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| 1 | Influences of occlusal and skeletal discrepancies on biomechanical environment in the TMJ during maximum clenching: an analytic approach with the finite element method显示文摘 | E.Tanaka M.Tanaka M.Watanabe R.Del Pozo K.Tanne | 2008 | Journal of Oral Rehabilitation2008，，： | 1 |
| 2 | STING regulates BCR signaling in normal and malignant B cells显示文摘STING is an endoplasmic reticulum(ER)-resident protein critical for sensing cytoplasmic DNA and promoting the production of type Ⅰ interferons;however,the role of STING in B cell receptor(BCR)signaling remains unclear.We generated STING V154M knock-in mice and showed that B cells carrying constitutively activated STING specifically degraded membrane-bound IgM,Ig a and Igβ via SEL1L/HRD1-mediated ER-associated degradation(ERAD).B cells with activated STING were thus less capable of responding to BCR activation by phosphorylating Igα and Syk than those without activated STING.When immunized with T-independent antigens,STING V154M mice produced significantly fewer antigen-specific plasma cells and antibodies than immunized wild-type(WT)mice.We further generated B cell-specific STING^(KO) mice and showed that STING^(KO) B cells indeed responded to activation by transducing stronger BCR signals than their STING-proficient counterparts.When B cell-specific STING^(KO) mice were T-independently immunized,they produced significantly more antigen-specific plasma cells and antibodies than immunized STIN^(WT)mice.Since both human and m ouse IGHV-unmutated malignant chronic lymphocytic leukemia(CLL)cells downregulated the expression of STING,we explored whether STING downregulation could contribute to the well-established robust BCR signaling phenotype in malignant CLL cells.We generated a STING-deficient CLL mouse model and showed that STING-deficient CLL cells were indeed more responsive to BCR activation than their STING-proficient counterparts.These results revealed a novel B cell-intrinsic role of STING in negatively regulating BCR signaling in both normal and malignant B cells. | Chih-Hang Anthony Tang Avery C.Lee Shiun Chang Qin Xu Andong Shao Yun Lo Walker T.Spalek Javier A.Pinilla-lbarz Juan R.Del Valle Chih-Chi Andrew Hu | 2021 | Cellular & Molecular Immunology2021，18，4： | 0 |
| 3 | LDH conversion films for active protection of AZ31 Mg alloy显示文摘Zinc aluminium(Zn-Al)and lithium aluminium(Li-Al)–layered double hydroxides(LDH)coatings with incorporated inhibitors(Li-,Mo-and W-based)were successfully synthesized on AZ31 Mg alloy.Zn-Al LDH W and Li-Al LDH Li showed the highest corrosion resistance and were selected for further evaluation.SEM cross-section examination revealed a bi-layer structure composed of an outer part with loose flakes and a denser inner layer.XRD,FTIR,and XPS analysis confirmed the incorporation of the inhibitors.Post-treatments with corrosion inhibitors containing solutions resulted in the selective dissolution of the most external layer of the LDH coating,reducing the surface roughness,hydrophilicity and paint adhesion of the layers.Active corrosion properties were confirmed by SVET evaluation for the Zn-Al LDH W coating.The proposed active corrosion mechanism involves the ion-exchange of aggressive Cl-ions,deposition of hydroxides and competitive adsorption of W-rich corrosion inhibitors. | B.Pillado B.Mingo R.del Olmo E.Matykina A.M.Kooijman Y.Gonzalez−Garcia R.Arrabal M.Mohedano | 2023 | Journal of Magnesium and Alloys2023，11，1： | 0 |
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