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| 1 | Biliary Drainage in Patients With Unresectable, Malignant Obstruction Where ERCP Fails: Endoscopic Ultrasonography-Guided Choledochoduodenostomy Versus Percutaneous Drainage显示文摘 | Everson L.A. Artifon Dayse Aparicio Jose B. Paione Simon K. Lo Andre Bordini Carolina Rabello Jose P. Otoch Kapil Gupta | 2012 | Journal of Clinical Gastroenterology2012，，9： | 5 |
| 2 | Distribution of the P2X2 receptor and chemical coding in ileal enteric neurons of obese male mice(ob/ob)显示文摘AIM:To investigate the colocalization,density and profile of neuronal areas of enteric neurons in the ileum of male obese mice.METHODS:The small intestinal samples of male mice in an obese group(OG)(C57BL/6J ob/ob)and a control group(CG)(+/+)were used.The tissues were analyzed using a double immunostaining technique for immunoreactivity(ir)of the P2X2 receptor,nitric oxide synthase(NOS),choline acetyl transferase(ChAT)and calretinin(Calr).Also,we investigated the density and profile of neuronal areas of the NOS-,ChAT-and Calrir neurons in the myenteric plexus.Myenteric neurons were labeled using an NADH-diaphorase histochemical staining method.RESULTS:The analysis demonstrated that the P2X2receptor was expressed in the cytoplasm and in the nuclear and cytoplasmic membranes only in the CG.Neuronal density values(neuron/cm2)decreased 31%(CG:6579±837;OG:4556±407)and 16.5%(CG:7796±528;OG:6513±610)in the NOS-ir and calretininir neurons in the OG,respectively(P<0.05).Density of ChAT-ir(CG:6200±310;OG:8125±749)neurons significantly increased 31%in the OG(P<0.05).Neuron size studies demonstrated that NOS,ChAT,and Calr-ir neurons did not differ significantly between the CG and OG groups.The examination of NADH-diaphorase-positive myenteric neurons revealed an overall similarity between the OG and CG.CONCLUSION:Obesity may exert its effects by promoting a decrease in P2X2 receptor expression and modifications in the density of the NOS-ir,ChAT-ir and CalR-ir myenteric neurons. | Márcia Sanae Mizuno Amanda Rabello Crisma Primavera Borelli Bárbara Tavares Schfer Mariana Póvoa Silveira Patricia Castelucci | 2014 | World Journal of Gastroenterology2014，20，38： | 3 |
| 3 | Photodegradation of polypropylene containing a nucleating agent显示文摘 | M S Rabello | 1997 | J Appl Polym Sci1997，64，： | 2 |
| 4 | Expression of the P2X_2 receptor in different classes of ileum myenteric neurons in the female obese ob/ob mouse显示文摘AIM:To examine whether the ob/ob mouse model of obesity is accompanied by enteric nervous system ab-normalities such as altered motility METHODS:The study examined the distribution of the P2X 2 receptor (P2X 2 R) in myenteric neurons of female ob/ob mice. Specifically, we used immunohistochemistry to analyze the co-expression of the P2X 2 R with neuronal nitric oxide synthase (nNOS), choline acetyltrans-ferase (ChAT), and calretinin (CalR) in neurons of the small intestine myenteric plexus in ob/ob and control female mice In these sections, we used scanning confocal microscopy to analyze the co-localization of these markers as well as the neuronal density (cm 2 ) and area profile (μm2) of P2X 2 R-positive neurons In addition, enteric neurons were labeled using the nicotinamide adenine dinucleotide (NA H) diaphorase method and analyzed with light microscopy as an alternate means by which to analyze neuronal density and areaRESULTS:In the present study, we observed a 29 6% increase in the body weight of the ob/ob animals (OG) compared to the control group (CG) In addition, the average small intestine area was increased by approxi-mately 29 6% in the OG compared to the CG Immu-noreactivity (IR) for the P2X 2 R, nNOS, ChAT and CalR was detectable in the myenteric plexus, as well as in the smooth muscle, in both groups This IR appeared to be mainly cytoplasmic and was also associated with the cell membrane of the myenteric plexus neurons, where it outlined the neuronal cell bodies and their processes P2X 2 R-IR was observed to co-localize 100% with that for nNOS, ChAT and CalR in neurons of both groups In the ob/ob group, however, we observed that the neuronal density (neuron/cm 2 ) of P2X 2 R-IR cells was in-creased by 62% compared to CG, while that of NOS-IR and ChAT-IR neurons was reduced by 49% and 57%, respectively, compared to control mice The neuronal density of CalR-IR neurons was not different between the groups Morphometric studies further demonstrated that the cell body profile area (μm2) of nNOS-IR, ChAT-IR and CalR-IR neurons was increased by 34%, 20% and 55%, respectively, in the OG compared to controls Staining for NA H diaphorase activity is widely used to detect alterations in the enteric nervous system; however, our qualitative examination of NA H-diaphorase positive neurons in the myenteric ganglia revealed an overall similarity between the two groups CONCLUSION:We demonstrate increases in P2X2R expression and alterations in nNOS, ChAT and CalR IR in ileal myenteric neurons of female ob/ob mice compared to wild-type controls. | Márcia Sanae Mizuno Amanda Rabello Crisma Primavera Borelli Patricia Castelucci | 2012 | World Journal of Gastroenterology2012，18，34： | 2 |
| 5 | CAR-T cells: Early successes in blood cancer and challenges in solid tumors显示文摘New approaches to cancer immunotherapy have been developed, showing the ability to harness the immune system to treat and eliminate cancer. For many solid tumors, therapy with checkpoint inhibitors has shown promise. For hematologic malignancies, adoptive and engineered cell therapies are being widely developed, using cells such as T lymphocytes, as well as natural killer(NK) cells, dendritic cells, and potentially others. Among these adoptive cell therapies, the most active and advanced therapy involves chimeric antigen receptor(CAR)-T cells, which are T cells in which a chimeric antigen receptor is used to redirect specificity and allow T cell recognition, activation and killing of cancers, such as leukemia and lymphoma. Two autologous CAR-T products have been approved by several health authorities,starting with the U.S. Food and Drug Administration(FDA) in 2017. These products have shown powerful, inducing, long-lasting effects against B cell cancers in many cases. In distinction to the results seen in hematologic malignancies, the field of using CAR-T products against solid tumors is in its infancy. Targeting solid tumors and trafficking CAR-T cells into an immunosuppressive microenvironment are both significant challenges. The goal of this review is to summarize some of the most recent aspects of CAR-T cell design and manufacturing that have led to successes in hematological malignancies, allowing the reader to appreciate the barriers that must be overcome to extend CAR-T therapies to solid tumors successfully. | Hassan Dana Ghanbar Mahmoodi Chalbatani Seyed Amir Jalali Hamid Reza Mirzaei Stephan A.Grupp Eloah Rabello Suarez Catarina Raposo Thomas J.Webster | 2021 | Acta Pharmaceutica Sinica B2021，11，5： | 2 |
| 6 | Critically ill patients with cancer and sepsis :clinical course and prog- nostic factors显示文摘 | Rosolem MM Rabello LS Lisboa T | 2012 | J Crit Care2012，27，3： | 1 |
| 7 | The impact of coagulation parameters on the outcomes of patients with severe community-acquired pneumonia requiring intensive care unit admission显示文摘 | Salluh JI Rabello LS Rosolem MM | 2011 | J Crit Care2011，26，5： | 1 |
| 8 | Effect of dietary metabolizable energy on energymetabolism and performance in broiler chickens 显示文摘 | SAKOMURA N K LONGO F A RABELLO C B V | 2004 | Revista Brasileira de Zootecnia2004，33，6： | 1 |
| 9 | Detection by polymerase chain reaction of Schistosoma mansoni DNA in human serum and feces显示文摘 | Pontes LA Dias-Neto E Rabello A | 2002 | Am J Trop Med Hyg2002，66，： | 1 |
| 10 | Diagnosing schistosomiasis:where are we ? 显示文摘 | Gomes LI Enk MJ Rabello A | 2014 | Rev Soc Bras Med Trop2014，，47： | 1 |
| 11 | Stability of asynchronous dynamical systems with rate constraints and applications显示文摘 | Rabello A Bhaya | 2003 | IEE Proc Control Theory2003，150，5： | 1 |
| 12 | MicroRNA-21 integrates pathogenic signaling to control pulmonary hypertension: results of a network bioinformatics approach 显示文摘 | Parikh VN Jin RC Rabello S | 2012 | Circulation2012，125，12： | 1 |
| 13 | Humoral immune responses in acute schistosomiasis mansoni : relation to morbidity 显示文摘 | Rabello AT Garcia M da Silva P | 1995 | Clin Inf Dis1995，21，3： | 1 |
| 14 | Metabolizable energy requirements for mainte-nance and growth of broilers显示文摘 | LONGO F A ’ SAKOMURA N K RABELLO CB-V | 2006 | Revista Brasileira deZootecnia2006，35，1： | 1 |
| 15 | Stability of Asynchronous Dynamical Systems with Rate Constraints and Applications显示文摘 | Rabello A Bhaya A | 2003 | Control Theory Applications2003，150，5： | 1 |
| 16 | Detection by polymerase chain reaction of Schistosoma rnansoni DNA in human serum and faeces显示文摘 | Pontes LA Dias-Neto E Rabello A | 2002 | Am J Trop Med Hyg2002，66，： | 1 |
| 17 | Sexual activity after myo- cardial infarction:Taboo or lack of knowledge显示文摘 | Lunelli RP Rabello ER Stein R | 2008 | Arq Bras Cardi ol2008，90，3： | 1 |
| 18 | MicroRNA-21integrates pathogenic signaling to control pulmonary hypertension:results of a network bioinformatics approach显示文摘 | Parikh VN Jin RC Rabello S | 2012 | Circulation2012，125，12： | 1 |
| 19 | Update on hypertrophic scar treatment显示文摘 | Rabello FB Souza CD Farina Jt~nior JA | 2014 | Clinics (Sao Paulo)2014，69，8： | 1 |
| 20 | Update on hypertrophicscar treatment 显示文摘 | Rabello FB Souza CD Farina Jfinior JA | 2014 | Clinics (San Paulo)2014，69，8： | 1 |
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