5篇
您的检索式：作者名="R.Campbell"
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| 1 | MARKET SIZE MATTERS显示文摘 | Jeffrey R.Campbell Hugo A.Hopenhayn | 2005 | The Journal of Industrial Economics2005，，1： | 1 |
| 2 | The prevalence of, and molecular defects underlying, inherited protein S deficiency in the general population显示文摘 | Nicholas J.Beauchamp Anne C.Dykes NirzariParikh R.Campbell Tait Martina E.Daly | 2004 | British Journal of Haematology2004，，5： | 1 |
| 3 | 评价植酸酶的活性首先应了解所用的测定方法显示文摘在进行植酸酶活性的化学分析时存在着许多可影响分析结果的因素,这些因素并不会以一种并行和同步的方式影响所有的植酸酶。因此,要正确评价植酸酶活性首先应了解所采用的分析方法。 | 方正锋 Nelson E.Ward Donnie R.Campbell | 2008 | 国外畜牧学(猪与禽)2008，28，1： | 0 |
| 4 | Refinement of saliva microRNA biomarkers for sports-related concussion显示文摘Background:Recognizing sport-related concussion(SRC)is challenging and relies heavily on subjective symptom reports.An objective,biological marker could improve recognition and understanding of SRC.There is emerging evidence that salivary micro-ribonucleic acids(miRNAs)may serve as biomarkers of concussion;however,it remains unclear whether concussion-related miRNAs are impacted by exercise.We sought to determine whether40 miRNAs previously implicated in concussion pathophysiology were affected by participation in a variety of contact and non-contact sports.Our goal was to refine a miRNA-based tool capable of identifying athletes with SRC without the confounding effects of exercise.Methods:This case-control study harmonized data from concussed and non-concussed athletes recruited across 10 sites.Levels of salivary miRNAs within 455 samples from 314 individuals were measured with RNA sequencing.Within-subjects testing was used to identify and exclude miRNAs that changed with either(a)a single episode of exercise(166 samples from 83 individuals)or(b)season-long participation in contact sports(212 samples from 106 individuals).The miRNAs that were not impacted by exercise were interrogated for SRC diagnostic utility using logistic regression(172 samples from 75 concussed and 97 non-concussed individuals).Results:Two miRNAs(miR-532-5p and miR-182-5p)decreased(adjusted p<0.05)after a single episode of exercise,and 1 miRNA(miR-4510)increased only after contact sports participation.Twenty-three miRNAs changed at the end of a contact sports season.Two of these miRNAs(miR-26b-3p and miR-29c-3p)were associated(R>0.50;adjusted p<0.05)with the number of head impacts sustained in a single football practice.Among the 15 miRNAs not confounded by exercise or season-long contact sports participation,11 demonstrated a significant difference(adjusted p<0.05)between concussed and non-concussed participants,and 6 displayed moderate ability(area under curve>0.70)to identify concussion.A single ratio(miR-27a-5p/miR-30a-3p)displayed the highest accuracy(AUC=0.810,sensitivity=82.4%,specificity=73.3%)for differentiating concussed and non-concussed participants.Accuracy did not differ between participants with SRC and non-SRC(z=0.5,p=0.60).Conclusion:Salivary miRNA levels may accurately identify SRC when not confounded by exercise.Refinement of this approach in a large cohort of athletes could eventually lead to a non-invasive,sideline adjunct for SRC assessment. | Steven D.Hicks Cayce Onks Raymond Y.Kim Kevin J.Zhen Jayson Loeffert Andrea C.Loeffert Robert P.Olympia Gregory Fedorchak Samantha DeVita Zofia Gagnon Callan McLoughlin Miguel M.Madeira Scott L.Zuckerman Timothy Lee Matthew Heller Chuck Monteith Thomas R.Campbell Christopher Neville Elise Fengler Michael N.Dretsch | 2023 | Journal of Sport and Health Science2023，12，3： | 0 |
| 5 | 培养的血管平滑肌细胞表型转变过程中张力纤维及中间丝变化的扫描电镜观察显示文摘为揭示体外培养的血管平滑肌细胞(VSMC)在表型转变过程中张力纤维及中间丝三维构筑的变化,采用Triton消化和扫描电镜技术,对不同表型的VSMC进行了观察。结果证实,收缩型VSMC胞质中含大量平行排列的张力纤维;中问丝则密布于张力纤维之间,形成支撑和连接张力纤维的复杂网络。随着VSMC由收缩型向合成型转变,胞核附近的中间丝逐渐向细胞周边胞质分布,以至核周出现明显的“中间丝稀疏区”。张力纤维亦逐渐分解变细,且在部分合成型VSMC中完全消失。本文对上述变化的可能机制进行了讨论。 | 宋健 万瑜 Gordon R.Campbell Julie H.Campbell | 1997 | 解剖与临床1997，2，3： | 0 |
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