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| 1 | Navigating the dynamic landscape of alpha-synuclein morphology: a review of the physiologically relevant tetrameric conformation显示文摘N-acetylatedα-synuclein(αSyn)has long been established as an intrinsically disordered protein associated with a dysfunctional role in Parkinson’s disease.In recent years,a physiologically relevant,higher order conformation has been identified as a helical tetramer that is tailored by buried hydrophobic interactions and is distinctively aggregation resistant.The canonical mechanism by which the tetramer assembles remains elusive.As novel biochemical approaches,computational methods,pioneering purification platforms,and powerful imaging techniques continue to develop,puzzling information that once sparked debate as to the veracity of the tetramer has now shed light upon this new counterpart inαSyn neurobiology.Nuclear magnetic resonance and computational studies on multimericαSyn structure have revealed that the protein folding propensity is controlled by small energy barriers that enable large scale reconfiguration.Alternatively,familial mutations ablate tetramerization and reconfigure polymorphic fibrillization.In this review,we will discuss the dynamic landscape ofαSyn quaternary structure with a focus on the tetrameric conformation. | Heather R.Lucas Ricardo D.Fernández | 2020 | Neural Regeneration Research2020，15，3： | 1 |
| 2 | General Equilibrium Analysis of the Eaton-Kortum Model of International Trade显示文摘 | F.Alvarez R.Lucas Jr | | 0，，06： | 1 |
| 3 | 无需地面控制点的空中三角测量显示文摘引言由十八颗卫星组成的卫星系统全面展开工作以后,实时航空导航将成为全球定位系统(GPS)的一个重要功能。预计实时导航的精度将达到数十米量级,这对多种测图应用来说,可能是适当的。在控制点稀少或没有控制点的边远地区,进行这种精度级别的空中三角测量,或许会成为一种重要的需求。不过本文谈及的。 | James R.Lucas 郭宝月 | 1989 | 测绘科学1989，20，3： | 0 |
| 4 | GPS综合导航和姿态确定系统(GINAS)显示文摘欧洲哥伦布(Columbu s)自由飞行试验室以7km/s的速度绕地球轨道飞行时,利用全球定位系统(GPS)可不依靠地面,在星上确定其瞬时位置,精度优于100m。欧洲航天飞机赫尔姆斯(Hermes)与哥伦布飞行单元进行交会机动时,它们也要利用GPS的测量数据去计算交会的距离。赫尔姆斯首次执行其飞行任务时,将不采用星上导航手段,而准备使用GPS导航技术为首次飞行任务和着陆提供导航。本文介绍在欧洲空间研究和技术中心(ESTEC)无线导航试验实验室进行的GPS现场测量实验。实验中采用了一种新型的GPS综合导航和姿态确定系统(GINAS)。 | R.Lucas M.Martin-Neira 张舜英 | 1994 | 控制工程(北京)1994，，2： | 0 |
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