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| 1 | 肝内胆管细胞癌诊断及治疗的现状与挑战显示文摘肝内胆管细胞癌(intrahepatic cholangiocarcinoma,ICC)是一类起源于肝内胆管上皮细胞的恶性肿瘤。ICC发病较隐匿,早期无明显的临床症状,临床上尚缺少特异度高的早期筛查诊断标志物,很多患者在发现时已进展到中晚期,失去采取根治性切除术治疗的机会;即使手术切除,复发及转移等诸多因素也会导致ICC患者病死率高、远期生存预后差的局面。国际上尚无成熟的ICC个体化精准治疗推荐策略,现有的分期及预后模型主要基于手术切除的患者所创建,缺少普适性,临床应用受限。因此提高ICC患者早期确诊率、制定精准的治疗策略、探索预后风险因素是临床改善生存结局的途径。本文结合ICC研究进展,分析了ICC的诊断和治疗现状以及面临的挑战。 | 张宁 卢姗姗 Rifaat Safadi Roberts R.Lewis 陆荫英 | 2018 | 传染病信息2018，31，1： | 8 |
| 2 | Meta‐analysis: deamidated gliadin peptide antibody and tissue transglutaminase antibody compared as screening tests for coeliac disease显示文摘 | N. R.LEWIS B. B.SCOTT | 2009 | Alimentary Pharmacology & Therapeutics2009，，： | 2 |
| 3 | Characterisation of Contact Pressure Distribution in Bolted Joints显示文摘 | M. B.Marshall R.Lewis R. S.Dwyer‐Joyce | 2006 | Strain2006，，1： | 1 |
| 4 | Systematic review: the use of serology to exclude or diagnose coeliac disease (a comparison of the endomysial and tissue transglutaminase antibody tests)显示文摘 | N. R.LEWIS B. B.SCOTT | 2006 | Alimentary Pharmacology & Therapeutics2006，，1： | 1 |
| 5 | Technological Change and the Boundaries of the Firm显示文摘 | Tracy R.Lewis E.M.Sappington | | 0，，： | 1 |
| 6 | Forecasting of in situ electron energy loss spectroscopy显示文摘Forecasting models are a central part of many control systems,where high-consequence decisions must be made on long latency control variables.These models are particularly relevant for emerging artificial intelligence(AI)-guided instrumentation,in which prescriptive knowledge is needed to guide autonomous decision-making.Here we describe the implementation of a long short-term memory model(LSTM)for forecasting in situ electron energy loss spectroscopy(EELS)data,one of the richest analytical probes of materials and chemical systems.We describe key considerations for data collection,preprocessing,training,validation,and benchmarking,showing how this approach can yield powerful predictive insight into order-disorder phase transitions.Finally,we comment on how such a model may integrate with emerging AI-guided instrumentation for powerful high-speed experimentation. | Nicholas R.Lewis Yicheng Jin Xiuyu Tang Vidit Shah Christina Doty Bethany E.Matthews Sarah Akers Steven R.Spurgeon | 2022 | npj Computational Materials2022，，1： | 1 |
| 7 | Meta‐analysis: deamidated gliadin peptide antibody and tissue transglutaminase antibody compared as screening tests for coeliac disease显示文摘 | N. R.LEWIS B. B.SCOTT | 2009 | Alimentary Pharmacology & Therapeutics2009，，1： | 1 |
| 8 | Antagonizing the irreversible thrombomodulin-initiated proteolytic signaling alleviates age-related liver fibrosis via senescent cell killing显示文摘Cellular senescence is a stress-induced,stable cell cycle arrest phenotype which generates a pro-inflammatory microenvironment,leading to chronic inflammation and age-associated diseases.Determining the fundamental molecular pathways driving senescence instead of apoptosis could enable the identification of senolytic agents to restore tissue homeostasis.Here,we identify thrombomodulin(THBD)signaling as a key molecular determinant of the senescent cell fate.Although normally restricted to endothelial cells,THBD is rapidly upregulated and maintained throughout all phases of the senescence program in aged mammalian tissues and in senescent cell models.Mechanistically,THBD activates a proteolytic feed-forward signaling pathway by stabilizing a multi-protein complex in early endosomes,thus forming a molecular basis for the irreversibility of the senescence program and ensuring senescent cell viability.Therapeutically,THBD signaling depletion or inhibition using vorapaxar,an FDA-approved drug,effectively ablates senescent cells and restores tissue homeostasis in liver fibrosis models.Collectively,these results uncover proteolytic THBD signaling as a conserved pro-survival pathway essential for senescent cell viability,thus providing a pharmacologically exploitable senolytic target for senescence-associated diseases. | Christopher C.Pan Raquel Maeso-Díaz Tylor R.Lewis Kun Xiang Lianmei Tan Yaosi Liang Liuyang Wang Fengrui Yang Tao Yin Calvin Wang Kuo Du De Huang Seh Hoon Oh Ergang Wang Bryan Jian Wei Lim Mengyang Chong Peter B.Alexander Xuebiao Yao Vadim Y.Arshavsky Qi-Jing Li Anna Mae Diehl Xiao-Fan Wang | 2023 | Cell Research2023，33，7： | 0 |
| 9 | 宗教宣传中“发展最快”的悖论及其解释——以摩门教在西方发达国家的发展为例显示文摘以摩门教为代表的一些新兴宗教自称是“世界上增长最快的宗教”,这种说法暗含的逻辑是将增长速度与信仰的真理性等价。本文从现实和逻辑两方面揭示了其中的矛盾:多国人口普查数据证实,如此宣传的这些宗教并没有发展速度上的优势;通过逻辑论证发现,这种数量上的宣传没有神学依据且与其神学理论相悖。悖论的产生是宗教多元化环境和信徒选择宗教时非理性状态共同作用的结果,这种作用使宗教的救赎意义在多元竞争中异化成为灵性产品。 | 覃俊辉 | 2022 | 科学与无神论2022，，2： | 0 |
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