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| 1 | Is it possible to stop nucleos(t)ide analogue treatment in chronic hepatitis B patients?显示文摘Chronic hepatitis B(CHB) remains a challenging global health problem, with nearly one million related deaths per year. Nucleos(t)ide analogue(NA) treatment suppresses viral replication but does not provide complete cure of the hepatitis B virus(HBV) infection. The accepted endpoint for therapy is the loss of hepatitis B surface antigen(HBs Ag), but this is hardly ever achieved. Therefore, indefinite treatment is usually required. Many different studies have evaluated NA therapy discontinuation after several years of NA treatment and before HBs Ag loss. The results have indicated that the majority of patients can remain off therapy, with some even reaching HBs Ag seroconversion. Fortunately, this strategy has proved to be safe, but it is essential to consider the risk of liver damage and other comorbidities and to ensure aclose follow-up of the candidates before considering this strategy. Unanswered questions remain, namely in which patients could this strategy be effective and what is the optimal time point at which to perform it. To solve this enigma, we should keep in mind that the outcome will ultimately depend on the equilibrium between HBV and the host's immune system. Viral parameters that have been described as good predictors of response in HBe Ag(+) cases, have proven useless in HBe Ag(-) ones. Since antiviral immunity plays an essential role in the control of HBV infection, we sought to review and explain potential immunological biomarkers to predict safe NA discontinuation in both groups. | Elia Moreno-Cubero Robert T Sánchez del Arco Julia Pena-Asensio Eduardo Sanz de Villalobos Joaquín Míquel Juan Ramón Larrubia | 2018 | World Journal of Gastroenterology2018，24，17： | 5 |
| 2 | Preclinical evaluation of azathioprine plus buthionine sulfoximine in the treatment of human hepatocarcinoma and colon carcinoma显示文摘AIM: To evaluate the efficacy and the safety of azathioprine (AZA) and buthionine sulfoximine (BSO) bylocalized application into HepG2 tumor in vivo.METHODS: Different hepatoma and colon carcinoma cell lines (HepG2, HuH7, Chang liver, LoVo, RKO, SW-48, SW-480) were grown in minimal essencial medium supplemented with 10% fetal bovine serum and 1% antibiotic/antimycotic solution and maintained in a humidified 37 ℃ incubator with 5% CO2. These cells were pretreated with BSO for 24 h and then with AZA for different times. We examined the effects of this combination on some proteins and on cellular death. We also studied the eff icacy and the safety of AZA (6 mg/kg per day) and BSO (90 mg/kg per day) in HepG2 tumor growth in vivo using athymic mice. We measured safety by serological markers such as aminotransferases and creatine kinase.RESULTS: The in vitro studies revealed a new mechanism of action for the AZA plus BSO combination in the cancer cells compared with other thiopurines (6-mercaptopurine, 6-methylmercaptopurine, 6-thioguanine and 6-methylthioguanine) in combination with BSO. The cytotoxic effect of AZA plus BSO in HepG2 cells resulted from necroptosis induction in a mitochondrial-dependent manner. From kinetic studies we suggest that glutathione (GSH) depletion stimulates c-Jun amino-terminal kinase and Bax translocation in HepG2 cells with subsequent deregulation of mitochondria (cytochrome c release, loss of membrane potential), and proteolysis activation leading to loss of membrane integrity, release of lactate dehydrogenase and DNA degradation. Some of this biochemical and cellular changes could be reversed by N-acetylcysteine (a GSH replenisher). In vivo studies showed that HepG2 tumor growth was inhibited when AZA was combined with BSO.CONCLUSION: Our studies suggest that a combination of AZA plus BSO could be useful for localizedtreatment of hepatocellular carcinoma as in the currently used transarterial chemoembolization method. | Borja Hernández-Breijo Jorge Monserrat Sara Ramírez-Rubio Eva P Cuevas Diana Vara Inés Díaz-Laviada M Dolores Fernández-Moreno Irene D Román Javier P Gisbert Luis G Guijarro | 2011 | World Journal of Gastroenterology2011，17，34： | 2 |
| 3 | Early experience in human hybrid transgastric and transvaginal endoscopic cholecystectomy显示文摘 | Gustavo Salinas Lil Saavedra Hellen Agurto Rosa Quispe Edwin Ramírez José Grande Juan Tamayo Victoria Sánchez Daniel Málaga Jeffrey M. Marks | 2010 | Surgical Endoscopy2010，，5： | 2 |
| 4 | Susceptibility Genetic Variants Associated With Colorectal Cancer Risk Correlate With Cancer Phenotype显示文摘 | Anna Abulí Xavier Bessa Juan Ramón González Clara Ruiz–Ponte Alejandro Cáceres Jenifer Mu?oz Victoria Gonzalo Francesc Balaguer Ceres Fernández–Rozadilla Dolors González Luisa de Castro Juan Clofent Luís Bujanda Joaquín Cubiella Josep M a Re?é Juan Diego | 2010 | Gastroenterology2010，，3： | 2 |
| 5 | 外科减肥手术后高血压缓解和复发的预测因素显示文摘目前,只有很少量研究涉及外科减肥手术后高血压得到缓解和复发的影响因素,没有可用于预测高血压复发相关因素的信息。该研究的目的是评估在外科减肥手术后第1年和第3年里高血压的缓解情况和复发率,并寻找可能的预测因素。 | Benaiges D Sagué M Flores-Le Roux JA Pedro-Botet J Ramón JM Villatoro M Chillarón JJ Pera M Más A Grande L Goday A 陈云 | 2016 | 中华高血压杂志2016，24，9： | 2 |
| 6 | Maintenance treatment with Pegylated liposomal doxorubicin versus observation following induction chemotherapy for metastatic breast cancer: GEICAM 2001-01 study显示文摘 | Emilio Alba Manuel Ruiz-Borrego Mireia Margelí álvaro Rodríguez-Lescure Pedro Sánchez-Rovira Amparo Ruiz Jose Ramón Mel-Lorenzo Manuel Ramos-Vázquez Nuria Ribelles Elisa Calvo Antonio Casado Antonia Márquez David Vicente José Angel García-Sáenz Miguel Mar | 2010 | Breast Cancer Research and Treatment2010，，1： | 2 |
| 7 | Optical and electrochemical properties of poly(o-toluidine) multiwalled carbon nanotubes composite Langmuir - schaefer films显示文摘 | BAVASTRELLO V CARRARA S RAM M K | 2004 | Langmuir2004，20，： | 1 |
| 8 | Synthesis and Characterization of Some Transition Metal Complexes of N-( 2- Hydroxyl -Naphthylidene) Amino Acids显示文摘 | Praveen K S Ram N H Bhowon M G | 1996 | Inorg Met Org Chem1996，26，7： | 1 |
| 9 | A simple method of DNA extraction from coffee seeds suitable for PCR analysis显示文摘 | MISHRA M K RANI N S RAM A S | 2008 | Biotechnol2008，7，4： | 1 |
| 10 | Orthogonality and partial pole assignment for the symmetric definite quadratic pencil显示文摘 | Datta B N Elhay S Ram Y M | | 0，，： | 1 |
| 11 | A comparison of modeling and imaginary in the acqui- sition and retention of motor skills 显示文摘 | Ram N Riggs S M Landers D M McCullagh P | 2007 | Journal of Sports Sciences2007，25，5： | 1 |
| 12 | Human C4b-binding protein selectively interacts with Neisseria gonorrhoeae and results in species-specific infection显示文摘 | Ngampasutadol J Ram S Biota A M | 2005 | Proc Natl Acad Sci USA2005，102，17： | 1 |
| 13 | Influence of dietary HUFA levels on reproductive performance, tissue fatty acid profile and desaturase and elongase mRNAs expression in female zebrafish( Danio rerio) 显示文摘 | Jaya - Ram A Kuah M K Lim P S | 2008 | Aquaculture2008，277，： | 1 |
| 14 | Pole assignment in vibratory systems by multi-input control显示文摘 | Ram Y M Elhay S | | 0，，02： | 1 |
| 15 | Antivirals for management of herpes zoster including ophthalmicus: a systematic review of high-quality randomized controlled trials 显示文摘 | McDonald E M de Kock J Ram F S | 2012 | Antivir Ther2012，17，2： | 1 |
| 16 | Origin and basipetal transport of the IAA reponsible for rooting of carnation cuttings显示文摘 | Garrido G Ramón Guerrero J Angel Cano E Acosta M Sánchez-Bravo J | 2002 | Physiologia Plantarum2002，114，2： | 1 |
| 17 | The anti- fungal protein AFP from Aspergillus giganteus inhibits chitin synthesis in sensitive fungi 显示文摘 | Hagen S Florentine M Ram A F Meyer V | 2007 | Appl Environ Microbiol2007，73，7： | 1 |
| 18 | Outcome of cataract surgery with primary intraocularlens implantation in children 显示文摘 | RAM J GUPTA N SUKHIJA JS CHAUDHARY M VERMA N KUMAR S | 2011 | Br J Ophthal- mol2011，95，6： | 1 |
| 19 | Influence of an organic mulching on fertilizer nitrogen use efficiency and herb and essential oil yields in geranium (Pelargonium graveolens)显示文摘 | Ram M Ram D Roy S K | 2005 | Bioresource Technology2005，87，3： | 1 |
| 20 | Enterococci in river Ganga surface waters: propensity of species distribution, dissemination of antimicrobial-resistance and virulence-markers among species along landscape显示文摘 | Lata P Ram S Agrawal M | 2009 | BMC Microbiology2009，9，： | 1 |
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