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| 1 | A gist of gastrointestinal stromal tumors: A review显示文摘Gastrointestinal stromal tumors (GISTs) have been recognized as a biologically distinctive tumor type, different from smooth muscle and neural tumors of the gastrointestinal tract (GIT). They constitute the majority of gastrointestinal mesenchymal tumors of the GIT and are known to be refractory to conventional chemotherapy or radiation. They are defined and diagnosed by the expression of a proto-oncogene protein detected by immunohistochemistry which serves as a crucial diagnostic and therapeutic target. The identification of these mutations has resulted in a better understanding of their oncogenic mechanisms. The remarkable antitumor effects of the molecular inhibitor imatinib have necessitated accurate diagnosis of GIST and their distinction from other gastrointestinal mes-enchymal tumors. Both traditional and minimally invasive surgery are used to remove these tumors with minimal morbidity and excellent perioperative outcomes. The revolutionary use of specific, molecularlytargeted therapies, such as imatinib mesylate, reduces the frequency of disease recurrence when used as an adjuvant following complete resection. Neoadjuvant treatment with these agents appears to stabilize disease in the majority of patients and may reduce the extent of surgical resection required for subsequent complete tumor removal. The important interplay between the molecular genetics of GIST and responses to targeted therapeutics serves as a model for the study of targeted therapies in other solid tumors. This review summarizes our current knowledge and recent advances regarding the histogenesis, pathology, molecular biology, the basis for the novel targeted cancer therapy and current evidence based management of these unique tumors. | Ashwin Rammohan Jeswanth Sathyanesan Kamalakannan Rajendran Anbalagan Pitchaimuthu Senthil-Kumar Perumal UP Srinivasan Ravi Ramasamy Ravichandran Palaniappan Manoharan Govindan | 2013 | World Journal of Gastrointestinal Oncology2013，5，6： | 27 |
| 2 | 华北地区不同规模畜禽养殖场粪便中抗生素抗性基因污染特征显示文摘为调查华北地区畜禽养殖环境抗生素抗性基因(ARGs)污染特征及影响因素,采集河北省和天津市不同规模的养猪场和养鸡场新鲜粪便样品,分析粪便中ARGs污染水平及有机质与ARGs含量的相关性。实时荧光定量PCR结果显示,不同种类畜禽养殖场粪便ARGs的相对丰度有显著区别,鸡粪中sul和erm基因的相对丰度高于猪粪,而编码核糖体保护蛋白的tet基因(4.24×10^-3~5.85×10^-1)在猪粪和鸡粪中的相对丰度无明显差异,均显著高于sul(1.07×10^-4~2.26×10^-1)、erm(6.36×10^-4~2.62×10^-1)以及编码外派泵蛋白和酶抑制剂的tet基因(1.24×10^-4~5.41×10^-2)。不同规模的养猪场粪便ARGs污染水平趋势为:中型>大型>小型,而不同规模养鸡场粪便中ARGs相对丰度无显著性差异(P=0.551);此外,正交偏最小二乘判别(OPLS-DA)与典型相关分析(CCA)结果显示,畜禽粪便中编码核糖体保护蛋白的tet基因(tetM、tetO和tetW)相对丰度与有机碳(OC)和有机氮(ON)含量高度相关(VIP>1),sul基因则与OC/ON明显相关。综上,粪便中有机质和生物可利用碳氮比是影响畜禽养殖业ARGs污染水平的重要因素。 | 邹威 金彩霞 魏闪 Ramasamy Rajesh Kumar 周启星 | 2020 | 农业环境科学学报2020，39，11： | 17 |
| 3 | The role of estradiol in male reproductive function显示文摘传统地,睾丸激素和雌激素被认为分别地是男、女的性荷尔蒙。然而, estradiol,雌激素的占优势的表格,也在男性功能起一个关键作用。在人的 Estradiol 为 modulating 性欲,可勃起的功能,和精子发生是必要的。雌激素受体,以及 aromatase,把睾丸激素变换成雌激素的酶,充满大脑,阴茎,和睾丸,为性功能重要的机关。在大脑, estradiol 合成在与性唤起有关的区域被增加。在阴茎,另外,雌激素受体在神经与血管的捆附近与高集中在整个阴茎海绵体被发现。低睾丸激素和提高的雌激素独立于对方增加可勃起的机能障碍的发生。在睾丸,精子发生被雌激素在每水平调制,以 hypothalamus-pituitary-gonadal 轴开始,由 Leydig, Sertoli,和细菌房间列在后面,并且与 ductal 上皮, epididymis,和成熟精子完成。由 estradiol 的阴囊的房间的规定显示出两个一禁止并且 stimulatory 影响,显示剂量依赖者并且时间地的一曲复杂交响乐敏感调整。我们在这评论的目标是阐明到由看荷尔蒙的男性功能的 estradiol 的全面贡献在可勃起的功能,精子发生,和性欲上完成。 | Michael Schulster Aaron M Bernie Ranjith Ramasamy | 2016 | Asian Journal of Andrology2016，18，3： | 17 |
| 4 | Fast and interpretable classification of small X-ray diffraction datasets using data augmentation and deep neural networks显示文摘X-ray diffraction(XRD)data acquisition and analysis is among the most time-consuming steps in the development cycle of novel thin-film materials.We propose a machine learning-enabled approach to predict crystallographic dimensionality and space group from a limited number of thin-film XRD patterns.We overcome the scarce data problem intrinsic to novel materials development by coupling a supervised machine learning approach with a model-agnostic,physics-informed data augmentation strategy using simulated data from the Inorganic Crystal Structure Database(ICSD)and experimental data.As a test case,115 thin-film metalhalides spanning three dimensionalities and seven space groups are synthesized and classified.After testing various algorithms,we develop and implement an all convolutional neural network,with cross-validated accuracies for dimensionality and space group classification of 93 and 89%,respectively.We propose average class activation maps,computed from a global average pooling layer,to allow high model interpretability by human experimentalists,elucidating the root causes of misclassification.Finally,we systematically evaluate the maximum XRD pattern step size(data acquisition rate)before loss of predictive accuracy occurs,and determine it to be 0.16°2θ,which enables an XRD pattern to be obtained and classified in 5.5 min or less. | Felipe Oviedo Zekun Ren Shijing Sun Charles Settens Zhe Liu Noor Titan Putri Hartono Savitha Ramasamy Brian L.DeCost Siyu I.P.Tian Giuseppe Romano Aaron Gilad Kusne Tonio Buonassisi | 2019 | npj Computational Materials2019，，1： | 15 |
| 5 | The varicocele: diagnostic dilemmas, therapeutic challenges and future perspectives显示文摘精索静脉曲张在精索以内被定义为内部阴囊的静脉和 pampiniform venus 丛的反常膨胀。如果精液分析没从青春期的男性被获得,当另外的症状不在时,主要临床的指示由许多泌尿科医师使用了建议修理是阴囊的萎缩。精索静脉曲张可以在与损害精子引起阴囊的萎缩的一些男性导致阴囊的损坏生产和减少的 Leydig 房间工作,当在另外的男性精索静脉曲张可以看起来不引起有病的效果时。在成年的人,精索静脉曲张经常在场、通过手术可改正,还外科的修理的可测量的好处根据 Cochrane 评论是细微的。当比肥沃的人更通常发生在不肥沃的人时,仅仅,有记录精索静脉曲张的 20% 人将受不了富饶问题。在青少年发现的大多数精索静脉曲张在平淡的体格检查期间被检测,并且预言与精索静脉曲张的青春期的介绍哪个将最终在青春期或成人生活显示出减少的阴囊的功能是困难的。作为在成年人,为在青少年的精索静脉曲张的处理的支柱是外科的修正。然而,不同于成年 varicocelectomy (microsurgical 途径是最普通) ,为青春期的精索静脉曲张的处理更经常是 laparoscopic。不过,治疗的目标是在青春期、成年的病人的一样。至于病人,并且什么类型治疗,,对待开始治疗是最好的争吵遗体。这评论将介绍青春期的精索静脉曲张的病原学,诊断和治疗的当前的理解。 | Koji Chiba Ranjith Ramasamy Dolores J Lamb Larry I Lipshultz | 2016 | Asian Journal of Andrology2016，18，2： | 14 |
| 6 | Embolization of liver tumors:Past,present and future显示文摘Curative therapies for hepatocellular carcinoma(HCC),such as resection and liver transplantation,can only be applied in selected patients with early tumors.More advanced stages require local or systemic therapies.Resection of HCC offers the only hope for cure.Even in patients undergoing resection,recurrences are common.Chemoembolization,a technique combining intraarterial chemotherapy with selective tumor ischemia,has been shown by randomized controlled trials to be efficacious in the palliative setting.There is now renewed interest in transarterial embolization/transarterial chemoembolization(TACE) with regards to its use as a palliative tool in a combined modality approach,as a neoadjuvant therapy,in bridging therapy before transplantation,for symptomatic indications,and even as an alternative to resection.There have also been rapid advances in the agents being embolized trans-arterially(genes,biological response modifiers,etc.).The current review provides an evidence-based overview of the past,present and future trends of TACE in patients with HCC. | Ashwin Rammohan Jeswanth Sathyanesan Sukumar Ramaswami Anand Lakshmanan Perumal Senthil-Kumar Ulagendra Perumal Srinivasan Ravi Ramasamy Palaniappan Ravichandran | 2012 | World Journal of Radiology2012，4，9： | 11 |
| 7 | Bibliometrics: tracking research impact by selecting Lhe appropriate metrics显示文摘 | Ashok Agarwal Damayanthi Durairajanayagam Sindhuja Tatagari Sandro C Esteves Avi Harlev Ralf Henkel Shubhadeep Roychoudhury Sheryl Homa Nicolas Garrido Puchalt Ranjith Ramasamy Ahmad Majzoub Kim Dao Ly Eva Tvrda Mourad Assidi Kavindra Kesai Reecha Sharma Saleem Banihani Edmund Ko Muhammad Abu-Elmagd Jaime Gosalvez Asher Bashiri | 2016 | Asian Journal of Andrology2016，18，2： | 10 |
| 8 | Enhanced recovery after surgery protocol enhances early postoperative recovery after pancreaticoduodenectomy显示文摘Background: Enhanced recovery after surgery(ERAS) protocol is a multimodal, multidisciplinary and evidence-based approach to reduce surgical stress and enhance recovery in the postoperative period. This study aimed to analyze the outcome of ERAS protocol in patients after pancreaticoduodenectomy(PD). Methods: A total of 50 consecutive patients with pancreatic/periampullary cancer who underwent PD between January 2016 to August 2017 were included in the study. As per the institute ERAS protocol, nasogastric tube(NGT) was removed on postoperative day(POD) 1 if output was less than 200 mL and oral sips were allowed; oral liquids were allowed on POD2; semisolid diet by POD3; abdominal drain was removed on POD 4 if output was less than 100 mL with no evidence of postoperative pancreatic fistula(POPF); normal diet was allowed on POD5. Discharge criteria on POD6 were afebrile, tolerating oral normal diet, pain free and no surgery related complications(defined as per the ISGPS definitions). Results: NGT was removed on POD1 in 45(90%) patients, abdominal drain removed by POD4 in 41(82%) and 43(86%) patients were discharged on POD6. There was no 30-day postoperative mortality. Three(6%) patients had delayed gastric emptying(DGE). None had postoperative hemorrhage and POPF. Readmission rate was 8%. A significant relation was found between the length of hospital stay(LOS) with age( P < 0.05) and a marginal relation between LOS and postoperative albumin( P = 0.05). Conclusions: ERAS protocol can be safely followed in the perioperative care of patients who undergo PD. Early removal of NGT and allowing oral diet restore bowel function early. ERAS decreases the LOS and postoperative complications. | Ramasamy Mahendran Mallika Tewari Vinod Kumar Dixit Hari Shankar Shukla | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，2： | 9 |
| 9 | Effective and Efficient Feature Selection for Large-scale Data Using Bayes' Theorem显示文摘This paper proposes one method of feature selection by using Bayes theorem. The purpose of the proposed method is to reduce the computational complexity and increase the classification accuracy of the selected feature subsets. The dependence between two attributes (binary) is determined based on the probabilities of their joint values that contribute to positive and negative classification decisions. If opposing sets of attribute values do not lead to opposing classification decisions (zero probability), then the two attributes are considered independent of each other, otherwise dependent, and one of them can be removed and thus the number of attributes is reduced. The process must be repeated on all combinations of attributes. The paper also evaluates the approach by comparing it with existing feature selection algorithms over 8 datasets from University of California, Irvine (UCI) machine learning databases. The proposed method shows better results in terms of number of selected features, classi?cation accuracy, and running time than most existing algorithms. | Subramanian Appavu Alias Balamurugan Ramasamy Rajaram | 2009 | International Journal of Automation and computing2009，6，1： | 7 |
| 10 | Genetically modified mouse models for the study of nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD) is associated with obesity,insulin resistance,and type 2 diabetes.NAFLD represents a large spectrum of diseases ranging from(1) fatty liver(hepatic steatosis);(2) steatosis with inflammation and necrosis;to(3) cirrhosis.The animal models to study NAFLD/nonalcoholic steatohepatitis(NASH) are extremely useful,as there are still many events to be elucidated in the pathology of NASH.The study of the established animal models has provided many clues in the pathogenesis of steatosis and steatohepatitis,but these remain incompletely understood.The different mouse models can be classified in two large groups.The first one includes genetically modified(transgenic or knockout) mice that spontaneously develop liver disease,and the second one includes mice that acquire the disease after dietary or pharmacological manipulation.Although the molecular mechanism leading to the development of hepatic steatosis in the pathogenesis of NAFLD is complex,genetically modified animal models may be a key for the treatment of NAFLD.Ideal animal models for NASH should closely resemble the pathological characteristics observed in humans.To date,no single animal model has encompassed the full spectrum of human disease progression,but they can imitate particular characteristics of human disease.Therefore,it is important that the researchers choose the appropriate animal model.This review discusses various genetically modified animal models developed and used in research on NAFLD. | Perumal Nagarajan M Jerald Mahesh Kuma Ramasamy Venkatesan Subeer S Majundar Ramesh C Juyal M Jerald Mahesh Kuma | 2012 | World Journal of Gastroenterology2012，18，11： | 7 |
| 11 | Study on Classification Algorithms for Network Intrusion Systems显示文摘 | Saravanan Subramanian Vijay Bhanu Srinivasan Chandrasekaran Ramasamy | 2012 | 通讯和计算机(中英文版)2012，9，11： | 5 |
| 12 | Percutaneous embolization of varicocele: technique, indications, relative contraindications, and complications显示文摘为精索静脉曲张的处理有几种选择,也包括外科的修理由开或 microsurgical 途径, laparoscopy,或通过内部精子的静脉的经皮的 embolization。精索静脉曲张处理的最终的目标依靠排干睾丸的扩大静脉的吸藏。经皮的 embolization 提供快速的恢复和罐头成功地在约 90% 尝试被完成。然而,这种技术要求 interventional 放射线学的专家知识并且有 pampiniform 的潜在的严肃的复杂并发症,包括的脉管的穿孔,卷迁居,和血栓丛。这评论讨论与精索静脉曲张的经皮的 embolization 联系的普通指示,相对禁止徵候,技术细节,和风险。 | Joshua Halpern Sameer Mittal Keith Pereira Shivank Bhatia Ranjith Ramasamy | 2016 | Asian Journal of Andrology2016，18，2： | 5 |
| 13 | 间充质的干细胞的隔离和描述源于人的胎盘组织显示文摘 AIM: To explore the feasibility of placenta tissue as a reliable and efficient source for generating mesenchymal stem cells (MSC). METHODS: MSC were generated from human placenta tissue by enzymatic digestion and mechanical dissociation. The placenta MSC (PLC-MSC) were characterized for expression of cell surface markers, embryonic stem cell (ECS) gene expression and their differentiation ability into adipocytes and osteocytes. The immunosuppressive properties of PLC-MSC on resting and phytohemagglutinin (PHA) stimulated allogenic T cells were assessed by means of cell proliferation via incorporation of tritium thymidine (3H-TdR). RESULTS: The generated PLC-MSC appeared as spindle-shaped cells, expressed common MSC surface markers and ESC transcriptional factors. They also differen-tiated into adipogenic and osteogenic lineages when induced. However, continuous cultivation up to passage 15 caused changes in morphological appearance and cellular senescence, although the stem cell nature of their protein expression was unchanged. In terms of their immunosuppressive properties, PLC-MSC were unable to stimulate resting T cell proliferation; they inhibited the PHA stimulated T cells in a dose dependent manner through cell to cell contact. In our study, MSC generated from human placenta exhibited similar mesenchymal cell surface markers; MSC-like gene expression pattern and MSC-like differentiation potential were comparable to other sources of MSC. CONCLUSION: We suggest that placenta tissues can serve as an alternative source of MSC for future experimental and clinical studies. | Shalini Vellasamy Pratheep Sandrasaigaran Sharmili Vidyadaran Elizabeth George Rajesh Ramasamy | 2012 | World Journal of Stem Cells2012，4，6： | 5 |
| 14 | 世界皮革业的未来(Ⅱ)(续) 预测未来皮革的要求显示文摘随着替代型材料的发展 ,在新千年里皮革工业将面临严峻的挑战。在系统回顾制革化学及工艺技术的基础上 ,对未来皮革工业的发展进行了分析和预测 ,对一些亟待解决的问题提出了解决办法。此外 ,还从经济、环境和市场等角度为制革行业提出良好建议。 | 石碧 熊喜竹 Ramasami Thirumalachari | 2001 | 中国皮革2001，30，15： | 5 |
| 15 | 铁鞣新方法显示文摘将铁鞣与铬鞣进行了优化结合,这种鞣制技术不仅可以加工出质量上呈的皮革制品,同时又可以满足废液中铬与铁的含量低于100mg/kg的标准。此工艺制造的皮革可耐沸水试验,阐述了其鞣制技术和鞣制机理。对铁鞣法在加工山羊绒面革和绵羊全粒面服装革中出现的问题进行了研究。用扫描电镜对鞣革的结构特性进行了研究,对成革的物理机械性能及染色特性也做了分析和阐述。 | N K Chandra Babu R Karthikeyan R Ramesh Usha Ramamurthi T Ramasami 范贵洋 李彦春 | 2007 | 中国皮革2007，36，9： | 4 |
| 16 | 性腺功能减退患者的生育能力保护:研究进展显示文摘越来越多的年轻人和中年人有治疗性腺功能减退症(雄激素含量缺乏相关症状)的需求,其症状包括抑郁症,性冷淡,勃起功能障碍,疲劳。然而,睾酮补充疗法(包括使用天然和合成的类固醇)引起的睾丸功能衰退的患者人数正在增加,特别是那些年轻的运动员,外源性类固醇的使用对这些人的睾丸功能产生了消极影响。外源性睾酮治疗可以影响下丘脑垂体性腺轴的自然调节,造成生精功能受损,可能会导致严重后果,例如无精子症等男性不育症。对于那些患有性腺功能减退症的育龄男性,选择治疗方法时,保护生育能力很重要。研究显示,人绒毛膜促性腺激素(HCG)不仅可以治疗那些睾酮补充疗法引起的无精子症,还有助于维持升高的睾丸内睾酮水平。此外,选择性雌激素受体调节剂常与人绒毛膜促性腺激素联合使用治疗性腺功能减退症,该疗法不仅可以提高总睾酮水平,还有助于保护这些患者的生精功能。 | Ranjith Ramasamy Joseph M Armstrong Larry I Lipshultz | 2015 | Asian Journal of Andrology2015，17，2： | 4 |
| 17 | Microsurgical epididymal sperm aspiration: indications, techniques and outcomes显示文摘Microsurgical epididymal 精子渴望(方山) 从被选择并且取样了使用一台操作显微镜提供的高力量的光放大的 epididymis 的最佳的区域指包含精子的液体的检索。检索精子随后被使用让 intracytoplasmic 精子注射(ICSI ) 导致授精和怀孕。方山被是为在有给它复杂并发症的优秀精子,优秀报导授精和怀孕率,和低风险的高收益的妨碍的精子缺乏的人的精子检索的标准答案技术的许多专家考虑。然而,方山必须在一个操作房间里被执行,要求 microsurgical 技巧并且为用 ICSI 的复制仅仅是有用的。此处我们在场为方山,过程的技术表演和被报导了的结果的候选人病人的评估的概述。 | Aaron M Bernie Ranjith Ramasamy Doron S Stember Peter J Stahl | 2013 | Asian Journal of Andrology2013，15，1： | 4 |
| 18 | 生精障碍的疗法显示文摘与继发性睾丸衰竭相比,男性生精障碍的治疗目前大都收效甚微。从激素治疗,到补充相应营养成分(抗氧化作用),很多种疗法都被尝试过了。虽然有些研究表明某些疗法有一定的效果,但是没有任何一种疗法能够对所有患者都起效,同时又无法预测该疗法能够适用于哪类患者。先天生精障碍可能由许多不同的还未被证实的精子产生方面的缺陷引起的。深入理解这些缺陷,能够帮助我们寻求更有效的治疗方案,同时能够帮助我们筛选某种疗法的适用患者群。本文着眼于综述目前男性不育激素和抗氧化疗法的基本原理和成效,特别关注生精障碍的相关疗法。尽管目前辅助生殖技术已经大大取代了生精障碍的传统医疗方法,但二者将继续齐头并进发挥作用,相互结合共同起效。 | Ranjith Ramasamy Peter J Stahl Peter N Schlegel | 2012 | Asian Journal of Andrology2012，14，1： | 3 |
| 19 | Evaluation of antipyretic activity of ethyl acetate extract of Adenema hyssopifolium G.Don in a rat model显示文摘Objective:To evaluate the effect of ethyl acetate extract of Adenema hyssopifolium(AHEAE) on normal body temperature and brewer’s yeast-induced pyrexia rats.Methods:Preliminary phytochemical tests,acute toxicity tests and antipyretic evaluation were carried out in ethyl acetate extract of Adenoma hyssopifolium,.Two doses of the extract(300 or 600 mg/kg orally) and standard antipyretic agent,paracetamol at a dose of 150 mg/kg were administered to various group of the rats.Mean rectal temperature before and after treatment was noted.Results:The phytochemical analysis of AHEAE revealed the presence of flavonoid and iridoid glycosides as major phytoconstituents.The administration of AHEAE at a dose of 300 or 600 mg/kg produced significant reduction(P<0.001 and P<0.01) of the body temperature in normal and pyrexia rats on a dose dependent manner.The antipyretic influence of AHEAE was comparable to that of standard antipyretic agent,paracetamol(150 mg/kg),and onset of action and reduction in pyrexia towards normal body temperature was delayed when compared to paracetamol treatment.At dose of 600 mg/kg,AHEAE reduced pyrexia to normal body temperature at 4 h after its administration compared to reduction of pyrexia to normal body temperature at 2 h by standard drug.The reduction of fever was consistent in paracetamol group from 2 to 4 h after its administration to normal body temperature compared to AHEAE treatments.Conclusions:Our present results corroborate with the traditional notion of Adenema hyssopifolium G.DON that is being used as an effective cure of fever and add authenticity to claim of indigenous healers that the taxon is a potential antipyretic agent. | Aiyalu Rajasekaran Ramasamy Arivukkarasu Shanmugasundaram Murugesh | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，7： | 3 |
| 20 | 先进的扇出晶圆级封装进展显示文摘扇出WLP是在晶圆一级加工的埋置型封装,也是一个I/O数量大,集成灵活性高的主要先进封装工艺。而且,它能在一个封装内实现垂直和水平方向多芯片集成且不用衬底。这样,扇出WLP技术目前正在发展成为下一代封装技术,如多芯片、低剖面封装和3D SiP。扇出WLP不仅用于电子封装,而且用于传感器、功率IC和LED封装。本文报导作为先进封装解决方案的下一代扇出WLP的进展情况。 | Yonggang Jin Jerome Teysseyre Anandan Ramasamy Yun Liu Bing Hong Huang | 2013 | 功能材料与器件学报2013，19，4： | 3 |
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