 | Balamurugan S Bhagavannarayana G Ramasamy P | 2008 | Materials Letters2008，62，： | 1 |
| 11 | Neural stem cell survival factors 显示文摘 | RAMASAMY S NARAYANAN G SANKARAN S | 2013 | Archives of biochemistry and biophysics2013，534，12： | 1 |
| 12 | China' s outward foreign direct investment: Location choice and firm ownership 显示文摘 | Ramasamy B Yeung M Laforet S | 2012 | Journal of World Business2012，47，1： | 1 |
| 13 | Reactive oxygen species produced by macrophagederived foam cells regulate the activity of vascular matrix metalloproteinases in vitro显示文摘 | Rajagopalan S Meng XP Ramasamy S | 1996 | ] Clin Invest1996，98，11： | 1 |
| 14 | Growth and characterization of antimony doped tin oxidethin films显示文摘 | Shanthi S Subramanian C Ramasamy P | 1999 | Journal of Crystal Growth1999，197，4： | 1 |
| 15 | Glass frit overcoated silver grid lines for nano-crystalline dye sensitized solar cells显示文摘 | LEE W J RAMASAMY E LEE D Y SONG J S | 2006 | Journal of Photochemistry and Photobiology A2006，183，1： | 1 |
| 16 | Molecular changesfrom dysplastic nodule to hepatocellular carcinoma throughgene expression profiling显示文摘 | Nam S W Park J Y Ramasamy A | 2005 | Hepatology2005，42，4： | 1 |
| 17 | Modulation of expression of endothelial nitric oxide synthase by nordihydroguaiaretic acid,a phenolic antioxidant in cultured endothelial cells显示文摘 | Ramasamy S Drummond G R Ahn J | 1999 | Mol Pharmacol1999，56，1： | 1 |
| 18 | Bulk growth of < 101 > KDP crystal by Sankaranarayanan-Ramasam method and its characterization显示文摘 | Balamurugan S Ramasamy P | 2008 | Materals Chemistry and Physics2008，112，： | 1 |
| 19 | Expression of Fhit,cell adhesion molecules and matrix metalloproteinases in atypical adenomatous hyperplasia and pulmonary adenocarcinoma显示文摘 | Kerr KM Mackenzie SJ Ramasami S | 2004 | J Pathol2004，203，2： | 1 |
| 20 | Use of aquatic weed salvinia as full partial feed in commercial digesters显示文摘 | ABBASI S A NIPANEY P C RAMASAMY E V | 1992 | Indian J Technol1992，30，： | 1 |
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